PharmaCoNets

PharmaCoNets of Tamoxifen (S_PCN: 201.74 )

Tamoxifen regulated-network (S_DN: 27.41)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Tamoxifen

hsa00030

Pentose phosphate pathway

1.79E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Tamoxifen

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Tamoxifen

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Tamoxifen

hsa00100

Steroid biosynthesis

3.94E-02

P35610

SOAT1

Tamoxifen

hsa00190

Oxidative phosphorylation

8.49E-07

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Tamoxifen

hsa00220

Arginine biosynthesis

4.30E-08

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Tamoxifen

hsa00250

Alanine, aspartate and glutamate metabolism

4.13E-06

Q96RQ9, P49448, P15104

IL4I1, GLUD2, GLUL

Tamoxifen

hsa00270

Cysteine and methionine metabolism

3.39E-02

Q96RQ9, P40926

IL4I1, MDH2

Tamoxifen

hsa00471

D-Glutamine and D-glutamate metabolism

3.94E-02

P49448

GLUD2

Tamoxifen

hsa00500

Starch and sucrose metabolism

6.40E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Tamoxifen

hsa00520

Amino sugar and nucleotide sugar metabolism

7.87E-03

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Tamoxifen

hsa00531

Glycosaminoglycan degradation

3.78E-02

P15586

GNS

Tamoxifen

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

6.96E-04

Q9NY97

B3GNT2

Tamoxifen

hsa00561

Glycerolipid metabolism

1.12E-02

Q8NEB5, P14550, Q86XP1

PPAPDC1B, AKR1A1, DGKH

Tamoxifen

hsa00562

Inositol phosphate metabolism

4.13E-03

P27987, P19174, P42338

ITPKB, PLCG1, PIK3CB

Tamoxifen

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Tamoxifen

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Tamoxifen

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Tamoxifen

hsa00600

Sphingolipid metabolism

3.76E-02

P15289

ARSA

Tamoxifen

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Tamoxifen

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

4.30E-03

P06865, O75752

HEXA, B3GALNT1

Tamoxifen

hsa00730

Thiamine metabolism

5.86E-04

P05186, P24666

ALPL, ACP1

Tamoxifen

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Tamoxifen

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Tamoxifen

hsa00900

Terpenoid backbone biosynthesis

1.22E-02

P49354, Q9UHG3

FNTA, PCYOX1

Tamoxifen

hsa00910

Nitrogen metabolism

1.85E-04

P15104, P49448

GLUL, GLUD2

Tamoxifen

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Tamoxifen

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Tamoxifen

hsa00983

Drug metabolism - other enzymes

1.60E-04

P04183, P20839, P32320, P05164

TK1, IMPDH1, CDA, MPO

Tamoxifen

hsa01100

Metabolic pathways

3.02E-03

Q9NR34, P05089, P21953, P15104, P42338, P27987, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P53004, P05186, P24666, Q9HCC0, P33121, P09917, P57054, Q9UNP4, Q9BX95, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, BCKDHB, GLUL, PIK3CB, ITPKB, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, BLVRA, ALPL, ACP1, MCCC2, ACSL1, ALOX5, PIGP, ST3GAL5, SGPP1, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P21953	BCKDHB	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial	0.765
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P15104	GLUL	Glutamine synthetase	-0.819
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.733
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P27987	ITPKB	Inositol-trisphosphate 3-kinase B	0.745
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P53004	BLVRA	Biliverdin reductase A	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	-0.705
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P32321	DCTD	Deoxycytidylate deaminase	0.79
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P49448	GLUD2	Glutamate dehydrogenase 2, mitochondrial	0.74
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	-0.798
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P46976	GYG1	Glycogenin-1	-0.82
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Tamoxifen

hsa01210

2-Oxocarboxylic acid metabolism

1.91E-02

P50213

IDH3A

Tamoxifen

hsa01230

Biosynthesis of amino acids

3.21E-02

P51854, P60891, P05089, P37837

TKTL1, PRPS1, ARG1, TALDO1

Tamoxifen

hsa01523

Antifolate resistance

1.72E-04

P41440, Q92820, P04818, P01375

SLC19A1, GGH, TYMS, TNF

Tamoxifen

hsa01524

Platinum drug resistance

3.69E-03

Q14790, P48023, P31751

CASP8, FASLG, AKT2

Tamoxifen

hsa02010

ABC transporters

2.17E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Tamoxifen

hsa03010

Ribosome

7.34E-03

P62753, P62829, P62888, P61927, P61513, P36578

RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4

Tamoxifen

hsa03013

RNA transport

4.49E-02

P62826, Q9UBU9, P63279, P68104, Q14232

RAN, NXF1, UBE2I, EEF1A1, EIF2B1

Tamoxifen

hsa03020

RNA polymerase

1.07E-09

P30876, P24928, P62487, Q9GZM3, P52435, Q9Y535

POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J, POLR3H

Tamoxifen

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Tamoxifen

hsa03060

Protein export

4.42E-02

P37108, Q15005

SRP14, SPCS2

Tamoxifen

hsa03320

PPAR signaling pathway

3.78E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Tamoxifen

hsa03430

Mismatch repair

4.38E-02

P20585

MSH3

Tamoxifen

hsa04010

MAPK signaling pathway

1.53E-02

Q9H2K8, Q12933

TAOK3, TRAF2

Tamoxifen

hsa04012

ErbB signaling pathway

3.69E-02

Q13191, P19174, P42338

CBLB, PLCG1, PIK3CB

Tamoxifen

hsa04014

Ras signaling pathway

7.30E-03

P31751, P0DP23

AKT2, CALM1

Tamoxifen

hsa04015

Rap1 signaling pathway

1.10E-04

P06213, O00522, P31751, P0DP23

INSR, KRIT1, AKT2, CALM1

Tamoxifen

hsa04020

Calcium signaling pathway

3.03E-03

Q96DU7, Q08828, Q13557, P21860, P0DP23, P05141, P51828, P26678, P63092

ITPKC, ADCY1, CAMK2D, ERBB3, CALM1, SLC25A5, ADCY7, PLN, GNAS

Tamoxifen

hsa04022

cGMP-PKG signaling pathway

2.81E-04

P18848, P31751, Q08828, P51828, P05141, P0DP23

ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1

Tamoxifen

hsa04024

cAMP signaling pathway

2.48E-03

Q08828, P51828, P31751, P0DP23

ADCY1, ADCY7, AKT2, CALM1

Tamoxifen

hsa04060

Cytokine-cytokine receptor interaction

1.23E-05

P14784, P27930, P14778, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P09341, P19875, P01730, Q93038

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, CXCL1, CXCL2, CD4, TNFRSF25

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
Q15131	CDK10	Cyclin-dependent kinase 10	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.753
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q15131	CDK10	Cyclin-dependent kinase 10	P27930	IL1R2	Interleukin-1 receptor type 2	-0.771
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
Q15131	CDK10	Cyclin-dependent kinase 10	P14778	IL1R1	Interleukin-1 receptor type 1	-0.746
P06239	LCK	Tyrosine-protein kinase Lck	P26842	CD27	CD27 antigen	0.817
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
P24723	PRKCH	Protein kinase C eta type	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.747
Q15131	CDK10	Cyclin-dependent kinase 10	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.758
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
Q15131	CDK10	Cyclin-dependent kinase 10	Q9HBE5	IL21R	Interleukin-21 receptor	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q15131	CDK10	Cyclin-dependent kinase 10	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
Q15131	CDK10	Cyclin-dependent kinase 10	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.703
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
Q15131	CDK10	Cyclin-dependent kinase 10	P47992	XCL1	Lymphotactin	0.703
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P24723	PRKCH	Protein kinase C eta type	Q93038	TNFRSF25	Tumor necrosis factor receptor superfamily member 25	0.761
Q15131	CDK10	Cyclin-dependent kinase 10	Q93038	TNFRSF25	Tumor necrosis factor receptor superfamily member 25	0.701

