PharmaCoNets

PharmaCoNets of Telaprevir (S_PCN: 48.53 )

Telaprevir regulated-network (S_DN: 12.67)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Telaprevir

hsa00071

Fatty acid degradation

4.66E-02

O75521, P11766, P33121

ECI2, ADH5, ACSL1

Telaprevir

hsa00072

Synthesis and degradation of ketone bodies

2.78E-02

Q01581

HMGCS1

Telaprevir

hsa00220

Arginine biosynthesis

1.21E-02

P15104

GLUL

Telaprevir

hsa00240

Pyrimidine metabolism

4.29E-02

P21589, P04183

NT5E, TK1

Telaprevir

hsa00250

Alanine, aspartate and glutamate metabolism

2.42E-02

P15104

GLUL

Telaprevir

hsa00310

Lysine degradation

8.45E-03

Q96KQ7, P51648

EHMT2, ALDH3A2

Telaprevir

hsa00500

Starch and sucrose metabolism

4.45E-05

O43451, P46976, P06737

MGAM, GYG1, PYGL

Telaprevir

hsa00513

Various types of N-glycan biosynthesis

4.96E-02

Q9NR34

MAN1C1

Telaprevir

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Telaprevir

hsa00564

Glycerophospholipid metabolism

4.29E-02

Q6P1A2, P23743

MBOAT5, DGKA

Telaprevir

hsa00730

Thiamine metabolism

4.66E-02

P05186, P24666

ALPL, ACP1

Telaprevir

hsa00770

Pantothenate and CoA biosynthesis

7.90E-03

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Telaprevir

hsa00900

Terpenoid backbone biosynthesis

1.40E-02

Q01581

HMGCS1

Telaprevir

hsa00910

Nitrogen metabolism

2.42E-02

P15104

GLUL

Telaprevir

hsa00970

Aminoacyl-tRNA biosynthesis

1.58E-04

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Telaprevir

hsa01210

2-Oxocarboxylic acid metabolism

3.43E-02

P50213

IDH3A

Telaprevir

hsa01230

Biosynthesis of amino acids

4.06E-03

P60891, P05089, P15104, P37837

PRPS1, ARG1, GLUL, TALDO1

Telaprevir

hsa01521

EGFR tyrosine kinase inhibitor resistance

2.18E-02

P49841, Q9NRA1

GSK3B, PDGFC

Telaprevir

hsa03013

RNA transport

4.09E-02

P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Telaprevir

hsa03015

mRNA surveillance pathway

4.36E-02

Q9BZI7, O43809, Q9H307

UPF3B, NUDT21, PNN

Telaprevir

hsa03050

Proteasome

1.21E-02

P28074

PSMB5

Telaprevir

hsa04015

Rap1 signaling pathway

3.07E-02

P25116, Q8TEU7, P08514, P17252

F2R, RAPGEF6, ITGA2B, PRKCA

Telaprevir

hsa04060

Cytokine-cytokine receptor interaction

2.05E-02

P27930, P14778, P26842, Q13651, P25024, P25025, Q9UBD3, P47992, P09341, P18510, P01730

IL1R2, IL1R1, CD27, IL10RA, CXCR1, CXCR2, XCL2, XCL1, CXCL1, IL1RN, CD4

Telaprevir

hsa04061

Viral protein interaction with cytokine and cytokine receptor

3.04E-02

P09341, P25024, P25025, P47992, Q9UBD3, Q13651

CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA

Telaprevir

hsa04062

Chemokine signaling pathway

9.25E-05

P25024, P25025, P09341, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841

CXCR1, CXCR2, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P25024	CXCR1	C-X-C chemokine receptor type 1	0.843
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.892
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09341	CXCL1	Growth-regulated alpha protein	0.788
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P47992	XCL1	Lymphotactin	-0.796
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.796
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.749
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.736
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.754
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.709
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.798
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Telaprevir

hsa04064

NF-kappa B signaling pathway

8.34E-07

P10415, Q13489, P25963, P51617, O00463, Q13546, P14778, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q13315, P24522, P09341, Q9UNE0

