PharmaCoNets of Suvorexant (SPCN: 288.57 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Suvorexanthsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Suvorexanthsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Suvorexanthsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Suvorexanthsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Suvorexanthsa00190Oxidative phosphorylation1.86E-083Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Suvorexanthsa00220Arginine biosynthesis3.02E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Suvorexanthsa00230Purine metabolism1.83E-033P21589, P20839, Q02153NT5E, IMPDH1, GUCY1B3More
Suvorexanthsa00240Pyrimidine metabolism1.94E-033P21589, P32320, P04183NT5E, CDA, TK1More
Suvorexanthsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Suvorexanthsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Suvorexanthsa00310Lysine degradation1.98E-033Q96KQ7, Q02809, P51648EHMT2, PLOD1, ALDH3A2More
Suvorexanthsa00500Starch and sucrose metabolism5.75E-063O43451, P46976, P06737MGAM, GYG1, PYGLMore
Suvorexanthsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Suvorexanthsa00512Mucin type O-glycan biosynthesis3.19E-033O95395, Q8N4A0, Q9NY28GCNT3, GALNT4, GALNT8More
Suvorexanthsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Suvorexanthsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Suvorexanthsa00533Glycosaminoglycan biosynthesis - keratan sulfate6.96E-041Q9NY97B3GNT2More
Suvorexanthsa00562Inositol phosphate metabolism2.00E-024P27987, P19174, P42338, Q02252ITPKB, PLCG1, PIK3CB, ALDH6A1More
Suvorexanthsa00565Ether lipid metabolism3.00E-031Q8N661TMEM86BMore
Suvorexanthsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Suvorexanthsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Suvorexanthsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Suvorexanthsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Suvorexanthsa00630Glyoxylate and dicarboxylate metabolism1.28E-084P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Suvorexanthsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Suvorexanthsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Suvorexanthsa00730Thiamine metabolism1.15E-063Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Suvorexanthsa00740Riboflavin metabolism2.80E-032P30043, P24666BLVRB, ACP1More
Suvorexanthsa00760Nicotinate and nicotinamide metabolism6.37E-041P21589NT5EMore
Suvorexanthsa00770Pantothenate and CoA biosynthesis4.29E-042O95498, Q9NRN7VNN2, AASDHPPTMore
Suvorexanthsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Suvorexanthsa00790Folate biosynthesis4.74E-022P07101, P42330TH, AKR1C3More
Suvorexanthsa00830Retinol metabolism2.27E-035P00325, P11766, P00352, Q9BPW9, O75911ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3More
Suvorexanthsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Suvorexanthsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Suvorexanthsa00970Aminoacyl-tRNA biosynthesis2.24E-033O95363, P14868, Q15046FARS2, DARS, KARSMore
Suvorexanthsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Suvorexanthsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Suvorexanthsa00983Drug metabolism - other enzymes1.12E-033P04183, P32320, P05164TK1, CDA, MPOMore
Suvorexanthsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Suvorexanthsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Suvorexanthsa01230Biosynthesis of amino acids2.16E-035P51854, Q99707, P50213, P15104, P37837TKTL1, MTR, IDH3A, GLUL, TALDO1More
Suvorexanthsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Suvorexanthsa01522Endocrine resistance2.45E-046P22694, P04049, Q9UM47, P08069, P10415, Q13323PRKACB, RAF1, NOTCH3, IGF1R, BCL2, BIKMore
Suvorexanthsa01523Antifolate resistance6.83E-053Q92820, P04818, P18054GGH, TYMS, ALOX12More
Suvorexanthsa01524Platinum drug resistance4.78E-021P31751AKT2More
Suvorexanthsa02010ABC transporters1.66E-043P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Suvorexanthsa03008Ribosome biogenesis in eukaryotes1.46E-024Q9NYH9, P78345, Q9BVP2, Q9GZY0UTP6, RPP38, GNL3, NXF2; NXF2BMore
Suvorexanthsa03013RNA transport1.00E-0927P62826, P52298, Q09161, O14893, P61326, P38919, Q15287, Q9UBU9, Q9GZY0, P37198, Q7Z3B4, P35658, P63279, P68104, Q14152, P55884, O15371, O75822, P78345, Q9H777, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, Q53GS7RAN, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, RNPS1, NXF1, NXF2; NXF2B, NUP62, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, GLE1More