Tamoxifen

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.17E-05

Q8NHW4, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784

CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB

Tamoxifen

hsa04062

Chemokine signaling pathway

9.33E-07

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q15131	CDK10	Cyclin-dependent kinase 10	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.726
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
Q15131	CDK10	Cyclin-dependent kinase 10	P47992	XCL1	Lymphotactin	0.703
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
Q15131	CDK10	Cyclin-dependent kinase 10	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.703
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P07948	LYN	Tyrosine-protein kinase Lyn	-0.724
Q15131	CDK10	Cyclin-dependent kinase 10	P07948	LYN	Tyrosine-protein kinase Lyn	-0.713
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.733
Q15131	CDK10	Cyclin-dependent kinase 10	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.791
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
Q15131	CDK10	Cyclin-dependent kinase 10	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.81
Q15131	CDK10	Cyclin-dependent kinase 10	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.758
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P51817	PRKX	cAMP-dependent protein kinase catalytic subunit PRKX	P49407	ARRB1	Beta-arrestin-1	0.803
Q15131	CDK10	Cyclin-dependent kinase 10	P49407	ARRB1	Beta-arrestin-1	0.807
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774

Tamoxifen

hsa04064

NF-kappa B signaling pathway

6.73E-11

P10415, Q13489, O00463, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, BIRC3, TRAF5, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
Q04759	PRKCQ	Protein kinase C theta type	O00463	TRAF5	TNF receptor-associated factor 5	0.81
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P17252	PRKCA	Protein kinase C alpha type	P29965	CD40LG	CD40 ligand	0.788
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P17252	PRKCA	Protein kinase C alpha type	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.769
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q04759	PRKCQ	Protein kinase C theta type	Q16548	BCL2A1	Bcl-2-related protein A1	-0.76
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
P17252	PRKCA	Protein kinase C alpha type	Q8WV28	BLNK	B-cell linker protein	0.838
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q04759	PRKCQ	Protein kinase C theta type	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.846
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q04759	PRKCQ	Protein kinase C theta type	P09341	CXCL1	Growth-regulated alpha protein	-0.885
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P24723	PRKCH	Protein kinase C eta type	Q06643	LTB	Lymphotoxin-beta	0.763
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753

Tamoxifen

hsa04068

FoxO signaling pathway

1.25E-02

P48023, Q96BR1

FASLG, SGK3

Tamoxifen

hsa04070

Phosphatidylinositol signaling system

1.00E-03

P0DP23, Q14643, O14986, P23743, Q16760, P48426, P17252

CALM1, ITPR1, PIP5K1B, DGKA, DGKD, PIP4K2A, PRKCA

Tamoxifen

hsa04071

Sphingolipid signaling pathway

2.45E-05

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2, Q12933, Q02156

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2, TRAF2, PRKCE

Tamoxifen

hsa04072

Phospholipase D signaling pathway

4.96E-04

P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760

AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD

Tamoxifen

hsa04080

Neuroactive ligand-receptor interaction

2.16E-02

P08311, Q15722, P21453, Q9H228, P21462, P21730, P07550

CTSG, LTB4R, S1PR1, EDG8, FPR1, C5AR1, ADRB2

Tamoxifen

hsa04110

Cell cycle

1.97E-05

P06493, O60566, O75293, P30304, P33981, P42773, P01106

CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC

Tamoxifen

hsa04114

Oocyte meiosis

8.00E-06

Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738

MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D

Tamoxifen

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Tamoxifen

hsa04140

Autophagy - animal

7.93E-04

Q9Y4H2, P42338, P31751, Q7L523, Q9NQL2, O75460, Q04759, Q96GC9, Q8TEV9

IRS2, PIK3CB, AKT2, RRAGA, RRAGD, ERN1, PRKCQ, TMEM49, SMCR8

Tamoxifen

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Tamoxifen

hsa04144

Endocytosis

1.67E-02

P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12

Tamoxifen

hsa04145

Phagosome

1.19E-05

O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765

FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOB

Tamoxifen

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Tamoxifen

hsa04151

PI3K-Akt signaling pathway

5.38E-03

P43657, P25116, P09603, P49767, Q9GZP0, Q13362, P62873, P63218, P50151, P13612, P16144, O15335, Q13751, O60603, P01568, P10415, P17252

P2RY5, F2R, CSF1, VEGFC, PDGFD, PPP2R5C, GNB1, GNG5, GNG10, ITGA4, ITGB4, CHAD, LAMB3, TLR2, IFNA21, BCL2, PRKCA

Tamoxifen

hsa04210

Apoptosis

2.00E-03

O76075, Q14790, P01375, P48023, Q9NR28, Q16548, P42575

DFFB, CASP8, TNF, FASLG, DIABLO, BCL2A1, CASP2

Tamoxifen

hsa04211

Longevity regulating pathway

1.88E-02

P31751, Q08828, P51828, P18848

AKT2, ADCY1, ADCY7, ATF4

Tamoxifen

hsa04213

Longevity regulating pathway - multiple species

1.65E-05

P31751, P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547

AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1

Tamoxifen

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Tamoxifen

hsa04217

Necroptosis

7.77E-08

P01375, P01568, P48023, Q13489, Q9NQC7, P42224, Q14765, P07900, P08238, P15104, P01584, Q6FI13, Q99878, Q93077, P10415, Q9H444, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, IL1B, H2AC18; H2AC19, H2AC14, HIST1H2AC, BCL2, CHMP4B, CHMP2A, PPID

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
O00141	SGK	Serine/threonine-protein kinase Sgk1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.749
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P14416	DRD2	D(2) dopamine receptor	Q14765	STAT4	Signal transducer and activator of transcription 4	0.71
O00141	SGK	Serine/threonine-protein kinase Sgk1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
P09960	LTA4H	Leukotriene A-4 hydrolase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.737
O00141	SGK	Serine/threonine-protein kinase Sgk1	P15104	GLUL	Glutamine synthetase	0.761
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P09960	LTA4H	Leukotriene A-4 hydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.702
P14416	DRD2	D(2) dopamine receptor	Q99878	H2AC14	Histone H2A type 1-J	-0.784
P09960	LTA4H	Leukotriene A-4 hydrolase	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.714
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
O00141	SGK	Serine/threonine-protein kinase Sgk1	Q9H444	CHMP4B	Charged multivesicular body protein 4b	0.717
P17252	PRKCA	Protein kinase C alpha type	O43633	CHMP2A	Charged multivesicular body protein 2a	-0.836
P09960	LTA4H	Leukotriene A-4 hydrolase	O43633	CHMP2A	Charged multivesicular body protein 2a	0.815
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P09960	LTA4H	Leukotriene A-4 hydrolase	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	-0.771

