PharmaCoNets of Tadalafil (SPCN: 51.48 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Tadalafilhsa00190Oxidative phosphorylation1.07E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Tadalafilhsa00520Amino sugar and nucleotide sugar metabolism1.59E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Tadalafilhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Tadalafilhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Tadalafilhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Tadalafilhsa00600Sphingolipid metabolism2.44E-022Q9BX95, Q06136SGPP1, FVT1More
Tadalafilhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.10E-032P06865, O75752HEXA, B3GALNT1More
Tadalafilhsa00730Thiamine metabolism1.15E-032Q9Y6K8, P24666AK5, ACP1More
Tadalafilhsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Tadalafilhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Tadalafilhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Tadalafilhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Tadalafilhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Tadalafilhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Tadalafilhsa03040Spliceosome2.09E-027Q14562, O43143, O75940, O75494, Q07955, Q01130, Q13243DHX8, DHX15, SMNDC1, FUSIP1, SFRS1, SFRS2, SFRS5More
Tadalafilhsa03050Proteasome2.26E-022P55036, P28074PSMD4, PSMB5More
Tadalafilhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Tadalafilhsa04014Ras signaling pathway1.70E-027P20827, Q9NRA1, P49767, P17252, P0DP23, P62873, P19174EFNA1, PDGFC, VEGFC, PRKCA, CALM1, GNB1, PLCG1More
Tadalafilhsa04015Rap1 signaling pathway4.58E-026P20827, Q9NRA1, P49767, P0DP23, P17252, P19174EFNA1, PDGFC, VEGFC, CALM1, PRKCA, PLCG1More
Tadalafilhsa04020Calcium signaling pathway2.01E-026P17252, P19174, P0DP23, P20020, Q9NRA1, P49767PRKCA, PLCG1, CALM1, ATP2B1, PDGFC, VEGFCMore
Tadalafilhsa04070Phosphatidylinositol signaling system4.40E-024P19174, P0DP23, P23743, P17252PLCG1, CALM1, DGKA, PRKCAMore
Tadalafilhsa04114Oocyte meiosis1.35E-025Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Tadalafilhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Tadalafilhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Tadalafilhsa04145Phagosome4.68E-025Q15080, P14598, Q13509, P68371, Q13488NCF4, NCF1, TUBB3, TUBB2C, TCIRG1More
Tadalafilhsa04217Necroptosis7.22E-0513P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Tadalafilhsa04360Axon guidance2.29E-025P16333, P20827, O95631, P17252, P19174NCK1, EFNA1, NTN1, PRKCA, PLCG1More
Tadalafilhsa04370VEGF signaling pathway9.69E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Tadalafilhsa04390Hippo signaling pathway5.79E-034P04628, Q9UJU2, O43623, Q13489WNT1, LEF1, SNAI2, BIRC3More
Tadalafilhsa04512ECM-receptor interaction2.93E-022P07359, P08514GP1BA, ITGA2BMore
Tadalafilhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Tadalafilhsa04540Gap junction1.67E-024P17252, Q13509, P68371, Q9NRA1PRKCA, TUBB3, TUBB2C, PDGFCMore
Tadalafilhsa04610Complement and coagulation cascades3.52E-022P09871, P20023C1S, CR2More
Tadalafilhsa04611Platelet activation5.13E-044P08514, Q15746, Q8WYR1, P07359ITGA2B, MYLK, PIK3R5, GP1BAMore
Tadalafilhsa04612Antigen processing and presentation4.78E-026P48382, P26715, P26717, Q13241, O43908, P01375RFX5, KLRC1, KLRC2, KLRD1, KLRC4, TNFMore
Tadalafilhsa04613Neutrophil extracellular trap formation9.78E-048P16109, Q99878, Q93077, P62807, O60814, P68431, P08514, P07359SELP, H2AC14, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ITGA2B, GP1BAMore
Tadalafilhsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Tadalafilhsa04623Cytosolic DNA-sensing pathway4.28E-043P01568, Q13546, P25963IFNA21, RIPK1, NFKBIAMore
Tadalafilhsa04640Hematopoietic cell lineage2.62E-023P07359, P08514, P20023GP1BA, ITGA2B, CR2More
Tadalafilhsa04650Natural killer cell mediated cytotoxicity1.25E-028P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Tadalafilhsa04657IL-17 signaling pathway2.97E-025P25963, P08238, Q07955, P04141, P06702NFKBIA, HSP90AB1, SFRS1, CSF2, S100A9More
Tadalafilhsa04660T cell receptor signaling pathway3.80E-026P04141, P25963, P10747, P19174, P16333, P29350CSF2, NFKBIA, CD28, PLCG1, NCK1, PTPN6More
Tadalafilhsa04662B cell receptor signaling pathway4.53E-033P20023, Q8WV28, P11912CR2, BLNK, CD79AMore
Tadalafilhsa04713Circadian entrainment3.32E-024P0DP23, P17252, P62873, O15055CALM1, PRKCA, GNB1, PER2More