Suvorexanthsa03015mRNA surveillance pathway1.75E-038Q9BZI7, O43148, Q16537, O94913, P61326, Q9GZY0, P52298, Q53GS7UPF3B, RNMT, PPP2R5E, PCF11, MAGOH, NXF2; NXF2B, NCBP2, GLE1More
Suvorexanthsa03020RNA polymerase6.63E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Suvorexanthsa03022Basal transcription factors2.68E-043O00268, Q5H9L4, Q15544TAF4, TAF7L, TAF11More
Suvorexanthsa03040Spliceosome8.28E-1321Q14562, O43143, O60508, P17844, P08579, Q15427, P26368, O75940, P51991, P38159, P61978, O75494, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, DDX5, SNRPB2, SF3B4, U2AF2, SMNDC1, HNRPA3, RBMX, HNRPK, FUSIP1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Suvorexanthsa03050Proteasome4.83E-021P55036PSMD4More
Suvorexanthsa03060Protein export1.20E-032P37108, Q15005SRP14, SPCS2More
Suvorexanthsa03320PPAR signaling pathway4.55E-022O00767, Q02318SCD, CYP27A1More
Suvorexanthsa03430Mismatch repair4.38E-021P20585MSH3More
Suvorexanthsa03450Non-homologous end-joining1.58E-043Q9NP87, P78527, P13010POLM, PRKDC, XRCC5More
Suvorexanthsa03460Fanconi anemia pathway2.71E-021O94782USP1More
Suvorexanthsa04010MAPK signaling pathway1.69E-032P04049, P08069RAF1, IGF1RMore
Suvorexanthsa04012ErbB signaling pathway7.36E-059P21860, P16333, P17252, Q13557, P19174, O14944, P42338, P01106, P04049ERBB3, NCK1, PRKCA, CAMK2D, PLCG1, EREG, PIK3CB, MYC, RAF1More
Suvorexanthsa04014Ras signaling pathway1.14E-0816P04049, P31751, P42338, P20827, Q9NRA1, P49767, P08069, Q13009, P17252, P14921, Q7LDG7, P0DP23, P62873, P63218, P50151, P19174RAF1, AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, PRKCA, ETS1, RASGRP2, CALM1, GNB1, GNG5, GNG10, PLCG1More
Suvorexanthsa04015Rap1 signaling pathway2.68E-0716P04049, P20827, Q9NRA1, P49767, P08069, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P31751, P0DP23, P17252, P19174RAF1, EFNA1, PDGFC, VEGFC, IGF1R, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, AKT2, CALM1, PRKCA, PLCG1More
Suvorexanthsa04020Calcium signaling pathway1.10E-0717P27987, Q96DU7, Q08828, P45880, Q13557, P17252, P21860, O15399, P19174, P0DP23, P0DP24, P05141, P51828, P20020, P23634, Q9NRA1, P49767ITPKB, ITPKC, ADCY1, VDAC2, CAMK2D, PRKCA, ERBB3, GRIN2D, PLCG1, CALM1, CALM2, SLC25A5, ADCY7, ATP2B1, ATP2B4, PDGFC, VEGFCMore
Suvorexanthsa04022cGMP-PKG signaling pathway2.75E-0612Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP23, P0DP24GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM1, CALM2More
Suvorexanthsa04024cAMP signaling pathway1.97E-0510Q08828, P51828, P42338, P31751, P0DP23, P04049, Q13370, O15399, P25963, Q13009ADCY1, ADCY7, PIK3CB, AKT2, CALM1, RAF1, PDE3B, GRIN2D, NFKBIA, TIAM1More
Suvorexanthsa04060Cytokine-cytokine receptor interaction1.77E-0417P14784, P27930, P14778, P26842, Q06643, Q13651, P48551, P78552, P25024, Q9UBD3, P47992, P02775, O75509, P09341, P32248, P51684, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, IFNAR2, IL13RA1, CXCR1, XCL2, XCL1, PPBP, TNFRSF21, CXCL1, CCR7, CCR6, CD4More
Suvorexanthsa04061Viral protein interaction with cytokine and cytokine receptor2.72E-0610Q8NHW4, P51684, P32248, P09341, P25024, P02775, P47992, Q9UBD3, Q13651, P14784CCL4L2, CCR6, CCR7, CXCL1, CXCR1, PPBP, XCL1, XCL2, IL10RA, IL2RBMore
Suvorexanthsa04062Chemokine signaling pathway4.47E-0820P25024, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P14598, P42224, P04049, P25963, Q8WYR1CXCR1, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, NCF1, STAT1, RAF1, NFKBIA, PIK3R5More
Suvorexanthsa04064NF-kappa B signaling pathway1.22E-1020P10415, P51617, O00463, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7BCL2, IRAK1, TRAF5, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLDMore
Suvorexanthsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Suvorexanthsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Suvorexanthsa04070Phosphatidylinositol signaling system2.20E-0811P19174, P0DP23, P42338, O14986, P23743, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Suvorexanthsa04071Sphingolipid signaling pathway1.47E-026P04049, P17252, Q16537, Q9BX95, P04637, P10415RAF1, PRKCA, PPP2R5E, SGPP1, TP53, BCL2More
Suvorexanthsa04072Phospholipase D signaling pathway2.39E-059P04049, P31751, Q92529, O14986, Q14344, Q15438, Q08828, P51828, Q16760RAF1, AKT2, SHC3, PIP5K1B, GNA13, PSCD1, ADCY1, ADCY7, DGKDMore
Suvorexanthsa04080Neuroactive ligand-receptor interaction4.90E-036P08311, Q15722, P21453, Q9H228, O00398, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, ADRB2More
