PharmaCoNets

PharmaCoNets of Tacrine (S_PCN: 196.10 )

Tacrine regulated-network (S_DN: 24.00)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Tacrine

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Tacrine

hsa00190

Oxidative phosphorylation

1.10E-03

Q16718, P36542, O14521

NDUFA5, ATP5C1, SDHD

Tacrine

hsa00220

Arginine biosynthesis

3.83E-02

P05089, P49448

ARG1, GLUD2

Tacrine

hsa00230

Purine metabolism

4.02E-02

P31350, P21589

RRM2, NT5E

Tacrine

hsa00240

Pyrimidine metabolism

2.54E-04

P31350, P21589, P04818

RRM2, NT5E, TYMS

Tacrine

hsa00310

Lysine degradation

1.98E-03

Q96KQ7, Q02809, P51648

EHMT2, PLOD1, ALDH3A2

Tacrine

hsa00500

Starch and sucrose metabolism

2.52E-05

O43451, P46976, P06737

MGAM, GYG1, PYGL

Tacrine

hsa00512

Mucin type O-glycan biosynthesis

4.86E-02

O95395, Q9NY28

GCNT3, GALNT8

Tacrine

hsa00520

Amino sugar and nucleotide sugar metabolism

7.85E-04

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Tacrine

hsa00562

Inositol phosphate metabolism

2.00E-02

P27987, P19174, P42338, Q02252

ITPKB, PLCG1, PIK3CB, ALDH6A1

Tacrine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Tacrine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Tacrine

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

7.10E-03

P06865, O75752

HEXA, B3GALNT1

Tacrine

hsa00630

Glyoxylate and dicarboxylate metabolism

4.95E-07

P40925, P40926, P15104

MDH1, MDH2, GLUL

Tacrine

hsa00640

Propanoate metabolism

3.83E-02

Q02252, Q9P2R7

ALDH6A1, SUCLA2

Tacrine

hsa00670

One carbon pool by folate

1.33E-02

P04818, Q99707

TYMS, MTR

Tacrine

hsa00730

Thiamine metabolism

1.55E-03

P05186, P24666

ALPL, ACP1

Tacrine

hsa00740

Riboflavin metabolism

4.77E-02

P30043

BLVRB

Tacrine

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Tacrine

hsa00830

Retinol metabolism

2.14E-03

P00325, P00352, Q9BPW9, O75911

ADH1B, ALDH1A1, DHRS9, DHRS3

Tacrine

hsa00970

Aminoacyl-tRNA biosynthesis

2.12E-02

P14868

DARS

Tacrine

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Tacrine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Tacrine

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Tacrine

hsa01523

Antifolate resistance

2.05E-04

Q92820, P04818

GGH, TYMS

Tacrine

hsa01524

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Tacrine

hsa02010

ABC transporters

1.98E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Tacrine

hsa03013

RNA transport

9.00E-07

P62826, O14980, Q09161, O14893, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, P47813, Q14152, O75822, Q14240, Q9BZI7, Q14232, Q06787, P51114

RAN, XPO1, NCBP1, GEMIN2, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, EIF2B1, FMR1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14980	XPO1	Exportin-1	0.799
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14893	GEMIN2	Gem-associated protein 2	0.72
P49759	CLK1	Dual specificity protein kinase CLK1	O14893	GEMIN2	Gem-associated protein 2	0.76
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.844
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.869
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.77
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.849
P49759	CLK1	Dual specificity protein kinase CLK1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.704
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.764
P49759	CLK1	Dual specificity protein kinase CLK1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.758
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q06787	FMR1	Synaptic functional regulator FMR1	0.863
P49759	CLK1	Dual specificity protein kinase CLK1	Q06787	FMR1	Synaptic functional regulator FMR1	0.793
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.798

Tacrine

hsa03015

mRNA surveillance pathway

4.81E-02

Q9BZI7, O94913

UPF3B, PCF11

Tacrine

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Tacrine

hsa03020

RNA polymerase

6.63E-05

P30876, P24928, P62487, Q9Y535

POLR2B, POLR2A, POLR2G, POLR3H

Tacrine

hsa03022

Basal transcription factors

3.79E-04

P20226, O00268, Q12962, Q15544

TBP, TAF4, TAF10, TAF11

Tacrine

hsa03040

Spliceosome

4.16E-06

Q14562, O43143, O60508, P17844, P08579, P51991, P61978, Q07955, Q01130, Q13243, P11142, O43447

DHX8, DHX15, CDC40, DDX5, SNRPB2, HNRPA3, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8, PPIH

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.888
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.708
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14562	DHX8	ATP-dependent RNA helicase DHX8	0.775
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.953
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O43143	DHX15	ATP-dependent RNA helicase DHX15	0.871
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O60508	CDC40	Pre-mRNA-processing factor 17	0.838
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O60508	CDC40	Pre-mRNA-processing factor 17	-0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O60508	CDC40	Pre-mRNA-processing factor 17	0.716
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	0.788
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.702
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.787
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.827
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.935
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.882
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.835
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.886
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.746
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.876
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.761

