PharmaCoNets of Terazosin (SPCN: 73.87 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Terazosinhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Terazosinhsa00053Ascorbate and aldarate metabolism5.61E-032P51648, Q9UEF7ALDH3A2, KLMore
Terazosinhsa00280Valine, leucine and isoleucine degradation4.55E-022P21953, P51648BCKDHB, ALDH3A2More
Terazosinhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Terazosinhsa00630Glyoxylate and dicarboxylate metabolism5.34E-032P40925, P15104MDH1, GLULMore
Terazosinhsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Terazosinhsa00970Aminoacyl-tRNA biosynthesis1.09E-022O95363, Q15046FARS2, KARSMore
Terazosinhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Terazosinhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Terazosinhsa01524Platinum drug resistance4.78E-021P31751AKT2More
Terazosinhsa02010ABC transporters4.48E-021Q8IZY2ABCA7More
Terazosinhsa03020RNA polymerase1.31E-022P24928, P62487POLR2A, POLR2GMore
Terazosinhsa03040Spliceosome4.19E-025Q14562, O60508, P08579, Q01130, O43447DHX8, CDC40, SNRPB2, SFRS2, PPIHMore
Terazosinhsa03450Non-homologous end-joining4.48E-031P78527PRKDCMore
Terazosinhsa04010MAPK signaling pathway4.93E-021P10600TGFB3More
Terazosinhsa04014Ras signaling pathway7.30E-032P31751, P0DP23AKT2, CALM1More
Terazosinhsa04015Rap1 signaling pathway6.14E-032P31751, P0DP23AKT2, CALM1More
Terazosinhsa04022cGMP-PKG signaling pathway5.07E-032P31751, P0DP23AKT2, CALM1More
Terazosinhsa04024cAMP signaling pathway3.23E-032P31751, P0DP23AKT2, CALM1More
Terazosinhsa04060Cytokine-cytokine receptor interaction2.02E-021P10600TGFB3More
Terazosinhsa04064NF-kappa B signaling pathway2.63E-0311P10415, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341BCL2, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1More
Terazosinhsa04068FoxO signaling pathway1.57E-021P10600TGFB3More
Terazosinhsa04070Phosphatidylinositol signaling system2.96E-023P19174, P49619, P27987PLCG1, DGKG, ITPKBMore
Terazosinhsa04071Sphingolipid signaling pathway1.19E-024P21453, Q9H228, P01375, Q13362S1PR1, EDG8, TNF, PPP2R5CMore
Terazosinhsa04080Neuroactive ligand-receptor interaction1.97E-025P28472, P21453, Q9H228, P21730, P07550GABRB3, S1PR1, EDG8, C5AR1, ADRB2More
Terazosinhsa04110Cell cycle1.30E-047P06493, P78527, P10600, P30304, P33981, P01106, Q13547CDK1, PRKDC, TGFB3, CDC25A, TTK, MYC, HDAC1More
Terazosinhsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Terazosinhsa04141Protein processing in endoplasmic reticulum9.57E-034P30101, P49257, P60604, Q9H173PDIA3, LMAN1, UBE2G2, SIL1More
Terazosinhsa04145Phagosome3.69E-027O75015, Q15080, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Terazosinhsa04213Longevity regulating pathway - multiple species2.85E-022Q9Y4H2, Q13547IRS2, HDAC1More
Terazosinhsa04218Cellular senescence1.74E-043P31751, P0DP23, P10600AKT2, CALM1, TGFB3More
Terazosinhsa04261Adrenergic signaling in cardiomyocytes2.83E-036P07550, P22694, P31751, P18848, Q13362, P0DP23ADRB2, PRKACB, AKT2, ATF4, PPP2R5C, CALM1More
Terazosinhsa04350TGF-beta signaling pathway1.12E-021P10600TGFB3More
Terazosinhsa04370VEGF signaling pathway3.60E-021P31751AKT2More
Terazosinhsa04371Apelin signaling pathway3.23E-032P31751, P0DP23AKT2, CALM1More
Terazosinhsa04380Osteoclast differentiation2.11E-032Q9NQC7, P31751CYLD, AKT2More
Terazosinhsa04390Hippo signaling pathway1.12E-021P10600TGFB3More
Terazosinhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Terazosinhsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Terazosinhsa04612Antigen processing and presentation3.33E-048P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Terazosinhsa04613Neutrophil extracellular trap formation1.22E-047P19174, P11215, Q13547, P58876, P62807, Q16778, O60814PLCG1, ITGAM, HDAC1, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Terazosinhsa04620Toll-like receptor signaling pathway4.78E-021P31751AKT2More
Terazosinhsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Terazosinhsa04625C-type lectin receptor signaling pathway1.38E-053Q9NQC7, P31751, P0DP23CYLD, AKT2, CALM1More
Terazosinhsa04630JAK-STAT signaling pathway3.20E-024P01106, P42224, P14784, Q13651MYC, STAT1, IL2RB, IL10RAMore
