PharmaCoNets

PharmaCoNets of Terbinafine (S_PCN: 3.15 )

Terbinafine regulated-network (S_DN: 2.00)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Terbinafine

Oxidative phosphorylation

3.37E-02

2

Q16718, Q13488

NDUFA5, TCIRG1

Terbinafine

Pantothenate and CoA biosynthesis

1.15E-02

2

O95498, Q9NRN7

VNN2, AASDHPPT

Terbinafine

Ubiquitin mediated proteolysis

3.44E-02

4

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Terbinafine

Phagosome

2.57E-02

4

Q15080, P14598, Q13488, O60603

NCF4, NCF1, TCIRG1, TLR2

Terbinafine

Necroptosis

2.34E-02

4

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Terbinafine

Neurotrophin signaling pathway

3.27E-02

3

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Terbinafine

Non-alcoholic fatty liver disease

2.74E-02

3

P01375, P49841, P48023

TNF, GSK3B, FASLG

Terbinafine

Type I diabetes mellitus

1.87E-02

2

P48023, P01375

FASLG, TNF

Terbinafine

Leishmaniasis

1.09E-02

4

P14598, P42224, O60603, Q15080

NCF1, STAT1, TLR2, NCF4

Terbinafine

African trypanosomiasis

2.72E-02

2

P01375, P48023

TNF, FASLG

Terbinafine

Hepatitis C

1.27E-02

4

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Terbinafine

Rheumatoid arthritis

2.00E-02

3

Q13488, P10747, O60603

TCIRG1, CD28, TLR2

Terbinafine

Allograft rejection

2.72E-02

2

P48023, P01375

FASLG, TNF

Terbinafine

Graft-versus-host disease

3.70E-02

2

P48023, P01375

FASLG, TNF

Community members of Terbinafine (S_DC: 1.57)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

RLBP1

RetinaldehydeNonebinding protein 1

0

0.084

0.1062

0

0.2543

DRD2

D(2) dopamine receptor

0

0.0604

1

0.4779

2.5081

This pair is Reported in Drugbank.

Gene name	UniProt_ID	Bioactivity	Value (nM)