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, IL1R1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, ATM, GADD45A, CXCL1, EDAR

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08235	NR3C2	Mineralocorticoid receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.868
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.786
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08235	NR3C2	Mineralocorticoid receptor	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.749
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.923
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08235	NR3C2	Mineralocorticoid receptor	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.708
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16548	BCL2A1	Bcl-2-related protein A1	0.82
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07948	LYN	Tyrosine-protein kinase Lyn	0.749
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.793
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09341	CXCL1	Growth-regulated alpha protein	0.788
P08235	NR3C2	Mineralocorticoid receptor	Q9UNE0	EDAR	Tumor necrosis factor receptor superfamily member EDAR	0.819

Telaprevir

hsa04071

Sphingolipid signaling pathway

9.39E-03

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Telaprevir

hsa04080

Neuroactive ligand-receptor interaction

5.67E-03

P08311, Q15722, P21453, Q9H228, O00398, Q01726, P41968, P21462, P21730

CTSG, LTB4R, S1PR1, EDG8, P2RY10, MC1R, MC3R, FPR1, C5AR1

Telaprevir

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Telaprevir

hsa04141

Protein processing in endoplasmic reticulum

2.78E-02

P07384, O95487, O95816

CAPN1, SEC24B, BAG2

Telaprevir

hsa04142

Lysosome

2.64E-02

Q99437, P25774

ATP6V0B, CTSS

Telaprevir

hsa04145

Phagosome

7.50E-03

Q15080, P14598, Q13509, Q13488, Q99437, P05164, O60603, P35443, P13765, P25774

NCF4, NCF1, TUBB3, TCIRG1, ATP6V0B, MPO, TLR2, THBS4, HLA-DOB, CTSS

Telaprevir

hsa04210

Apoptosis

1.52E-02

Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643

ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1

Telaprevir

hsa04211

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Telaprevir

hsa04217

Necroptosis

2.93E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Telaprevir

hsa04360

Axon guidance

1.50E-02

P20827, P23528, Q06124

EFNA1, CFL1, PTPN11

Telaprevir

hsa04371

Apelin signaling pathway

1.94E-03

P63218, Q14344, Q13485, P84022, Q16566

GNG5, GNA13, SMAD4, SMAD3, CAMK4

Telaprevir

hsa04530

Tight junction

2.08E-02

P63261, Q9Y478, Q92974

ACTG1, PRKAB1, ARHGEF2

Telaprevir

hsa04610

Complement and coagulation cascades

3.16E-03

P00734, P0C0L4

F2, C4A

Telaprevir

hsa04611

Platelet activation

3.39E-02

P25116, P08514, P07359

F2R, ITGA2B, GP1BA

Telaprevir

hsa04612

Antigen processing and presentation

1.51E-02

P13765, P48382, P26715, P26717, Q13241, O43908, P01732

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A

Telaprevir

hsa04613

Neutrophil extracellular trap formation

1.30E-03

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, P21730, P21462

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1

Telaprevir

hsa04620

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Telaprevir

hsa04621

NOD-like receptor signaling pathway

7.18E-04

Q14643, P01568, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q13546, Q05823, P01375, P49913, P12838

ITPR1, IFNA21, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RIPK1, RNASEL, TNF, CAMP, DEFA4

Telaprevir

hsa04622

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Telaprevir

hsa04623

Cytosolic DNA-sensing pathway

2.20E-03

P01568, Q13546

IFNA21, RIPK1

Telaprevir

hsa04640

Hematopoietic cell lineage

3.31E-03

P13612, P14778, P27930, P11836, P07766, P09693, P01732, P01730, P13765

ITGA4, IL1R1, IL1R2, MS4A1, CD3E, CD3G, CD8A, CD4, HLA-DOB

Telaprevir

hsa04650

Natural killer cell mediated cytotoxicity

8.81E-06

P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715

TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P78314	SH3BP2	SH3 domain-binding protein 2	0.807
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.799
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13241	KLRD1	Natural killer cells antigen CD94	-0.733
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.888
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.712
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721

