PharmaCoNets of Tamsulosin (SPCN: 45.61 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tamsulosinhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Tamsulosinhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Tamsulosinhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Tamsulosinhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Tamsulosinhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Tamsulosinhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Tamsulosinhsa01522Endocrine resistance4.55E-025P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Tamsulosinhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Tamsulosinhsa03050Proteasome4.83E-021P55036PSMD4More
Tamsulosinhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Tamsulosinhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Tamsulosinhsa04064NF-kappa B signaling pathway6.48E-0416P10415, Q13489, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, P24522, P09341, P19875, Q06643BCL2, BIRC3, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, GADD45A, CXCL1, CXCL2, LTBMore
Tamsulosinhsa04071Sphingolipid signaling pathway4.68E-058P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Tamsulosinhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Tamsulosinhsa04080Neuroactive ligand-receptor interaction3.82E-0310P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2More
Tamsulosinhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Tamsulosinhsa04140Autophagy - animal4.55E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Tamsulosinhsa04145Phagosome1.08E-028O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOBMore
Tamsulosinhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Tamsulosinhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Tamsulosinhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Tamsulosinhsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Tamsulosinhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Tamsulosinhsa04612Antigen processing and presentation2.31E-049P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Tamsulosinhsa04613Neutrophil extracellular trap formation6.32E-0416P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Tamsulosinhsa04621NOD-like receptor signaling pathway2.62E-0211Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Tamsulosinhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Tamsulosinhsa04650Natural killer cell mediated cytotoxicity5.49E-0612P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, Q14953, P26715PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1More
Tamsulosinhsa04657IL-17 signaling pathway3.69E-038O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Tamsulosinhsa04658Th1 and Th2 cell differentiation1.54E-0513Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Tamsulosinhsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Tamsulosinhsa04660T cell receptor signaling pathway5.05E-0515P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Tamsulosinhsa04666Fc gamma R-mediated phagocytosis3.08E-025O75015, P06396, O14494, P14598, P17252FCGR3B, GSN, PLPP1, NCF1, PRKCAMore
Tamsulosinhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Tamsulosinhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Tamsulosinhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Tamsulosinhsa04742Taste transduction1.01E-021P30939HTR1FMore
Tamsulosinhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Tamsulosinhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Tamsulosinhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Tamsulosinhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Tamsulosinhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Tamsulosinhsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Tamsulosinhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Tamsulosinhsa04940Type I diabetes mellitus2.61E-034P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Tamsulosinhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Tamsulosinhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Tamsulosinhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Tamsulosinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Tamsulosinhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Tamsulosinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Tamsulosinhsa05133Pertussis4.20E-021P0C0L4C4AMore
Tamsulosinhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Tamsulosinhsa05140Leishmaniasis4.75E-049P13612, O75015, P14598, P13765, O60603, P01375, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MAPK14, IRAK1, NCF4More
Tamsulosinhsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Tamsulosinhsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Tamsulosinhsa05146Amoebiasis7.00E-0613P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Tamsulosinhsa05150Staphylococcus aureus infection1.65E-026P21730, P21462, O75015, P13765, Q16581, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMPMore
Tamsulosinhsa05152Tuberculosis8.54E-039O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Tamsulosinhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Tamsulosinhsa05202Transcriptional misregulation in cancer2.28E-0317Q12778, Q15532, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522FOXO1, SS18, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Tamsulosinhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Tamsulosinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Tamsulosinhsa05310Asthma9.08E-043P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Tamsulosinhsa05321Inflammatory bowel disease7.09E-066O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Tamsulosinhsa05322Systemic lupus erythematosus2.82E-028O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, P05455FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, SSBMore
Tamsulosinhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Tamsulosinhsa05332Graft-versus-host disease8.64E-066P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Tamsulosinhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Tamsulosin (SDC: 4.36)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)