PharmaCoNets of Sulindac (SPCN: 60.95 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Sulindachsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Sulindachsa00220Arginine biosynthesis2.33E-022P05089, P49448ARG1, GLUD2More
Sulindachsa00310Lysine degradation6.96E-032Q96KQ7, P51648EHMT2, ALDH3A2More
Sulindachsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Sulindachsa00500Starch and sucrose metabolism3.06E-054O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Sulindachsa00515Mannose type O-glycan biosynthesis4.96E-021O75072FCMDMore
Sulindachsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Sulindachsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Sulindachsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Sulindachsa00620Pyruvate metabolism1.39E-034P40925, P40926, P51648, P14550MDH1, MDH2, ALDH3A2, AKR1A1More
Sulindachsa00630Glyoxylate and dicarboxylate metabolism2.40E-032P40925, P15104MDH1, GLULMore
Sulindachsa00730Thiamine metabolism1.38E-053Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Sulindachsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Sulindachsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Sulindachsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Sulindachsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Sulindachsa01100Metabolic pathways3.55E-0334Q9NR34, P35790, P05089, Q16772, P09211, Q9UJ14, P30041, P32320, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, Q7KZN9, P05186, P24666, P15121, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6MAN1C1, CHKA, ARG1, GSTA3, GSTP1, GGTL3, PRDX6, CDA, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, COX15, ALPL, ACP1, AKR1B1, MCCC2, ACSL1, AMACR, SGMS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1More
Sulindachsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Sulindachsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Sulindachsa01524Platinum drug resistance8.70E-047P10415, Q13489, Q16772, P09211, P78417, P23025, P43246BCL2, BIRC3, GSTA3, GSTP1, GSTO1, XPA, MSH2More
Sulindachsa03008Ribosome biogenesis in eukaryotes2.52E-023P78345, O15381, Q9GZY0RPP38, NVL, NXF2; NXF2BMore
Sulindachsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Sulindachsa03013RNA transport1.12E-0317P62826, O14980, P52298, Q09161, O14893, P61326, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, Q14240, Q9Y6A5, Q14232, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, EIF4A2, TACC3, EIF2B1, FXR1More
Sulindachsa03020RNA polymerase6.08E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Sulindachsa03040Spliceosome3.37E-0511Q14562, O43143, O60508, Q99633, P26368, Q13595, Q01130, Q13243, Q9UMS4, P11142, O43447DHX8, DHX15, CDC40, PRPF18, U2AF2, TRA2A, SFRS2, SFRS5, PRPF19, HSPA8, PPIHMore
Sulindachsa03450Non-homologous end-joining4.96E-021Q9NP87POLMMore
Sulindachsa04015Rap1 signaling pathway1.58E-026P20827, P49767, P63261, P25116, P0DP23, P17252EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCAMore
Sulindachsa04020Calcium signaling pathway1.93E-0410Q08828, Q16566, P17252, O15399, P25116, P0DP23, P05141, P51828, P23634, P49767ADCY1, CAMK4, PRKCA, GRIN2D, F2R, CALM1, SLC25A5, ADCY7, ATP2B4, VEGFCMore
Sulindachsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Sulindachsa04024cAMP signaling pathway2.95E-038Q08828, P51828, P31751, P0DP23, P23634, Q16566, O15399, P25116ADCY1, ADCY7, AKT2, CALM1, ATP2B4, CAMK4, GRIN2D, F2RMore
Sulindachsa04060Cytokine-cytokine receptor interaction8.61E-039P14784, P27930, P14778, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, Q93038IL2RB, IL1R2, IL1R1, IL10RA, IL21R, CXCR1, XCL2, XCL1, TNFRSF25More
Sulindachsa04061Viral protein interaction with cytokine and cytokine receptor2.06E-036Q8NHW4, P25024, P47992, Q9UBD3, Q13651, P14784CCL4L2, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Sulindachsa04062Chemokine signaling pathway4.68E-038P25024, P47992, Q9UBD3, P07948, P42338, P63218, P50151, P49407CXCR1, XCL1, XCL2, LYN, PIK3CB, GNG5, GNG10, ARRB1More
Sulindachsa04064NF-kappa B signaling pathway6.91E-0615P10415, O00463, P14778, P01584, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q9NQC7BCL2, TRAF5, IL1R1, IL1B, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CYLDMore
Sulindachsa04070Phosphatidylinositol signaling system9.86E-034P0DP23, O14986, Q16760, P48426CALM1, PIP5K1B, DGKD, PIP4K2AMore
Sulindachsa04071Sphingolipid signaling pathway1.88E-058P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Sulindachsa04072Phospholipase D signaling pathway2.40E-036P31751, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Sulindachsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Sulindachsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Sulindachsa04114Oocyte meiosis1.35E-025P0DP23, Q08828, P51828, Q13362, Q14738CALM1, ADCY1, ADCY7, PPP2R5C, PPP2R5DMore
Sulindachsa04140Autophagy - animal1.92E-039P31751, Q7L523, O75460, P22694, Q14643, P10415, Q04759, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, PRKCQ, TMEM49, SMCR8More
Sulindachsa04141Protein processing in endoplasmic reticulum2.01E-037P18848, P30101, O60337, P60604, P11142, P07900, P08238ATF4, PDIA3, MARH6, UBE2G2, HSPA8, HSP90AA1, HSP90AB1More