Tacrine

hsa03060

Protein export

6.47E-04

Q15070, P37108, O76094, Q15005

OXA1L, SRP14, SRP72, SPCS2

Tacrine

hsa03320

PPAR signaling pathway

3.60E-02

Q13418

ILK

Tacrine

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Tacrine

hsa04012

ErbB signaling pathway

1.02E-03

P16333, P17252, P19174, P42338, P01106

NCK1, PRKCA, PLCG1, PIK3CB, MYC

Tacrine

hsa04014

Ras signaling pathway

5.65E-06

P42338, P20827, Q9NRA1, P49767, Q13009, P17252, Q15311, P14921, P0DP23, P62873, P63218, P50151, P19174, P17612

PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, PRKCA, RALBP1, ETS1, CALM1, GNB1, GNG5, GNG10, PLCG1, PRKACA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P20827	EFNA1	Ephrin-A1	-0.872
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.776
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.792
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
Q8NFZ4	NLGN2	Neuroligin-2	Q15311	RALBP1	RalA-binding protein 1	0.71
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14921	ETS1	Protein C-ets-1	0.731
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q8NFZ4	NLGN2	Neuroligin-2	P0DP23	CALM1	Calmodulin-1	0.717
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
Q8NFZ4	NLGN2	Neuroligin-2	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.713

Tacrine

hsa04015

Rap1 signaling pathway

9.88E-03

P20827, P49767, P11215, Q13009, P42338, P0DP23, P17252, P19174

EFNA1, VEGFC, ITGAM, TIAM1, PIK3CB, CALM1, PRKCA, PLCG1

Tacrine

hsa04020

Calcium signaling pathway

5.71E-03

P27987, Q08828, P17252, O15399, P19174, P0DP23, P05141, P51828, P49767

ITPKB, ADCY1, PRKCA, GRIN2D, PLCG1, CALM1, SLC25A5, ADCY7, VEGFC

Tacrine

hsa04022

cGMP-PKG signaling pathway

4.38E-03

P18848, P31751, Q08828, P51828, P05141, P0DP23

ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1

Tacrine

hsa04024

cAMP signaling pathway

4.64E-03

Q08828, P51828, P42338, P31751, P0DP23, Q13370, O15399, P25963, Q13009

ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1

Tacrine

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Tacrine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.28E-03

Q8NHW4, P09341, P25024, P47992, Q9UBD3, Q13651, P14784

CCL4L2, CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB

Tacrine

hsa04062

Chemokine signaling pathway

2.09E-06

P25024, P09341, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q13009, P14598, P42224, P25963

CXCR1, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, TIAM1, NCF1, STAT1, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P43250	GRK6	G protein-coupled receptor kinase 6	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.792
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.746
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14598	NCF1	Neutrophil cytosol factor 1	0.908
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14598	NCF1	Neutrophil cytosol factor 1	0.785
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818

Tacrine

hsa04064

NF-kappa B signaling pathway

1.05E-06

O00463, P14778, P01584, Q04759, Q13077, Q16548, P07948, P06239, Q8WV28, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7

TRAF5, IL1R1, IL1B, PRKCQ, TRAF1, BCL2A1, LYN, LCK, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P23458	JAK1	Tyrosine-protein kinase JAK1	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P23458	JAK1	Tyrosine-protein kinase JAK1	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.825
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753

Tacrine

hsa04070

Phosphatidylinositol signaling system

8.85E-06

P19174, P0DP23, P42338, O14986, P23743, Q16760, P48426, P27987, P17252

PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, DGKD, PIP4K2A, ITPKB, PRKCA

Tacrine

hsa04071

Sphingolipid signaling pathway

2.43E-03

P17252, P21453, Q9H228, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, PPP2R5C, SGPP1, MAPK14, BCL2

Tacrine

hsa04072

Phospholipase D signaling pathway

2.40E-03

P31751, O14986, Q15438, Q08828, P51828, Q16760

AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD

Tacrine

hsa04110

Cell cycle

2.90E-06

Q9UBD5, P06493, O60566, Q14683, P30304, P33981, P42773, P01106

ORC3, CDK1, BUB1B, SMC1A, CDC25A, TTK, CDKN2C, MYC

Tacrine

hsa04114

Oocyte meiosis

1.71E-06

Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, P17612, Q08828, P51828, Q13362, Q14738

MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, PRKACA, ADCY1, ADCY7, PPP2R5C, PPP2R5D

Tacrine

hsa04115

p53 signaling pathway

3.34E-02

P31350, P06493

RRM2, CDK1

Tacrine

hsa04120

Ubiquitin mediated proteolysis

1.08E-03

Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669

SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12

Tacrine

hsa04140

Autophagy - animal

1.71E-02

P31751, Q7L523, O75460, Q96GC9, Q8TEV9

AKT2, RRAGA, ERN1, TMEM49, SMCR8

Tacrine

hsa04141

Protein processing in endoplasmic reticulum

1.22E-04

P18848, P30101, Q15437, P60604, Q99941, P11142, P07900, P08238, Q9NR31, Q9H173, Q9UNL2

ATF4, PDIA3, SEC23B, UBE2G2, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3

Tacrine

hsa04142

Lysosome

1.46E-02

P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916

HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2

Tacrine

hsa04144

Endocytosis

4.97E-04

P0DMV8, Q9H444, O75351, P62491, P42566, Q96B97, Q15438, Q14161, Q9UMY4

HSPA1A, CHMP4B, VPS4B, RAB11A, EPS15, SH3KBP1, PSCD1, GIT2, SNX12

Tacrine

hsa04145

Phagosome

4.10E-04

O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Tacrine

hsa04146

Peroxisome

4.83E-02

O96011, P56589, Q9UKG9, O75521

PEX11B, PEX3, CROT, ECI2

Tacrine

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Tacrine

hsa04151

PI3K-Akt signaling pathway

3.71E-04

P62753, P42338, P27348, P20827, P49767, P07900, P08238, P62873, P50151, P16144, O15335, Q13751, P22105, P14784, P01568, Q99941, P18848, P17252, O00141

