PharmaCoNets

PharmaCoNets of Telmisartan (S_PCN: 197.82 )

Telmisartan regulated-network (S_DN: 25.26)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Telmisartan

hsa00052

Galactose metabolism

6.39E-04

P06280, O43451

GLA, MGAM

Telmisartan

hsa00071

Fatty acid degradation

1.99E-04

P11310, O75521, P00325, P11766, P28332, P33121

ACADM, ECI2, ADH1B, ADH5, ADH6, ACSL1

Telmisartan

hsa00190

Oxidative phosphorylation

9.38E-07

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Telmisartan

hsa00220

Arginine biosynthesis

1.58E-03

P15104, P05089

GLUL, ARG1

Telmisartan

hsa00230

Purine metabolism

8.54E-04

Q7LG56, P51828, P20839, Q9Y227, Q02153

RRM2B, ADCY7, IMPDH1, ENTPD4, GUCY1B3

Telmisartan

hsa00240

Pyrimidine metabolism

1.45E-02

Q7LG56, Q9Y227

RRM2B, ENTPD4

Telmisartan

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Telmisartan

hsa00280

Valine, leucine and isoleucine degradation

1.67E-02

P55809, Q9HCC0, Q02252, P11310

OXCT1, MCCC2, ALDH6A1, ACADM

Telmisartan

hsa00310

Lysine degradation

2.59E-02

Q96KQ7, P51648

EHMT2, ALDH3A2

Telmisartan

hsa00500

Starch and sucrose metabolism

4.13E-08

O43451, P46976, P35573, P06737

MGAM, GYG1, AGL, PYGL

Telmisartan

hsa00512

Mucin type O-glycan biosynthesis

3.19E-03

O95395, Q8N4A0, Q9NY28

GCNT3, GALNT4, GALNT8

Telmisartan

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

1.91E-02

Q9NY97

B3GNT2

Telmisartan

hsa00561

Glycerolipid metabolism

4.33E-04

O14494, P06280, P23743

PLPP1, GLA, DGKA

Telmisartan

hsa00564

Glycerophospholipid metabolism

2.80E-02

P23743, O14494, Q3LIE5

DGKA, PLPP1, ADPRM

Telmisartan

hsa00565

Ether lipid metabolism

3.94E-02

Q8N661

TMEM86B

Telmisartan

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Telmisartan

hsa00591

Linoleic acid metabolism

1.29E-03

P11712

CYP2C9

Telmisartan

hsa00600

Sphingolipid metabolism

3.28E-03

Q9BX95, Q8TCT0, O14494, P06280, P15289

SGPP1, CERK, PLPP1, GLA, ARSA

Telmisartan

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Telmisartan

hsa00630

Glyoxylate and dicarboxylate metabolism

2.29E-07

P40925, P15104

MDH1, GLUL

Telmisartan

hsa00670

One carbon pool by folate

1.63E-02

O95954, Q99707

FTCD, MTR

Telmisartan

hsa00730

Thiamine metabolism

1.73E-06

P05186, P24666

ALPL, ACP1

Telmisartan

hsa00770

Pantothenate and CoA biosynthesis

2.26E-04

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Telmisartan

hsa00830

Retinol metabolism

1.07E-03

P00325, P11766, Q9BPW9, O75911, P11712

ADH1B, ADH5, DHRS9, DHRS3, CYP2C9

Telmisartan

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Telmisartan

hsa00970

Aminoacyl-tRNA biosynthesis

3.63E-07

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Telmisartan

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Telmisartan

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Telmisartan

hsa00983

Drug metabolism - other enzymes

1.10E-04

P04183, P32320, P05164

TK1, CDA, MPO

Telmisartan

hsa01040

Biosynthesis of unsaturated fatty acids

2.92E-02

P22307, Q9H5J4

SCP2, ELOVL6

Telmisartan

hsa01100

Metabolic pathways

6.34E-04

Q9NR34, Q9Y234, P05089, O14521, Q99707, P11310, P27707, P32320, Q3LIE5, P22748, P55809, P06280, Q16875, O43286, O43451, P11712, P05186, P24666, P23743, O14494, Q02252, O60701, O14772, P28332, Q9HCC0, P33121, P04406, Q9NY28, P57054, Q9UNP4, Q9BX95, Q53FZ2, P09960, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q13488, Q16718, Q02809

MAN1C1, LIPT1, ARG1, SDHD, MTR, ACADM, DCK, CDA, ADPRM, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, CYP2C9, ALPL, ACP1, DGKA, PLPP1, ALDH6A1, UGDH, FPGT, ADH6, MCCC2, ACSL1, GAPDH, GALNT8, PIGP, ST3GAL5, SGPP1, ACSM3, LTA4H, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, TCIRG1, NDUFA5, PLOD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.705
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.814
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q99707	MTR	Methionine synthase	0.725
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P11310	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	0.909
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P27707	DCK	Deoxycytidine kinase	0.85
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q3LIE5	ADPRM	Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase	-0.736
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P06280	GLA	Alpha-galactosidase A	-0.785
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P11712	CYP2C9	Cytochrome P450 2C9	0.761
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	0.704
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P23743	DGKA	Diacylglycerol kinase alpha	-0.77
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	O14494	PLPP1	Phospholipid phosphatase 1	0.756
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	0.803
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	O60701	UGDH	UDP-glucose 6-dehydrogenase	0.858
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	O14772	FPGT	Fucose-1-phosphate guanylyltransferase	0.897
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P28332	ADH6	Alcohol dehydrogenase 6	0.821
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	-0.757
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.777
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q9NY28	GALNT8	Probable polypeptide N-acetylgalactosaminyltransferase 8	0.876
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q53FZ2	ACSM3	Acyl-coenzyme A synthetase ACSM3, mitochondrial	0.753
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P09960	LTA4H	Leukotriene A-4 hydrolase	-0.874
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q9UHY7	ENOPH1	Enolase-phosphatase E1	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.79
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.755
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q02809	PLOD1	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	-0.724

Telmisartan

hsa01210

2-Oxocarboxylic acid metabolism

6.96E-04

P50213

IDH3A

Telmisartan

hsa01240

Biosynthesis of cofactors

2.95E-02

P13716, P14618

ALAD, PKM2

Telmisartan

hsa01522

Endocrine resistance

4.48E-02

P22694, Q02750, Q9UM47, P46527

PRKACB, MAP2K1, NOTCH3, CDKN1B

Telmisartan

hsa01524

Platinum drug resistance

1.13E-02

P10415, Q13489, P78417, P23025, P43246

BCL2, BIRC3, GSTO1, XPA, MSH2

Telmisartan

hsa03008

Ribosome biogenesis in eukaryotes

1.03E-04

Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0

UTP6, RPP38, GNL3, NVL, NXF2; NXF2B

Telmisartan

hsa03010

Ribosome

1.49E-05

P62753, P25398, P32969, P62829, P46776, P62888, P62899, P18077, P61927, P61513, P36578

RPS6, RPS12, RPL9, RPL23, RPL27A, RPL30, RPL31, RPL35A, RPL37, RPL37A, RPL4

Telmisartan

hsa03013

RNA transport

7.86E-10

O14980, P52298, Q09161, O14893, P61326, P38919, Q15287, Q9UBU9, Q9GZY0, P37198, Q7Z3B4, P35658, P63279, P68104, Q14152, P55884, O15371, O75822, P78345, P11940, P20042, Q14240, Q9Y6A5, P51114, Q53GS7

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, RNPS1, NXF1, NXF2; NXF2B, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, PABPC1, EIF2S2, EIF4A2, TACC3, FXR1, GLE1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21462	FPR1	fMet-Leu-Phe receptor	O14980	XPO1	Exportin-1	-0.742
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.915
P10415	BCL2	Apoptosis regulator Bcl-2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.888
P21462	FPR1	fMet-Leu-Phe receptor	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.874
P51684	CCR6	C-C chemokine receptor type 6	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.924
P10415	BCL2	Apoptosis regulator Bcl-2	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
P21462	FPR1	fMet-Leu-Phe receptor	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.78
P10415	BCL2	Apoptosis regulator Bcl-2	O14893	GEMIN2	Gem-associated protein 2	0.853
P21462	FPR1	fMet-Leu-Phe receptor	O14893	GEMIN2	Gem-associated protein 2	-0.87
P51684	CCR6	C-C chemokine receptor type 6	O14893	GEMIN2	Gem-associated protein 2	0.771
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P61326	MAGOH	Protein mago nashi homolog	0.764
P21462	FPR1	fMet-Leu-Phe receptor	P61326	MAGOH	Protein mago nashi homolog	-0.835
P51684	CCR6	C-C chemokine receptor type 6	P61326	MAGOH	Protein mago nashi homolog	0.704
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.729
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.746
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
P10415	BCL2	Apoptosis regulator Bcl-2	Q7Z3B4	NUP54	Nucleoporin p54	0.774
P21462	FPR1	fMet-Leu-Phe receptor	Q7Z3B4	NUP54	Nucleoporin p54	-0.903
P51684	CCR6	C-C chemokine receptor type 6	Q7Z3B4	NUP54	Nucleoporin p54	0.811
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P10415	BCL2	Apoptosis regulator Bcl-2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.751
P21462	FPR1	fMet-Leu-Phe receptor	P35658	NUP214	Nuclear pore complex protein Nup214	0.971
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P68104	EEF1A1	Elongation factor 1-alpha 1	0.848
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.707
P10415	BCL2	Apoptosis regulator Bcl-2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.734
P21462	FPR1	fMet-Leu-Phe receptor	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.89
P51684	CCR6	C-C chemokine receptor type 6	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.701
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.782
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.788
P10415	BCL2	Apoptosis regulator Bcl-2	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.837
P21462	FPR1	fMet-Leu-Phe receptor	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.953
P51684	CCR6	C-C chemokine receptor type 6	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.711
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P78345	RPP38	Ribonuclease P protein subunit p38	0.869
P10415	BCL2	Apoptosis regulator Bcl-2	P78345	RPP38	Ribonuclease P protein subunit p38	0.852
P51684	CCR6	C-C chemokine receptor type 6	P78345	RPP38	Ribonuclease P protein subunit p38	0.861
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P11940	PABPC1	Polyadenylate-binding protein 1	0.767
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P21462	FPR1	fMet-Leu-Phe receptor	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	-0.721
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.815
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.812
P21462	FPR1	fMet-Leu-Phe receptor	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.904
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.732
P21462	FPR1	fMet-Leu-Phe receptor	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	-0.713
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q53GS7	GLE1	mRNA export factor GLE1	-0.723