Telaprevir

hsa04658

Th1 and Th2 cell differentiation

1.64E-06

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, P23771, Q9UL17, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, GATA3, TBX21, HLA-DOB, RUNX3

Telaprevir

hsa04659

Th17 cell differentiation

2.83E-05

Q04759, Q16539, P01730, P06239, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963

PRKCQ, MAPK14, CD4, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247

Telaprevir

hsa04660

T cell receptor signaling pathway

7.21E-08

P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.727
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.709
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.759
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.75
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P06239	LCK	Tyrosine-protein kinase Lck	-0.835
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.798
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Telaprevir

hsa04662

B cell receptor signaling pathway

2.57E-02

P49841, P60033, P07948, P21854, Q8N149

GSK3B, CD81, LYN, CD72, LILRA2

Telaprevir

hsa04668

TNF signaling pathway

2.59E-02

P01375, O00463, Q13489, P25963, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9

Telaprevir

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Telaprevir

hsa04672

Intestinal immune network for IgA production

1.35E-02

P29965, P13765

CD40LG, HLA-DOB

Telaprevir

hsa04714

Thermogenesis

1.25E-02

P15336, P63261, Q9Y478

ATF2, ACTG1, PRKAB1

Telaprevir

hsa04724

Glutamatergic synapse

1.84E-02

O15399, P63218, Q9NSB8

GRIN2D, GNG5, HOMER2

Telaprevir

hsa04728

Dopaminergic synapse

2.82E-02

P14416, P63218, P50151, P49841, Q16539, P49407

DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1

Telaprevir

hsa04730

Long-term depression

1.63E-02

Q14344, P07948

GNA13, LYN

Telaprevir

hsa04916

Melanogenesis

2.18E-02

P49841, Q01726

GSK3B, MC1R

Telaprevir

hsa04918

Thyroid hormone synthesis

3.16E-02

P17252, P27824

PRKCA, CANX

Telaprevir

hsa04920

Adipocytokine signaling pathway

4.71E-03

P25963, Q06124, P33121, Q9Y478, Q04759, P01375

NFKBIA, PTPN11, ACSL1, PRKAB1, PRKCQ, TNF

Telaprevir

hsa04970

Salivary secretion

4.49E-02

P22694, Q14643, P17252, P49913

PRKACB, ITPR1, PRKCA, CAMP

Telaprevir

hsa04975

Fat digestion and absorption

2.80E-02

O14494

PLPP1

Telaprevir

hsa05010

Alzheimer disease

2.57E-02

O15399, Q9NZJ5, Q13564, Q71U36, P21796

GRIN2D, EIF2AK3, APPBP1, TUBA1A, VDAC1

Telaprevir

hsa05014

Amyotrophic lateral sclerosis

1.56E-02

O15399, Q9NZJ5, Q71U36, P21796, P43243, P84103

GRIN2D, EIF2AK3, TUBA1A, VDAC1, MATR3, SFRS3

Telaprevir

hsa05017

Spinocerebellar ataxia

2.43E-02

P28074

PSMB5

Telaprevir

hsa05020

Prion disease

4.79E-02

O15399, Q9NZJ5, P21796, Q71U36

GRIN2D, EIF2AK3, VDAC1, TUBA1A

Telaprevir

hsa05110

Vibrio cholerae infection

4.78E-02

Q99437

ATP6V0B

Telaprevir

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

5.83E-04

Q16539, P09341, P25024, P25025, P07948

MAPK14, CXCL1, CXCR1, CXCR2, LYN

Telaprevir

hsa05130

Pathogenic Escherichia coli infection

9.80E-03

Q92974, P63261, Q06124, O95487

ARHGEF2, ACTG1, PTPN11, SEC24B

Telaprevir

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Telaprevir

hsa05132

Salmonella infection

2.05E-03

P51617, P25963, P01375, Q9UJU2, Q13546, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371