RPS6, PIK3CB, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, GNB1, GNG10, ITGB4, CHAD, LAMB3, TNXB, IL2RB, IFNA21, CREBL1, ATF4, PRKCA, SGK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P62753	RPS6	40S ribosomal protein S6	0.722
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P27348	YWHAQ	14-3-3 protein theta	0.833
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P20827	EFNA1	Ephrin-A1	-0.872
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P16144	ITGB4	Integrin beta-4	-0.705
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O15335	CHAD	Chondroadherin	-0.719
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13751	LAMB3	Laminin subunit beta-3	-0.705
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P22105	TNXB	Tenascin-X	0.777
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.709

Tacrine

hsa04211

Longevity regulating pathway

1.32E-03

P31751, Q08828, P51828, Q99941, P18848

AKT2, ADCY1, ADCY7, CREBL1, ATF4

Tacrine

hsa04213

Longevity regulating pathway - multiple species

3.76E-04

P31751, Q9Y4H2, Q08828, P51828, P0DMV8, Q13547

AKT2, IRS2, ADCY1, ADCY7, HSPA1A, HDAC1

Tacrine

hsa04217

Necroptosis

1.01E-04

P01375, P01568, P23458, P48023, Q13489, Q9NQC7, P42224, Q14765, P08238, P15104, Q6FI13, Q99878, Q9H444, O43633, O75351

TNF, IFNA21, JAK1, FASLG, BIRC3, CYLD, STAT1, STAT4, HSP90AB1, GLUL, H2AC18; H2AC19, H2AC14, CHMP4B, CHMP2A, VPS4B

Tacrine

hsa04261

Adrenergic signaling in cardiomyocytes

1.92E-06

Q08828, P51828, P17612, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557

ADCY1, ADCY7, PRKACA, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2D

Tacrine

hsa04270

Vascular smooth muscle contraction

6.96E-03

P0DP23, Q08828, P51828, P35579, P35749, P35318

CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM

Tacrine

hsa04360

Axon guidance

2.13E-03

P16333, P20827, O95631, P17252, P42338, P23528, P19174

NCK1, EFNA1, NTN1, PRKCA, PIK3CB, CFL1, PLCG1

Tacrine

hsa04370

VEGF signaling pathway

2.59E-06

P19174, P16298, P42338, P17252, Q05397, Q02750

PLCG1, PPP3CB, PIK3CB, PRKCA, PTK2, MAP2K1

Tacrine

hsa04371

Apelin signaling pathway

1.12E-04

P62873, P63218, P50151, P31751, Q08828, P51828, Q13370, Q14344, P84022, P0DP23

GNB1, GNG5, GNG10, AKT2, ADCY1, ADCY7, PDE3B, GNA13, SMAD3, CALM1

Tacrine

hsa04380

Osteoclast differentiation

5.27E-04

Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149

CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2

Tacrine

hsa04510

Focal adhesion

7.77E-03

P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P49767

ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, VEGFC

Tacrine

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Tacrine

hsa04540

Gap junction

1.08E-02

Q13509, P68371, Q71U36, Q9NRA1

TUBB3, TUBB2C, TUBA1A, PDGFC

Tacrine

hsa04610

Complement and coagulation cascades

1.14E-05

P00734, P0C0L4

F2, C4A

Tacrine

hsa04612

Antigen processing and presentation

1.75E-02

P13765, P01730, P26715, P26717, Q13241, P01732

HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8A

Tacrine

hsa04613

Neutrophil extracellular trap formation

2.86E-06

P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, Q15080, O75015, P21730, P21462, O43315, Q16539

PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.799
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
Q15722	LTB4R	Leukotriene B4 receptor 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.833
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
O15245	SLC22A1	Solute carrier family 22 member 1	P58876	H2BC5	Histone H2B type 1-D	0.947
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
O15245	SLC22A1	Solute carrier family 22 member 1	Q16778	HIST2H2BE	Histone H2B type 2-E	0.793
O15245	SLC22A1	Solute carrier family 22 member 1	O60814	H2BC12	Histone H2B type 1-K	0.72
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.918
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
Q15722	LTB4R	Leukotriene B4 receptor 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.875
Q15722	LTB4R	Leukotriene B4 receptor 1	P21462	FPR1	fMet-Leu-Phe receptor	0.888
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
Q15722	LTB4R	Leukotriene B4 receptor 1	O43315	AQP9	Aquaporin-9	0.79
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721