Telmisartan

hsa03015

mRNA surveillance pathway

9.78E-03

O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7

RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1

Telmisartan

hsa03020

RNA polymerase

2.01E-06

P24928, P62487, Q9GZM3, P52435

POLR2A, POLR2G, POLR2J2, POLR2J

Telmisartan

hsa03030

DNA replication

5.00E-02

P27694

RPA1

Telmisartan

hsa03040

Spliceosome

4.08E-11

Q14562, O43143, O60508, Q99633, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, Q9UMS4, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, PRPF18, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, PRPF19, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.708
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.775
P46091	GPR1	Chemerin-like receptor 2	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.819
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.871
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P46091	GPR1	Chemerin-like receptor 2	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.816
P35610	SOAT1	Sterol O-acyltransferase 1	O60508	CDC40	Pre-mRNA-processing factor 17	0.76
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O60508	CDC40	Pre-mRNA-processing factor 17	-0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O60508	CDC40	Pre-mRNA-processing factor 17	0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P46091	GPR1	Chemerin-like receptor 2	O60508	CDC40	Pre-mRNA-processing factor 17	-0.778
P46091	GPR1	Chemerin-like receptor 2	Q99633	PRPF18	Pre-mRNA-splicing factor 18	-0.711
P35610	SOAT1	Sterol O-acyltransferase 1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.787
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P46091	GPR1	Chemerin-like receptor 2	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.753
P35610	SOAT1	Sterol O-acyltransferase 1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.712
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P35610	SOAT1	Sterol O-acyltransferase 1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.822
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.835
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P46091	GPR1	Chemerin-like receptor 2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P46091	GPR1	Chemerin-like receptor 2	Q9UMS4	PRPF19	Pre-mRNA-processing factor 19	0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P35610	SOAT1	Sterol O-acyltransferase 1	Q9Y2W2	WBP11	WW domain-binding protein 11	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Telmisartan

hsa03050

Proteasome

1.53E-03

P55036

PSMD4

Telmisartan

hsa03060

Protein export

5.99E-04

Q15070, P37108, O76094, Q15005

OXA1L, SRP14, SRP72, SPCS2

Telmisartan

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Telmisartan

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Telmisartan

hsa04012

ErbB signaling pathway

3.74E-02

P21860, Q13557, O14944

ERBB3, CAMK2D, EREG

Telmisartan

hsa04014

Ras signaling pathway

9.87E-06

Q02750, P42338, P20827, Q15389, Q9NRA1, P49767, Q13009, P17252, Q7LDG7, P21359, P0DP23, P62873, P62879, P63218, P50151, P19174, P22694

MAP2K1, PIK3CB, EFNA1, ANGPT1, PDGFC, VEGFC, TIAM1, PRKCA, RASGRP2, NF1, CALM1, GNB1, GNB2, GNG5, GNG10, PLCG1, PRKACB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13315	ATM	Serine-protein kinase ATM	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	-0.797
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
Q13315	ATM	Serine-protein kinase ATM	Q15389	ANGPT1	Angiopoietin-1	0.726
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.776
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P35610	SOAT1	Sterol O-acyltransferase 1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.71
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q13315	ATM	Serine-protein kinase ATM	P17252	PRKCA	Protein kinase C alpha type	0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
Q13315	ATM	Serine-protein kinase ATM	P21359	NF1	Neurofibromin	0.762
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
Q13315	ATM	Serine-protein kinase ATM	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	-0.716
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13315	ATM	Serine-protein kinase ATM	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.858

Telmisartan

hsa04015

Rap1 signaling pathway

1.45E-04

P20827, P49767, P63261, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P0DP23, P08514, P17252, P19174

EFNA1, VEGFC, ACTG1, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, CALM1, ITGA2B, PRKCA, PLCG1

Telmisartan

hsa04020

Calcium signaling pathway

2.59E-06

Q96DU7, P45880, Q16566, Q13557, P17252, P21860, O15399, P25116, P0DP23, P51828, P23634, P49767

ITPKC, VDAC2, CAMK4, CAMK2D, PRKCA, ERBB3, GRIN2D, F2R, CALM1, ADCY7, ATP2B4, VEGFC

Telmisartan

hsa04022

cGMP-PKG signaling pathway

3.25E-03

Q99941, P18848, P23634, Q8WYR1, P51828, P05141, P45880, P0DP24

CREBL1, ATF4, ATP2B4, PIK3R5, ADCY7, SLC25A5, VDAC2, CALM2

Telmisartan

hsa04024

cAMP signaling pathway

2.84E-02

P0DP23, P23634, Q16566, O15399, P25116

CALM1, ATP2B4, CAMK4, GRIN2D, F2R

Telmisartan

hsa04060

Cytokine-cytokine receptor interaction

9.80E-04

P27930, P14778, P26842, Q9UHF4, Q13651, P16871, P25024, Q9UBD3, P47992, P02775, P09341, P32248, P51684, P18510, P09603, P01730

IL1R2, IL1R1, CD27, IL20RA, IL10RA, IL7R, CXCR1, XCL2, XCL1, PPBP, CXCL1, CCR7, CCR6, IL1RN, CSF1, CD4

Telmisartan

hsa04061

Viral protein interaction with cytokine and cytokine receptor

7.74E-04

P51684, P32248, P02775, P47992, Q9UBD3, Q9UHF4

CCR6, CCR7, PPBP, XCL1, XCL2, IL20RA

Telmisartan

hsa04062

Chemokine signaling pathway

1.13E-06

P25024, P25025, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P14598, P42224, P25963, P49841, Q8WYR1

CXCR1, CXCR2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, NCF1, STAT1, NFKBIA, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Telmisartan

hsa04064

NF-kappa B signaling pathway

1.75E-04

P10415, P51617, O00463, Q13546, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, Q9NQC7

BCL2, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P51684	CCR6	C-C chemokine receptor type 6	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P51684	CCR6	C-C chemokine receptor type 6	Q13077	TRAF1	TNF receptor-associated factor 1	0.768
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799

Telmisartan

hsa04066

HIF-1 signaling pathway

4.52E-03

Q09472, P17252, P07195, Q15389, Q02750, P10415, P46527

EP300, PRKCA, LDHB, ANGPT1, MAP2K1, BCL2, CDKN1B

Telmisartan

hsa04068

FoxO signaling pathway

3.52E-02

Q96BR1

SGK3

Telmisartan

hsa04070

Phosphatidylinositol signaling system

3.02E-03

P19174, P0DP23, Q14643, P23743, O14732, P27987, P17252

PLCG1, CALM1, ITPR1, DGKA, IMPA2, ITPKB, PRKCA

Telmisartan

hsa04071

Sphingolipid signaling pathway

3.51E-08

P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415, Q9UQC2

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
P21462	FPR1	fMet-Leu-Phe receptor	P17252	PRKCA	Protein kinase C alpha type	-0.731
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
Q15722	LTB4R	Leukotriene B4 receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.832
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.733
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.787
P21462	FPR1	fMet-Leu-Phe receptor	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.716
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P21462	FPR1	fMet-Leu-Phe receptor	P01375	TNF	Tumor necrosis factor	0.77
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.773
P21462	FPR1	fMet-Leu-Phe receptor	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.878
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.718
P51684	CCR6	C-C chemokine receptor type 6	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.819
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.884
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.884
P21462	FPR1	fMet-Leu-Phe receptor	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.932
P51684	CCR6	C-C chemokine receptor type 6	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.876
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
P51684	CCR6	C-C chemokine receptor type 6	P04637	TP53	Cellular tumor antigen p53	0.728
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
Q15722	LTB4R	Leukotriene B4 receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.865
P21462	FPR1	fMet-Leu-Phe receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.855
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P08183	ABCB1	ATP-dependent translocase ABCB1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	-0.866

Telmisartan

hsa04110

Cell cycle

2.06E-02

Q9UJX4, O60566, Q09472, P24522, P04637, P49918

ANAPC5, BUB1B, EP300, GADD45A, TP53, CDKN1C

Telmisartan

hsa04114

Oocyte meiosis

2.21E-04

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Telmisartan

hsa04120

Ubiquitin mediated proteolysis

4.04E-04

Q14145, Q13042, P62837, Q15751, O95071, P0CG47

KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBB

Telmisartan

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Telmisartan

hsa04137

Mitophagy - animal

9.52E-03

Q07817, P0CG47

BCL2L1, UBB

Telmisartan

hsa04141

Protein processing in endoplasmic reticulum

3.62E-06

P18848, Q12933, P30101, P07384, O95487, Q15436, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, O95816, Q9H173, Q9UNL2