Tamoxifen

hsa04218

Cellular senescence

2.09E-03

P01106, P31751, O75293, P30304, P06493, P0DP23

MYC, AKT2, GADD45B, CDC25A, CDK1, CALM1

Tamoxifen

hsa04261

Adrenergic signaling in cardiomyocytes

8.95E-06

P09493, Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23, P17252, P10415

TPM1, ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1, PRKCA, BCL2

Tamoxifen

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Tamoxifen

hsa04310

Wnt signaling pathway

1.79E-02

P17612, P67870

PRKACA, CSNK2B

Tamoxifen

hsa04330

Notch signaling pathway

1.12E-02

Q92542, P49768, P46531

NCSTN, PSEN1, NOTCH1

Tamoxifen

hsa04340

Hedgehog signaling pathway

2.36E-03

P49841, P17612, P22694

GSK3B, PRKACA, PRKACB

Tamoxifen

hsa04360

Axon guidance

2.19E-02

P42338, O14639, P24844

PIK3CB, ABLIM1, MYL9

Tamoxifen

hsa04370

VEGF signaling pathway

6.07E-07

P19174, P16298, P31751, P42338, Q05397, Q02750

PLCG1, PPP3CB, AKT2, PIK3CB, PTK2, MAP2K1

Tamoxifen

hsa04371

Apelin signaling pathway

2.48E-03

P31751, Q08828, P51828, P0DP23

AKT2, ADCY1, ADCY7, CALM1

Tamoxifen

hsa04380

Osteoclast differentiation

7.82E-04

Q9NQC7, P23458, P31751, P01584

CYLD, JAK1, AKT2, IL1B

Tamoxifen

hsa04390

Hippo signaling pathway

2.17E-03

P63261, P84022, Q13485, O15105, Q13489

ACTG1, SMAD3, SMAD4, SMAD7, BIRC3

Tamoxifen

hsa04512

ECM-receptor interaction

4.41E-02

Q13751, P13612, O15335

LAMB3, ITGA4, CHAD

Tamoxifen

hsa04530

Tight junction

3.60E-03

P63261, P16989, P56750, Q92974, Q14247

ACTG1, CSDA, CLDN17, ARHGEF2, CTTN

Tamoxifen

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Tamoxifen

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Tamoxifen

hsa04611

Platelet activation

2.12E-02

Q9Y490, P17612

TLN1, PRKACA

Tamoxifen

hsa04612

Antigen processing and presentation

1.36E-07

P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P30101, P11142, P01375

HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, PDIA3, HSPA8, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.76
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P48382	RFX5	DNA-binding protein RFX5	-0.738
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P48382	RFX5	DNA-binding protein RFX5	0.726
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q04759	PRKCQ	Protein kinase C theta type	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.803
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.838
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.972
Q04759	PRKCQ	Protein kinase C theta type	P26717	KLRC2	NKG2-C type II integral membrane protein	0.803
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.838
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P26717	KLRC2	NKG2-C type II integral membrane protein	0.972
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
Q04759	PRKCQ	Protein kinase C theta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.849
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.856
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q13241	KLRD1	Natural killer cells antigen CD94	0.883
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.741
Q04759	PRKCQ	Protein kinase C theta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.861
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.816
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
P24723	PRKCH	Protein kinase C eta type	P30101	PDIA3	Protein disulfide-isomerase A3	0.751
P24723	PRKCH	Protein kinase C eta type	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.715
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01375	TNF	Tumor necrosis factor	-0.813

Tamoxifen

hsa04613

Neutrophil extracellular trap formation

2.90E-06

P17252, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60603	TLR2	Toll-like receptor 2	0.867
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P05164	MPO	Myeloperoxidase	0.711
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P05164	MPO	Myeloperoxidase	-0.817
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08246	ELA2	Neutrophil elastase	0.703
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P08246	ELA2	Neutrophil elastase	-0.772
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.825
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.809
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13547	HDAC1	Histone deacetylase 1	-0.742
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q92769	HDAC2	Histone deacetylase 2	-0.746
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.764
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q15080	NCF4	Neutrophil cytosol factor 4	-0.742
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P20160	AZU1	Azurocidin	-0.771
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08311	CTSG	Cathepsin G	0.709
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P08311	CTSG	Cathepsin G	-0.847
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P49913	CAMP	Cathelicidin antimicrobial peptide	-0.722
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.893
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.704
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	1
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.779
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P21462	FPR1	fMet-Leu-Phe receptor	0.842
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P21462	FPR1	fMet-Leu-Phe receptor	-0.737
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O43315	AQP9	Aquaporin-9	0.915
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833

Tamoxifen

hsa04620

Toll-like receptor signaling pathway

4.91E-04

P01584, P31751, Q8NHW4

IL1B, AKT2, CCL4L2

Tamoxifen

hsa04621

NOD-like receptor signaling pathway

2.12E-03

P01584, P07900, Q14643, P10599, P43490, O00463, P29728, P01375, P09341, P12838

IL1B, HSP90AA1, ITPR1, TXN, PBEF1, TRAF5, OAS2, TNF, CXCL1, DEFA4

Tamoxifen

hsa04622

RIG-I-like receptor signaling pathway

2.75E-04

Q9NQC7, Q12933, P10145

CYLD, TRAF2, IL8

Tamoxifen

hsa04623

Cytosolic DNA-sensing pathway

7.34E-07

P01584, P01568, P25963, Q9Y535, Q8NHW4

IL1B, IFNA21, NFKBIA, POLR3H, CCL4L2

Tamoxifen

hsa04625

C-type lectin receptor signaling pathway

2.74E-05

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP23, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM1, MAPK14

Tamoxifen

hsa04630

JAK-STAT signaling pathway

4.54E-02

P31751, P23458, Q13651

AKT2, JAK1, IL10RA

Tamoxifen

hsa04640

Hematopoietic cell lineage

2.19E-11

P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375

ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13612	ITGA4	Integrin alpha-4	-0.771
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.762
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
Q15131	CDK10	Cyclin-dependent kinase 10	P14778	IL1R1	Interleukin-1 receptor type 1	-0.746
Q04759	PRKCQ	Protein kinase C theta type	P27930	IL1R2	Interleukin-1 receptor type 2	-0.733
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.924
Q15131	CDK10	Cyclin-dependent kinase 10	P27930	IL1R2	Interleukin-1 receptor type 2	-0.771
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P15144	ANPEP	Aminopeptidase N	0.879
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P11836	MS4A1	B-lymphocyte antigen CD20	-0.705
Q04759	PRKCQ	Protein kinase C theta type	P25063	CD24	Signal transducer CD24	-0.903
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
P24723	PRKCH	Protein kinase C eta type	P25063	CD24	Signal transducer CD24	-0.838
Q15131	CDK10	Cyclin-dependent kinase 10	P25063	CD24	Signal transducer CD24	-0.787
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q15131	CDK10	Cyclin-dependent kinase 10	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.855
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
Q04759	PRKCQ	Protein kinase C theta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.861
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.816
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
Q15131	CDK10	Cyclin-dependent kinase 10	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P24723	PRKCH	Protein kinase C eta type	P09564	CD7	T-cell antigen CD7	0.865
Q15131	CDK10	Cyclin-dependent kinase 10	P09564	CD7	T-cell antigen CD7	0.723
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774

Tamoxifen

hsa04650

Natural killer cell mediated cytotoxicity

2.13E-15

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.84
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01375	TNF	Tumor necrosis factor	-0.813
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P78314	SH3BP2	SH3 domain-binding protein 2	0.809
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q04759	PRKCQ	Protein kinase C theta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.855
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.81
P24723	PRKCH	Protein kinase C eta type	O60880	SH2D1A	SH2 domain-containing protein 1A	0.835
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	O60880	SH2D1A	SH2 domain-containing protein 1A	0.912
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
Q04759	PRKCQ	Protein kinase C theta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.849
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.856
P24723	PRKCH	Protein kinase C eta type	Q13241	KLRD1	Natural killer cells antigen CD94	0.768
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q13241	KLRD1	Natural killer cells antigen CD94	0.883
Q04759	PRKCQ	Protein kinase C theta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.918
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.879
P24723	PRKCH	Protein kinase C eta type	P26718	KLRK1	NKG2-D type II integral membrane protein	0.822
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P26718	KLRK1	NKG2-D type II integral membrane protein	0.794
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P24723	PRKCH	Protein kinase C eta type	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.828
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.893
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.704
Q04759	PRKCQ	Protein kinase C theta type	P26717	KLRC2	NKG2-C type II integral membrane protein	0.803
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.838
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P26717	KLRC2	NKG2-C type II integral membrane protein	0.972
P24723	PRKCH	Protein kinase C eta type	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.723
Q04759	PRKCQ	Protein kinase C theta type	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.803
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.838
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.972