Tacrine

hsa04620

Toll-like receptor signaling pathway

2.54E-03

P01584, P31751, Q8NHW4

IL1B, AKT2, CCL4L2

Tacrine

hsa04621

NOD-like receptor signaling pathway

3.15E-02

Q16539, Q14643, P21796, P10599, Q9H1Y0, P43490, O00463, P01375, P09341, P12838

MAPK14, ITPR1, VDAC1, TXN, ATG5, PBEF1, TRAF5, TNF, CXCL1, DEFA4

Tacrine

hsa04623

Cytosolic DNA-sensing pathway

6.36E-08

P01584, P01568, P25963, Q9Y535, Q8NHW4

IL1B, IFNA21, NFKBIA, POLR3H, CCL4L2

Tacrine

hsa04625

C-type lectin receptor signaling pathway

1.14E-03

Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539

CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14

Tacrine

hsa04630

JAK-STAT signaling pathway

4.54E-02

P31751, P23458, Q13651

AKT2, JAK1, IL10RA

Tacrine

hsa04640

Hematopoietic cell lineage

3.30E-05

P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765

ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB

Tacrine

hsa04650

Natural killer cell mediated cytotoxicity

8.66E-06

P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, O75015, P26717, P26715

PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.701
O75475	PSIP1	PC4 and SFRS1-interacting protein	P01375	TNF	Tumor necrosis factor	-0.72
O75475	PSIP1	PC4 and SFRS1-interacting protein	P78314	SH3BP2	SH3 domain-binding protein 2	-0.731
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O75475	PSIP1	PC4 and SFRS1-interacting protein	O60880	SH2D1A	SH2 domain-containing protein 1A	0.734
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
O75475	PSIP1	PC4 and SFRS1-interacting protein	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.734
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O75475	PSIP1	PC4 and SFRS1-interacting protein	Q13241	KLRD1	Natural killer cells antigen CD94	0.772
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
O75475	PSIP1	PC4 and SFRS1-interacting protein	P26718	KLRK1	NKG2-D type II integral membrane protein	0.83
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
O75475	PSIP1	PC4 and SFRS1-interacting protein	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.879
O75475	PSIP1	PC4 and SFRS1-interacting protein	P26717	KLRC2	NKG2-C type II integral membrane protein	0.783
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
O75475	PSIP1	PC4 and SFRS1-interacting protein	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.783
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756

Tacrine

hsa04657

IL-17 signaling pathway

1.88E-03

O00463, Q16539, P49841, P09341, P14780, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNF

Tacrine

hsa04658

Th1 and Th2 cell differentiation

2.44E-07

Q04759, P07766, P20963, P09693, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Tacrine