ATF4, TRAF2, PDIA3, CAPN1, SEC24B, SEC23A, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, BAG2, SIL1, SSR3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.773
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	Q12933	TRAF2	TNF receptor-associated factor 2	0.802
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	P07384	CAPN1	Calpain-1 catalytic subunit	-0.859
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95487	SEC24B	Protein transport protein Sec24B	-0.754
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	Q15436	SEC23A	Protein transport protein Sec23A	0.702
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P60604	UBE2G2	Ubiquitin-conjugating enzyme E2 G2	0.775
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.72
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.769
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.731
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9H3Z4	DNAJC5	DnaJ homolog subfamily C member 5	0.703
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.786
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.714
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
Q06124	PTPN11	Tyrosine-protein phosphatase non-receptor type 11	O95816	BAG2	BAG family molecular chaperone regulator 2	-0.871
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9H173	SIL1	Nucleotide exchange factor SIL1	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9UNL2	SSR3	Translocon-associated protein subunit gamma	-0.706

Telmisartan

hsa04142

Lysosome

2.23E-02

P22304, Q13510, Q04900, Q9Y227

IDS, ASAH1, CD164, ENTPD4

Telmisartan

hsa04144

Endocytosis

2.25E-02

O75351, P42566, Q15438, Q14161, Q9UNH7

VPS4B, EPS15, PSCD1, GIT2, SNX6

Telmisartan

hsa04145

Phagosome

5.88E-11

O75015, P11215, P60709, P63261, Q15075, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P27824, P13765

FCGR3B, ITGAM, ACTB, ACTG1, EEA1, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, CANX, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P60709	ACTB	Actin, cytoplasmic 1	0.837
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P46091	GPR1	Chemerin-like receptor 2	P63261	ACTG1	Actin, cytoplasmic 2	0.776
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15075	EEA1	Early endosome antigen 1	-0.821
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.918
P10415	BCL2	Apoptosis regulator Bcl-2	Q15080	NCF4	Neutrophil cytosol factor 4	-0.951
P46091	GPR1	Chemerin-like receptor 2	Q15080	NCF4	Neutrophil cytosol factor 4	-0.702
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P10415	BCL2	Apoptosis regulator Bcl-2	P14598	NCF1	Neutrophil cytosol factor 1	-0.844
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	0.707
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P10415	BCL2	Apoptosis regulator Bcl-2	Q13509	TUBB3	Tubulin beta-3 chain	-0.809
P46091	GPR1	Chemerin-like receptor 2	Q13509	TUBB3	Tubulin beta-3 chain	-0.748
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741
P10415	BCL2	Apoptosis regulator Bcl-2	P68371	TUBB2C	Tubulin beta-4B chain	-0.766
P46091	GPR1	Chemerin-like receptor 2	P68371	TUBB2C	Tubulin beta-4B chain	-0.751
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.753
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.717
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.759
P10415	BCL2	Apoptosis regulator Bcl-2	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P10415	BCL2	Apoptosis regulator Bcl-2	P05164	MPO	Myeloperoxidase	-0.81
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P35443	THBS4	Thrombospondin-4	-0.744
Q15722	LTB4R	Leukotriene B4 receptor 1	P35443	THBS4	Thrombospondin-4	0.855
P10415	BCL2	Apoptosis regulator Bcl-2	P35443	THBS4	Thrombospondin-4	-0.765
P46091	GPR1	Chemerin-like receptor 2	P27824	CANX	Calnexin	-0.779
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
Q15722	LTB4R	Leukotriene B4 receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.792
P10415	BCL2	Apoptosis regulator Bcl-2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.754

Telmisartan

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Telmisartan

hsa04151

PI3K-Akt signaling pathway

1.57E-06

P62753, P42338, P43657, O43521, P27348, P20827, P49767, P07900, P08238, Q8WYR1, P63218, P50151, O15335, Q16363, Q13751, P22105, P14784, Q99941, P18848, O00141, Q6ZUJ8, P30281

RPS6, PIK3CB, P2RY5, BCL2L11, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMA4, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGK, PIK3AP1, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P62753	RPS6	40S ribosomal protein S6	0.716
P61073	CXCR4	C-X-C chemokine receptor type 4	P62753	RPS6	40S ribosomal protein S6	0.709
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P35610	SOAT1	Sterol O-acyltransferase 1	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P27348	YWHAQ	14-3-3 protein theta	0.742
P61073	CXCR4	C-X-C chemokine receptor type 4	P27348	YWHAQ	14-3-3 protein theta	0.708
P35610	SOAT1	Sterol O-acyltransferase 1	P20827	EFNA1	Ephrin-A1	-0.763
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P35610	SOAT1	Sterol O-acyltransferase 1	P49767	VEGFC	Vascular endothelial growth factor C	-0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.786
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P61073	CXCR4	C-X-C chemokine receptor type 4	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P35610	SOAT1	Sterol O-acyltransferase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.838
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P35610	SOAT1	Sterol O-acyltransferase 1	O15335	CHAD	Chondroadherin	-0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	Q16363	LAMA4	Laminin subunit alpha-4	0.729
P35610	SOAT1	Sterol O-acyltransferase 1	Q13751	LAMB3	Laminin subunit beta-3	-0.805
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P22105	TNXB	Tenascin-X	0.72
P35610	SOAT1	Sterol O-acyltransferase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.779
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.72
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.773
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.755
P61073	CXCR4	C-X-C chemokine receptor type 4	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Telmisartan

hsa04210

Apoptosis

3.78E-05

P04637, P10415, O76075, P01375, Q9NR28, O75460, P24522, Q16548, Q13077, O43521, P43234, Q9UBR2, P18848, Q14643

TP53, BCL2, DFFB, TNF, DIABLO, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, CTSO, CTSZ, ATF4, ITPR1

Telmisartan

hsa04217

Necroptosis

5.79E-10

P01375, Q12933, P01568, P48023, Q13489, Q9NQC7, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q13557, Q9H444, O43633, Q08752

TNF, TRAF2, IFNA21, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CAMK2D, CHMP4B, CHMP2A, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	Q12933	TRAF2	TNF receptor-associated factor 2	0.802
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P01568	IFNA21	Interferon alpha-21	0.785
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.815
O00141	SGK	Serine/threonine-protein kinase Sgk1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
O00141	SGK	Serine/threonine-protein kinase Sgk1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.786
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.729
O00141	SGK	Serine/threonine-protein kinase Sgk1	P15104	GLUL	Glutamine synthetase	0.761
P61073	CXCR4	C-X-C chemokine receptor type 4	P15104	GLUL	Glutamine synthetase	0.754
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P05141	SLC25A5	ADP/ATP translocase 2	0.778
P61073	CXCR4	C-X-C chemokine receptor type 4	P05141	SLC25A5	ADP/ATP translocase 2	0.797
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786
P61073	CXCR4	C-X-C chemokine receptor type 4	P01584	IL1B	Interleukin-1 beta	0.825
P61073	CXCR4	C-X-C chemokine receptor type 4	P0C0S5	H2AFZ	Histone H2A.Z	0.732
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.737
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	0.741
O00141	SGK	Serine/threonine-protein kinase Sgk1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.717
P61073	CXCR4	C-X-C chemokine receptor type 4	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.731
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.767
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.75

Telmisartan

hsa04261

Adrenergic signaling in cardiomyocytes

4.32E-03

P51828, Q99941, Q16537, P0DP23, Q13557, P17252, P10415, P20020, P23634

ADCY7, CREBL1, PPP2R5E, CALM1, CAMK2D, PRKCA, BCL2, ATP2B1, ATP2B4

Telmisartan

hsa04270

Vascular smooth muscle contraction

2.89E-02

P35579, P35318

MYH9, ADM

Telmisartan

hsa04330

Notch signaling pathway

2.46E-03

Q92542, P49768, P46531

NCSTN, PSEN1, NOTCH1

Telmisartan

hsa04340

Hedgehog signaling pathway

4.15E-03

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Telmisartan

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Telmisartan

hsa04360

Axon guidance

2.74E-03

P16333, P20827, O95631, P42338, P07332, P23528, P19174, Q06124

NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1, PTPN11

Telmisartan

hsa04370

VEGF signaling pathway

1.79E-05

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Telmisartan

hsa04371

Apelin signaling pathway

3.84E-05

P62873, P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022, P0DP23

GNB1, GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, CALM1

Telmisartan

hsa04380

Osteoclast differentiation

2.05E-03

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPA

Telmisartan

hsa04390

Hippo signaling pathway

2.11E-03

P63261, Q13485, O15105, Q9UJU2, O43623, Q13489

ACTG1, SMAD4, SMAD7, LEF1, SNAI2, BIRC3

Telmisartan

hsa04510

Focal adhesion

3.21E-02

Q15942, P17252, Q13489, P10415, P49767, P63261

ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1

Telmisartan

hsa04512

ECM-receptor interaction

1.62E-03

P07359, P26012, P08514, P16070

GP1BA, ITGB8, ITGA2B, CD44

Telmisartan

hsa04514

Cell adhesion molecules

2.76E-04

P23229, P16109, P30511, P56750, O00501

ITGA6, SELP, HLA-F, CLDN17, CLDN5

Telmisartan

hsa04520

Adherens junction

3.36E-02

Q13485, Q9UJU2, O43623, P63261

SMAD4, LEF1, SNAI2, ACTG1

Telmisartan

hsa04530

Tight junction

2.04E-07

Q8TEU7, P63261, P16989, P56750, O00501, Q9Y478, Q92974, Q14247

RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, PRKAB1, ARHGEF2, CTTN

Telmisartan

hsa04540

Gap junction

1.13E-05

P17252, P22694, Q13509, P68371, Q71U36, Q02750, Q9NRA1, Q14643

PRKCA, PRKACB, TUBB3, TUBB2C, TUBA1A, MAP2K1, PDGFC, ITPR1

Telmisartan

hsa04550

Signaling pathways regulating pluripotency of stem cells

4.73E-02

Q13873, Q02750, Q86SE9

BMPR2, MAP2K1, PCGF5

Telmisartan

hsa04610

Complement and coagulation cascades

4.47E-02

P25116, P09871

F2R, C1S

Telmisartan

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Telmisartan

hsa04612

Antigen processing and presentation

1.10E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Telmisartan

hsa04613

Neutrophil extracellular trap formation

7.48E-09

P17252, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q93077, P62807, P33778, O60814, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P08514, P21462, P63261, P07359, O43315, Q16539