Tamoxifen

hsa04657

IL-17 signaling pathway

5.89E-06

P07900, O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O00141	SGK	Serine/threonine-protein kinase Sgk1	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.709
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O00463	TRAF5	TNF receptor-associated factor 5	-0.875
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	O00463	TRAF5	TNF receptor-associated factor 5	0.844
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.781
P08183	ABCB1	ATP-dependent translocase ABCB1	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.725
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09341	CXCL1	Growth-regulated alpha protein	0.781
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P09341	CXCL1	Growth-regulated alpha protein	-0.826
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.942
P08183	ABCB1	ATP-dependent translocase ABCB1	P14780	MMP9	Matrix metalloproteinase-9	-0.775
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P14780	MMP9	Matrix metalloproteinase-9	-0.826
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.721
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	-0.826
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P08183	ABCB1	ATP-dependent translocase ABCB1	P01375	TNF	Tumor necrosis factor	-0.769
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01375	TNF	Tumor necrosis factor	-0.813
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786

Tamoxifen

hsa04658

Th1 and Th2 cell differentiation

3.78E-22

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q04759	PRKCQ	Protein kinase C theta type	-0.762
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q04759	PRKCQ	Protein kinase C theta type	0.755
Q15131	CDK10	Cyclin-dependent kinase 10	Q04759	PRKCQ	Protein kinase C theta type	0.79
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q15131	CDK10	Cyclin-dependent kinase 10	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.855
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.776
Q15131	CDK10	Cyclin-dependent kinase 10	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.895
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q15131	CDK10	Cyclin-dependent kinase 10	P06239	LCK	Tyrosine-protein kinase Lck	0.867
Q04759	PRKCQ	Protein kinase C theta type	Q14765	STAT4	Signal transducer and activator of transcription 4	0.746
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.768
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q14765	STAT4	Signal transducer and activator of transcription 4	0.928
Q04759	PRKCQ	Protein kinase C theta type	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.867
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.767
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.715
Q04759	PRKCQ	Protein kinase C theta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.843
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9UL17	TBX21	T-box transcription factor TBX21	-0.861
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q9UL17	TBX21	T-box transcription factor TBX21	0.852
Q15131	CDK10	Cyclin-dependent kinase 10	Q9UL17	TBX21	T-box transcription factor TBX21	0.79
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
Q15131	CDK10	Cyclin-dependent kinase 10	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.753
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.76
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P24723	PRKCH	Protein kinase C eta type	Q13761	RUNX3	Runt-related transcription factor 3	0.915
Q15131	CDK10	Cyclin-dependent kinase 10	Q13761	RUNX3	Runt-related transcription factor 3	0.82

Tamoxifen

hsa04659

Th17 cell differentiation

2.34E-18

P25963, Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q04759	PRKCQ	Protein kinase C theta type	-0.762
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
Q15131	CDK10	Cyclin-dependent kinase 10	Q04759	PRKCQ	Protein kinase C theta type	0.79
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q15131	CDK10	Cyclin-dependent kinase 10	P06239	LCK	Tyrosine-protein kinase Lck	0.867
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P24723	PRKCH	Protein kinase C eta type	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.876
Q15131	CDK10	Cyclin-dependent kinase 10	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.753
Q04759	PRKCQ	Protein kinase C theta type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.82
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.762
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
Q15131	CDK10	Cyclin-dependent kinase 10	P14778	IL1R1	Interleukin-1 receptor type 1	-0.746
Q04759	PRKCQ	Protein kinase C theta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.8
P24723	PRKCH	Protein kinase C eta type	Q9HBE5	IL21R	Interleukin-21 receptor	0.776
Q15131	CDK10	Cyclin-dependent kinase 10	Q9HBE5	IL21R	Interleukin-21 receptor	0.841
Q04759	PRKCQ	Protein kinase C theta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.843
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9UL17	TBX21	T-box transcription factor TBX21	-0.861
P24723	PRKCH	Protein kinase C eta type	Q9UL17	TBX21	T-box transcription factor TBX21	0.856
Q15131	CDK10	Cyclin-dependent kinase 10	Q9UL17	TBX21	T-box transcription factor TBX21	0.79
Q04759	PRKCQ	Protein kinase C theta type	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.867
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.767
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q15131	CDK10	Cyclin-dependent kinase 10	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.855
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q15131	CDK10	Cyclin-dependent kinase 10	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.895

Tamoxifen

hsa04660

T cell receptor signaling pathway

1.22E-15

P01375, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01375	TNF	Tumor necrosis factor	-0.813
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q04759	PRKCQ	Protein kinase C theta type	-0.762
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q04759	PRKCQ	Protein kinase C theta type	0.755
Q15131	CDK10	Cyclin-dependent kinase 10	Q04759	PRKCQ	Protein kinase C theta type	0.79
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q15131	CDK10	Cyclin-dependent kinase 10	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.791
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.79
Q04759	PRKCQ	Protein kinase C theta type	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.733
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.806
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.754
Q04759	PRKCQ	Protein kinase C theta type	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.803
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.812
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.873
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q15131	CDK10	Cyclin-dependent kinase 10	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.855
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.77
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.776
Q15131	CDK10	Cyclin-dependent kinase 10	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.895
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.815
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
Q04759	PRKCQ	Protein kinase C theta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.861
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.816
P24723	PRKCH	Protein kinase C eta type	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.838
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.812
Q15131	CDK10	Cyclin-dependent kinase 10	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.744
Q04759	PRKCQ	Protein kinase C theta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.816
P24723	PRKCH	Protein kinase C eta type	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.779
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.734
Q15131	CDK10	Cyclin-dependent kinase 10	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.738
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q15131	CDK10	Cyclin-dependent kinase 10	P06239	LCK	Tyrosine-protein kinase Lck	0.867
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.781

Tamoxifen

hsa04662

B cell receptor signaling pathway

1.42E-06

P31751, P42338, P60033, P07948, P21854, Q8N149

AKT2, PIK3CB, CD81, LYN, CD72, LILRA2

Tamoxifen

hsa04664

Fc epsilon RI signaling pathway

5.48E-04

P31751, P42338, P07948, P09917

AKT2, PIK3CB, LYN, ALOX5

Tamoxifen

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Tamoxifen

hsa04710

Circadian rhythm

1.44E-03

O15516, Q16526, Q9Y478

CLOCK, CRY1, PRKAB1

Tamoxifen

hsa04713

Circadian entrainment

1.37E-04

P0DP23, Q13557, Q02153, P17252, P62873, P61952, Q14643, Q08828, P51828, P63092

CALM1, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG11, ITPR1, ADCY1, ADCY7, GNAS

Tamoxifen

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Tamoxifen

hsa04720

Long-term potentiation

1.70E-05

P17252, P16298, P0DP23, P51812, P18848, Q08828, Q02750, Q14643

PRKCA, PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1, ITPR1

Tamoxifen

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Tamoxifen

hsa04722

Neurotrophin signaling pathway

5.24E-05

Q05655, P31751, P49841, O43524, P48023, P52566, P0DP23

PRKCD, AKT2, GSK3B, FOXO3, FASLG, ARHGDIB, CALM1

Tamoxifen

hsa04723

Retrograde endocannabinoid signaling

1.88E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Tamoxifen

hsa04724

Glutamatergic synapse

9.51E-03

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Tamoxifen

hsa04725

Cholinergic synapse

7.24E-04

Q08828, P51828, Q14643, P17252, P62873, P18848, P31751, P10415

ADCY1, ADCY7, ITPR1, PRKCA, GNB1, ATF4, AKT2, BCL2

Tamoxifen

hsa04727

GABAergic synapse

2.03E-03

P63218, P50151, P15104

GNG5, GNG10, GLUL

Tamoxifen

hsa04728

Dopaminergic synapse

5.90E-06

P63092, Q14643, P17252, P62873, P61952, P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23, O15516

GNAS, ITPR1, PRKCA, GNB1, GNG11, AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1, CLOCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q6PL18	ATAD2	ATPase family AAA domain-containing protein 2	P63092	GNAS	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	-0.724
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
Q6PL18	ATAD2	ATPase family AAA domain-containing protein 2	P61952	GNG11	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	0.841
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
Q6PL18	ATAD2	ATPase family AAA domain-containing protein 2	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	-0.742
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q6PL18	ATAD2	ATPase family AAA domain-containing protein 2	Q13557	CAMK2D	Calcium/calmodulin-dependent protein kinase type II subunit delta	-0.807
P17252	PRKCA	Protein kinase C alpha type	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.745
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14738	PPP2R5D	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	0.781
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
Q6PL18	ATAD2	ATPase family AAA domain-containing protein 2	O15516	CLOCK	Circadian locomoter output cycles protein kaput	-0.703