hsa04659

Th17 cell differentiation

1.29E-07

P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927

Tacrine

hsa04660

T cell receptor signaling pathway

8.91E-04

Q04759, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239

PRKCQ, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK

Tacrine

hsa04662

B cell receptor signaling pathway

1.49E-03

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Tacrine

hsa04664

Fc epsilon RI signaling pathway

2.74E-06

P01375, P04141, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P09917

TNF, CSF2, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, ALOX5

Tacrine

hsa04666

Fc gamma R-mediated phagocytosis

8.08E-03

P42338, P19174, P23528, P14598, P17252

PIK3CB, PLCG1, CFL1, NCF1, PRKCA

Tacrine

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Tacrine

hsa04713

Circadian entrainment

1.36E-05

O15399, P0DP23, P17252, P62873, P63218, P50151, Q08828, P51828, P17612

GRIN2D, CALM1, PRKCA, GNB1, GNG5, GNG10, ADCY1, ADCY7, PRKACA

Tacrine

hsa04714

Thermogenesis

6.01E-04

Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521

MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHD

Tacrine

hsa04720

Long-term potentiation

2.75E-05

P16298, P0DP23, P51812, P18848, P17612, Q08828, Q02750

PPP3CB, CALM1, RPS6KA3, ATF4, PRKACA, ADCY1, MAP2K1

Tacrine

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Tacrine

hsa04723

Retrograde endocannabinoid signaling

1.75E-02

Q14643, P17252, P22694, Q16539, Q16718

ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5

Tacrine

hsa04724

Glutamatergic synapse

6.66E-06

O15399, P17252, P62873, P63218, P50151, P15104

GRIN2D, PRKCA, GNB1, GNG5, GNG10, GLUL

Tacrine

hsa04725

Cholinergic synapse

1.83E-05

Q08828, P51828, P17252, P62873, P63218, P50151, P18848, Q13557, P42338, P31751

ADCY1, ADCY7, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, AKT2

Tacrine

hsa04726

Serotonergic synapse

2.52E-03

P17252, P62873, P63218, P50151, P33260, P09917

PRKCA, GNB1, GNG5, GNG10, CYP2C18, ALOX5

Tacrine

hsa04727

GABAergic synapse

6.10E-06

P62873, P63218, P50151, P15104, P17252

GNB1, GNG5, GNG10, GLUL, PRKCA

Tacrine

hsa04728

Dopaminergic synapse

5.34E-05

P17612, P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23

PRKACA, AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1

Tacrine

hsa04730

Long-term depression

4.86E-02

Q14344, P07948

GNA13, LYN

Tacrine

hsa04740

Olfactory transduction

6.71E-03

P0DP23, P17612

CALM1, PRKACA

Tacrine

hsa04744

Phototransduction

1.59E-04

P62873, P0DP23

GNB1, CALM1

Tacrine

hsa04750

Inflammatory mediator regulation of TRP channels

1.17E-03

P01584, Q08828, P51828, P0DP23

IL1B, ADCY1, ADCY7, CALM1

Tacrine

hsa04910

Insulin signaling pathway

3.62E-02

P0DP23, P17612

CALM1, PRKACA

Tacrine

hsa04911

Insulin secretion

4.09E-05

Q08828, P51828, Q99941, P18848, Q13557

ADCY1, ADCY7, CREBL1, ATF4, CAMK2D

Tacrine

hsa04912

GnRH signaling pathway

3.07E-05

P17252, Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23, P22694

PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1, PRKACB

Tacrine

hsa04914

Progesterone-mediated oocyte maturation

8.45E-05

Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750

CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1

Tacrine

hsa04915

Estrogen signaling pathway

3.35E-05

Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788

CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1

Tacrine

hsa04916

Melanogenesis

1.77E-03

P17612, P0DP23, Q08828, P51828

PRKACA, CALM1, ADCY1, ADCY7

Tacrine

hsa04918

Thyroid hormone synthesis

1.69E-03

P51828, Q99941, P18848, P02768

ADCY7, CREBL1, ATF4, ALB

Tacrine

hsa04921

Oxytocin signaling pathway

1.84E-02

P0DP23, P17612, Q96RR4

CALM1, PRKACA, CAMKK2

Tacrine

hsa04923

Regulation of lipolysis in adipocytes

5.15E-03

Q08828, P51828, P31751

ADCY1, ADCY7, AKT2

Tacrine

hsa04924

Renin secretion

1.09E-02

P17612, P0DP23

PRKACA, CALM1

Tacrine

hsa04925

Aldosterone synthesis and secretion

5.46E-05

Q99941, P18848, Q08828, P51828, P0DP23, Q13557

CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2D

Tacrine

hsa04926

Relaxin signaling pathway

2.41E-06

P31751, P25963, P42338, P62873, P63218, P50151, Q99941, P18848, P49767, Q08828, P51828, P17252, P49407

AKT2, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, PRKCA, ARRB1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.747
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.752
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P49767	VEGFC	Vascular endothelial growth factor C	0.73
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P49407	ARRB1	Beta-arrestin-1	-0.709

Tacrine

hsa04927

Cortisol synthesis and secretion

1.76E-04

Q99941, P18848, Q08828, P51828

CREBL1, ATF4, ADCY1, ADCY7

Tacrine

hsa04928

Parathyroid hormone synthesis, secretion and action

3.47E-03

Q14643, P51828, P22694, P23771, P17252, Q99941, P18848, P10415

ITPR1, ADCY7, PRKACB, GATA3, PRKCA, CREBL1, ATF4, BCL2

Tacrine

hsa04929

GnRH secretion

4.62E-02

P42338, P49407

PIK3CB, ARRB1

Tacrine

hsa04932

Non-alcoholic fatty liver disease

2.20E-06

P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521

AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHD

Tacrine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.43E-02

P42224, P42338, P49767, P17252, P19174

STAT1, PIK3CB, VEGFC, PRKCA, PLCG1

Tacrine

hsa04934

Cushing syndrome

2.20E-04

Q99941, P18848, Q08828, P51828, Q13557

CREBL1, ATF4, ADCY1, ADCY7, CAMK2D

Tacrine

hsa04935

Growth hormone synthesis, secretion and action

1.32E-03

Q08828, P51828, Q99941, P18848, P31751

ADCY1, ADCY7, CREBL1, ATF4, AKT2

Tacrine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Tacrine

hsa04964

Proximal tubule bicarbonate reclamation

4.48E-02

P00918

CA2

Tacrine

hsa04966

Collecting duct acid secretion

4.48E-02

P00918

CA2

Tacrine

hsa04970

Salivary secretion

1.45E-04

Q08828, P51828, P17612, P0DP23

ADCY1, ADCY7, PRKACA, CALM1

Tacrine

hsa04971

Gastric acid secretion

1.90E-04

Q08828, P51828, P17612, P15311, P0DP23

ADCY1, ADCY7, PRKACA, VIL2, CALM1

Tacrine

hsa04976

Bile secretion

1.02E-05

O43315, Q08828, P51828, P17612, P08183, Q14032

AQP9, ADCY1, ADCY7, PRKACA, ABCB1, BAAT

Tacrine

hsa05010

Alzheimer disease

4.94E-03

O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070

NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4

Tacrine

hsa05012

Parkinson disease

1.77E-02

P60604, P19174, P0DP23, Q71U36, Q13509, P68371

UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C

Tacrine

hsa05014

Amyotrophic lateral sclerosis

2.72E-02

P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629

TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7

Tacrine

hsa05016

Huntington disease

1.76E-03

O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232

NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12

Tacrine

hsa05017

Spinocerebellar ataxia

3.94E-02

O75460, P31751, P28070, P05141

ERN1, AKT2, PSMB4, SLC25A5

Tacrine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Tacrine

hsa05022

Pathways of neurodegeneration - multiple diseases

4.63E-04

P49841, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, Q16539, Q00535, P01584, Q08752, P0DP23, P28070