IRAK1, NFKBIA, TNF, LEF1, RIPK1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C

Telaprevir

hsa05133

Pertussis

2.24E-02

P0DP23, P0C0L4

CALM1, C4A

Telaprevir

hsa05135

Yersinia infection

2.14E-03

P13612, P06239, Q16539, P01375, P49841, P01730, P01732

ITGA4, LCK, MAPK14, TNF, GSK3B, CD4, CD8A

Telaprevir

hsa05140

Leishmaniasis

1.18E-02

P14598, P13765, O60603, P25963, P01375, P51617, Q15080

NCF1, HLA-DOB, TLR2, NFKBIA, TNF, IRAK1, NCF4

Telaprevir

hsa05143

African trypanosomiasis

4.81E-02

P69905, P68871

HBA2, HBB

Telaprevir

hsa05144

Malaria

1.64E-03

P60033, O60603, P01375, P35443, P26718

CD81, TLR2, TNF, THBS4, KLRK1

Telaprevir

hsa05145

Toxoplasmosis

3.07E-02

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Telaprevir

hsa05152

Tuberculosis

9.13E-03

Q13488, Q99437, P48382, O60603, P01375, P10415, P13765, P25774, P49913, Q9UDY8, P51617

TCIRG1, ATP6V0B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CTSS, CAMP, MALT1, IRAK1

Telaprevir

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Telaprevir

hsa05163

Human cytomegalovirus infection

4.44E-04

P01375, P63218, P50151, P49841, P14778, Q13651, P25025, Q16539, O00463, P30101

TNF, GNG5, GNG10, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5, PDIA3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.736
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.754
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.798
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P14778	IL1R1	Interleukin-1 receptor type 1	0.923
P25024	CXCR1	C-X-C chemokine receptor type 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.857
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.713
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P25025	CXCR2	C-X-C chemokine receptor type 2	0.892
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.786
P25024	CXCR1	C-X-C chemokine receptor type 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.788
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P30101	PDIA3	Protein disulfide-isomerase A3	-0.721

Telaprevir

hsa05166

Human T-cell leukemia virus 1 infection

3.68E-02

P27824, P30279, P21796, P84022, Q13485, Q13042

CANX, CCND2, VDAC1, SMAD3, SMAD4, CDC16

Telaprevir

hsa05169

Epstein-Barr virus infection

1.68E-03

P13765, Q13547, O00463, Q16539, P07948, P30101, Q13761, P24522, P29728, P07766, P09693, P20963

HLA-DOB, HDAC1, TRAF5, MAPK14, LYN, PDIA3, RUNX3, GADD45A, OAS2, CD3E, CD3G, CD247

Telaprevir

hsa05170

Human immunodeficiency virus 1 infection

1.56E-04

P63218, P50151, P01375, P17252, O00463, P30101, Q14643, P01730, Q16539, P51617, P25963, O60603, Q13315, O95067, P07766, P09693, P20963, P10415, Q13619, Q93034, Q9Y6Q5

GNG5, GNG10, TNF, PRKCA, TRAF5, PDIA3, ITPR1, CD4, MAPK14, IRAK1, NFKBIA, TLR2, ATM, CCNB2, CD3E, CD3G, CD247, BCL2, CUL4A, CUL5, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.736
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.754
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	O00463	TRAF5	TNF receptor-associated factor 5	-0.786
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P30101	PDIA3	Protein disulfide-isomerase A3	-0.721
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P01730	CD4	T-cell surface glycoprotein CD4	-0.766
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.842
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	O95067	CCNB2	G2/mitotic-specific cyclin-B2	0.711
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.885
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.804
P11169	SLC2A3	Solute carrier family 2, facilitated glucose transporter member 3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.823
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13619	CUL4A	Cullin-4A	-0.707
P08246	ELA2	Neutrophil elastase	Q93034	CUL5	Cullin-5	-0.744
P08246	ELA2	Neutrophil elastase	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.811

