PharmaCoNets of Temsirolimus (SPCN: 20.15 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Temsirolimushsa00052Galactose metabolism1.12E-042P06280, O43451GLA, MGAMMore
Temsirolimushsa00280Valine, leucine and isoleucine degradation3.41E-034P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Temsirolimushsa00500Starch and sucrose metabolism3.16E-042O43451, P06737MGAM, PYGLMore
Temsirolimushsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Temsirolimushsa00730Thiamine metabolism2.53E-052P05186, P24666ALPL, ACP1More
Temsirolimushsa00770Pantothenate and CoA biosynthesis5.59E-032O95498, O95497VNN2, VNN1More
Temsirolimushsa00980Metabolism of xenobiotics by cytochrome P4503.20E-022P78417, P11766GSTO1, ADH5More
Temsirolimushsa00982Drug metabolism - cytochrome P4503.20E-022P78417, P11766GSTO1, ADH5More
Temsirolimushsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Temsirolimushsa01521EGFR tyrosine kinase inhibitor resistance2.60E-022P17252, Q9NRA1PRKCA, PDGFCMore
Temsirolimushsa03013RNA transport4.13E-026Q09161, P35658, P47813, Q14152, O75822, P51114NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1More
Temsirolimushsa03060Protein export4.22E-022P37108, Q15005SRP14, SPCS2More
Temsirolimushsa04014Ras signaling pathway5.92E-045Q9NRA1, P49767, P17252, Q14644, P62873PDGFC, VEGFC, PRKCA, RASA3, GNB1More
Temsirolimushsa04015Rap1 signaling pathway4.88E-045Q9NRA1, P49767, P25116, P08514, P17252PDGFC, VEGFC, F2R, ITGA2B, PRKCAMore
Temsirolimushsa04020Calcium signaling pathway2.39E-034P17252, P25116, Q9NRA1, P49767PRKCA, F2R, PDGFC, VEGFCMore
Temsirolimushsa04060Cytokine-cytokine receptor interaction3.62E-024P27930, P14778, P25024, P25025IL1R2, IL1R1, CXCR1, CXCR2More
Temsirolimushsa04061Viral protein interaction with cytokine and cytokine receptor2.60E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Temsirolimushsa04064NF-kappa B signaling pathway4.09E-035P01584, P67870, P63279, Q8NHW4, Q9NQC7IL1B, CSNK2B, UBE2I, CCL4L2, CYLDMore
Temsirolimushsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Temsirolimushsa04072Phospholipase D signaling pathway6.69E-057Q9UQC2, P25116, P25024, P25025, P17252, P23743, Q9NRA1GAB2, F2R, CXCR1, CXCR2, PRKCA, DGKA, PDGFCMore
Temsirolimushsa04151PI3K-Akt signaling pathway1.71E-036P25116, Q9NRA1, P49767, P62873, P08514, P17252F2R, PDGFC, VEGFC, GNB1, ITGA2B, PRKCAMore
Temsirolimushsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Temsirolimushsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Temsirolimushsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Temsirolimushsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Temsirolimushsa04371Apelin signaling pathway4.39E-024P63218, P50151, Q14344, Q13485GNG5, GNG10, GNA13, SMAD4More
Temsirolimushsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Temsirolimushsa04510Focal adhesion8.11E-034P08514, P17252, Q9NRA1, P49767ITGA2B, PRKCA, PDGFC, VEGFCMore
Temsirolimushsa04512ECM-receptor interaction3.19E-022P07359, P08514GP1BA, ITGA2BMore
Temsirolimushsa04540Gap junction2.29E-033P17252, P68371, Q9NRA1PRKCA, TUBB2C, PDGFCMore
Temsirolimushsa04611Platelet activation7.90E-033P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Temsirolimushsa04613Neutrophil extracellular trap formation2.31E-024P17252, O60814, P08514, P07359PRKCA, H2BC12, ITGA2B, GP1BAMore
Temsirolimushsa04623Cytosolic DNA-sensing pathway1.54E-022P01584, Q8NHW4IL1B, CCL4L2More
Temsirolimushsa04640Hematopoietic cell lineage2.96E-023P07359, P08514, P04141GP1BA, ITGA2B, CSF2More
Temsirolimushsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Temsirolimushsa04659Th17 cell differentiation3.17E-023P25963, P84022, Q13485NFKBIA, SMAD3, SMAD4More
Temsirolimushsa04664Fc epsilon RI signaling pathway2.60E-022P04141, P17252CSF2, PRKCAMore