PRKCA, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, ITGA2B, FPR1, ACTG1, GP1BA, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P16109	SELP	P-selectin	0.819
Q99527	GPER1	G-protein coupled estrogen receptor 1	P11215	ITGAM	Integrin alpha-M	0.734
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P51684	CCR6	C-C chemokine receptor type 6	P08246	ELA2	Neutrophil elastase	-0.706
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.799
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.859
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
Q15722	LTB4R	Leukotriene B4 receptor 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.833
P51684	CCR6	C-C chemokine receptor type 6	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.86
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P51684	CCR6	C-C chemokine receptor type 6	P33778	H2BC3	Histone H2B type 1-B	0.704
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q99527	GPER1	G-protein coupled estrogen receptor 1	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.753
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	O60814	H2BC12	Histone H2B type 1-K	0.783
Q99527	GPER1	G-protein coupled estrogen receptor 1	O60814	H2BC12	Histone H2B type 1-K	0.793
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P51684	CCR6	C-C chemokine receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.713
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.918
P51684	CCR6	C-C chemokine receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.803
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
Q15722	LTB4R	Leukotriene B4 receptor 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.875
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P08514	ITGA2B	Integrin alpha-IIb	0.941
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P21462	FPR1	fMet-Leu-Phe receptor	-0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
Q15722	LTB4R	Leukotriene B4 receptor 1	P21462	FPR1	fMet-Leu-Phe receptor	0.888
P51684	CCR6	C-C chemokine receptor type 6	P21462	FPR1	fMet-Leu-Phe receptor	-0.7
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P18054	ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	P07359	GP1BA	Platelet glycoprotein Ib alpha chain	0.876
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
Q15722	LTB4R	Leukotriene B4 receptor 1	O43315	AQP9	Aquaporin-9	0.79
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721

Telmisartan

hsa04614

Renin-angiotensin system

7.48E-03

P50052, P15144, P08311, O75787

AGTR2, ANPEP, CTSG, ATP6AP2

Telmisartan

hsa04621

NOD-like receptor signaling pathway

1.38E-03

P01584, P07900, Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838

IL1B, HSP90AA1, MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4

Telmisartan

hsa04623

Cytosolic DNA-sensing pathway

7.04E-05

P01568, P25963

IFNA21, NFKBIA

Telmisartan

hsa04625

C-type lectin receptor signaling pathway

8.11E-03

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Telmisartan

hsa04640

Hematopoietic cell lineage

1.79E-03

P13612, P14778, P27930, P15144, P11836, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P09603, P01584

ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, CSF1, IL1B

Telmisartan

hsa04650

Natural killer cell mediated cytotoxicity

8.98E-09

P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
P13612	ITGA4	Integrin alpha-4	Q13241	KLRD1	Natural killer cells antigen CD94	0.814
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P13612	ITGA4	Integrin alpha-4	P26718	KLRK1	NKG2-D type II integral membrane protein	0.818
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P13612	ITGA4	Integrin alpha-4	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.729
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P13612	ITGA4	Integrin alpha-4	P26717	KLRC2	NKG2-C type II integral membrane protein	0.772
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P13612	ITGA4	Integrin alpha-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.772
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Telmisartan

hsa04657

IL-17 signaling pathway

4.23E-07

P07900, O00463, Q12933, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, TRAF2, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O00141	SGK	Serine/threonine-protein kinase Sgk1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
Q86Z02	HIPK1	Homeodomain-interacting protein kinase 1	Q12933	TRAF2	TNF receptor-associated factor 2	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Telmisartan

hsa04658

Th1 and Th2 cell differentiation

2.32E-07

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
P43657	P2RY5	Lysophosphatidic acid receptor 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
P43657	P2RY5	Lysophosphatidic acid receptor 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.758
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
P43657	P2RY5	Lysophosphatidic acid receptor 6	P06239	LCK	Tyrosine-protein kinase Lck	0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P13612	ITGA4	Integrin alpha-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P13612	ITGA4	Integrin alpha-4	Q9UL17	TBX21	T-box transcription factor TBX21	0.822
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q9UL17	TBX21	T-box transcription factor TBX21	0.731
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P13612	ITGA4	Integrin alpha-4	Q13761	RUNX3	Runt-related transcription factor 3	0.78
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q13761	RUNX3	Runt-related transcription factor 3	0.712

Telmisartan

hsa04659

Th17 cell differentiation

2.11E-06

P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P43657	P2RY5	Lysophosphatidic acid receptor 6	P01730	CD4	T-cell surface glycoprotein CD4	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P43657	P2RY5	Lysophosphatidic acid receptor 6	P06239	LCK	Tyrosine-protein kinase Lck	0.788
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q9UL17	TBX21	T-box transcription factor TBX21	0.731
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P43657	P2RY5	Lysophosphatidic acid receptor 6	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P43657	P2RY5	Lysophosphatidic acid receptor 6	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.758
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Telmisartan

hsa04660

T cell receptor signaling pathway

4.48E-08

P01375, Q9UDY8, Q04759, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
P13612	ITGA4	Integrin alpha-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.834
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P13612	ITGA4	Integrin alpha-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P13612	ITGA4	Integrin alpha-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.7
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P13612	ITGA4	Integrin alpha-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.83
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Telmisartan

hsa04662

B cell receptor signaling pathway

5.15E-07

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Telmisartan

hsa04664

Fc epsilon RI signaling pathway

1.04E-07

P04141, P42338, Q9UQC2, P07948, P19174, P09917, P20292

CSF2, PIK3CB, GAB2, LYN, PLCG1, ALOX5, ALOX5AP

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.79
P35610	SOAT1	Sterol O-acyltransferase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.813
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P20292	ALOX5AP	Arachidonate 5-lipoxygenase-activating protein	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.719
P35610	SOAT1	Sterol O-acyltransferase 1	P07948	LYN	Tyrosine-protein kinase Lyn	-0.731
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07948	LYN	Tyrosine-protein kinase Lyn	0.735
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P35610	SOAT1	Sterol O-acyltransferase 1	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.808
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.777
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	1
P20292	ALOX5AP	Arachidonate 5-lipoxygenase-activating protein	P20292	ALOX5AP	Arachidonate 5-lipoxygenase-activating protein	1