Telaprevir

hsa05202

Transcriptional misregulation in cancer

1.51E-04

Q12778, Q15532, Q13315, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P24522

FOXO1, SS18, ATM, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45A

Telaprevir

hsa05205

Proteoglycans in cancer

4.46E-02

Q12955, Q14247, P17252, P08962

ANK3, CTTN, PRKCA, CD63

Telaprevir

hsa05211

Renal cell carcinoma

1.06E-02

Q06124, Q99814

PTPN11, EPAS1

Telaprevir

hsa05222

Small cell lung cancer

2.79E-02

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Telaprevir

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

9.92E-04

O95267, P07766, P20963, P09693, P06239, Q04759, Q16539, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4

Telaprevir

hsa05310

Asthma

1.70E-03

P13765, P29965, P12724, P01375

HLA-DOB, CD40LG, RNASE3, TNF

Telaprevir

hsa05320

Autoimmune thyroid disease

3.16E-02

P13765, P29965

HLA-DOB, CD40LG

Telaprevir

hsa05321

Inflammatory bowel disease

1.28E-02

O60603, P01375, P13765, Q14765, P23771

TLR2, TNF, HLA-DOB, STAT4, GATA3

Telaprevir

hsa05322

Systemic lupus erythematosus

4.20E-02

P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455

ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSB

Telaprevir

hsa05330

Allograft rejection

3.16E-02

P13765, P29965

HLA-DOB, CD40LG

Telaprevir

hsa05332

Graft-versus-host disease

9.30E-03

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Telaprevir

hsa05340

Primary immunodeficiency

3.99E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Telaprevir

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

1.82E-02

P14923, P08514, Q9UJU2

JUP, ITGA2B, LEF1

Telaprevir

hsa05416

Viral myocarditis

4.29E-02

P13765, P29965

HLA-DOB, CD40LG

Telaprevir

hsa05418

Fluid shear stress and atherosclerosis

3.61E-02

Q16539, P10599, P14780, P01375, P14778, P27930

MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Telaprevir (S_DC: 3.83)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P25774

CTSS

Cathepsin S

Predicted

0.3185

0.4932

0.5168

1.6625

P28074

PSMB5

Proteasome subunit beta typeNone5

Predicted

0.2839

0.4723

0.5439

1.6305

P11169

SLC2A3

Solute carrier family 2, facilitated glucose transporter member 3

Predicted

0.1357

0.0658

0.1995

P41968

MC3R

Melanocortin receptor 3

Predicted

0.2235

0.2637

0.6392

Q01726

MC1R

MelanocyteNonestimulating hormone receptor

Predicted

0.047

0.2375

0.011

0.5095

Q06124

PTPN11

TyrosineNoneprotein phosphatase nonNonereceptor type 11

Predicted

0.1513

0.4566

0.613

1.6017

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P25116

F2R

ProteinaseNoneactivated receptor 1

Predicted

0.2038

0.3196

0.5136

1.2547

P08235

NR3C2

Mineralocorticoid receptor

Predicted

0.1855

0.0137

2.1064

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

Q9UIG8

SLCO3A1

Solute carrier organic anion transporter family member 3A1

Predicted

0.0405

0.0069

0.034

PharmaCoNets of Telaprevir (SPCN: 48.53 )

Telaprevir regulated-network (SDN: 12.67)

Community members of Telaprevir (SDC: 3.83)

PharmaCoNets of Telaprevir (S_PCN: 48.53 )

Telaprevir regulated-network (S_DN: 12.67)

Community members of Telaprevir (S_DC: 3.83)