Suvorexanthsa04110Cell cycle9.11E-0810Q9UBD5, P06493, O60566, P78527, Q14683, O75293, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, PRKDC, SMC1A, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Suvorexanthsa04114Oocyte meiosis1.78E-0410P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1RMore
Suvorexanthsa04120Ubiquitin mediated proteolysis7.75E-058Q9UBT2, Q14145, Q13042, P62837, Q15751, O95071, Q14669, P0CG47SAE2, KEAP1, CDC16, UBE2D2, HERC1, UBR5, TRIP12, UBBMore
Suvorexanthsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Suvorexanthsa04140Autophagy - animal3.71E-0513P08069, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Suvorexanthsa04141Protein processing in endoplasmic reticulum2.65E-0614P18848, P30101, Q15437, Q15436, P60604, Q99941, O75460, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9H173, Q9UNL2ATF4, PDIA3, SEC23B, SEC23A, UBE2G2, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3More
Suvorexanthsa04142Lysosome2.45E-039Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Suvorexanthsa04144Endocytosis2.89E-038P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Suvorexanthsa04145Phagosome4.08E-0916O75015, P11215, P63261, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, ITGAM, ACTG1, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Suvorexanthsa04150mTOR signaling pathway1.32E-035P08069, P04049, Q02750, Q9NQL2, P51812IGF1R, RAF1, MAP2K1, RRAGD, RPS6KA3More
Suvorexanthsa04151PI3K-Akt signaling pathway6.27E-0626P62753, P42338, P21860, P43657, P27348, P20827, P49767, P07900, P08238, Q8WYR1, P62873, P63218, P50151, P61952, P16144, O15335, Q16363, Q13751, P22105, P14784, P01568, Q99941, P18848, P17252, O00141, P30281RPS6, PIK3CB, ERBB3, P2RY5, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, GNG11, ITGB4, CHAD, LAMA4, LAMB3, TNXB, IL2RB, IFNA21, CREBL1, ATF4, PRKCA, SGK, CCND3More
Suvorexanthsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Suvorexanthsa04210Apoptosis2.16E-021P04049RAF1More
Suvorexanthsa04211Longevity regulating pathway3.68E-046P31751, P08069, Q08828, P51828, Q99941, P18848AKT2, IGF1R, ADCY1, ADCY7, CREBL1, ATF4More
Suvorexanthsa04213Longevity regulating pathway - multiple species1.01E-035P31751, P08069, Q08828, P51828, P0DMV8AKT2, IGF1R, ADCY1, ADCY7, HSPA1AMore
Suvorexanthsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Suvorexanthsa04217Necroptosis1.90E-0819P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q13557, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CAMK2D, CHMP2A, PPIDMore
Suvorexanthsa04218Cellular senescence3.00E-047P01106, P31751, P04049, O75293, P30304, P06493, P0DP23MYC, AKT2, RAF1, GADD45B, CDC25A, CDK1, CALM1More
Suvorexanthsa04261Adrenergic signaling in cardiomyocytes2.60E-0710Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557, P23634ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2D, ATP2B4More
Suvorexanthsa04270Vascular smooth muscle contraction2.48E-047P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Suvorexanthsa04330Notch signaling pathway2.46E-033Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Suvorexanthsa04340Hedgehog signaling pathway9.74E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Suvorexanthsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Suvorexanthsa04360Axon guidance1.17E-069P16333, P20827, O95631, P17252, P42338, P07332, P23528, P04049, P19174NCK1, EFNA1, NTN1, PRKCA, PIK3CB, FES, CFL1, RAF1, PLCG1More
Suvorexanthsa04370VEGF signaling pathway5.65E-068P19174, P16298, P31751, P42338, P17252, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PRKCA, PTK2, MAP2K1, RAF1More
Suvorexanthsa04371Apelin signaling pathway3.19E-0817P62873, P63218, P50151, P61952, Q8WYR1, P31751, P04049, Q08828, P51828, Q13370, Q14814, Q14344, Q13485, P84022, P62753, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, PDE3B, MEF2D, GNA13, SMAD4, SMAD3, RPS6, CALM1, CALM2More
Suvorexanthsa04380Osteoclast differentiation3.07E-0714Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Suvorexanthsa04390Hippo signaling pathway3.80E-058P63261, P84022, Q13485, O15105, P04628, Q9UJU2, O43623, Q13489ACTG1, SMAD3, SMAD4, SMAD7, WNT1, LEF1, SNAI2, BIRC3More
Suvorexanthsa04510Focal adhesion8.44E-0411P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P04049, P08069, P49767ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, RAF1, IGF1R, VEGFCMore
Suvorexanthsa04520Adherens junction8.29E-031P08069IGF1RMore