Tadalafilhsa04720Long-term potentiation4.54E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Tadalafilhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Tadalafilhsa04744Phototransduction1.18E-022P62873, P0DP23GNB1, CALM1More
Tadalafilhsa04914Progesterone-mediated oocyte maturation1.88E-024Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Tadalafilhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Tadalafilhsa04933AGE-RAGE signaling pathway in diabetic complications1.72E-025P42224, Q12778, P49767, P17252, P19174STAT1, FOXO1, VEGFC, PRKCA, PLCG1More
Tadalafilhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Tadalafilhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Tadalafilhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Tadalafilhsa05012Parkinson disease3.12E-026Q16718, O14521, P19174, P0DP23, Q13509, P68371NDUFA5, SDHD, PLCG1, CALM1, TUBB3, TUBB2CMore
Tadalafilhsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Tadalafilhsa05022Pathways of neurodegeneration - multiple diseases2.29E-029Q13509, P68371, Q16718, O14521, Q13561, P19174, P17252, Q08752, P0DP23TUBB3, TUBB2C, NDUFA5, SDHD, DCTN2, PLCG1, PRKCA, PPID, CALM1More
Tadalafilhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Tadalafilhsa05100Bacterial invasion of epithelial cells4.54E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Tadalafilhsa05110Vibrio cholerae infection1.98E-023Q13488, P17252, P19174TCIRG1, PRKCA, PLCG1More
Tadalafilhsa05131Shigellosis2.93E-026Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q13315RRAGD, UBB, SEPT6, ELMO2, PTK2, ATMMore
Tadalafilhsa05132Salmonella infection1.91E-0411P25963, P08238, Q9UJU2, Q13546, Q13489, P04406, O75369, Q13561, Q13509, P68371, P49754NFKBIA, HSP90AB1, LEF1, RIPK1, BIRC3, GAPDH, FLNB, DCTN2, TUBB3, TUBB2C, VPS41More
Tadalafilhsa05140Leishmaniasis1.72E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Tadalafilhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Tadalafilhsa05144Malaria3.12E-024P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Tadalafilhsa05150Staphylococcus aureus infection2.03E-049P09871, P21730, P21462, O75015, P16109, P59665, P59666, P12838, P49913C1S, C5AR1, FPR1, FCGR3B, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Tadalafilhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Tadalafilhsa05167Kaposi sarcoma-associated herpesvirus infection5.71E-038P01568, P42224, P25963, P40189, P62873, P19174, P04141, P0DP23IFNA21, STAT1, NFKBIA, IL6ST, GNB1, PLCG1, CSF2, CALM1More
Tadalafilhsa05168Herpes simplex virus 1 infection4.15E-0312P25963, P01568, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13398, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, ZNF211, ZNF85, ZNF140, ZNF189, ZNF212More
Tadalafilhsa05170Human immunodeficiency virus 1 infection3.80E-025Q02750, P62879, P16298, Q05397, Q13315MAP2K1, GNB2, PPP3CB, PTK2, ATMMore
Tadalafilhsa05171Coronavirus disease - COVID-191.36E-027P25963, P42224, P01568, P40189, P04141, P19174, P17252NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PLCG1, PRKCAMore
Tadalafilhsa05200Pathways in cancer1.75E-0214P08238, P42224, P25963, P19174, P17252, P43246, P14923, P49767, Q12778, P62873, O75293, P0DP23, P01568, P40189HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, JUP, VEGFC, FOXO1, GNB1, GADD45B, CALM1, IFNA21, IL6STMore
Tadalafilhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Tadalafilhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Tadalafilhsa05214Glioma1.09E-024P0DP23, P17252, P19174, O75293CALM1, PRKCA, PLCG1, GADD45BMore
Tadalafilhsa05217Basal cell carcinoma4.31E-022P04628, Q9UJU2WNT1, LEF1More
Tadalafilhsa05231Choline metabolism in cancer2.25E-035Q9NRA1, Q9Y259, P19174, P23743, P17252PDGFC, CHKB, PLCG1, DGKA, PRKCAMore
Tadalafilhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.97E-025P25963, P19174, P29350, P42224, P10747NFKBIA, PLCG1, PTPN6, STAT1, CD28More
Tadalafilhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Tadalafilhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Tadalafilhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Tadalafilhsa05340Primary immunodeficiency2.93E-022P11912, Q8WV28CD79A, BLNKMore
Tadalafilhsa05415Diabetic cardiomyopathy1.20E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore

Community members of Tadalafil (SDC: 5.05)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)