PharmaCoNets of Talazoparib (SPCN: 138.09 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Talazoparibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Talazoparibhsa00051Fructose and mannose metabolism3.35E-022P60174, P04075TPI1, ALDOAMore
Talazoparibhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Talazoparibhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Talazoparibhsa00310Lysine degradation3.15E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Talazoparibhsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Talazoparibhsa00500Starch and sucrose metabolism1.91E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Talazoparibhsa00562Inositol phosphate metabolism4.28E-022Q14642, P19174INPP5A, PLCG1More
Talazoparibhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Talazoparibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Talazoparibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Talazoparibhsa00600Sphingolipid metabolism2.77E-023Q9BX95, Q8TCT0, P15289SGPP1, CERK, ARSAMore
Talazoparibhsa00630Glyoxylate and dicarboxylate metabolism6.37E-052P40925, P15104MDH1, GLULMore
Talazoparibhsa00670One carbon pool by folate7.39E-043O95954, P04818, Q99707FTCD, TYMS, MTRMore
Talazoparibhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Talazoparibhsa00860Porphyrin and chlorophyll metabolism3.15E-022P36551, P30043CPOX, BLVRBMore
Talazoparibhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Talazoparibhsa00980Metabolism of xenobiotics by cytochrome P4508.40E-043P78417, P28332, P11712GSTO1, ADH6, CYP2C9More
Talazoparibhsa00982Drug metabolism - cytochrome P4508.40E-043P11712, P78417, P28332CYP2C9, GSTO1, ADH6More
Talazoparibhsa00983Drug metabolism - other enzymes1.64E-023P04183, P32320, P05164TK1, CDA, MPOMore
Talazoparibhsa01040Biosynthesis of unsaturated fatty acids2.92E-022P22307, Q9H5J4SCP2, ELOVL6More
Talazoparibhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Talazoparibhsa01230Biosynthesis of amino acids1.98E-023P60174, P04075, O75390TPI1, ALDOA, CSMore
Talazoparibhsa01240Biosynthesis of cofactors2.05E-022P36551, O60701CPOX, UGDHMore
Talazoparibhsa01521EGFR tyrosine kinase inhibitor resistance1.82E-021P08069IGF1RMore
Talazoparibhsa01522Endocrine resistance1.49E-025P22694, Q02750, Q9UM47, P46527, P08069PRKACB, MAP2K1, NOTCH3, CDKN1B, IGF1RMore
Talazoparibhsa01523Antifolate resistance7.05E-043Q92820, P04818, P18054GGH, TYMS, ALOX12More
Talazoparibhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Talazoparibhsa03013RNA transport8.33E-0614O14980, Q09161, P61326, P38919, Q9H307, P37198, Q7Z3B4, P35658, Q14152, P55884, O75822, Q14240, Q06787, P51114XPO1, NCBP1, MAGOH, EIF4A3, PNN, NUP62, NUP54, NUP214, EIF3A, EIF3B, EIF3J, EIF4A2, FMR1, FXR1More
Talazoparibhsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Talazoparibhsa03040Spliceosome4.08E-0512Q14562, O60508, P08579, P26368, Q13595, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Talazoparibhsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Talazoparibhsa03320PPAR signaling pathway4.55E-022O00767, Q02318SCD, CYP27A1More
Talazoparibhsa03450Non-homologous end-joining1.02E-032P78527, P13010PRKDC, XRCC5More
Talazoparibhsa04010MAPK signaling pathway4.15E-021P08069IGF1RMore
Talazoparibhsa04012ErbB signaling pathway1.90E-034P16333, Q13191, P19174, P01106NCK1, CBLB, PLCG1, MYCMore
Talazoparibhsa04014Ras signaling pathway1.64E-027Q02750, Q15389, P08069, P17252, P21359, P62879, P22694MAP2K1, ANGPT1, IGF1R, PRKCA, NF1, GNB2, PRKACBMore
Talazoparibhsa04015Rap1 signaling pathway2.99E-021P08069IGF1RMore
Talazoparibhsa04060Cytokine-cytokine receptor interaction3.20E-023P37173, P78552, P80075TGFBR2, IL13RA1, CCL8More
Talazoparibhsa04061Viral protein interaction with cytokine and cytokine receptor3.02E-023P09341, P02775, Q13651CXCL1, PPBP, IL10RAMore
Talazoparibhsa04064NF-kappa B signaling pathway2.28E-0311O00463, P14778, P01584, Q13077, Q16548, Q8WV28, P63279, P24522, Q8NHW4, P09341, Q9NQC7TRAF5, IL1R1, IL1B, TRAF1, BCL2A1, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CYLDMore