Suvorexanthsa04530Tight junction3.00E-048Q8TEU7, P63261, P16989, P56750, O00501, Q92974, Q14247, P24844RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTN, MYL9More
Suvorexanthsa04540Gap junction1.26E-068P17252, P22694, Q13509, P68371, Q71U36, P04049, Q9NRA1, Q14643PRKCA, PRKACB, TUBB3, TUBB2C, TUBA1A, RAF1, PDGFC, ITPR1More
Suvorexanthsa04550Signaling pathways regulating pluripotency of stem cells3.80E-042P04049, P08069RAF1, IGF1RMore
Suvorexanthsa04610Complement and coagulation cascades4.27E-061P0C0L4C4AMore
Suvorexanthsa04612Antigen processing and presentation1.33E-0510P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNFMore
Suvorexanthsa04613Neutrophil extracellular trap formation1.10E-0524P17252, P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P08311, O75015, P21730, P21462, P63261, O43315, Q16539PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, ACTG1, AQP9, MAPK14More
Suvorexanthsa04614Renin-angiotensin system7.48E-034P50052, P15144, P08311, O75787AGTR2, ANPEP, CTSG, ATP6AP2More
Suvorexanthsa04620Toll-like receptor signaling pathway4.91E-043P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Suvorexanthsa04621NOD-like receptor signaling pathway2.27E-029Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Suvorexanthsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Suvorexanthsa04623Cytosolic DNA-sensing pathway3.57E-126P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Suvorexanthsa04625C-type lectin receptor signaling pathway1.30E-0712Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Suvorexanthsa04630JAK-STAT signaling pathway8.73E-034P31751, P23458, Q13651, P04049AKT2, JAK1, IL10RA, RAF1More
Suvorexanthsa04640Hematopoietic cell lineage8.85E-0716P13612, P21926, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, CD9, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Suvorexanthsa04650Natural killer cell mediated cytotoxicity3.65E-1216P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Suvorexanthsa04657IL-17 signaling pathway1.42E-0513P25963, P08238, O00463, Q07955, Q16539, P49841, P09341, P14780, P04141, P80188, P01375, P06702, P01584NFKBIA, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, CSF2, LCN2, TNF, S100A9, IL1BMore
Suvorexanthsa04658Th1 and Th2 cell differentiation1.51E-1414Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Suvorexanthsa04659Th17 cell differentiation2.32E-1622P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Suvorexanthsa04660T cell receptor signaling pathway1.19E-1021P01375, P04141, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P29350, P04049, Q16539, P49841TNF, CSF2, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, PTPN6, RAF1, MAPK14, GSK3BMore
Suvorexanthsa04662B cell receptor signaling pathway4.90E-047P31751, P42338, P60033, P07948, P21854, Q8N149, P04049AKT2, PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Suvorexanthsa04664Fc epsilon RI signaling pathway1.60E-0812P01375, P31751, P04141, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P04049, P09917, P20292TNF, AKT2, CSF2, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, RAF1, ALOX5, ALOX5APMore
Suvorexanthsa04666Fc gamma R-mediated phagocytosis3.26E-069P42338, P19174, P04049, P23528, P49006, P06396, O14494, P14598, P17252PIK3CB, PLCG1, RAF1, CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCAMore
Suvorexanthsa04668TNF signaling pathway9.77E-0510P01375, O00463, Q16539, Q99941, P18848, P01584, P20749, P14780, P20333, O95429TNF, TRAF5, MAPK14, CREBL1, ATF4, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Suvorexanthsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Suvorexanthsa04713Circadian entrainment2.54E-0813O15399, P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P63218, P50151, P61952, Q08828, P51828, O15055GRIN2D, CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG5, GNG10, GNG11, ADCY1, ADCY7, PER2More
Suvorexanthsa04714Thermogenesis6.01E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Suvorexanthsa04720Long-term potentiation4.18E-059Q13557, P16298, P0DP23, P0DP24, P51812, P18848, Q08828, Q02750, P04049CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1More
Suvorexanthsa04721Synaptic vesicle cycle9.45E-042Q13488, P31645TCIRG1, SLC6A4More
Suvorexanthsa04722Neurotrophin signaling pathway3.42E-058P31751, P04049, P49841, O43524, P48023, P51617, P10415, P0DP23AKT2, RAF1, GSK3B, FOXO3, FASLG, IRAK1, BCL2, CALM1More
Suvorexanthsa04723Retrograde endocannabinoid signaling3.71E-024P62873, P61952, Q08828, O15239GNB1, GNG11, ADCY1, NDUFA1More