Temsirolimushsa04713Circadian entrainment4.51E-022P17252, P62873PRKCA, GNB1More
Temsirolimushsa04723Retrograde endocannabinoid signaling3.83E-022P17252, P62873PRKCA, GNB1More
Temsirolimushsa04724Glutamatergic synapse3.09E-033P17252, P62873, Q9NSB8PRKCA, GNB1, HOMER2More
Temsirolimushsa04725Cholinergic synapse3.83E-022P17252, P62873PRKCA, GNB1More
Temsirolimushsa04726Serotonergic synapse6.44E-033P17252, P62873, P18054PRKCA, GNB1, ALOX12More
Temsirolimushsa04727GABAergic synapse2.06E-022P62873, P17252GNB1, PRKCAMore
Temsirolimushsa04730Long-term depression3.20E-022Q14344, P07948GNA13, LYNMore
Temsirolimushsa04750Inflammatory mediator regulation of TRP channels4.51E-022P18054, P17252ALOX12, PRKCAMore
Temsirolimushsa04810Regulation of actin cytoskeleton2.06E-023P08514, Q9NRA1, P25116ITGA2B, PDGFC, F2RMore
Temsirolimushsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Temsirolimushsa04918Thyroid hormone synthesis1.14E-022P17252, P27824PRKCA, CANXMore
Temsirolimushsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Temsirolimushsa04926Relaxin signaling pathway1.14E-023P62873, P49767, P17252GNB1, VEGFC, PRKCAMore
Temsirolimushsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Temsirolimushsa04932Non-alcoholic fatty liver disease1.24E-026O43521, O75460, P01584, P13073, P12074, O15239BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1More
Temsirolimushsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Temsirolimushsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Temsirolimushsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Temsirolimushsa05010Alzheimer disease2.21E-0210O15239, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P67870, P28070NDUFA1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, CSNK2B, PSMB4More
Temsirolimushsa05032Morphine addiction1.20E-036P62873, P63218, P50151, Q07343, P17252, P43250GNB1, GNG5, GNG10, PDE4B, PRKCA, GRK6More
Temsirolimushsa05120Epithelial cell signaling in Helicobacter pylori infection3.73E-022P25024, P25025CXCR1, CXCR2More
Temsirolimushsa05130Pathogenic Escherichia coli infection3.65E-023Q14247, P68371, P25116CTTN, TUBB2C, F2RMore
Temsirolimushsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Temsirolimushsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Temsirolimushsa05150Staphylococcus aureus infection2.44E-024P21462, Q14532, P59665, P59666FPR1, KRT32, DEFA1; DEFA1B, DEFA3More
Temsirolimushsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Temsirolimushsa05163Human cytomegalovirus infection2.89E-027P0DP23, Q8NHW4, Q08828, P23458, P01584, P61073, Q13651CALM1, CCL4L2, ADCY1, JAK1, IL1B, CXCR4, IL10RAMore
Temsirolimushsa05200Pathways in cancer1.37E-026P08514, P17252, P49767, P25116, P62873, P78417ITGA2B, PRKCA, VEGFC, F2R, GNB1, GSTO1More
Temsirolimushsa05205Proteoglycans in cancer4.43E-023Q12955, Q14247, P17252ANK3, CTTN, PRKCAMore
Temsirolimushsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Temsirolimushsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Temsirolimushsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Temsirolimushsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Temsirolimushsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Temsirolimushsa05231Choline metabolism in cancer2.29E-033Q9NRA1, P23743, P17252PDGFC, DGKA, PRKCAMore

Community members of Temsirolimus (SDC: 2.25)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
P26358DNMT1DNAPredicted00.34040.28090.26590.998
P68106FKBP1BPeptidylNoneprolyl cisNonetrans isomerase FKBP1BPredicted00.08140.038100.1169
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q53EL6PDCD4Programmed cell death protein 4Predicted00.38990.06530.32020.6457
Q13451FKBP5PeptidylNoneprolyl cisNonetrans isomerase FKBP5Predicted00.22890.05860.14230.374
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)