GSK3B, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4

Tacrine

hsa05030

Cocaine addiction

4.87E-02

Q99941, P18848

CREBL1, ATF4

Tacrine

hsa05031

Amphetamine addiction

4.18E-04

P0DP23, Q13557, P17612, Q99941, P18848

CALM1, CAMK2D, PRKACA, CREBL1, ATF4

Tacrine

hsa05032

Morphine addiction

7.16E-04

P62873, P63218, P50151, Q13370, P17252, P43250

GNB1, GNG5, GNG10, PDE3B, PRKCA, GRK6

Tacrine

hsa05034

Alcoholism

8.54E-07

P17612, Q13547, P0DP23, Q96RR4, Q93077, P58876, P62807, Q16778, O60814, P68431

PRKACA, HDAC1, CALM1, CAMKK2, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Tacrine

hsa05100

Bacterial invasion of epithelial cells

4.54E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Tacrine

hsa05110

Vibrio cholerae infection

3.15E-02

Q13488, P17252, P19174

TCIRG1, PRKCA, PLCG1

Tacrine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

6.88E-04

Q16539, P25963, Q13488, P09341, P19174, P25024, P25025, P07948

MAPK14, NFKBIA, TCIRG1, CXCL1, PLCG1, CXCR1, CXCR2, LYN

Tacrine

hsa05130

Pathogenic Escherichia coli infection

3.19E-02

Q71U36, P16333, Q13509, P68371, Q14344, P25963

TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIA

Tacrine

hsa05131

Shigellosis

2.93E-02

Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q13315

RRAGD, UBB, SEPT6, ELMO2, PTK2, ATM

Tacrine

hsa05132

Salmonella infection

2.75E-02

P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754

NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41

Tacrine

hsa05133

Pertussis

2.35E-03

P0DP23, P0C0L4

CALM1, C4A

Tacrine

hsa05134

Legionellosis

2.84E-03

P01584, P25963, Q9NR31, P11215, P0DMV8, P11142

IL1B, NFKBIA, SAR1A, ITGAM, HSPA1A, HSPA8

Tacrine

hsa05140

Leishmaniasis

3.37E-03

O75015, P14598, P11215, P42224, P13765, O60603, P25963, P49006, Q16539

FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, MARCKSL1, MAPK14

Tacrine

hsa05143

African trypanosomiasis

3.01E-03

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Tacrine

hsa05145

Toxoplasmosis

3.45E-02

P25963, Q13489, P42224, P09917, Q13751, P11142

NFKBIA, BIRC3, STAT1, ALOX5, LAMB3, HSPA8

Tacrine

hsa05146

Amoebiasis

1.32E-03

P09341, P14778, P27930, O60603, P05089, P12814, P08311

CXCL1, IL1R1, IL1R2, TLR2, ARG1, ACTN1, CTSG

Tacrine

hsa05150

Staphylococcus aureus infection

2.35E-05

P0C0L4, P21462, O75015, P13646, Q14532, P59665, P59666, P12838, P49913

C4A, FPR1, FCGR3B, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Tacrine

hsa05152

Tuberculosis

1.26E-02

Q13488, O75015, P48382, O60603, P10415, P13765, Q9UDY8, Q16539

TCIRG1, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, MALT1, MAPK14

Tacrine

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Tacrine

hsa05161

Hepatitis B

3.34E-02

Q99941, P18848, P27348

CREBL1, ATF4, YWHAQ

Tacrine

hsa05162

Measles

3.18E-02

P23458, P0DMV8, P01584, Q9NP90

JAK1, HSPA1A, IL1B, RAB9B

Tacrine

hsa05163

Human cytomegalovirus infection

1.45E-10

P31751, P42338, P01375, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568

AKT2, PIK3CB, TNF, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O75475	PSIP1	PC4 and SFRS1-interacting protein	P01375	TNF	Tumor necrosis factor	-0.72
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
O75475	PSIP1	PC4 and SFRS1-interacting protein	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.701
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
O75475	PSIP1	PC4 and SFRS1-interacting protein	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.721
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
O75475	PSIP1	PC4 and SFRS1-interacting protein	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.723
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P23458	JAK1	Tyrosine-protein kinase JAK1	P0DP23	CALM1	Calmodulin-1	0.822
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.802
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P23458	JAK1	Tyrosine-protein kinase JAK1	Q08828	ADCY1	Adenylate cyclase type 1	0.84
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
P23458	JAK1	Tyrosine-protein kinase JAK1	P51828	ADCY7	Adenylate cyclase type 7	0.834
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
P23458	JAK1	Tyrosine-protein kinase JAK1	P23458	JAK1	Tyrosine-protein kinase JAK1	1
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
O75475	PSIP1	PC4 and SFRS1-interacting protein	P49841	GSK3B	Glycogen synthase kinase-3 beta	-0.742
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
O75475	PSIP1	PC4 and SFRS1-interacting protein	P14778	IL1R1	Interleukin-1 receptor type 1	-0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P23458	JAK1	Tyrosine-protein kinase JAK1	P01584	IL1B	Interleukin-1 beta	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
P23458	JAK1	Tyrosine-protein kinase JAK1	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
O75475	PSIP1	PC4 and SFRS1-interacting protein	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.903
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
O75475	PSIP1	PC4 and SFRS1-interacting protein	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.875
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
O75475	PSIP1	PC4 and SFRS1-interacting protein	O00463	TRAF5	TNF receptor-associated factor 5	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733

Tacrine

hsa05164

Influenza A

4.49E-02

P31751, P01584, P23458, P05141, Q9UBU9

AKT2, IL1B, JAK1, SLC25A5, NXF1

Tacrine

hsa05166

Human T-cell leukemia virus 1 infection

3.90E-02

P23458, P05141, P62826, Q08828, P51828, P18848, P31751

JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2

Tacrine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.20E-07

P01568, P42224, P25963, P42338, P40189, P62873, P62879, P63218, P50151, P19174, P16298, Q02750, P07948, P04141, P0DP23, P0CG47

IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, MAP2K1, LYN, CSF2, CALM1, UBB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P07948	LYN	Tyrosine-protein kinase Lyn	-0.782
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.79
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P11511	CYP19A1	Aromatase	P0CG47	UBB	Polyubiquitin-B	-0.741

Tacrine

hsa05168

Herpes simplex virus 1 infection

1.38E-04

P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.825
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.935
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.827
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.882
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.783
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.781
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.886
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.943
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q9Y2A4	ZNF443	Zinc finger protein 443	0.731
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13398	ZNF211	Zinc finger protein 211	0.956
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q13398	ZNF211	Zinc finger protein 211	0.849
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P51522	ZNF83	Zinc finger protein 83	0.851
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P17038	ZNF43	Zinc finger protein 43	0.718
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q03923	ZNF85	Zinc finger protein 85	-0.731
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	P52738	ZNF140	Zinc finger protein 140	0.71
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O75820	ZNF189	Zinc finger protein 189	-0.756
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75820	ZNF189	Zinc finger protein 189	-0.766
Q13627	DYRK1A	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	O75820	ZNF189	Zinc finger protein 189	0.768
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q9UDV6	ZNF212	Zinc finger protein 212	0.798

Tacrine

hsa05169

Epstein-Barr virus infection

5.94E-04

P13765, P01106, Q13547, O00463, P42338, P07948, Q13761, P24522, O75293, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, CD3E, CD3G, CD247

Tacrine

hsa05170

Human immunodeficiency virus 1 infection

8.33E-07

P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P17252, P30101, P01568, P25963, Q13315, P19174, P23528, P20333

PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PRKCA, PDIA3, IFNA21, NFKBIA, ATM, PLCG1, CFL1, TNFRSF1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.93
P11511	CYP19A1	Aromatase	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.96
P11511	CYP19A1	Aromatase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.93
P11511	CYP19A1	Aromatase	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.706
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q05397	PTK2	Focal adhesion kinase 1	0.932
P11511	CYP19A1	Aromatase	Q05397	PTK2	Focal adhesion kinase 1	0.75
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P30101	PDIA3	Protein disulfide-isomerase A3	0.739
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P30101	PDIA3	Protein disulfide-isomerase A3	0.83
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
P51812	RPS6KA3	Ribosomal protein S6 kinase alpha-3	Q13315	ATM	Serine-protein kinase ATM	-0.748
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P23528	CFL1	Cofilin-1	-0.853
P11511	CYP19A1	Aromatase	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	-0.75

Tacrine

hsa05171

Coronavirus disease - COVID-19

3.30E-02

P25963, P42224, P01568, P40189, P42338, P19174, P17252

NFKBIA, STAT1, IFNA21, IL6ST, PIK3CB, PLCG1, PRKCA

Tacrine

hsa05200

Pathways in cancer

8.82E-07

Q13751, P42338, P08238, P42224, P25963, P19174, P17252, P43246, P84022, P20585, P10826, P14923, Q13489, P49767, P14921, P62873, P63218, P50151, Q14344, P78417, O75293, P0DP23, P01568, P14784, P40189

LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, SMAD3, MSH3, RARB, JUP, BIRC3, VEGFC, ETS1, GNB1, GNG5, GNG10, GNA13, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13751	LAMB3	Laminin subunit beta-3	-0.705
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.743
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.802
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	1
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.841
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.783
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.73
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.818
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.785
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.869
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P17252	PRKCA	Protein kinase C alpha type	-0.725
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P43246	MSH2	DNA mismatch repair protein Msh2	0.925
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.816
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P84022	SMAD3	Mothers against decapentaplegic homolog 3	-0.77
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P20585	MSH3	DNA mismatch repair protein Msh3	0.825
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P10826	RARB	Retinoic acid receptor beta	0.779
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14923	JUP	Junction plakoglobin	-0.716
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.747
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P49767	VEGFC	Vascular endothelial growth factor C	-0.871
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14921	ETS1	Protein C-ets-1	0.731
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.837
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.82
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.712
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.704
P08238	HSP90AB1	Heat shock protein HSP 90-beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.756
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P78417	GSTO1	Glutathione S-transferase omega-1	-0.703
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.919
P08238	HSP90AB1	Heat shock protein HSP 90-beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.742
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P0DP23	CALM1	Calmodulin-1	0.926
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P0DP23	CALM1	Calmodulin-1	0.775
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P01568	IFNA21	Interferon alpha-21	-0.868
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P01568	IFNA21	Interferon alpha-21	-0.733
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.865
P08238	HSP90AB1	Heat shock protein HSP 90-beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.717
O95271	TNKS	Poly [ADP-ribose] polymerase tankyrase-1	P40189	IL6ST	Interleukin-6 receptor subunit beta	0.748

Tacrine

hsa05202

Transcriptional misregulation in cancer

2.35E-04

Q12778, Q15532, P41732, P14780, P27930, Q16548, P11215, Q13489, O15550, P35226, P05164, P08246, Q9C0K0, Q13547, P12980, P24522

FOXO1, SS18, TSPAN7, MMP9, IL1R2, BCL2A1, ITGAM, BIRC3, UTX, BMI1, MPO, ELA2, BCL11B, HDAC1, LYL1, GADD45A

Tacrine

hsa05203

Viral carcinogenesis

9.17E-05

Q99941, P18848, P27348, Q13547, Q15283, P61978, P58876, P62807, Q16778, O60814

CREBL1, ATF4, YWHAQ, HDAC1, RASA2, HNRPK, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12