Suvorexanthsa04724Glutamatergic synapse2.43E-058O15399, Q08828, P17252, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, PRKCA, GNB1, GNG5, GNG10, GNG11, GLULMore
Suvorexanthsa04725Cholinergic synapse5.06E-0713Q08828, P51828, P22694, Q14643, P17252, P62873, P50151, P61952, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Suvorexanthsa04726Serotonergic synapse4.22E-047P17252, P62873, P63218, P50151, P33260, P09917, P04049PRKCA, GNB1, GNG5, GNG10, CYP2C18, ALOX5, RAF1More
Suvorexanthsa04727GABAergic synapse6.56E-068Q08828, P62873, P63218, P50151, P61952, P15104, Q15111, P17252ADCY1, GNB1, GNG5, GNG10, GNG11, GLUL, PLCL1, PRKCAMore
Suvorexanthsa04728Dopaminergic synapse4.57E-0711P62873, P61952, P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23, P0DP24, O15516GNB1, GNG11, AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1, CALM2, CLOCKMore
Suvorexanthsa04730Long-term depression4.15E-044Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Suvorexanthsa04740Olfactory transduction4.52E-054P62873, Q13557, P0DP23, P0DP24GNB1, CAMK2D, CALM1, CALM2More
Suvorexanthsa04744Phototransduction3.23E-113P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Suvorexanthsa04750Inflammatory mediator regulation of TRP channels8.23E-0711P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, Q14643, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCQ, CALM2, CALM1More
Suvorexanthsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Suvorexanthsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Suvorexanthsa04911Insulin secretion6.46E-085Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Suvorexanthsa04912GnRH signaling pathway1.79E-0411Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P04049ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, RAF1More
Suvorexanthsa04913Ovarian steroidogenesis6.44E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Suvorexanthsa04914Progesterone-mediated oocyte maturation3.02E-0510P08069, Q17RY0, P42338, Q13370, Q9UJX4, P30304, P08238, P51812, Q02750, P04049IGF1R, CPEB4, PIK3CB, PDE3B, ANAPC5, CDC25A, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Suvorexanthsa04915Estrogen signaling pathway2.25E-0812P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1More
Suvorexanthsa04916Melanogenesis3.38E-047P0DP23, Q9UJU2, Q08828, P51828, P17252, P04628, P04049CALM1, LEF1, ADCY1, ADCY7, PRKCA, WNT1, RAF1More
Suvorexanthsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Suvorexanthsa04918Thyroid hormone synthesis3.37E-045Q08828, P51828, Q99941, P18848, P02768ADCY1, ADCY7, CREBL1, ATF4, ALBMore
Suvorexanthsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Suvorexanthsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Suvorexanthsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Suvorexanthsa04922Glucagon signaling pathway1.79E-032P31751, P0DP23AKT2, CALM1More
Suvorexanthsa04923Regulation of lipolysis in adipocytes8.08E-054Q08828, P51828, P06213, P31751ADCY1, ADCY7, INSR, AKT2More
Suvorexanthsa04924Renin secretion4.82E-055P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Suvorexanthsa04925Aldosterone synthesis and secretion2.27E-088Q99941, P18848, Q08828, P51828, P0DP23, P0DP24, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM1, CALM2, CAMK2D, ATP2B4More
Suvorexanthsa04926Relaxin signaling pathway3.39E-0613P31751, P25963, P42338, P62873, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P17252AKT2, NFKBIA, PIK3CB, GNB1, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, PRKCAMore
Suvorexanthsa04927Cortisol synthesis and secretion1.57E-066Q14643, Q99941, P18848, Q08828, P51828, P22694ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Suvorexanthsa04928Parathyroid hormone synthesis, secretion and action1.61E-048Q14643, P51828, P22694, P23771, P04049, Q99941, P18848, P10415ITPR1, ADCY7, PRKACB, GATA3, RAF1, CREBL1, ATF4, BCL2More
Suvorexanthsa04929GnRH secretion1.87E-042P31751, P04049AKT2, RAF1More
Suvorexanthsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Suvorexanthsa04932Non-alcoholic fatty liver disease3.81E-0714P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Suvorexanthsa04933AGE-RAGE signaling pathway in diabetic complications1.19E-059P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Suvorexanthsa04934Cushing syndrome4.17E-089Q14643, Q99941, P18848, Q08828, P51828, P22694, O15169, Q13557, P04628ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1More
Suvorexanthsa04935Growth hormone synthesis, secretion and action3.68E-046Q08828, P51828, P04049, Q99941, P18848, P31751ADCY1, ADCY7, RAF1, CREBL1, ATF4, AKT2More
Suvorexanthsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Suvorexanthsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Suvorexanthsa04960Aldosterone-regulated sodium reabsorption2.32E-032P06213, P48048INSR, KCNJ1More
Suvorexanthsa04962Vasopressin-regulated water reabsorption2.95E-043P52566, P62491, P46459ARHGDIB, RAB11A, NSFMore
Suvorexanthsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Suvorexanthsa04966Collecting duct acid secretion1.06E-043P02730, P00918, Q9Y666SLC4A1, CA2, SLC12A7More
Suvorexanthsa04970Salivary secretion3.58E-068P07550, Q08828, P51828, P22694, Q14643, P0DP23, P0DP24, Q02153ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM1, CALM2, GUCY1B3More
Suvorexanthsa04971Gastric acid secretion2.02E-055Q08828, P51828, P15311, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM1, CAMK2DMore
Suvorexanthsa04972Pancreatic secretion1.99E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Suvorexanthsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Suvorexanthsa04975Fat digestion and absorption1.68E-031O14494PLPP1More
Suvorexanthsa04976Bile secretion1.26E-045O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Suvorexanthsa05010Alzheimer disease1.63E-0514Q92542, O95298, P05496, P12074, Q00535, O75460, P0DP23, P01584, P18848, O15169, P31751, P05141, P45880, P28070NCSTN, NDUFC2, ATP5G1, COX6A1, CDK5, ERN1, CALM1, IL1B, ATF4, AXIN1, AKT2, SLC25A5, VDAC2, PSMB4More
Suvorexanthsa05012Parkinson disease1.89E-0416O15239, Q16718, O14521, P13073, P12074, P05496, P05141, P60604, P18848, P19174, P0DP23, P0DP24, Q13557, Q71U36, Q13509, P68371NDUFA1, NDUFA5, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, UBE2G2, ATF4, PLCG1, CALM1, CALM2, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Suvorexanthsa05016Huntington disease1.76E-0310O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Suvorexanthsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Suvorexanthsa05020Prion disease5.71E-0515P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P13073, P12074, P18848, P05141, P45880, P49841, Q99941, Q16539IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, VDAC2, GSK3B, CREBL1, MAPK14More
Suvorexanthsa05022Pathways of neurodegeneration - multiple diseases4.22E-0519Q13509, P68371, P49841, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P19174, P05141, P17252, Q16539, Q00535, P01584, Q08752, P0DP23, P28070TUBB3, TUBB2C, GSK3B, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, PLCG1, SLC25A5, PRKCA, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4More
Suvorexanthsa05030Cocaine addiction6.96E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Suvorexanthsa05031Amphetamine addiction5.03E-055P0DP24, P0DP23, Q13557, Q99941, P18848CALM2, CALM1, CAMK2D, CREBL1, ATF4More
Suvorexanthsa05032Morphine addiction7.16E-046P62873, P63218, P50151, Q13370, P17252, P43250GNB1, GNG5, GNG10, PDE3B, PRKCA, GRK6More
Suvorexanthsa05034Alcoholism3.82E-0613Q99941, P18848, P0DP24, Q96RR4, P62873, P61952, P04049, P0C0S5, Q93077, P62807, O60814, P84243, P68431CREBL1, ATF4, CALM2, CAMKK2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Suvorexanthsa05110Vibrio cholerae infection2.08E-044Q13488, Q99437, P17252, P19174TCIRG1, ATP6V0B, PRKCA, PLCG1More
Suvorexanthsa05120Epithelial cell signaling in Helicobacter pylori infection6.88E-048Q16539, P25963, Q13488, P09341, P19174, P25024, P25025, P07948MAPK14, NFKBIA, TCIRG1, CXCL1, PLCG1, CXCR1, CXCR2, LYNMore
Suvorexanthsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Suvorexanthsa05132Salmonella infection8.02E-1018P51617, P25963, P08238, P04049, Q9UJU2, P63261, Q13546, Q13489, P10415, P04406, O75369, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, GAPDH, FLNB, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41More
Suvorexanthsa05133Pertussis3.02E-031P0C0L4C4AMore
Suvorexanthsa05134Legionellosis1.93E-047P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8More
Suvorexanthsa05140Leishmaniasis4.73E-1015P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, NCF4More
Suvorexanthsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Suvorexanthsa05144Malaria5.86E-078P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1More
Suvorexanthsa05145Toxoplasmosis3.86E-037P25963, P10415, Q13489, P42224, P09917, Q13751, P11142NFKBIA, BCL2, BIRC3, STAT1, ALOX5, LAMB3, HSPA8More