Terazosinhsa04640Hematopoietic cell lineage4.72E-028P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Terazosinhsa04650Natural killer cell mediated cytotoxicity5.26E-0510P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, Q14953, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Terazosinhsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Terazosinhsa04658Th1 and Th2 cell differentiation8.66E-0613Q04759, P07766, P20963, P09693, P19174, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Terazosinhsa04659Th17 cell differentiation5.60E-0412Q04759, P19174, P06239, P42224, P14784, P13765, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL21R, TBX21, GATA3, CD3E, CD3G, CD247More
Terazosinhsa04660T cell receptor signaling pathway4.75E-0310P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCKMore
Terazosinhsa04662B cell receptor signaling pathway1.60E-046P31751, P42338, P60033, P07948, P21854, Q8N149AKT2, PIK3CB, CD81, LYN, CD72, LILRA2More
Terazosinhsa04664Fc epsilon RI signaling pathway4.79E-034P31751, P42338, P07948, P09917AKT2, PIK3CB, LYN, ALOX5More
Terazosinhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Terazosinhsa04722Neurotrophin signaling pathway2.83E-032P31751, P0DP23AKT2, CALM1More
Terazosinhsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Terazosinhsa04725Cholinergic synapse4.10E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Terazosinhsa04727GABAergic synapse1.68E-033P63218, P50151, P15104GNG5, GNG10, GLULMore
Terazosinhsa04728Dopaminergic synapse3.23E-032P31751, P0DP23AKT2, CALM1More
Terazosinhsa04740Olfactory transduction9.46E-042Q9H255, P0DP23OR51E2, CALM1More
Terazosinhsa04742Taste transduction1.01E-021P30939HTR1FMore
Terazosinhsa04744Phototransduction1.81E-021P0DP23CALM1More
Terazosinhsa04910Insulin signaling pathway9.82E-042P0DP23, P31751CALM1, AKT2More
Terazosinhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Terazosinhsa04915Estrogen signaling pathway5.07E-032P31751, P0DP23AKT2, CALM1More
Terazosinhsa04916Melanogenesis4.78E-021P0DP23CALM1More
Terazosinhsa04917Prolactin signaling pathway2.41E-021P31751AKT2More
Terazosinhsa04919Thyroid hormone signaling pathway1.64E-024P19174, P42224, Q13547, P01106PLCG1, STAT1, HDAC1, MYCMore
Terazosinhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Terazosinhsa04922Glucagon signaling pathway1.79E-032P31751, P0DP23AKT2, CALM1More
Terazosinhsa04923Regulation of lipolysis in adipocytes3.01E-021P31751AKT2More
Terazosinhsa04924Renin secretion6.02E-033P22694, P07550, P0DP23PRKACB, ADRB2, CALM1More
Terazosinhsa04926Relaxin signaling pathway3.93E-049P42338, P63218, P50151, P18848, P22694, P49767, P14780, P30679, P49407PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15, ARRB1More
Terazosinhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Terazosinhsa04929GnRH secretion3.61E-033P42338, P31751, P49407PIK3CB, AKT2, ARRB1More
Terazosinhsa04933AGE-RAGE signaling pathway in diabetic complications1.12E-021P10600TGFB3More
Terazosinhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Terazosinhsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Terazosinhsa04970Salivary secretion2.96E-034P07550, P22694, P0DP23, P49913ADRB2, PRKACB, CALM1, CAMPMore
Terazosinhsa04971Gastric acid secretion4.78E-021P0DP23CALM1More
Terazosinhsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Terazosinhsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Terazosinhsa05010Alzheimer disease8.59E-043Q00535, P0DP23, P31751CDK5, CALM1, AKT2More
Terazosinhsa05022Pathways of neurodegeneration - multiple diseases1.60E-034Q06055, Q00535, O15020, P0DP23ATP5G2, CDK5, SPTBN2, CALM1More
Terazosinhsa05030Cocaine addiction4.19E-021Q00535CDK5More
Terazosinhsa05031Amphetamine addiction6.98E-034P0DP23, P22694, P18848, Q13547CALM1, PRKACB, ATF4, HDAC1More
Terazosinhsa05034Alcoholism6.27E-045Q13547, P58876, P62807, Q16778, O60814HDAC1, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Terazosinhsa05133Pertussis3.51E-021P0C0L4C4AMore
Terazosinhsa05140Leishmaniasis3.29E-027P13612, O75015, P13765, O60603, P10600, P01375, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TGFB3, TNF, NCF4More
Terazosinhsa05142Chagas disease1.79E-021P10600TGFB3More