Telmisartan

hsa04666

Fc gamma R-mediated phagocytosis

4.29E-05

P23528, P49006, P06396, O14494, P14598, P17252

CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCA

Telmisartan

hsa04668

TNF signaling pathway

1.81E-04

Q12933, Q99941, P18848, P01584, P20333, O95429

TRAF2, CREBL1, ATF4, IL1B, TNFRSF1B, BAG4

Telmisartan

hsa04672

Intestinal immune network for IgA production

1.62E-02

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Telmisartan

hsa04710

Circadian rhythm

1.44E-03

O15516, Q16526, Q9Y478

CLOCK, CRY1, PRKAB1

Telmisartan

hsa04713

Circadian entrainment

2.18E-02

P0DP23, P62873, P63218, P50151

CALM1, GNB1, GNG5, GNG10

Telmisartan

hsa04714

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Telmisartan

hsa04720

Long-term potentiation

7.45E-08

P17252, Q16566, P16298, P0DP23, P51812, O15399, P22694, Q02750, Q14643

PRKCA, CAMK4, PPP3CB, CALM1, RPS6KA3, GRIN2D, PRKACB, MAP2K1, ITPR1

Telmisartan

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Telmisartan

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Telmisartan

hsa04723

Retrograde endocannabinoid signaling

1.75E-02

Q14643, P17252, P22694, Q16539, Q16718

ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5

Telmisartan

hsa04724

Glutamatergic synapse

2.18E-07

P48058, O15399, P43003, P62873, P63218, P50151, P15104

GRIA4, GRIN2D, SLC1A3, GNB1, GNG5, GNG10, GLUL

Telmisartan

hsa04725

Cholinergic synapse

2.59E-03

P22694, P17252, P62879, P63218, P50151, P42338, Q02750

PRKACB, PRKCA, GNB2, GNG5, GNG10, PIK3CB, MAP2K1

Telmisartan

hsa04726

Serotonergic synapse

2.16E-03

P22694, P17252, P62873, P62879, P63218, P50151, P09917, Q02750

PRKACB, PRKCA, GNB1, GNB2, GNG5, GNG10, ALOX5, MAP2K1

Telmisartan

hsa04727

GABAergic synapse

2.44E-06

P62873, P62879, P63218, P50151, P15104, P22694, O60296, P17252

GNB1, GNB2, GNG5, GNG10, GLUL, PRKACB, TRAK2, PRKCA

Telmisartan

hsa04728

Dopaminergic synapse

3.73E-03

P14416, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407

DRD2, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1

Telmisartan

hsa04730

Long-term depression

7.22E-03

Q14344, P07948

GNA13, LYN

Telmisartan

hsa04744

Phototransduction

2.97E-04

P62873, P0DP23

GNB1, CALM1

Telmisartan

hsa04750

Inflammatory mediator regulation of TRP channels

1.51E-03

P14778, P01584, P51828, P22694, Q13557, Q16539, Q14643, Q04759, P0DP24

IL1R1, IL1B, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCQ, CALM2

Telmisartan

hsa04810

Regulation of actin cytoskeleton

1.90E-03

Q15746, P23229, P08514, Q14344, P25116

MYLK, ITGA6, ITGA2B, GNA13, F2R

Telmisartan

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Telmisartan

hsa04911

Insulin secretion

2.04E-04

P51828, Q99941, P18848, Q13557

ADCY7, CREBL1, ATF4, CAMK2D

Telmisartan

hsa04912

GnRH signaling pathway

1.66E-05

P17252, P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P45985

PRKCA, ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, MAP2K4

Telmisartan

hsa04914

Progesterone-mediated oocyte maturation

7.22E-04

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Telmisartan

hsa04915

Estrogen signaling pathway

4.72E-02

Q99941, P51828, P07900, P11142

CREBL1, ADCY7, HSP90AA1, HSPA8

Telmisartan

hsa04916

Melanogenesis

4.47E-03

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Telmisartan

hsa04918

Thyroid hormone synthesis

1.44E-02

Q99941, P18848, P02768

CREBL1, ATF4, ALB

Telmisartan

hsa04919

Thyroid hormone signaling pathway

6.35E-04

P17252, P49841, Q02750, P22694, O60244, Q9NVC6, Q12778, Q9UM47

PRKCA, GSK3B, MAP2K1, PRKACB, MED14, MED17, FOXO1, NOTCH3

Telmisartan

hsa04920

Adipocytokine signaling pathway

2.62E-03

Q06124, Q9Y478, Q96RR4

PTPN11, PRKAB1, CAMKK2

Telmisartan

hsa04921

Oxytocin signaling pathway

4.19E-02

P0DP23, P17252, Q16566, P63261

CALM1, PRKCA, CAMK4, ACTG1

Telmisartan

hsa04922

Glucagon signaling pathway

4.18E-02

P14618, P06737

PKM2, PYGL

Telmisartan

hsa04925

Aldosterone synthesis and secretion

3.26E-07

Q14643, Q99941, P18848, P51828, P0DP23, P17252, Q16566, Q13557, P20020, P23634

ITPR1, CREBL1, ATF4, ADCY7, CALM1, PRKCA, CAMK4, CAMK2D, ATP2B1, ATP2B4

Telmisartan

hsa04926

Relaxin signaling pathway

5.70E-03

P42338, P63218, P50151, P49767, P49407

PIK3CB, GNG5, GNG10, VEGFC, ARRB1

Telmisartan

hsa04927

Cortisol synthesis and secretion

4.36E-02

Q99941, P18848

CREBL1, ATF4

Telmisartan

hsa04928

Parathyroid hormone synthesis, secretion and action

5.51E-03

Q14643, P22694, P23771, Q02750, P17252, P10415, Q9Y5Q3

ITPR1, PRKACB, GATA3, MAP2K1, PRKCA, BCL2, MAFB

Telmisartan

hsa04929

GnRH secretion

4.62E-02

P42338, P49407

PIK3CB, ARRB1

Telmisartan

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Telmisartan

hsa04932

Non-alcoholic fatty liver disease

1.52E-05

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1

Telmisartan

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.93E-03

P84022, Q13485, P10415, P42338, P49767, P17252, P19174

SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PRKCA, PLCG1

Telmisartan

hsa04934

Cushing syndrome

9.05E-06

Q99941, P18848, P51828, O15169, Q13557

CREBL1, ATF4, ADCY7, AXIN1, CAMK2D

Telmisartan

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Telmisartan

hsa04960

Aldosterone-regulated sodium reabsorption

4.40E-02

O00141

SGK

Telmisartan

hsa04962

Vasopressin-regulated water reabsorption

7.22E-03

P52566, P62491

ARHGDIB, RAB11A

Telmisartan

hsa04966

Collecting duct acid secretion

3.15E-02

P02730, Q9Y666

SLC4A1, SLC12A7

Telmisartan

hsa04970

Salivary secretion

1.27E-05

P51828, P22694, Q14643, P20020, P23634, P17252, P0DP24, P0DP23, P49913

ADCY7, PRKACB, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM2, CALM1, CAMP

Telmisartan

hsa04971

Gastric acid secretion

1.87E-03

P51828, P17252, P15311, P63261, P0DP23, Q13557

ADCY7, PRKCA, VIL2, ACTG1, CALM1, CAMK2D

Telmisartan

hsa04972

Pancreatic secretion

4.09E-04

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Telmisartan

hsa04976

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Telmisartan

hsa04978

Mineral absorption

3.94E-02

P23634, Q9BXS9

ATP2B4, SLC26A6

Telmisartan

hsa05010

Alzheimer disease

1.70E-03

Q92542, P05496, P13073, P12074, O75460, P0DP24, P01584, P18848, O15169, P05141, P45880

NCSTN, ATP5G1, COX4I1, COX6A1, ERN1, CALM2, IL1B, ATF4, AXIN1, SLC25A5, VDAC2

Telmisartan

hsa05012

Parkinson disease

3.44E-03

P13073, P05141, P60604, O75460, P18848, P19174, P0DP23, P0DP24, Q71U36, Q13509, P68371

COX4I1, SLC25A5, UBE2G2, ERN1, ATF4, PLCG1, CALM1, CALM2, TUBA1A, TUBB3, TUBB2C

Telmisartan

hsa05014

Amyotrophic lateral sclerosis

4.31E-02

O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0

GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2B

Telmisartan

hsa05016

Huntington disease

1.46E-03

P13073, Q9GZM3, P24928, P62487, P52435, P05141, O75460, P55036

COX4I1, POLR2J2, POLR2A, POLR2G, POLR2J, SLC25A5, ERN1, PSMD4

Telmisartan

hsa05020

Prion disease

1.81E-02

P01584, P46531, P11142, P05496, P12074, P45880, Q99941

IL1B, NOTCH1, HSPA8, ATP5G1, COX6A1, VDAC2, CREBL1

Telmisartan

hsa05022

Pathways of neurodegeneration - multiple diseases

1.98E-02

P13073, O75460, P18848, P05141, P20333, P01584, P0DP24

COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2

Telmisartan

hsa05030

Cocaine addiction

4.36E-02

Q99941, P18848

CREBL1, ATF4

Telmisartan

hsa05031

Amphetamine addiction

2.40E-04

O15399, P0DP23, Q16566, Q13557, Q99941, P18848, P17252

GRIN2D, CALM1, CAMK4, CAMK2D, CREBL1, ATF4, PRKCA

Telmisartan

hsa05032

Morphine addiction

2.18E-02

P62873, P63218, P50151, Q13370

GNB1, GNG5, GNG10, PDE3B

Telmisartan

hsa05034

Alcoholism

3.11E-05

Q96RR4, Q93077, P62807, O60814, P84243, P68431

CAMKK2, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Telmisartan

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Telmisartan

hsa05110

Vibrio cholerae infection

4.50E-03

Q13488, P17252, P19174, P60709

TCIRG1, PRKCA, PLCG1, ACTB

Telmisartan

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

5.79E-06

Q16539, P25963, Q13488, P09341, P19174, P25024, P25025, P07948

MAPK14, NFKBIA, TCIRG1, CXCL1, PLCG1, CXCR1, CXCR2, LYN

Telmisartan

hsa05130

Pathogenic Escherichia coli infection

4.88E-05

Q71U36, Q14247, P56750, O00501, P16333, Q92974, Q13509, P68371, P63261, P25116, Q14344, P25963, Q06124, O95487

TUBA1A, CTTN, CLDN17, CLDN5, NCK1, ARHGEF2, TUBB3, TUBB2C, ACTG1, F2R, GNA13, NFKBIA, PTPN11, SEC24B

Telmisartan

hsa05132

Salmonella infection

2.57E-07

P51617, P25963, P08238, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q71U36, Q13509, P68371, P49754