Suvorexanthsa05146Amoebiasis1.98E-0610P01584, P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311IL1B, CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Suvorexanthsa05150Staphylococcus aureus infection7.53E-0610P0C0L4, P21730, P21462, O75015, P13646, Q14532, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Suvorexanthsa05152Tuberculosis1.64E-0513P04049, Q13488, Q99437, P0DP23, P48382, O60603, P31751, P10415, P13765, P25774, P01568, Q9UDY8, P51617RAF1, TCIRG1, ATP6V0B, CALM1, RFX5, TLR2, AKT2, BCL2, HLA-DOB, CTSS, IFNA21, MALT1, IRAK1More
Suvorexanthsa05160Hepatitis C2.17E-0510P52630, P60033, O00501, P29728, Q9NZJ5, P04049, P49841, P01375, P48023, P01106STAT2, CD81, CLDN5, OAS2, EIF2AK3, RAF1, GSK3B, TNF, FASLG, MYCMore
Suvorexanthsa05161Hepatitis B1.14E-048P04049, Q99941, P18848, P25963, Q13485, P10415, P27348, P84022RAF1, CREBL1, ATF4, NFKBIA, SMAD4, BCL2, YWHAQ, SMAD3More
Suvorexanthsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Suvorexanthsa05163Human cytomegalovirus infection3.09E-1131P31751, P42338, P04049, P01375, P25963, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P30101, P61769, P01568AKT2, PIK3CB, RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, PDIA3, B2M, IFNA21More
Suvorexanthsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Suvorexanthsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Suvorexanthsa05167Kaposi sarcoma-associated herpesvirus infection7.00E-1118P01568, P31751, P42224, P25963, P42338, P40189, P62873, P62879, P63218, P50151, P19174, P16298, P04049, Q02750, P07948, P04141, P0DP23, P0CG47IFNA21, AKT2, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, RAF1, MAP2K1, LYN, CSF2, CALM1, UBBMore
Suvorexanthsa05168Herpes simplex virus 1 infection2.26E-0920P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, Q9HCX3, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF304, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Suvorexanthsa05169Epstein-Barr virus infection1.09E-0416P13765, P01106, Q13547, P04637, O00463, P10415, Q16539, P07948, Q13761, P24522, P48551, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TP53, TRAF5, BCL2, MAPK14, LYN, RUNX3, GADD45A, IFNAR2, TLR2, OAS2, CD3E, CD3G, CD247More
Suvorexanthsa05170Human immunodeficiency virus 1 infection3.51E-1025P31751, P42338, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, P19174, P23528, P10415, Q93034, Q9Y6Q5, P20333AKT2, PIK3CB, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, PLCG1, CFL1, BCL2, CUL5, AP1M2, TNFRSF1BMore
Suvorexanthsa05171Coronavirus disease - COVID-191.39E-038P25963, P42224, P01568, P40189, P04141, P42338, P19174, P17252NFKBIA, STAT1, IFNA21, IL6ST, CSF2, PIK3CB, PLCG1, PRKCAMore
Suvorexanthsa05200Pathways in cancer2.22E-1136Q13751, P42338, P08238, P42224, P25963, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, Q13547, P10826, P14923, P30281, P10415, Q13489, Q13077, P49767, P14921, Q12778, P31751, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P40189LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, HDAC1, RARB, JUP, CCND3, BCL2, BIRC3, TRAF1, VEGFC, ETS1, FOXO1, AKT2, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Suvorexanthsa05202Transcriptional misregulation in cancer1.58E-0725Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Suvorexanthsa05203Viral carcinogenesis2.63E-037Q99941, P18848, P27348, Q15283, P61978, P62807, O60814CREBL1, ATF4, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12More
Suvorexanthsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Suvorexanthsa05205Proteoglycans in cancer2.74E-0514Q13009, Q12955, Q14643, O75369, P63261, P04049, P04637, P14780, P17252, O60603, P08069, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, ACTG1, RAF1, TP53, MMP9, PRKCA, TLR2, IGF1R, WNT1, PTCH1, CD63More
Suvorexanthsa05206MicroRNAs in cancer6.19E-047P15311, P21860, P61978, P46531, P63279, P22105, P04049VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1More
Suvorexanthsa05210Colorectal cancer1.68E-034P84022, Q13485, P04049, P10415SMAD3, SMAD4, RAF1, BCL2More
Suvorexanthsa05211Renal cell carcinoma1.29E-032P31751, P04049AKT2, RAF1More
Suvorexanthsa05212Pancreatic cancer2.76E-0810P42338, P31751, P04049, Q15311, P23458, P42224, P37173, P84022, Q13485, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, STAT1, TGFBR2, SMAD3, SMAD4, GADD45BMore
Suvorexanthsa05213Endometrial cancer9.61E-057O15169, Q9UJU2, P31751, Q02750, P04049, P04637, P24522AXIN1, LEF1, AKT2, MAP2K1, RAF1, TP53, GADD45AMore