Terazosinhsa05144Malaria2.19E-046P60033, O60603, P01375, P35443, P10600, P26718CD81, TLR2, TNF, THBS4, TGFB3, KLRK1More
Terazosinhsa05145Toxoplasmosis3.59E-021P10600TGFB3More
Terazosinhsa05146Amoebiasis6.12E-0410P09341, P19875, P27930, P01375, O60603, P05089, P30679, P22694, P10600, P08311CXCL1, CXCL2, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, TGFB3, CTSGMore
Terazosinhsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Terazosinhsa05152Tuberculosis9.92E-032P0DP23, P31751CALM1, AKT2More
Terazosinhsa05161Hepatitis B2.69E-021P10600TGFB3More
Terazosinhsa05163Human cytomegalovirus infection1.21E-022P31751, P0DP23AKT2, CALM1More
Terazosinhsa05167Kaposi sarcoma-associated herpesvirus infection5.07E-032P31751, P0DP23AKT2, CALM1More
Terazosinhsa05169Epstein-Barr virus infection3.90E-038P01106, Q13547, P42338, P07948, Q13761, O75293, P42224, P07766MYC, HDAC1, PIK3CB, LYN, RUNX3, GADD45B, STAT1, CD3EMore
Terazosinhsa05170Human immunodeficiency virus 1 infection6.71E-032P31751, P0DP23AKT2, CALM1More
Terazosinhsa05200Pathways in cancer3.07E-022P31751, P0DP23AKT2, CALM1More
Terazosinhsa05202Transcriptional misregulation in cancer2.90E-0315Q13315, P14780, P27930, Q15744, Q16548, P11215, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, Q13547, P12980, P24522ATM, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC1, LYL1, GADD45AMore
Terazosinhsa05203Viral carcinogenesis2.31E-047Q13547, P12814, P06493, P58876, P62807, Q16778, O60814HDAC1, ACTN1, CDK1, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Terazosinhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Terazosinhsa05210Colorectal cancer1.57E-021P10600TGFB3More
Terazosinhsa05211Renal cell carcinoma1.46E-032P10600, P31751TGFB3, AKT2More
Terazosinhsa05212Pancreatic cancer1.46E-032P31751, P10600AKT2, TGFB3More
Terazosinhsa05213Endometrial cancer3.60E-021P31751AKT2More
Terazosinhsa05214Glioma5.75E-042P0DP23, P31751CALM1, AKT2More
Terazosinhsa05218Melanoma3.01E-021P31751AKT2More
Terazosinhsa05220Chronic myeloid leukemia1.06E-032P10600, P31751TGFB3, AKT2More
Terazosinhsa05221Acute myeloid leukemia4.19E-021P31751AKT2More
Terazosinhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Terazosinhsa05223Non-small cell lung cancer2.41E-021P31751AKT2More
Terazosinhsa05225Hepatocellular carcinoma1.35E-021P10600TGFB3More
Terazosinhsa05226Gastric cancer7.27E-042P31751, P10600AKT2, TGFB3More
Terazosinhsa05230Central carbon metabolism in cancer4.78E-021P31751AKT2More
Terazosinhsa05231Choline metabolism in cancer1.39E-023Q9Y259, P19174, P49619CHKB, PLCG1, DGKGMore
Terazosinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.46E-035P19174, P07766, P06239, P42224, Q9HC35PLCG1, CD3E, LCK, STAT1, EML4More
Terazosinhsa05310Asthma1.92E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Terazosinhsa05321Inflammatory bowel disease1.68E-058O60603, P01375, P10600, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, TGFB3, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Terazosinhsa05322Systemic lupus erythematosus1.15E-035P58876, P62807, Q16778, O60814, P12814H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, ACTN1More
Terazosinhsa05323Rheumatoid arthritis2.24E-021P10600TGFB3More
Terazosinhsa05332Graft-versus-host disease6.25E-044P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Terazosinhsa05410Hypertrophic cardiomyopathy8.97E-031P10600TGFB3More
Terazosinhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Terazosinhsa05414Dilated cardiomyopathy5.18E-033P54284, P26678, P10600CACNB3, PLN, TGFB3More
Terazosinhsa05415Diabetic cardiomyopathy3.59E-021P10600TGFB3More
Terazosinhsa05418Fluid shear stress and atherosclerosis3.65E-032P31751, P0DP23AKT2, CALM1More

Community members of Terazosin (SDC: 4.12)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
P16083NQO2Ribosyldihydronicotinamide dehydrogenase [quinone]Predicted00.29580.313400.7747
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
O95259KCNH1Potassium voltageNonegated channel subfamily H member 1Predicted00.04250.046500.1143
P10600TGFB3Transforming growth factor betaNone3 proprotein [Cleaved into: LatencyNoneassociated peptidePredicted00.45970.00311.2359
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)