IRAK1, NFKBIA, HSP90AB1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.787
P10415	BCL2	Apoptosis regulator Bcl-2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.908
P46091	GPR1	Chemerin-like receptor 2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.736
P51684	CCR6	C-C chemokine receptor type 6	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.835
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P46091	GPR1	Chemerin-like receptor 2	P63261	ACTG1	Actin, cytoplasmic 2	0.776
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
P46091	GPR1	Chemerin-like receptor 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.759
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
P46091	GPR1	Chemerin-like receptor 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.808
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75369	FLNB	Filamin-B	0.706
P10415	BCL2	Apoptosis regulator Bcl-2	O75369	FLNB	Filamin-B	-0.762
P51684	CCR6	C-C chemokine receptor type 6	O75369	FLNB	Filamin-B	-0.717
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
P10415	BCL2	Apoptosis regulator Bcl-2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.929
P51684	CCR6	C-C chemokine receptor type 6	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.721
P51684	CCR6	C-C chemokine receptor type 6	P51808	DYNLT3	Dynein light chain Tctex-type 3	0.731
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13561	DCTN2	Dynactin subunit 2	-0.862
P10415	BCL2	Apoptosis regulator Bcl-2	Q13561	DCTN2	Dynactin subunit 2	-0.843
P51684	CCR6	C-C chemokine receptor type 6	Q13561	DCTN2	Dynactin subunit 2	-0.781
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.866
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13509	TUBB3	Tubulin beta-3 chain	0.789
P10415	BCL2	Apoptosis regulator Bcl-2	Q13509	TUBB3	Tubulin beta-3 chain	-0.809
P46091	GPR1	Chemerin-like receptor 2	Q13509	TUBB3	Tubulin beta-3 chain	-0.748
P51684	CCR6	C-C chemokine receptor type 6	Q13509	TUBB3	Tubulin beta-3 chain	-0.835
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P68371	TUBB2C	Tubulin beta-4B chain	0.741
P10415	BCL2	Apoptosis regulator Bcl-2	P68371	TUBB2C	Tubulin beta-4B chain	-0.766
P46091	GPR1	Chemerin-like receptor 2	P68371	TUBB2C	Tubulin beta-4B chain	-0.751
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.728

Telmisartan

hsa05133

Pertussis

1.68E-03

P0DP23, P23528, P09871, Q02556

CALM1, CFL1, C1S, IRF8

Telmisartan

hsa05134

Legionellosis

4.75E-02

P25963, P11215, P11142

NFKBIA, ITGAM, HSPA8

Telmisartan

hsa05135

Yersinia infection

6.38E-03

Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P49841, Q96JJ3

PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, GSK3B, ELMO2

Telmisartan

hsa05140

Leishmaniasis

1.51E-09

P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
P51684	CCR6	C-C chemokine receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	-0.713
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11215	ITGAM	Integrin alpha-M	-0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.81
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.841
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	1
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P49006	MARCKSL1	MARCKS-related protein	0.706
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
P51684	CCR6	C-C chemokine receptor type 6	P49006	MARCKSL1	MARCKS-related protein	0.727
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P51684	CCR6	C-C chemokine receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	-0.803

Telmisartan

hsa05143

African trypanosomiasis

2.72E-02

P01375, P48023

TNF, FASLG

Telmisartan

hsa05144

Malaria

1.35E-04

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Telmisartan

hsa05146

Amoebiasis

2.35E-05

P01584, Q13751, P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311

IL1B, LAMB3, CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43657	P2RY5	Lysophosphatidic acid receptor 6	Q13751	LAMB3	Laminin subunit beta-3	-0.763
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P43657	P2RY5	Lysophosphatidic acid receptor 6	P09341	CXCL1	Growth-regulated alpha protein	-0.839
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P43657	P2RY5	Lysophosphatidic acid receptor 6	P14778	IL1R1	Interleukin-1 receptor type 1	-0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P43657	P2RY5	Lysophosphatidic acid receptor 6	P27930	IL1R2	Interleukin-1 receptor type 2	-0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P43657	P2RY5	Lysophosphatidic acid receptor 6	P05089	ARG1	Arginase-1	-0.793
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
P43657	P2RY5	Lysophosphatidic acid receptor 6	P12814	ACTN1	Alpha-actinin-1	-0.814
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79

Telmisartan

hsa05152

Tuberculosis

2.24E-04

Q13488, P0DP23, O75015, P48382, O60603, P10415, P13765, P01568, Q9UDY8, Q16539, P51617

TCIRG1, CALM1, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, MAPK14, IRAK1

Telmisartan

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Telmisartan

hsa05161

Hepatitis B

2.86E-02

Q99941, P18848, P27348

CREBL1, ATF4, YWHAQ

Telmisartan

hsa05163

Human cytomegalovirus infection

6.30E-06

P01375, P30511, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, P49841, P14778, P25025, Q16539, P04637, O00463, P30101, P01568

TNF, HLA-F, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P27694	RPA1	Replication protein A 70 kDa DNA-binding subunit	P30511	HLA-F	HLA class I histocompatibility antigen, alpha chain F	0.898
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P27694	RPA1	Replication protein A 70 kDa DNA-binding subunit	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.727
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733

Telmisartan

hsa05165

Human papillomavirus infection

4.71E-03

P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315

CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATM

Telmisartan

hsa05167

Kaposi sarcoma-associated herpesvirus infection

4.88E-06

P01568, P42224, P25963, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P04141, P0DP23, P0CG47

IFNA21, STAT1, NFKBIA, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, CSF2, CALM1, UBB

Telmisartan

hsa05168

Herpes simplex virus 1 infection

3.44E-05

Q9UKJ0, P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13489, P30101, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6, P10415

PILRB, NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P46091	GPR1	Chemerin-like receptor 2	Q9UKJ0	PILRB	Paired immunoglobulin-like type 2 receptor beta	-0.781
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P46091	GPR1	Chemerin-like receptor 2	P01568	IFNA21	Interferon alpha-21	0.724
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P46091	GPR1	Chemerin-like receptor 2	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.707
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
P46091	GPR1	Chemerin-like receptor 2	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.746
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P46091	GPR1	Chemerin-like receptor 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.759
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13398	ZNF211	Zinc finger protein 211	0.849
P46091	GPR1	Chemerin-like receptor 2	Q13398	ZNF211	Zinc finger protein 211	-0.71
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P46091	GPR1	Chemerin-like receptor 2	Q03923	ZNF85	Zinc finger protein 85	0.705
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75820	ZNF189	Zinc finger protein 189	-0.766
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824
P46091	GPR1	Chemerin-like receptor 2	Q9UDV6	ZNF212	Zinc finger protein 212	-0.75
P46091	GPR1	Chemerin-like receptor 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.808

Telmisartan

hsa05169

Epstein-Barr virus infection

2.60E-04

P13765, Q13547, Q92769, P04637, Q13546, P10415, P42338, P07948, Q13761, P24522, O75293, O60603, P29728, P51617, P07766, P09693

HLA-DOB, HDAC1, HDAC2, TP53, RIPK1, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TLR2, OAS2, IRAK1, CD3E, CD3G

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P32248	CCR7	C-C chemokine receptor type 7	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.808
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13547	HDAC1	Histone deacetylase 1	-0.774
P51684	CCR6	C-C chemokine receptor type 6	Q92769	HDAC2	Histone deacetylase 2	0.702
P32248	CCR7	C-C chemokine receptor type 7	P04637	TP53	Cellular tumor antigen p53	0.77
P51684	CCR6	C-C chemokine receptor type 6	P04637	TP53	Cellular tumor antigen p53	0.728
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P32248	CCR7	C-C chemokine receptor type 7	P10415	BCL2	Apoptosis regulator Bcl-2	0.748
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07948	LYN	Tyrosine-protein kinase Lyn	0.735
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q13761	RUNX3	Runt-related transcription factor 3	-0.708
P32248	CCR7	C-C chemokine receptor type 7	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.862
P51684	CCR6	C-C chemokine receptor type 6	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.712
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.768
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P32248	CCR7	C-C chemokine receptor type 7	P29728	OAS2	2'-5'-oligoadenylate synthase 2	0.738
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.77
P32248	CCR7	C-C chemokine receptor type 7	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.864
P51684	CCR6	C-C chemokine receptor type 6	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.753

Telmisartan

hsa05170

Human immunodeficiency virus 1 infection

1.55E-07

Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P17252, Q13546, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, P19174, P23528, P09693, P10415, Q93034, Q9Y6Q5, P20333

MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PRKCA, RIPK1, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, PLCG1, CFL1, CD3G, BCL2, CUL5, AP1M2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P10415	BCL2	Apoptosis regulator Bcl-2	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.777
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P10415	BCL2	Apoptosis regulator Bcl-2	P0DP23	CALM1	Calmodulin-1	-0.772
P51684	CCR6	C-C chemokine receptor type 6	P0DP23	CALM1	Calmodulin-1	-0.734
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10415	BCL2	Apoptosis regulator Bcl-2	P17252	PRKCA	Protein kinase C alpha type	0.844
P51684	CCR6	C-C chemokine receptor type 6	P17252	PRKCA	Protein kinase C alpha type	0.738
P51684	CCR6	C-C chemokine receptor type 6	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.868
P10415	BCL2	Apoptosis regulator Bcl-2	O00463	TRAF5	TNF receptor-associated factor 5	0.773
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
P10415	BCL2	Apoptosis regulator Bcl-2	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.858
P51684	CCR6	C-C chemokine receptor type 6	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.81
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P10415	BCL2	Apoptosis regulator Bcl-2	P01568	IFNA21	Interferon alpha-21	0.721
P10415	BCL2	Apoptosis regulator Bcl-2	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.807
P51684	CCR6	C-C chemokine receptor type 6	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.722
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P10415	BCL2	Apoptosis regulator Bcl-2	O60603	TLR2	Toll-like receptor 2	-0.884
P51684	CCR6	C-C chemokine receptor type 6	O60603	TLR2	Toll-like receptor 2	-0.767
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P10415	BCL2	Apoptosis regulator Bcl-2	P23528	CFL1	Cofilin-1	0.741
P51684	CCR6	C-C chemokine receptor type 6	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.753
P10415	BCL2	Apoptosis regulator Bcl-2	P10415	BCL2	Apoptosis regulator Bcl-2	1
P51684	CCR6	C-C chemokine receptor type 6	P10415	BCL2	Apoptosis regulator Bcl-2	0.84
P10415	BCL2	Apoptosis regulator Bcl-2	Q93034	CUL5	Cullin-5	0.704
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.901
P51684	CCR6	C-C chemokine receptor type 6	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.86
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Telmisartan