Talazoparibhsa04066HIF-1 signaling pathway1.49E-025P08069, P17252, Q15389, Q02750, P46527IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1BMore
Talazoparibhsa04068FoxO signaling pathway1.99E-021P08069IGF1RMore
Talazoparibhsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Talazoparibhsa04110Cell cycle3.67E-069Q9UBD5, P06493, O60566, P78527, Q14683, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, PRKDC, SMC1A, CDC25A, TTK, CDKN2C, MYCMore
Talazoparibhsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Talazoparibhsa04140Autophagy - animal2.82E-021P08069IGF1RMore
Talazoparibhsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Talazoparibhsa04144Endocytosis1.13E-0314Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5More
Talazoparibhsa04150mTOR signaling pathway2.32E-021P08069IGF1RMore
Talazoparibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Talazoparibhsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Talazoparibhsa04213Longevity regulating pathway - multiple species2.61E-047P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Talazoparibhsa04218Cellular senescence1.70E-024P01889, P10321, P05141, P12236HLA-B, HLA-C, SLC25A5, SLC25A6More
Talazoparibhsa04270Vascular smooth muscle contraction9.46E-046P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Talazoparibhsa04310Wnt signaling pathway2.60E-023O15169, P17612, P67870AXIN1, PRKACA, CSNK2BMore
Talazoparibhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Talazoparibhsa04340Hedgehog signaling pathway2.62E-022O43791, P30279SPOP, CCND2More
Talazoparibhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Talazoparibhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Talazoparibhsa04510Focal adhesion3.48E-021P08069IGF1RMore
Talazoparibhsa04520Adherens junction8.29E-031P08069IGF1RMore
Talazoparibhsa04530Tight junction2.45E-036Q8TEU7, P16989, P56750, O00501, Q14247, P24844RAPGEF6, CSDA, CLDN17, CLDN5, CTTN, MYL9More
Talazoparibhsa04540Gap junction2.03E-024P17252, P22694, P68371, Q02750PRKCA, PRKACB, TUBB2C, MAP2K1More
Talazoparibhsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P08069IGF1RMore
Talazoparibhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Talazoparibhsa04612Antigen processing and presentation6.19E-038P48382, P26715, P26717, Q13241, O43908, P01732, P11142, P01375RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, HSPA8, TNFMore
Talazoparibhsa04613Neutrophil extracellular trap formation6.58E-047P19174, P11215, Q13547, Q93077, P62807, O60814, P68431PLCG1, ITGAM, HDAC1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Talazoparibhsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Talazoparibhsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Talazoparibhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Talazoparibhsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Talazoparibhsa04650Natural killer cell mediated cytotoxicity9.38E-0411P01375, O60880, P20963, Q29983, P10321, P01889, Q13241, P26718, O75015, P26717, P26715TNF, SH2D1A, CD247, MICA, HLA-C, HLA-B, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Talazoparibhsa04657IL-17 signaling pathway1.88E-036O00463, Q16539, P49841, P09341, P14780, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNFMore
Talazoparibhsa04658Th1 and Th2 cell differentiation2.71E-025P07766, P06239, Q9UL17, P14784, Q13761CD3E, LCK, TBX21, IL2RB, RUNX3More
Talazoparibhsa04659Th17 cell differentiation4.13E-037P06239, P14784, P14778, Q9UL17, Q13485, P08238, P07766LCK, IL2RB, IL1R1, TBX21, SMAD4, HSP90AB1, CD3EMore
Talazoparibhsa04662B cell receptor signaling pathway2.54E-045P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Talazoparibhsa04664Fc epsilon RI signaling pathway1.07E-047P01375, Q16539, P42338, Q9UQC2, P07948, P09917, P20292TNF, MAPK14, PIK3CB, GAB2, LYN, ALOX5, ALOX5APMore
Talazoparibhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Talazoparibhsa04720Long-term potentiation5.41E-047P17252, Q15418, P51812, P18848, P17612, P22694, Q02750PRKCA, RPS6KA1, RPS6KA3, ATF4, PRKACA, PRKACB, MAP2K1More
Talazoparibhsa04723Retrograde endocannabinoid signaling2.60E-023P48169, P62873, P17612GABRA4, GNB1, PRKACAMore