Tamoxifen

hsa04730

Long-term depression

3.72E-02

Q14344, P07948

GNA13, LYN

Tamoxifen

hsa04740

Olfactory transduction

2.41E-02

P0DP23

CALM1

Tamoxifen

hsa04742

Taste transduction

3.91E-02

P17612

PRKACA

Tamoxifen

hsa04744

Phototransduction

1.74E-03

P62873, P0DP23

GNB1, CALM1

Tamoxifen

hsa04750

Inflammatory mediator regulation of TRP channels

1.21E-08

P14778, P01584, Q08828, P51828, P19174, P42338, P24723, Q04759, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
Q15131	CDK10	Cyclin-dependent kinase 10	P14778	IL1R1	Interleukin-1 receptor type 1	-0.746
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q15131	CDK10	Cyclin-dependent kinase 10	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.791
Q13547	HDAC1	Histone deacetylase 1	P24723	PRKCH	Protein kinase C eta type	0.875
P24723	PRKCH	Protein kinase C eta type	P24723	PRKCH	Protein kinase C eta type	1
Q15131	CDK10	Cyclin-dependent kinase 10	P24723	PRKCH	Protein kinase C eta type	0.893
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
Q15131	CDK10	Cyclin-dependent kinase 10	Q04759	PRKCQ	Protein kinase C theta type	0.79
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857

Tamoxifen

hsa04910

Insulin signaling pathway

2.83E-04

P0DP23, P22694, P06737, P31751, P49841

CALM1, PRKACB, PYGL, AKT2, GSK3B

Tamoxifen

hsa04911

Insulin secretion

2.68E-03

Q08828, P51828, P63092, Q99941, P18848, Q13557

ADCY1, ADCY7, GNAS, CREBL1, ATF4, CAMK2D

Tamoxifen

hsa04912

GnRH signaling pathway

3.59E-04

P17252, Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP23, P22694

PRKCA, ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM1, PRKACB

Tamoxifen

hsa04913

Ovarian steroidogenesis

2.52E-02

P06213

INSR

Tamoxifen

hsa04914

Progesterone-mediated oocyte maturation

5.67E-04

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Tamoxifen

hsa04915

Estrogen signaling pathway

2.46E-04

P18848, Q08828, P51828, P31751, P0DMV8, P0DP23, Q15788

ATF4, ADCY1, ADCY7, AKT2, HSPA1A, CALM1, NCOA1

Tamoxifen

hsa04916

Melanogenesis

4.69E-03

P0DP23, Q08828, P51828

CALM1, ADCY1, ADCY7

Tamoxifen

hsa04917

Prolactin signaling pathway

2.41E-02

P31751

AKT2

Tamoxifen

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Tamoxifen

hsa04920

Adipocytokine signaling pathway

2.05E-03

P33121, Q9Y478, Q04759, Q96RR4, P31751, Q9Y4H2, P01375

ACSL1, PRKAB1, PRKCQ, CAMKK2, AKT2, IRS2, TNF

Tamoxifen

hsa04922

Glucagon signaling pathway

2.33E-03

Q12778, P31751, Q13370, P0DP23, Q14643

FOXO1, AKT2, PDE3B, CALM1, ITPR1

Tamoxifen

hsa04923

Regulation of lipolysis in adipocytes

9.57E-06

Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751

ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2

Tamoxifen

hsa04924

Renin secretion

7.82E-05

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Tamoxifen

hsa04925

Aldosterone synthesis and secretion

9.86E-03

P18848, Q08828, P51828, P0DP23

ATF4, ADCY1, ADCY7, CALM1

Tamoxifen

hsa04926

Relaxin signaling pathway

1.80E-03

P31751, P42338, P50151, P18848, Q08828, P51828, P49407

AKT2, PIK3CB, GNG10, ATF4, ADCY1, ADCY7, ARRB1

Tamoxifen

hsa04927

Cortisol synthesis and secretion

1.59E-02

P18848, Q08828, P51828

ATF4, ADCY1, ADCY7

Tamoxifen

hsa04929

GnRH secretion

6.70E-04

P42338, P31751, P49407

PIK3CB, AKT2, ARRB1

Tamoxifen

hsa04930

Type II diabetes mellitus

6.29E-05

P06213, Q05655, Q02156

INSR, PRKCD, PRKCE

Tamoxifen

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Tamoxifen

hsa04932

Non-alcoholic fatty liver disease

2.59E-08

P31751, P01375, P49841, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521

AKT2, TNF, GSK3B, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P14416	DRD2	D(2) dopamine receptor	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.812
Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	Q14790	CASP8	Caspase-8	-0.824
P23458	JAK1	Tyrosine-protein kinase JAK1	O43521	BCL2L11	Bcl-2-like protein 11	0.708
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
Q96BR1	SGK3	Serine/threonine-protein kinase Sgk3	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	-0.787
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
O00141	SGK	Serine/threonine-protein kinase Sgk1	P01584	IL1B	Interleukin-1 beta	0.786
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
O00141	SGK	Serine/threonine-protein kinase Sgk1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.742
O00141	SGK	Serine/threonine-protein kinase Sgk1	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.766
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732

Tamoxifen

hsa04933

AGE-RAGE signaling pathway in diabetic complications

5.84E-04

P84022, Q13485, P42224, P10415, Q12778, P49767, P17252

SMAD3, SMAD4, STAT1, BCL2, FOXO1, VEGFC, PRKCA

Tamoxifen

hsa04934

Cushing syndrome

1.86E-03

Q99941, P18848, Q08828, P51828, P63092, O15169, Q13557

CREBL1, ATF4, ADCY1, ADCY7, GNAS, AXIN1, CAMK2D

Tamoxifen

hsa04935

Growth hormone synthesis, secretion and action

1.88E-02

Q08828, P51828, P18848, P31751

ADCY1, ADCY7, ATF4, AKT2

Tamoxifen

hsa04940

Type I diabetes mellitus

7.38E-04

P10747, P48023, P13765, P01375

CD28, FASLG, HLA-DOB, TNF

Tamoxifen

hsa04960

Aldosterone-regulated sodium reabsorption

7.59E-03

O00141, P06213

SGK, INSR

Tamoxifen

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Tamoxifen

hsa04966

Collecting duct acid secretion

2.07E-03

Q13488, P00918, Q9Y666

TCIRG1, CA2, SLC12A7

Tamoxifen

hsa04970

Salivary secretion

2.25E-05

P07550, Q08828, P51828, P22694, Q14643, P0DP23, P49913

ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM1, CAMP

Tamoxifen

hsa04971

Gastric acid secretion

4.91E-04

Q08828, P51828, P15311, P0DP23

ADCY1, ADCY7, VIL2, CALM1

Tamoxifen

hsa04973

Carbohydrate digestion and absorption

4.61E-03

O43451, P42338, P31751

MGAM, PIK3CB, AKT2

Tamoxifen

hsa04974

Protein digestion and absorption

2.47E-02

Q7Z2H8

SLC36A1

Tamoxifen

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Tamoxifen

hsa04976

Bile secretion

7.42E-06

O43315, Q08828, P51828, P22694, P08183, Q14032

AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAAT

Tamoxifen

hsa05010

Alzheimer disease

2.18E-05

Q16718, O95298, O14521, Q14643, O15399, Q00535, Q9NZJ5, O75460, P0DP23, Q13564, P01584, P18848, Q71U36, Q13509, P68371, P09603, P31751, P05141, P21796, Q08752, P28070