Suvorexanthsa05214Glioma7.47E-1111P08069, P0DP23, Q16566, P17252, P04049, P42338, P31751, P04637, P19174, P24522, O75293IGF1R, CALM1, CAMK4, PRKCA, RAF1, PIK3CB, AKT2, TP53, PLCG1, GADD45A, GADD45BMore
Suvorexanthsa05215Prostate cancer1.65E-042P08069, P04049IGF1R, RAF1More
Suvorexanthsa05216Thyroid cancer1.13E-045P01106, Q9UJU2, P04637, P24522, O75293MYC, LEF1, TP53, GADD45A, GADD45BMore
Suvorexanthsa05217Basal cell carcinoma5.12E-066Q13635, P04628, P49841, Q9UJU2, P04637, P24522PTCH1, WNT1, GSK3B, LEF1, TP53, GADD45AMore
Suvorexanthsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Suvorexanthsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Suvorexanthsa05220Chronic myeloid leukemia2.22E-058Q13547, Q13485, P25963, P84022, P31751, P42338, P04049, O75293HDAC1, SMAD4, NFKBIA, SMAD3, AKT2, PIK3CB, RAF1, GADD45BMore
Suvorexanthsa05221Acute myeloid leukemia8.16E-042P31751, P04049AKT2, RAF1More
Suvorexanthsa05222Small cell lung cancer7.32E-058P10826, P31751, P42338, Q13751, Q13489, P10415, P25963, O75293RARB, AKT2, PIK3CB, LAMB3, BIRC3, BCL2, NFKBIA, GADD45BMore
Suvorexanthsa05223Non-small cell lung cancer7.34E-078P17252, P31751, P42338, P19174, P10826, P04049, Q9HC35, O75293PRKCA, AKT2, PIK3CB, PLCG1, RARB, RAF1, EML4, GADD45BMore
Suvorexanthsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Suvorexanthsa05225Hepatocellular carcinoma1.81E-054P04049, Q92529, P08069, P51531RAF1, SHC3, IGF1R, SMARCA2More
Suvorexanthsa05226Gastric cancer2.01E-0611P04049, Q02750, P31751, Q9UJU2, O15169, P04637, P24522, P84022, Q13485, P14923, P10415RAF1, MAP2K1, AKT2, LEF1, AXIN1, TP53, GADD45A, SMAD3, SMAD4, JUP, BCL2More
Suvorexanthsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Suvorexanthsa05231Choline metabolism in cancer6.85E-0811P04049, P31751, P42338, Q9NRA1, Q9Y259, P19174, P23743, P49619, Q16760, O14986, P17252RAF1, AKT2, PIK3CB, PDGFC, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PRKCAMore
Suvorexanthsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.42E-0917P25963, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P23458, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, JAK1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Suvorexanthsa05310Asthma1.92E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Suvorexanthsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Suvorexanthsa05321Inflammatory bowel disease1.72E-058O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Suvorexanthsa05322Systemic lupus erythematosus1.49E-058P08311, P09871, Q93077, P62807, Q16778, O60814, P68431, P12814CTSG, C1S, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1More
Suvorexanthsa05323Rheumatoid arthritis3.53E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Suvorexanthsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Suvorexanthsa05332Graft-versus-host disease2.41E-045P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Suvorexanthsa05340Primary immunodeficiency1.31E-045P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Suvorexanthsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Suvorexanthsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Suvorexanthsa05415Diabetic cardiomyopathy1.87E-058P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Suvorexanthsa05418Fluid shear stress and atherosclerosis3.54E-0716Q16539, P31751, P42338, Q14145, P14598, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, P0DP23, P08238, Q92974MAPK14, AKT2, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, HSP90AB1, ARHGEF2More

Community members of Suvorexant (SDC: 11.11)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q9NZJ5EIF2AK3Eukaryotic translation initiation factor 2Nonealpha kinase 3Predicted10.09390.15740.63981.0015
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Predicted00.00420.2820.12740.6935
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
O94782USP1Ubiquitin carboxylNoneterminal hydrolase 1Predicted00.4410.08980.02130.4215
O00767SCDStearoylNoneCoA desaturasePredicted10.16860.1870.19970.6581
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q13093PLA2G7PlateletNoneactivating factor acetylhydrolasePredicted00.05050.20960.15580.6001
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
O95271TNKSPoly [ADPNoneribose] polymerase tankyraseNone1Predicted00.10170.222400.4957
P32249GPR183GNoneprotein coupled receptor 183Predicted00.0710.048500.1324
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
Q13370PDE3BcGMPNoneinhibited 3',5'Nonecyclic phosphodiesterase BPredicted00.09060.16140.35580.7239
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)