hsa05171

Coronavirus disease - COVID-19

1.58E-05

P01584, P62753, P25398, P36578, P32969, P62888, P46776, P62899, P18077, P61927, P61513, P62829

IL1B, RPS6, RPS12, RPL4, RPL9, RPL30, RPL27A, RPL31, RPL35A, RPL37, RPL37A, RPL23

Telmisartan

hsa05200

Pathways in cancer

1.00E-06

Q13751, P42338, P08238, P42224, P25963, P19174, P04637, Q9UJU2, P17252, Q09472, P43246, P84022, Q13485, P20585, Q13547, P14923, P30281, P10415, Q13489, Q13077, P49767, P43657, P25116, P62873, P63218, P50151, Q14344, O95267, Q7LDG7, P78417, P24522, O75293, P0DP23, P01568, P14784, P16871

LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, TP53, LEF1, PRKCA, EP300, MSH2, SMAD3, SMAD4, MSH3, HDAC1, JUP, CCND3, BCL2, BIRC3, TRAF1, VEGFC, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP1, RASGRP2, GSTO1, GADD45A, GADD45B, CALM1, IFNA21, IL2RB, IL7R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P32248	CCR7	C-C chemokine receptor type 7	P04637	TP53	Cellular tumor antigen p53	0.77
P46091	GPR1	Chemerin-like receptor 2	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.736
P32248	CCR7	C-C chemokine receptor type 7	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.813
P46091	GPR1	Chemerin-like receptor 2	P17252	PRKCA	Protein kinase C alpha type	0.741
P32248	CCR7	C-C chemokine receptor type 7	Q09472	EP300	Histone acetyltransferase p300	-0.791
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P46091	GPR1	Chemerin-like receptor 2	P43246	MSH2	DNA mismatch repair protein Msh2	-0.838
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P46091	GPR1	Chemerin-like receptor 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.809
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P46091	GPR1	Chemerin-like receptor 2	P14923	JUP	Junction plakoglobin	0.883
P32248	CCR7	C-C chemokine receptor type 7	P14923	JUP	Junction plakoglobin	0.711
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P46091	GPR1	Chemerin-like receptor 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.808
P32248	CCR7	C-C chemokine receptor type 7	P10415	BCL2	Apoptosis regulator Bcl-2	0.748
P46091	GPR1	Chemerin-like receptor 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.759
P32248	CCR7	C-C chemokine receptor type 7	Q13077	TRAF1	TNF receptor-associated factor 1	0.748
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P46091	GPR1	Chemerin-like receptor 2	P49767	VEGFC	Vascular endothelial growth factor C	0.718
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P46091	GPR1	Chemerin-like receptor 2	P25116	F2R	Proteinase-activated receptor 1	0.76
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P32248	CCR7	C-C chemokine receptor type 7	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.792
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P46091	GPR1	Chemerin-like receptor 2	P78417	GSTO1	Glutathione S-transferase omega-1	0.738
P32248	CCR7	C-C chemokine receptor type 7	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.862
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P46091	GPR1	Chemerin-like receptor 2	P0DP23	CALM1	Calmodulin-1	-0.846
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
P46091	GPR1	Chemerin-like receptor 2	P01568	IFNA21	Interferon alpha-21	0.724
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P32248	CCR7	C-C chemokine receptor type 7	P16871	IL7R	Interleukin-7 receptor subunit alpha	0.743

Telmisartan

hsa05202

Transcriptional misregulation in cancer

3.21E-10

Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P46527, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, CDKN1B, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q12778	FOXO1	Forkhead box protein O1	0.714
Q15722	LTB4R	Leukotriene B4 receptor 1	Q12778	FOXO1	Forkhead box protein O1	-0.769
P10415	BCL2	Apoptosis regulator Bcl-2	Q12778	FOXO1	Forkhead box protein O1	0.794
Q13315	ATM	Serine-protein kinase ATM	Q12778	FOXO1	Forkhead box protein O1	0.821
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15532	SS18	Protein SSXT	0.893
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15532	SS18	Protein SSXT	-0.803
P10415	BCL2	Apoptosis regulator Bcl-2	Q15532	SS18	Protein SSXT	0.877
P32248	CCR7	C-C chemokine receptor type 7	Q15532	SS18	Protein SSXT	0.804
Q13315	ATM	Serine-protein kinase ATM	Q13315	ATM	Serine-protein kinase ATM	1
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P41732	TSPAN7	Tetraspanin-7	-0.834
Q15722	LTB4R	Leukotriene B4 receptor 1	P41732	TSPAN7	Tetraspanin-7	0.775
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
Q15722	LTB4R	Leukotriene B4 receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.861
P10415	BCL2	Apoptosis regulator Bcl-2	P14780	MMP9	Matrix metalloproteinase-9	-0.765
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q15722	LTB4R	Leukotriene B4 receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.734
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14923	JUP	Junction plakoglobin	0.914
P10415	BCL2	Apoptosis regulator Bcl-2	P14923	JUP	Junction plakoglobin	0.861
P32248	CCR7	C-C chemokine receptor type 7	P14923	JUP	Junction plakoglobin	0.711
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q13315	ATM	Serine-protein kinase ATM	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.709
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.837
P10415	BCL2	Apoptosis regulator Bcl-2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.746
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.797
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P10415	BCL2	Apoptosis regulator Bcl-2	Q13077	TRAF1	TNF receptor-associated factor 1	0.816
P32248	CCR7	C-C chemokine receptor type 7	Q13077	TRAF1	TNF receptor-associated factor 1	0.748
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O15550	UTX	Lysine-specific demethylase 6A	-0.808
Q15722	LTB4R	Leukotriene B4 receptor 1	O15550	UTX	Lysine-specific demethylase 6A	0.789
P32248	CCR7	C-C chemokine receptor type 7	O15550	UTX	Lysine-specific demethylase 6A	-0.715
Q13315	ATM	Serine-protein kinase ATM	P46527	CDKN1B	Cyclin-dependent kinase inhibitor 1B	0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
P32248	CCR7	C-C chemokine receptor type 7	P04637	TP53	Cellular tumor antigen p53	0.77
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P10415	BCL2	Apoptosis regulator Bcl-2	P05164	MPO	Myeloperoxidase	-0.81
Q13315	ATM	Serine-protein kinase ATM	P05164	MPO	Myeloperoxidase	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P10415	BCL2	Apoptosis regulator Bcl-2	P08246	ELA2	Neutrophil elastase	-0.942
Q13315	ATM	Serine-protein kinase ATM	P08246	ELA2	Neutrophil elastase	-0.742
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.808
P10415	BCL2	Apoptosis regulator Bcl-2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.766
Q13315	ATM	Serine-protein kinase ATM	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
P32248	CCR7	C-C chemokine receptor type 7	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.72
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.768
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
Q15722	LTB4R	Leukotriene B4 receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.764
P32248	CCR7	C-C chemokine receptor type 7	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.862

Telmisartan

hsa05203

Viral carcinogenesis

1.62E-04

Q12933, Q99941, P18848, P27348, Q15283, P62807, O60814

TRAF2, CREBL1, ATF4, YWHAQ, RASA2, HIST1H2BC, H2BC12

Telmisartan

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Telmisartan

hsa05205

Proteoglycans in cancer

9.14E-04

Q13009, Q12955, Q14643, O75369, P63261, P04637, P14780, P17252, O60603, P04628, Q13635, P08962

TIAM1, ANK3, ITPR1, FLNB, ACTG1, TP53, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63