NDUFA5, NDUFC2, SDHD, ITPR1, GRIN2D, CDK5, EIF2AK3, ERN1, CALM1, APPBP1, IL1B, ATF4, TUBA1A, TUBB3, TUBB2C, CSF1, AKT2, SLC25A5, VDAC1, PPID, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	O15399	GRIN2D	Glutamate receptor ionotropic, NMDA 2D	-0.707
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
P31751	AKT2	RAC-beta serine/threonine-protein kinase	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.726
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q9NZJ5	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	0.728
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q13564	APPBP1	NEDD8-activating enzyme E1 regulatory subunit	0.873
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.85
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P09603	CSF1	Macrophage colony-stimulating factor 1	-0.789
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
P61088	UBE2N	Ubiquitin-conjugating enzyme E2 N	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.88
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736

Tamoxifen

hsa05012

Parkinson disease

2.25E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C

Tamoxifen

hsa05016

Huntington disease

8.20E-06

O95298, P13073, P12074, Q9GZM3, P24928, P30876, P62487, P52435, P05141, Q9NYC9, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, DNAH9, ERN1, PSMB4, PSMD12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P23458	JAK1	Tyrosine-protein kinase JAK1	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.83
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P13073	COX4I1	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	0.722
P23458	JAK1	Tyrosine-protein kinase JAK1	P12074	COX6A1	Cytochrome c oxidase subunit 6A1, mitochondrial	0.761
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9GZM3	POLR2J2	DNA-directed RNA polymerase II subunit RPB11-b1	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.784
Q00535	CDK5	Cyclin-dependent-like kinase 5	P24928	POLR2A	DNA-directed RNA polymerase II subunit RPB1	0.709
P23458	JAK1	Tyrosine-protein kinase JAK1	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.795
Q00535	CDK5	Cyclin-dependent-like kinase 5	P30876	POLR2B	DNA-directed RNA polymerase II subunit RPB2	0.703
P23458	JAK1	Tyrosine-protein kinase JAK1	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.855
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62487	POLR2G	DNA-directed RNA polymerase II subunit RPB7	0.758
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	P52435	POLR2J	DNA-directed RNA polymerase II subunit RPB11-a	0.76
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9GZM3	POLR2J2	DNA-directed RNA polymerase II subunit RPB11-b1	0.76
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
P22001	KCNA3	Potassium voltage-gated channel subfamily A member 3	Q9NYC9	DNAH9	Dynein axonemal heavy chain 9	0.785
P23458	JAK1	Tyrosine-protein kinase JAK1	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.79
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
P23458	JAK1	Tyrosine-protein kinase JAK1	P28070	PSMB4	Proteasome subunit beta type-4	0.85
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736
P23458	JAK1	Tyrosine-protein kinase JAK1	O00232	PSMD12	26S proteasome non-ATPase regulatory subunit 12	-0.703

Tamoxifen

hsa05017

Spinocerebellar ataxia

3.94E-02

O75460, P31751, P28070, P05141

ERN1, AKT2, PSMB4, SLC25A5

Tamoxifen

hsa05020

Prion disease

1.31E-03

Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14

Tamoxifen

hsa05022

Pathways of neurodegeneration - multiple diseases

7.73E-06

Q14643, Q13509, P68371, P49841, P10415, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, P17252, Q16539, Q00535, P01584, Q08752, P0DP23, P28070

ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, PRKCA, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	Q13509	TUBB3	Tubulin beta-3 chain	-0.756
P17252	PRKCA	Protein kinase C alpha type	P68371	TUBB2C	Tubulin beta-4B chain	-0.842
P31645	SLC6A4	Sodium-dependent serotonin transporter	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.714
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.811
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	O95298	NDUFC2	NADH dehydrogenase [ubiquinone] 1 subunit C2	0.778
P17252	PRKCA	Protein kinase C alpha type	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.822
P31645	SLC6A4	Sodium-dependent serotonin transporter	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.732
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8TEV9	SMCR8	Guanine nucleotide exchange protein SMCR8	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	O75460	ERN1	Serine/threonine-protein kinase/endoribonuclease IRE1	0.734
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
P17252	PRKCA	Protein kinase C alpha type	Q13561	DCTN2	Dynactin subunit 2	-0.844
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q13561	DCTN2	Dynactin subunit 2	-0.771
Q00535	CDK5	Cyclin-dependent-like kinase 5	P05141	SLC25A5	ADP/ATP translocase 2	0.779
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q00535	CDK5	Cyclin-dependent-like kinase 5	1
P31751	AKT2	RAC-beta serine/threonine-protein kinase	Q00535	CDK5	Cyclin-dependent-like kinase 5	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P17252	PRKCA	Protein kinase C alpha type	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.725
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q08752	PPID	Peptidyl-prolyl cis-trans isomerase D	0.859
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
Q00535	CDK5	Cyclin-dependent-like kinase 5	P28070	PSMB4	Proteasome subunit beta type-4	0.736

Tamoxifen

hsa05030

Cocaine addiction

4.19E-02

Q00535

CDK5

Tamoxifen

hsa05031

Amphetamine addiction

1.00E-02

P0DP23, Q13557, P63092, Q99941

CALM1, CAMK2D, GNAS, CREBL1

Tamoxifen

hsa05032

Morphine addiction

1.34E-02

P63218, P50151, Q07343, P43250

GNG5, GNG10, PDE4B, GRK6

Tamoxifen

hsa05034

Alcoholism

2.89E-03

Q93077, P62807, O60814, P68431

HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Tamoxifen

hsa05100

Bacterial invasion of epithelial cells

4.50E-02

Q92529

SHC3

Tamoxifen

hsa05110

Vibrio cholerae infection

2.11E-03

Q99437, P17612

ATP6V0B, PRKACA

Tamoxifen

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.84E-05

Q16539, P09341, P19875, P19174, P25024, P25025

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Tamoxifen

hsa05131

Shigellosis

4.98E-04

Q12933, P68431, Q05655, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, P07737

TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1

Tamoxifen

hsa05132

Salmonella infection

4.10E-04

P25963, Q9UJU2, P84095, Q13489, P10415, P07737, O60603, Q9BQS8, Q13561, Q13509, P68371

NFKBIA, LEF1, RHOG, BIRC3, BCL2, PFN1, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Tamoxifen

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Tamoxifen

hsa05134

Legionellosis

1.31E-05

P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875

IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2

Tamoxifen

hsa05135

Yersinia infection

3.58E-03

Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732

PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8A

Tamoxifen

hsa05140

Leishmaniasis

2.60E-08

P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, Q15080

ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13612	ITGA4	Integrin alpha-4	-0.771
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.893
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P12271	RLBP1	Retinaldehyde-binding protein 1	P14598	NCF1	Neutrophil cytosol factor 1	0.774
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P12271	RLBP1	Retinaldehyde-binding protein 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.786
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P17252	PRKCA	Protein kinase C alpha type	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.709
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P12271	RLBP1	Retinaldehyde-binding protein 1	O60603	TLR2	Toll-like receptor 2	0.708
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60603	TLR2	Toll-like receptor 2	0.867
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P17252	PRKCA	Protein kinase C alpha type	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	-0.754
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.833
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P12271	RLBP1	Retinaldehyde-binding protein 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.764