Tacrine

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Tacrine

hsa05212

Pancreatic cancer

2.65E-04

P31751, Q15311, P23458, P42224, P84022, O75293

AKT2, RALBP1, JAK1, STAT1, SMAD3, GADD45B

Tacrine

hsa05213

Endometrial cancer

4.72E-03

O15169, Q13418, Q02750

AXIN1, ILK, MAP2K1

Tacrine

hsa05214

Glioma

3.70E-04

P0DP23, P17252, P42338, P19174, O75293

CALM1, PRKCA, PIK3CB, PLCG1, GADD45B

Tacrine

hsa05219

Bladder cancer

4.07E-02

P14780, P04637

MMP9, TP53

Tacrine

hsa05222

Small cell lung cancer

1.10E-02

P10826, P42338, Q13751, Q13489, P25963, O75293

RARB, PIK3CB, LAMB3, BIRC3, NFKBIA, GADD45B

Tacrine

hsa05223

Non-small cell lung cancer

4.91E-03

P17252, P42338, P19174, P10826, O75293

PRKCA, PIK3CB, PLCG1, RARB, GADD45B

Tacrine

hsa05224

Breast cancer

4.75E-02

P49841, Q92837, P04637, P24522

GSK3B, FRAT1, TP53, GADD45A

Tacrine

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Tacrine

hsa05231

Choline metabolism in cancer

3.25E-05

P31751, P42338, Q9Y259, P19174, P23743, P49619, Q16760, O14986, P17252

AKT2, PIK3CB, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PRKCA

Tacrine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.32E-03

O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4

Tacrine

hsa05321

Inflammatory bowel disease

3.69E-02

O60603, P13765, Q14765, P23771

TLR2, HLA-DOB, STAT4, GATA3

Tacrine

hsa05322

Systemic lupus erythematosus

4.80E-06

P09871, Q93077, P58876, P62807, Q16778, O60814, P68431

C1S, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Tacrine

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Tacrine

hsa05332

Graft-versus-host disease

1.40E-04

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Tacrine

hsa05340

Primary immunodeficiency

2.19E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Tacrine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.48E-02

P54284

CACNB3

Tacrine

hsa05414

Dilated cardiomyopathy

4.55E-02

P54284, P26678

CACNB3, PLN

Tacrine

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Tacrine

hsa05418

Fluid shear stress and atherosclerosis

1.26E-04

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Community members of Tacrine (S_DC: 8.17)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

O15245

SLC22A1

Solute carrier family 22 member 1

Predicted

0.0149

0.0219

2.0294

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P51608

MECP2

MethylNoneCpGNonebinding protein 2

Predicted

0.0407

0.0165

0.0534

P08238

HSP90AB1

Heat shock protein HSP 90Nonebeta

Predicted

0.0611

0.5208

0.741

1.8131

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P04818

TYMS

Thymidylate synthase

Predicted

0.4553

0.2706

0.1893

0.9582

O95271

TNKS

Poly [ADPNoneribose] polymerase tankyraseNone1

Predicted

0.1017

0.2224

0.4957

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P23458

JAK1

TyrosineNoneprotein kinase JAK1

Predicted

0.5546

0.9211

3.1195

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

O75475

PSIP1

PC4 and SFRS1Noneinteracting protein

Predicted

0.3332

0.0638

0.2943

Q00535

CDK5

CyclinNonedependentNonelike kinase 5

Predicted

0.1992

0.6633

0.2994

1.7256

P49759

CLK1

Dual specificity protein kinase CLK1

Predicted

0.2968

0.4546

0.1587

1.2163

Q13627

DYRK1A

Dual specificity tyrosineNonephosphorylationNoneregulated kinase 1A

Predicted

0.015

0.7082

1.4239

Q15078

CDK5R1

CyclinNonedependent kinase 5 activator 1

Predicted

0.1358

0.5004

0.2575

1.3263

Q96EB6

SIRT1

NADNonedependent protein deacetylase sirtuinNone1

Predicted

0.2865

0.4571

0.5784

1.6358

Q13133

NR1H3

Oxysterols receptor LXRNonealpha

Predicted

0.0162

0.439

0.2086

1.0947

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P33981

TTK

Dual specificity protein kinase TTK

Predicted

0.0039

0.5805

0.259

1.422

Q15722

LTB4R

Leukotriene B4 receptor 1

Predicted

0.0677

0.2199

0.4736

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P07900

HSP90AA1

Heat shock protein HSP 90Nonealpha

Predicted

0.4727

0.6064

0.741

2.1901

Q13418

ILK

IntegrinNonelinked protein kinase

Predicted

0.5885

0.0388

0.394

0.7658

P51812

RPS6KA3

Ribosomal protein S6 kinase alphaNone3

Predicted

0.2865

0.3936

0.4146

1.345

Q8NFZ4

NLGN2

NeuroliginNone2

Predicted

0.566

0.0692

0.1627

0.5841

PharmaCoNets of Tacrine (SPCN: 196.10 )

Tacrine regulated-network (SDN: 24.00)

Community members of Tacrine (SDC: 8.17)

PharmaCoNets of Tacrine (S_PCN: 196.10 )

Tacrine regulated-network (S_DN: 24.00)

Community members of Tacrine (S_DC: 8.17)