Talazoparibhsa04724Glutamatergic synapse3.88E-044O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Talazoparibhsa04725Cholinergic synapse2.43E-0410P17612, P22694, P17252, P62873, P62879, P63218, P50151, P18848, P42338, Q02750PRKACA, PRKACB, PRKCA, GNB1, GNB2, GNG5, GNG10, ATF4, PIK3CB, MAP2K1More
Talazoparibhsa04726Serotonergic synapse2.43E-024P22694, P17252, P62879, Q02750PRKACB, PRKCA, GNB2, MAP2K1More
Talazoparibhsa04727GABAergic synapse2.27E-0510P62873, P62879, P63218, P50151, P48169, P15104, P17612, P22694, O60296, P17252GNB1, GNB2, GNG5, GNG10, GABRA4, GLUL, PRKACA, PRKACB, TRAK2, PRKCAMore
Talazoparibhsa04728Dopaminergic synapse1.36E-024P17612, P62873, P18848, O15516PRKACA, GNB1, ATF4, CLOCKMore
Talazoparibhsa04730Long-term depression1.16E-021P08069IGF1RMore
Talazoparibhsa04740Olfactory transduction2.09E-022P62873, P17612GNB1, PRKACAMore
Talazoparibhsa04742Taste transduction3.78E-032P48169, P17612GABRA4, PRKACAMore
Talazoparibhsa04750Inflammatory mediator regulation of TRP channels4.01E-024P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Talazoparibhsa04910Insulin signaling pathway1.67E-023Q14642, Q13191, Q9Y4H2INPP5A, CBLB, IRS2More
Talazoparibhsa04913Ovarian steroidogenesis1.16E-021P08069IGF1RMore
Talazoparibhsa04914Progesterone-mediated oocyte maturation2.16E-021P08069IGF1RMore
Talazoparibhsa04915Estrogen signaling pathway3.17E-025Q08828, P51828, P0DMV8, P0DP23, Q15788ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Talazoparibhsa04919Thyroid hormone signaling pathway2.22E-025P17252, Q02750, P22694, Q12778, Q9UM47PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3More
Talazoparibhsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P49407PIK3CB, GNG5, GNG10, VEGFC, ARRB1More
Talazoparibhsa04928Parathyroid hormone synthesis, secretion and action4.48E-024P22694, Q02750, P17252, Q9Y5Q3PRKACB, MAP2K1, PRKCA, MAFBMore
Talazoparibhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Talazoparibhsa04932Non-alcoholic fatty liver disease1.39E-026O43521, O75460, P01584, P13073, P12074, O95298BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2More
Talazoparibhsa04934Cushing syndrome1.98E-023P18848, P17612, O15169ATF4, PRKACA, AXIN1More
Talazoparibhsa04962Vasopressin-regulated water reabsorption7.22E-032P52566, P62491ARHGDIB, RAB11AMore
Talazoparibhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Talazoparibhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Talazoparibhsa04970Salivary secretion4.84E-036Q08828, P51828, P22694, P17252, P0DP23, P49913ADCY1, ADCY7, PRKACB, PRKCA, CALM1, CAMPMore
Talazoparibhsa04976Bile secretion4.78E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Talazoparibhsa05010Alzheimer disease9.83E-037P13073, P18848, O15169, P67870, P05141, P12236, P28070COX4I1, ATF4, AXIN1, CSNK2B, SLC25A5, SLC25A6, PSMB4More
Talazoparibhsa05012Parkinson disease1.25E-026P13073, P05141, P12236, P17612, P18848, P28070COX4I1, SLC25A5, SLC25A6, PRKACA, ATF4, PSMB4More
Talazoparibhsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Talazoparibhsa05017Spinocerebellar ataxia2.22E-024Q92915, O15399, P42338, P21796FGF14, GRIN2D, PIK3CB, VDAC1More
Talazoparibhsa05020Prion disease2.79E-049P17612, P13073, Q92736, P18848, P05141, P12236, P28070, O60282, P67870PRKACA, COX4I1, RYR2, ATF4, SLC25A5, SLC25A6, PSMB4, KIF5C, CSNK2BMore
Talazoparibhsa05022Pathways of neurodegeneration - multiple diseases4.48E-039P67870, P13073, Q06055, P18848, P05141, P12236, O15169, O15020, P28070CSNK2B, COX4I1, ATP5G2, ATF4, SLC25A5, SLC25A6, AXIN1, SPTBN2, PSMB4More
Talazoparibhsa05032Morphine addiction1.01E-023P17612, P62873, P48169PRKACA, GNB1, GABRA4More
Talazoparibhsa05034Alcoholism1.06E-059P17612, P18848, Q96RR4, P62873, Q93077, P62807, O60814, P84243, P68431PRKACA, ATF4, CAMKK2, GNB1, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Talazoparibhsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Talazoparibhsa05132Salmonella infection4.83E-022O00471, O60282EXOC5, KIF5CMore
Talazoparibhsa05133Pertussis4.20E-021P0C0L4C4AMore
Talazoparibhsa05134Legionellosis3.59E-046P01584, Q9NR31, P11215, P0DMV8, P11142, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL2More
Talazoparibhsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Talazoparibhsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Talazoparibhsa05144Malaria3.76E-036P60033, P69905, P68871, P01375, P35443, P26718CD81, HBA2, HBB, TNF, THBS4, KLRK1More
Talazoparibhsa05146Amoebiasis4.55E-025P09341, P14778, P27930, O60603, P05089CXCL1, IL1R1, IL1R2, TLR2, ARG1More
Talazoparibhsa05150Staphylococcus aureus infection1.02E-037P21730, P21462, O75015, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Talazoparibhsa05160Hepatitis C4.55E-023O00501, P29728, P01106CLDN5, OAS2, MYCMore
Talazoparibhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Talazoparibhsa05163Human cytomegalovirus infection5.31E-0520P01375, P01889, P10321, P62873, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P17612, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463TNF, HLA-B, HLA-C, GNB1, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, PRKACA, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5More
Talazoparibhsa05165Human papillomavirus infection4.71E-0310P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATMMore
Talazoparibhsa05166Human T-cell leukemia virus 1 infection7.39E-037Q9Y490, P01889, P10321, P05141, P12236, P17612, P18848TLN1, HLA-B, HLA-C, SLC25A5, SLC25A6, PRKACA, ATF4More
Talazoparibhsa05167Kaposi sarcoma-associated herpesvirus infection3.02E-024P01889, P10321, P62873, Q29983HLA-B, HLA-C, GNB1, MICAMore
Talazoparibhsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Talazoparibhsa05202Transcriptional misregulation in cancer7.84E-038Q12778, Q13315, Q15744, P08069, P46527, P05164, P08246, Q9C0K0FOXO1, ATM, CEBPE, IGF1R, CDKN1B, MPO, ELA2, BCL11BMore
Talazoparibhsa05203Viral carcinogenesis3.47E-059P18848, P30279, Q13547, Q15283, P01889, P10321, P17612, P62807, O60814ATF4, CCND2, HDAC1, RASA2, HLA-B, HLA-C, PRKACA, HIST1H2BC, H2BC12More
Talazoparibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Talazoparibhsa05205Proteoglycans in cancer3.48E-021P08069IGF1RMore
Talazoparibhsa05206MicroRNAs in cancer2.41E-0310P46527, P30279, Q9Y4H2, Q9UM47, P16070, Q13547, Q13315, P17252, P19174, Q02750CDKN1B, CCND2, IRS2, NOTCH3, CD44, HDAC1, ATM, PRKCA, PLCG1, MAP2K1More
Talazoparibhsa05210Colorectal cancer3.43E-022Q9UKG1, P37173APPL1, TGFBR2More
Talazoparibhsa05214Glioma9.95E-031P08069IGF1RMore
Talazoparibhsa05215Prostate cancer1.33E-021P08069IGF1RMore
Talazoparibhsa05218Melanoma6.63E-031P08069IGF1RMore
Talazoparibhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Talazoparibhsa05224Breast cancer1.24E-025P08069, P49841, Q92837, P04637, P24522IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Talazoparibhsa05225Hepatocellular carcinoma1.33E-021P08069IGF1RMore
Talazoparibhsa05231Choline metabolism in cancer2.60E-023Q9Y259, P19174, P49619CHKB, PLCG1, DGKGMore
Talazoparibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.55E-025O95267, P09693, O60603, Q16539, P01730RASGRP1, CD3G, TLR2, MAPK14, CD4More
Talazoparibhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Talazoparibhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Talazoparibhsa05415Diabetic cardiomyopathy4.23E-022P30405, P37173PPIF, TGFBR2More
Talazoparibhsa05418Fluid shear stress and atherosclerosis1.26E-048Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More

Community members of Talazoparib (SDC: 7.49)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09874PARP1Poly [ADPNoneribose] polymerase 1Reported10.553610.44822.725
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Reported00.04350.26350.24610.7947
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
Q96SW2CRBNProtein cereblonPredicted00.2490.042700.2099
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
Q13315ATMSerineNoneprotein kinase ATMPredicted10.77470.20140.93911.7293
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P67870CSNK2BCasein kinase II subunit betaPredicted00.76770.02730.52970.9682
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
PARP1P09874IC500.57
PARP1P09874IC500.6
PARP1P09874IC507.2
PARP1P09874Ki1.2
PARP2Q9UGN5Ki0.85