Tamoxifen

hsa05142

Chagas disease

2.70E-02

P48023, Q14790

FASLG, CASP8

Tamoxifen

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Tamoxifen

hsa05144

Malaria

2.19E-03

P60033, P69905, P68871, O60603, P01375, P35443, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Tamoxifen

hsa05145

Toxoplasmosis

1.02E-03

P25963, P10415, Q13489, P42224, P13765, O60603, P29965

NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Tamoxifen

hsa05146

Amoebiasis

9.72E-16

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q04759	PRKCQ	Protein kinase C theta type	P09341	CXCL1	Growth-regulated alpha protein	-0.885
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P09341	CXCL1	Growth-regulated alpha protein	0.781
P24723	PRKCH	Protein kinase C eta type	P09341	CXCL1	Growth-regulated alpha protein	-0.707
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P09341	CXCL1	Growth-regulated alpha protein	-0.826
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P24723	PRKCH	Protein kinase C eta type	P19875	CXCL2	C-X-C motif chemokine 2	-0.853
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14778	IL1R1	Interleukin-1 receptor type 1	0.762
P24723	PRKCH	Protein kinase C eta type	P14778	IL1R1	Interleukin-1 receptor type 1	-0.705
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
Q15131	CDK10	Cyclin-dependent kinase 10	P14778	IL1R1	Interleukin-1 receptor type 1	-0.746
Q04759	PRKCQ	Protein kinase C theta type	P27930	IL1R2	Interleukin-1 receptor type 2	-0.733
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.924
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
Q15131	CDK10	Cyclin-dependent kinase 10	P27930	IL1R2	Interleukin-1 receptor type 2	-0.771
Q04759	PRKCQ	Protein kinase C theta type	P01375	TNF	Tumor necrosis factor	-0.725
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P01375	TNF	Tumor necrosis factor	0.774
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P01375	TNF	Tumor necrosis factor	-0.813
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	O60603	TLR2	Toll-like receptor 2	0.867
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q15131	CDK10	Cyclin-dependent kinase 10	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.791
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P24723	PRKCH	Protein kinase C eta type	P11215	ITGAM	Integrin alpha-M	-0.7
Q04759	PRKCQ	Protein kinase C theta type	P05089	ARG1	Arginase-1	-0.899
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P05089	ARG1	Arginase-1	0.811
P24723	PRKCH	Protein kinase C eta type	P05089	ARG1	Arginase-1	-0.749
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P05089	ARG1	Arginase-1	-0.791
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q15131	CDK10	Cyclin-dependent kinase 10	P05089	ARG1	Arginase-1	-0.79
Q04759	PRKCQ	Protein kinase C theta type	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.755
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.779
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	1
Q04759	PRKCQ	Protein kinase C theta type	P12814	ACTN1	Alpha-actinin-1	-0.821
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P24723	PRKCH	Protein kinase C eta type	P12814	ACTN1	Alpha-actinin-1	-0.869
Q15131	CDK10	Cyclin-dependent kinase 10	P12814	ACTN1	Alpha-actinin-1	-0.819
Q04759	PRKCQ	Protein kinase C theta type	P08311	CTSG	Cathepsin G	-0.913
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08311	CTSG	Cathepsin G	0.709
P24723	PRKCH	Protein kinase C eta type	P08311	CTSG	Cathepsin G	-0.744
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P08311	CTSG	Cathepsin G	-0.847
Q15131	CDK10	Cyclin-dependent kinase 10	P08311	CTSG	Cathepsin G	-0.734

Tamoxifen

hsa05150

Staphylococcus aureus infection

2.66E-03

P21730, P21462, O75015, P13765, P12838, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, DEFA4, CAMP

Tamoxifen

hsa05152

Tuberculosis

3.87E-04

Q13488, P0DP23, P42224, O60603, P31751, P10415, P13765, P01568, Q9UDY8

TCIRG1, CALM1, STAT1, TLR2, AKT2, BCL2, HLA-DOB, IFNA21, MALT1

Tamoxifen

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Tamoxifen

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Tamoxifen

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Tamoxifen

hsa05163

Human cytomegalovirus infection

1.90E-06

P31751, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463

AKT2, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837

Tamoxifen

hsa05164

Influenza A

4.49E-02

P31751, P01584, P23458, P05141, Q9UBU9

AKT2, IL1B, JAK1, SLC25A5, NXF1

Tamoxifen

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Tamoxifen

hsa05166

Human T-cell leukemia virus 1 infection

3.90E-02

P23458, P05141, P62826, Q08828, P51828, P18848, P31751

JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2

Tamoxifen

hsa05167

Kaposi sarcoma-associated herpesvirus infection

2.80E-04

P01568, P31751, P42224, P62873, P62879, P16298, Q14643, Q02750, P0DP23, P0CG47, Q9UJU2

IFNA21, AKT2, STAT1, GNB1, GNB2, PPP3CB, ITPR1, MAP2K1, CALM1, UBB, LEF1

Tamoxifen

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Tamoxifen

hsa05169

Epstein-Barr virus infection

5.59E-04

P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P01375, P29728, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, TNF, OAS2, CD3E, CD3G, CD247

Tamoxifen

hsa05170

Human immunodeficiency virus 1 infection

8.73E-07

P31751, Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5, P20333

AKT2, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.887
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.846
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.816
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
P10588	NR2F6	Nuclear receptor subfamily 2 group F member 6	Q05397	PTK2	Focal adhesion kinase 1	0.877
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	Q13315	ATM	Serine-protein kinase ATM	0.739
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.829
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Tamoxifen

hsa05171

Coronavirus disease - COVID-19

3.18E-03

P01584, P62753, P36578, P62888, P61927, P61513, P62829

IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23

Tamoxifen

hsa05200

Pathways in cancer

8.38E-03

P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P31751, P25116, P62873, P0DP23, P01568

STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, AKT2, F2R, GNB1, CALM1, IFNA21

Tamoxifen

hsa05202

Transcriptional misregulation in cancer

5.48E-06

Q12778, Q13315, P41732, P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, ATM, TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q12778	FOXO1	Forkhead box protein O1	0.716
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q13315	ATM	Serine-protein kinase ATM	0.858
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P41732	TSPAN7	Tetraspanin-7	0.703
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P41732	TSPAN7	Tetraspanin-7	-0.733
Q04759	PRKCQ	Protein kinase C theta type	P14780	MMP9	Matrix metalloproteinase-9	-0.787
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.942
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P14780	MMP9	Matrix metalloproteinase-9	-0.826
Q04759	PRKCQ	Protein kinase C theta type	P27930	IL1R2	Interleukin-1 receptor type 2	-0.733
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.924
Q04759	PRKCQ	Protein kinase C theta type	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.745
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.779
Q04759	PRKCQ	Protein kinase C theta type	Q16548	BCL2A1	Bcl-2-related protein A1	-0.76
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.913
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q16548	BCL2A1	Bcl-2-related protein A1	-0.769
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13077	TRAF1	TNF receptor-associated factor 1	-0.712
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P35226	BMI1	Polycomb complex protein BMI-1	0.759
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P35226	BMI1	Polycomb complex protein BMI-1	0.759
Q04759	PRKCQ	Protein kinase C theta type	P05164	MPO	Myeloperoxidase	-0.88
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P05164	MPO	Myeloperoxidase	0.711
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P05164	MPO	Myeloperoxidase	-0.817
Q04759	PRKCQ	Protein kinase C theta type	P12838	DEFA4	Neutrophil defensin 4	-0.833
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P12838	DEFA4	Neutrophil defensin 4	0.767
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P12838	DEFA4	Neutrophil defensin 4	-0.796
Q04759	PRKCQ	Protein kinase C theta type	P08246	ELA2	Neutrophil elastase	-0.748
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P08246	ELA2	Neutrophil elastase	0.703
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	P08246	ELA2	Neutrophil elastase	-0.772
Q04759	PRKCQ	Protein kinase C theta type	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.774
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.765
P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.807
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P41182	BCL6	B-cell lymphoma 6 protein	0.9
Q04759	PRKCQ	Protein kinase C theta type	Q13547	HDAC1	Histone deacetylase 1	0.723
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q13547	HDAC1	Histone deacetylase 1	-0.742
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	Q92769	HDAC2	Histone deacetylase 2	-0.746
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P12980	LYL1	Protein lyl-1	0.782
Q04759	PRKCQ	Protein kinase C theta type	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.846
P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.801