Telmisartan

hsa05206

MicroRNAs in cancer

5.33E-04

P46527, P15311, P21860, P61978, P46531, Q9UM47, P16070, P63279, Q13315, P22105, P17252, Q02750

CDKN1B, VIL2, ERBB3, HNRPK, NOTCH1, NOTCH3, CD44, UBE2I, ATM, TNXB, PRKCA, MAP2K1

Telmisartan

hsa05210

Colorectal cancer

2.41E-02

P10415, P04637, Q9UJU2, P24522

BCL2, TP53, LEF1, GADD45A

Telmisartan

hsa05211

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Telmisartan

hsa05212

Pancreatic cancer

1.23E-03

P42338, P42224, P37173, P84022, Q13485, O75293

PIK3CB, STAT1, TGFBR2, SMAD3, SMAD4, GADD45B

Telmisartan

hsa05213

Endometrial cancer

1.53E-03

O15169, Q9UJU2, Q02750, P04637, P24522

AXIN1, LEF1, MAP2K1, TP53, GADD45A

Telmisartan

hsa05214

Glioma

1.12E-04

P0DP23, Q16566, P17252, P04637, P19174, P24522, O75293

CALM1, CAMK4, PRKCA, TP53, PLCG1, GADD45A, GADD45B

Telmisartan

hsa05215

Prostate cancer

1.94E-02

P10415, Q9UJU2, Q09472, P04637

BCL2, LEF1, EP300, TP53

Telmisartan

hsa05216

Thyroid cancer

2.54E-05

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Telmisartan

hsa05217

Basal cell carcinoma

1.13E-05

Q13635, P49841, Q9UJU2, P04637, P24522

PTCH1, GSK3B, LEF1, TP53, GADD45A

Telmisartan

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Telmisartan

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Telmisartan

hsa05222

Small cell lung cancer

1.94E-02

P10415, Q13077, P04637, P24522

BCL2, TRAF1, TP53, GADD45A

Telmisartan

hsa05223

Non-small cell lung cancer

3.99E-02

P17252, O43524, P19174, O75293

PRKCA, FOXO3, PLCG1, GADD45B

Telmisartan

hsa05224

Breast cancer

5.34E-03

Q9UJU2, P49841, Q92837, P04637, P24522

LEF1, GSK3B, FRAT1, TP53, GADD45A

Telmisartan

hsa05226

Gastric cancer

7.13E-04

Q02750, Q9UJU2, O15169, P04637, P24522, P14923, P10415

MAP2K1, LEF1, AXIN1, TP53, GADD45A, JUP, BCL2

Telmisartan

hsa05230

Central carbon metabolism in cancer

4.04E-02

P07195, P04637

LDHB, TP53

Telmisartan

hsa05231

Choline metabolism in cancer

3.99E-02

P19174, P23743, O14494, P17252

PLCG1, DGKA, PLPP1, PRKCA

Telmisartan

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

5.71E-03

O95267, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539, P01730

RASGRP1, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14, CD4

Telmisartan

hsa05310

Asthma

2.81E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Telmisartan

hsa05320

Autoimmune thyroid disease

8.64E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Telmisartan

hsa05321

Inflammatory bowel disease

1.73E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B

Telmisartan

hsa05322

Systemic lupus erythematosus

1.49E-05

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Telmisartan

hsa05323

Rheumatoid arthritis

3.53E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Telmisartan

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Telmisartan

hsa05332

Graft-versus-host disease

1.53E-04

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Telmisartan

hsa05415

Diabetic cardiomyopathy

1.62E-04

P17252, P14598, Q15080, Q16718, O14521, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P17252	PRKCA	Protein kinase C alpha type	-0.754
P09960	LTA4H	Leukotriene A-4 hydrolase	P17252	PRKCA	Protein kinase C alpha type	-0.732
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P14598	NCF1	Neutrophil cytosol factor 1	0.818
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P14598	NCF1	Neutrophil cytosol factor 1	-0.781
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q15080	NCF4	Neutrophil cytosol factor 4	0.752
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q15080	NCF4	Neutrophil cytosol factor 4	-0.743
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.841
P09960	LTA4H	Leukotriene A-4 hydrolase	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	-0.816
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.755
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.931
P09960	LTA4H	Leukotriene A-4 hydrolase	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	-0.799
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.814
P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.978
P09960	LTA4H	Leukotriene A-4 hydrolase	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	0.725
Q9UNH5	CDC14A	Dual specificity protein phosphatase CDC14A	P04406	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	-0.777

Telmisartan

hsa05418

Fluid shear stress and atherosclerosis

2.93E-05

Q16539, P14598, P78417, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, P0DP23, Q92974

MAPK14, NCF1, GSTO1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P46091	GPR1	Chemerin-like receptor 2	P78417	GSTO1	Glutathione S-transferase omega-1	0.738
Q16539	MAPK14	Mitogen-activated protein kinase 14	P10599	TXN	Thioredoxin	0.749
P25024	CXCR1	C-X-C chemokine receptor type 1	P10599	TXN	Thioredoxin	0.867
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P25024	CXCR1	C-X-C chemokine receptor type 1	P14780	MMP9	Matrix metalloproteinase-9	0.814
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P46091	GPR1	Chemerin-like receptor 2	P63261	ACTG1	Actin, cytoplasmic 2	0.776
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
P46091	GPR1	Chemerin-like receptor 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.808
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P25024	CXCR1	C-X-C chemokine receptor type 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.955
P46091	GPR1	Chemerin-like receptor 2	P0DP23	CALM1	Calmodulin-1	-0.846
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.72
P46091	GPR1	Chemerin-like receptor 2	Q92974	ARHGEF2	Rho guanine nucleotide exchange factor 2	-0.815

Community members of Telmisartan (S_DC: 7.83)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P50052

AGTR2

TypeNone2 angiotensin II receptor

Predicted

0.0604

0.4365

0.1541

1.0572

Q86Z02

HIPK1

HomeodomainNoneinteracting protein kinase 1

Predicted

0.4631

0.2816

0.218

1.0128

P07947

YES1

TyrosineNoneprotein kinase Yes

Predicted

0.1212

0.4345

0.165

1.0947

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P18054

ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12

Predicted

0.0075

0.3703

0.2416

0.986

O14684

PTGES

Prostaglandin E synthase

Predicted

0.4531

0.6358

0.1565

1.6547

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P10826

RARB

Retinoic acid receptor beta

Predicted

0.0094

0.3466

0.3005

0.9983

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P13612

ITGA4

Integrin alphaNone4

Predicted

0.1165

0.2386

0.6862

1.2217

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

Q05397

PTK2

Focal adhesion kinase 1

Predicted

0.2153

0.5864

0.9713

2.2518

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

Q13315

ATM

SerineNoneprotein kinase ATM

Predicted

0.7747

0.2014

0.9391

1.7293

P20292

ALOX5AP

Arachidonate 5NonelipoxygenaseNoneactivating protein

Predicted

0.1303

0.2418

0.0907

0.6395

Q07817

BCL2L1

BclNone2Nonelike protein 1

Predicted

0.0872

0.4349

1.9134

P10415

BCL2

Apoptosis regulator BclNone2

Predicted

0.0341

0.5271

2.0714

Q06124

PTPN11

TyrosineNoneprotein phosphatase nonNonereceptor type 11

Predicted

0.1513

0.4566

0.613

1.6017

P29350

PTPN6

TyrosineNoneprotein phosphatase nonNonereceptor type 6

Predicted

0.2807

0.2459

0.5683

1.2004

P08575

PTPRC

ReceptorNonetype tyrosineNoneprotein phosphatase C

Predicted

0.2733

0.1358

0.4132

0.8216

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

O00141

SGK

Serine/threonineNoneprotein kinase Sgk1

Predicted

0.2413

0.3037

0.3059

1.034

P98170

BIRC4

E3 ubiquitinNoneprotein ligase XIAP

Predicted

0.2974

0.2298

0.79

1.3984

P43490

PBEF1

Nicotinamide phosphoribosyltransferase

Predicted

0.4423

0.7064

0.238

1.872

P24666

ACP1

Low molecular weight phosphotyrosine protein phosphatase

Predicted

0.0704

0.1048

0.2361

0.481

Q9UNH5

CDC14A

Dual specificity protein phosphatase CDC14A

Predicted

0.1855

0.0109

0.259

0.3735

P35610

SOAT1

Sterol ONoneacyltransferase 1

Predicted

0.3855

0.2936

0.0165

0.7964

Q13093

PLA2G7

PlateletNoneactivating factor acetylhydrolase

Predicted

0.0505

0.2096

0.1558

0.6001

Q15722

LTB4R

Leukotriene B4 receptor 1

Predicted

0.0677

0.2199

0.4736

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P27694

RPA1

Replication protein A 70 kDa DNANonebinding subunit

Predicted

0.2273

0.1756

0.2746

0.7395

Q9UNA4

POLI

DNA polymerase iota

Predicted

0.0207

0.012

0.0213

0.0557

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

P14780

MMP9

Matrix metalloproteinaseNone9

Predicted

0.1696

0.8424

0.7315

2.5012

Q02763

TEK

AngiopoietinNone1 receptor

Predicted

0.3206

0.6236

0.4304

1.8379

P49768

PSEN1

PresenilinNone1

Predicted

0.2677

0.6599

0.3308

1.7845

P50052

AGTR2

TypeNone2 angiotensin II receptor

Predicted

0.0604

0.4365

0.1541

1.0572

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P51684

CCR6

CNoneC chemokine receptor type 6

Predicted

0.085

0.1741

0.3304

0.7212

P10826

RARB

Retinoic acid receptor beta

Predicted

0.0094

0.3466

0.3005

0.9983

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

P46091

GPR1

ChemerinNonelike receptor 2

Predicted

0.2476

0.1372

0.3982

P32248

CCR7

CNoneC chemokine receptor type 7

Predicted

0.1391

0.0461

0.3304

0.4922

P21462

FPR1

fMetNoneLeuNonePhe receptor

Predicted

0.1205

0.3492

0.4378

1.1964

P43657

P2RY5

Lysophosphatidic acid receptor 6

Predicted

0.7539

0.0448

0.3708

0.8373

P32302

CXCR5

CNoneXNoneC chemokine receptor type 5

Predicted

0.2455

0.0459

0.3304

0.545

Q99527

GPER1

GNoneprotein coupled estrogen receptor 1

Predicted

0.0249

0.1294

0.2138

0.485

PharmaCoNets of Telmisartan (SPCN: 197.82 )

Telmisartan regulated-network (SDN: 25.26)

Community members of Telmisartan (SDC: 7.83)

PharmaCoNets of Telmisartan (S_PCN: 197.82 )

Telmisartan regulated-network (S_DN: 25.26)

Community members of Telmisartan (S_DC: 7.83)