PharmaCoNets of Sumatriptan (SPCN: 57.91 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Sumatriptanhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Sumatriptanhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Sumatriptanhsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Sumatriptanhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Sumatriptanhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Sumatriptanhsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Sumatriptanhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Sumatriptanhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Sumatriptanhsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Sumatriptanhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Sumatriptanhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Sumatriptanhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Sumatriptanhsa04064NF-kappa B signaling pathway1.04E-0313P10415, O00463, P14778, P19174, Q04759, Q9UDY8, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643BCL2, TRAF5, IL1R1, PLCG1, PRKCQ, MALT1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTBMore
Sumatriptanhsa04071Sphingolipid signaling pathway1.17E-036P21453, Q9H228, P01375, Q13362, Q9BX95, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Sumatriptanhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Sumatriptanhsa04080Neuroactive ligand-receptor interaction2.16E-039P08311, P28472, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2More
Sumatriptanhsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Sumatriptanhsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Sumatriptanhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Sumatriptanhsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Sumatriptanhsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Sumatriptanhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Sumatriptanhsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Sumatriptanhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Sumatriptanhsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Sumatriptanhsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Sumatriptanhsa04612Antigen processing and presentation2.09E-048P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Sumatriptanhsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Sumatriptanhsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Sumatriptanhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Sumatriptanhsa04650Natural killer cell mediated cytotoxicity3.09E-0715P16298, P50591, P19174, P01375, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, P26717, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KIR2DS5, KLRC1More
Sumatriptanhsa04657IL-17 signaling pathway2.41E-024P19875, P14780, P80188, P01375CXCL2, MMP9, LCN2, TNFMore
Sumatriptanhsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Sumatriptanhsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Sumatriptanhsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Sumatriptanhsa04668TNF signaling pathway3.55E-024P01375, P18848, P19875, P14780TNF, ATF4, CXCL2, MMP9More
Sumatriptanhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Sumatriptanhsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Sumatriptanhsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Sumatriptanhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Sumatriptanhsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Sumatriptanhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Sumatriptanhsa04742Taste transduction1.01E-021P30939HTR1FMore
Sumatriptanhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Sumatriptanhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Sumatriptanhsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Sumatriptanhsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Sumatriptanhsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Sumatriptanhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Sumatriptanhsa04924Renin secretion4.04E-022P22694, P07550PRKACB, ADRB2More
Sumatriptanhsa04926Relaxin signaling pathway2.41E-024P18848, P22694, P14780, P30679ATF4, PRKACB, MMP9, GNA15More
Sumatriptanhsa04927Cortisol synthesis and secretion4.44E-043Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Sumatriptanhsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Sumatriptanhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Sumatriptanhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Sumatriptanhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Sumatriptanhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Sumatriptanhsa04970Salivary secretion1.91E-023P07550, P22694, P49913ADRB2, PRKACB, CAMPMore
Sumatriptanhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Sumatriptanhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Sumatriptanhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Sumatriptanhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Sumatriptanhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Sumatriptanhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Sumatriptanhsa05133Pertussis4.20E-021P0C0L4C4AMore
Sumatriptanhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Sumatriptanhsa05140Leishmaniasis1.56E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Sumatriptanhsa05143African trypanosomiasis7.50E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Sumatriptanhsa05144Malaria1.44E-035P69905, P68871, P01375, P35443, P26718HBA2, HBB, TNF, THBS4, KLRK1More
Sumatriptanhsa05146Amoebiasis2.05E-0511P09341, P19875, P14778, P27930, P01375, P42338, P11215, P05089, P30679, P22694, P12814CXCL1, CXCL2, IL1R1, IL1R2, TNF, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1More
Sumatriptanhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Sumatriptanhsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Sumatriptanhsa05168Herpes simplex virus 1 infection3.38E-0312P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212More
Sumatriptanhsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Sumatriptanhsa05202Transcriptional misregulation in cancer1.77E-0211Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Sumatriptanhsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Sumatriptanhsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Sumatriptanhsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Sumatriptanhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Sumatriptanhsa05321Inflammatory bowel disease1.19E-036P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Sumatriptanhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Sumatriptanhsa05332Graft-versus-host disease1.91E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Sumatriptanhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Sumatriptanhsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore

Community members of Sumatriptan (SDC: 5.39)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P30939HTR1F5Nonehydroxytryptamine receptor 1FReported00.000910.01982.0202
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
HTR1FP30939IC50>1000
HTR1FP30939Ki22.9
HTR1FP30939Ki23
HTR1FP30939Ki25.7