Tamoxifen

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Tamoxifen

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Tamoxifen

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Tamoxifen

hsa05211

Renal cell carcinoma

4.78E-02

P31751

AKT2

Tamoxifen

hsa05212

Pancreatic cancer

3.94E-04

P31751, Q15311, P23458, P84022, Q13485

AKT2, RALBP1, JAK1, SMAD3, SMAD4

Tamoxifen

hsa05213

Endometrial cancer

4.72E-03

O15169, P31751, Q02750

AXIN1, AKT2, MAP2K1

Tamoxifen

hsa05214

Glioma

5.75E-04

P0DP23, P31751

CALM1, AKT2

Tamoxifen

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Tamoxifen

hsa05218

Melanoma

3.01E-02

P31751

AKT2

Tamoxifen

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Tamoxifen

hsa05220

Chronic myeloid leukemia

9.67E-04

Q13485, P25963, P84022, P31751

SMAD4, NFKBIA, SMAD3, AKT2

Tamoxifen

hsa05221

Acute myeloid leukemia

8.63E-03

P31751, P42338, Q15744, P11215

AKT2, PIK3CB, CEBPE, ITGAM

Tamoxifen

hsa05222

Small cell lung cancer

1.36E-03

P31751, Q13489, P10415, P25963

AKT2, BIRC3, BCL2, NFKBIA

Tamoxifen

hsa05223

Non-small cell lung cancer

7.73E-04

P31751, P10826, Q9HC35, O75293

AKT2, RARB, EML4, GADD45B

Tamoxifen

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Tamoxifen

hsa05226

Gastric cancer

3.92E-04

Q02750, P31751, O15169, P84022, Q13485, P10415

MAP2K1, AKT2, AXIN1, SMAD3, SMAD4, BCL2

Tamoxifen

hsa05230

Central carbon metabolism in cancer

4.78E-02

P31751

AKT2

Tamoxifen

hsa05231

Choline metabolism in cancer

3.38E-02

P31751, Q16760, O14986

AKT2, DGKD, PIP5K1B

Tamoxifen

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

5.62E-11

P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, Q9HC35, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, EML4, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P24723	PRKCH	Protein kinase C eta type	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.79
Q15131	CDK10	Cyclin-dependent kinase 10	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.791
Q04759	PRKCQ	Protein kinase C theta type	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.733
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P24723	PRKCH	Protein kinase C eta type	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.767
Q04759	PRKCQ	Protein kinase C theta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.713
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P24723	PRKCH	Protein kinase C eta type	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.887
Q15131	CDK10	Cyclin-dependent kinase 10	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.855
Q04759	PRKCQ	Protein kinase C theta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.92
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P24723	PRKCH	Protein kinase C eta type	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.939
Q15131	CDK10	Cyclin-dependent kinase 10	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.895
Q04759	PRKCQ	Protein kinase C theta type	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.756
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
Q04759	PRKCQ	Protein kinase C theta type	P06239	LCK	Tyrosine-protein kinase Lck	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P24723	PRKCH	Protein kinase C eta type	P06239	LCK	Tyrosine-protein kinase Lck	0.912
Q15131	CDK10	Cyclin-dependent kinase 10	P06239	LCK	Tyrosine-protein kinase Lck	0.867
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q04759	PRKCQ	Protein kinase C theta type	Q04759	PRKCQ	Protein kinase C theta type	1
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P24723	PRKCH	Protein kinase C eta type	Q04759	PRKCQ	Protein kinase C theta type	0.791
Q15131	CDK10	Cyclin-dependent kinase 10	Q04759	PRKCQ	Protein kinase C theta type	0.79
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707

Tamoxifen

hsa05310

Asthma

9.34E-05

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Tamoxifen

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Tamoxifen

hsa05321

Inflammatory bowel disease

1.26E-08

O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21R

Tamoxifen

hsa05322

Systemic lupus erythematosus

1.93E-06

O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Tamoxifen

hsa05323

Rheumatoid arthritis

7.58E-06

P01375, Q06643, P13765, Q13488, P10747, P09341, P19875, O60603

TNF, LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2

Tamoxifen

hsa05330

Allograft rejection

7.88E-05

P13765, P29965, P48023, P10747, P01375

HLA-DOB, CD40LG, FASLG, CD28, TNF

Tamoxifen

hsa05332

Graft-versus-host disease

1.69E-08

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Tamoxifen

hsa05340

Primary immunodeficiency

2.02E-05

P01730, P01732, P11912, P07766, P06239

CD4, CD8A, CD79A, CD3E, LCK

Tamoxifen

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Tamoxifen

hsa05415

Diabetic cardiomyopathy

5.60E-05

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Tamoxifen

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Tamoxifen

hsa05418

Fluid shear stress and atherosclerosis

2.84E-03

Q16539, P31751, P10599, P14780, P04637, P14778, P27930, P0DP23

MAPK14, AKT2, TXN, MMP9, TP53, IL1R1, IL1R2, CALM1

Community members of Tamoxifen (S_DC: 7.36)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

PRKCA

Protein kinase C alpha type

Reported

0.1409

0.6948

2.4601

Q05655

PRKCD

Protein kinase C delta type

Reported

0.0816

0.4194

0.6544

1.5339

Q02156

PRKCE

Protein kinase C epsilon type

Reported

0.1175

0.5287

0.5377

1.6539

Q04759

PRKCQ

Protein kinase C theta type

Reported

0.0405

0.4244

0.6173

1.4864

O75469

NR1I2

Nuclear receptor subfamily 1 group I member 2

Reported

0.0315

0.9493

1.9143

P61088

UBE2N

UbiquitinNoneconjugating enzyme E2 N

Predicted

0.1102

0.3825

0.3736

1.1937

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

O14684

PTGES

Prostaglandin E synthase

Predicted

0.4531

0.6358

0.1565

1.6547

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

P06213

INSR

Insulin receptor

Predicted

0.2794

0.7813

0.7209

2.4232

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P12271

RLBP1

RetinaldehydeNonebinding protein 1

Predicted

0.084

0.1062

0.2543

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P21730

C5AR1

C5a anaphylatoxin chemotactic receptor 1

Predicted

0.0258

0.2167

0.5396

0.986

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P22001

KCNA3

Potassium voltageNonegated channel subfamily A member 3

Predicted

0.1396

0.5055

1.0809

Q6PL18

ATAD2

ATPase family AAA domainNonecontaining protein 2

Predicted

0.1963

0.0512

0.2006

P24723

PRKCH

Protein kinase C eta type

Predicted

0.1955

0.3294

0.2048

0.9614

P31751

AKT2

RACNonebeta serine/threonineNoneprotein kinase

Predicted

0.4662

0.4856

2.2044

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

O00141

SGK

Serine/threonineNoneprotein kinase Sgk1

Predicted

0.2413

0.3037

0.3059

1.034

Q96BR1

SGK3

Serine/threonineNoneprotein kinase Sgk3

Predicted

0.026

0.2684

0.3114

0.8612

P22694

PRKACB

cAMPNonedependent protein kinase catalytic subunit beta

Predicted

0.3737

0.2984

1.7836

P17612

PRKACA

cAMPNonedependent protein kinase catalytic subunit alpha

Predicted

0.6937

0.5257

2.3982

P51817

PRKX

cAMPNonedependent protein kinase catalytic subunit PRKX

Predicted

0.4063

0.2765

0.7562

P10588

NR2F6

Nuclear receptor subfamily 2 group F member 6

Predicted

0.3923

0.068

0.3321

P10826

RARB

Retinoic acid receptor beta

Predicted

0.0094

0.3466

0.3005

0.9983

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

Q00535

CDK5

CyclinNonedependentNonelike kinase 5

Predicted

0.1992

0.6633

0.2994

1.7256

Q15131

CDK10

CyclinNonedependent kinase 10

Predicted

0.3612

0.0323

0.2453

PharmaCoNets of Tamoxifen (SPCN: 201.74 )

Tamoxifen regulated-network (SDN: 27.41)

Community members of Tamoxifen (SDC: 7.36)

PharmaCoNets of Tamoxifen (S_PCN: 201.74 )

Tamoxifen regulated-network (S_DN: 27.41)

Community members of Tamoxifen (S_DC: 7.36)