PharmaCoNets of Tapentadol (SPCN: 27.83 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tapentadolhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Tapentadolhsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Tapentadolhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Tapentadolhsa00500Starch and sucrose metabolism9.22E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Tapentadolhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Tapentadolhsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Tapentadolhsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Tapentadolhsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Tapentadolhsa00970Aminoacyl-tRNA biosynthesis1.58E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Tapentadolhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Tapentadolhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Tapentadolhsa01524Platinum drug resistance1.13E-025P10415, Q13489, P78417, P23025, P43246BCL2, BIRC3, GSTO1, XPA, MSH2More
Tapentadolhsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Tapentadolhsa03008Ribosome biogenesis in eukaryotes2.60E-035Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0UTP6, RPP38, GNL3, NVL, NXF2; NXF2BMore
Tapentadolhsa03013RNA transport2.29E-0413O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1More
Tapentadolhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Tapentadolhsa03040Spliceosome5.79E-037Q14562, O43143, O60508, Q99633, Q13595, Q01130, Q9UMS4DHX8, DHX15, CDC40, PRPF18, TRA2A, SFRS2, PRPF19More
Tapentadolhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Tapentadolhsa04015Rap1 signaling pathway1.58E-026P20827, P49767, P63261, P25116, P0DP23, P17252EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCAMore
Tapentadolhsa04020Calcium signaling pathway1.16E-037Q16566, P17252, O15399, P25116, P0DP23, P23634, P49767CAMK4, PRKCA, GRIN2D, F2R, CALM1, ATP2B4, VEGFCMore
Tapentadolhsa04024cAMP signaling pathway2.84E-025P0DP23, P23634, Q16566, O15399, P25116CALM1, ATP2B4, CAMK4, GRIN2D, F2RMore
Tapentadolhsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Tapentadolhsa04064NF-kappa B signaling pathway4.92E-026P10415, P51617, Q13546, Q9UDY8, Q13077, P24522BCL2, IRAK1, RIPK1, MALT1, TRAF1, GADD45AMore
Tapentadolhsa04070Phosphatidylinositol signaling system4.07E-024P0DP23, Q14643, O14732, P17252CALM1, ITPR1, IMPA2, PRKCAMore
Tapentadolhsa04071Sphingolipid signaling pathway1.90E-038P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2More
Tapentadolhsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Tapentadolhsa04145Phagosome1.86E-025P63261, Q15080, Q13509, P68371, P27824ACTG1, NCF4, TUBB3, TUBB2C, CANXMore
Tapentadolhsa04261Adrenergic signaling in cardiomyocytes3.44E-025Q16537, P0DP23, P17252, P10415, P20020PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Tapentadolhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Tapentadolhsa04390Hippo signaling pathway1.47E-025P63261, Q13485, Q9UJU2, O43623, Q13489ACTG1, SMAD4, LEF1, SNAI2, BIRC3More
Tapentadolhsa04510Focal adhesion3.21E-026Q15942, P17252, Q13489, P10415, P49767, P63261ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1More
Tapentadolhsa04520Adherens junction3.36E-024Q13485, Q9UJU2, O43623, P63261SMAD4, LEF1, SNAI2, ACTG1More
Tapentadolhsa04540Gap junction4.76E-023P17252, Q13509, P68371PRKCA, TUBB3, TUBB2CMore
Tapentadolhsa04610Complement and coagulation cascades6.23E-061P0C0L4C4AMore
Tapentadolhsa04612Antigen processing and presentation1.51E-027P13765, P48382, P26715, P26717, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8AMore
Tapentadolhsa04613Neutrophil extracellular trap formation2.23E-0314P17252, O60603, P08246, Q92769, P04908, Q6FI13, Q93077, P33778, P68431, P14598, Q15080, P21462, O43315, Q16539PRKCA, TLR2, ELA2, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC3, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1, AQP9, MAPK14More
Tapentadolhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Tapentadolhsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Tapentadolhsa04650Natural killer cell mediated cytotoxicity7.01E-0510P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Tapentadolhsa04660T cell receptor signaling pathway1.49E-0310P01375, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Tapentadolhsa04666Fc gamma R-mediated phagocytosis2.22E-024P49006, P06396, P14598, P17252MARCKSL1, GSN, NCF1, PRKCAMore
Tapentadolhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Tapentadolhsa04720Long-term potentiation3.70E-045P17252, Q16566, P0DP23, O15399, Q14643PRKCA, CAMK4, CALM1, GRIN2D, ITPR1More
Tapentadolhsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Tapentadolhsa04912GnRH signaling pathway4.42E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Tapentadolhsa04916Melanogenesis3.55E-023P0DP23, Q9UJU2, P17252CALM1, LEF1, PRKCAMore
Tapentadolhsa04921Oxytocin signaling pathway4.19E-024P0DP23, P17252, Q16566, P63261CALM1, PRKCA, CAMK4, ACTG1More
Tapentadolhsa04925Aldosterone synthesis and secretion2.90E-046Q14643, P0DP23, P17252, Q16566, P20020, P23634ITPR1, CALM1, PRKCA, CAMK4, ATP2B1, ATP2B4More
Tapentadolhsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Tapentadolhsa04933AGE-RAGE signaling pathway in diabetic complications3.36E-024Q13485, P10415, P49767, P17252SMAD4, BCL2, VEGFC, PRKCAMore
Tapentadolhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Tapentadolhsa04966Collecting duct acid secretion8.02E-053P02730, P00918, Q9Y666SLC4A1, CA2, SLC12A7More
Tapentadolhsa04970Salivary secretion8.71E-045Q14643, P20020, P23634, P17252, P0DP23ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1More
Tapentadolhsa04971Gastric acid secretion4.76E-023P17252, P63261, P0DP23PRKCA, ACTG1, CALM1More
Tapentadolhsa04972Pancreatic secretion1.00E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Tapentadolhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Tapentadolhsa04978Mineral absorption3.94E-022P23634, Q9BXS9ATP2B4, SLC26A6More
Tapentadolhsa05014Amyotrophic lateral sclerosis4.31E-027O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2BMore
Tapentadolhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Tapentadolhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Tapentadolhsa05031Amphetamine addiction1.49E-024O15399, P0DP23, Q16566, P17252GRIN2D, CALM1, CAMK4, PRKCAMore
Tapentadolhsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Tapentadolhsa05132Salmonella infection2.12E-0413P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2CMore
Tapentadolhsa05133Pertussis4.02E-044P0DP23, P23528, P09871, P0C0L4CALM1, CFL1, C1S, C4AMore
Tapentadolhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Tapentadolhsa05140Leishmaniasis1.56E-025P14598, O60603, P49006, P51617, Q15080NCF1, TLR2, MARCKSL1, IRAK1, NCF4More
Tapentadolhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Tapentadolhsa05144Malaria2.23E-047P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Tapentadolhsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Tapentadolhsa05168Herpes simplex virus 1 infection1.94E-029Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2More
Tapentadolhsa05169Epstein-Barr virus infection2.54E-028Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3GMore
Tapentadolhsa05170Human immunodeficiency virus 1 infection6.54E-039P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2More
Tapentadolhsa05200Pathways in cancer1.51E-0212Q9UJU2, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P25116, P78417, P0DP23, P01568LEF1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, F2R, GSTO1, CALM1, IFNA21More
Tapentadolhsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Tapentadolhsa05214Glioma8.71E-045P0DP23, Q16566, P17252, P04637, P24522CALM1, CAMK4, PRKCA, TP53, GADD45AMore
Tapentadolhsa05216Thyroid cancer1.85E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Tapentadolhsa05217Basal cell carcinoma4.42E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Tapentadolhsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Tapentadolhsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Tapentadolhsa05412Arrhythmogenic right ventricular cardiomyopathy5.12E-033Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Tapentadolhsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Tapentadolhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Tapentadolhsa05418Fluid shear stress and atherosclerosis2.49E-0311Q16539, P78417, P10599, P14780, P01375, P63261, P10415, P14778, P27930, P0DP23, Q92974MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2More

Community members of Tapentadol (SDC: 2.66)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P46091GPR1ChemerinNonelike receptor 2Predicted00.24760.137200.3982
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)