Sulindachsa04145Phagosome1.48E-0411O75015, P63261, Q15080, Q13509, P68371, Q13488, P05164, O60603, P35443, P27824, P13765FCGR3B, ACTG1, NCF4, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, CANX, HLA-DOBMore
Sulindachsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Sulindachsa04211Longevity regulating pathway1.88E-024P31751, Q08828, P51828, P18848AKT2, ADCY1, ADCY7, ATF4More
Sulindachsa04213Longevity regulating pathway - multiple species4.54E-023P31751, Q08828, P51828AKT2, ADCY1, ADCY7More
Sulindachsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Sulindachsa04261Adrenergic signaling in cardiomyocytes4.98E-047Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Sulindachsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Sulindachsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Sulindachsa04371Apelin signaling pathway3.94E-024P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Sulindachsa04380Osteoclast differentiation5.27E-0410Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Sulindachsa04390Hippo signaling pathway2.11E-036P63261, Q13485, O15105, Q9UJU2, O43623, Q13489ACTG1, SMAD4, SMAD7, LEF1, SNAI2, BIRC3More
Sulindachsa04510Focal adhesion3.21E-026Q15942, P17252, Q13489, P10415, P49767, P63261ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1More
Sulindachsa04520Adherens junction3.36E-024Q13485, Q9UJU2, O43623, P63261SMAD4, LEF1, SNAI2, ACTG1More
Sulindachsa04530Tight junction4.35E-022P63261, Q92974ACTG1, ARHGEF2More
Sulindachsa04540Gap junction4.76E-023P17252, Q13509, P68371PRKCA, TUBB3, TUBB2CMore
Sulindachsa04610Complement and coagulation cascades3.19E-021P0C0L4C4AMore
Sulindachsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Sulindachsa04613Neutrophil extracellular trap formation1.70E-0314P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Sulindachsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Sulindachsa04620Toll-like receptor signaling pathway2.54E-033P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Sulindachsa04623Cytosolic DNA-sensing pathway2.21E-043P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Sulindachsa04625C-type lectin receptor signaling pathway1.14E-038Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Sulindachsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Sulindachsa04640Hematopoietic cell lineage2.46E-038P14778, P27930, P25063, P07766, P01732, P01730, P06127, P09564IL1R1, IL1R2, CD24, CD3E, CD8A, CD4, CD5, CD7More
Sulindachsa04650Natural killer cell mediated cytotoxicity2.96E-026O60880, P20963, Q13241, P26718, P26717, P26715SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KLRC1More
Sulindachsa04657IL-17 signaling pathway1.62E-048P07900, O00463, Q16539, P49841, P09341, P14780, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, TNF, IL1BMore
Sulindachsa04658Th1 and Th2 cell differentiation1.31E-0611Q04759, P07766, P20963, P09693, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Sulindachsa04659Th17 cell differentiation2.42E-0511Q04759, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3E, CD3G, CD247More
Sulindachsa04660T cell receptor signaling pathway1.29E-0411Q9UDY8, Q04759, P42338, P10747, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239MALT1, PRKCQ, PIK3CB, CD28, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Sulindachsa04662B cell receptor signaling pathway4.02E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Sulindachsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Sulindachsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Sulindachsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Sulindachsa04713Circadian entrainment4.54E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Sulindachsa04720Long-term potentiation4.13E-046P17252, Q16566, P0DP23, P18848, O15399, Q08828PRKCA, CAMK4, CALM1, ATF4, GRIN2D, ADCY1More
Sulindachsa04723Retrograde endocannabinoid signaling1.75E-025Q14643, P17252, P22694, Q16539, Q16718ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5More
Sulindachsa04725Cholinergic synapse1.39E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Sulindachsa04728Dopaminergic synapse7.83E-035P31751, P18848, Q13362, Q14738, P0DP23AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Sulindachsa04730Long-term depression1.35E-022Q14344, P07948GNA13, LYNMore
Sulindachsa04750Inflammatory mediator regulation of TRP channels4.76E-048P14778, P01584, Q08828, P51828, P42338, P24723, Q04759, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PIK3CB, PRKCH, PRKCQ, CALM1More
Sulindachsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Sulindachsa04912GnRH signaling pathway2.67E-049P17252, Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP23, P22694PRKCA, ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM1, PRKACBMore
Sulindachsa04915Estrogen signaling pathway2.13E-025P18848, Q08828, P51828, P31751, P0DP23ATF4, ADCY1, ADCY7, AKT2, CALM1More
Sulindachsa04916Melanogenesis1.98E-035P0DP23, Q9UJU2, Q08828, P51828, P17252CALM1, LEF1, ADCY1, ADCY7, PRKCAMore
Sulindachsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Sulindachsa04921Oxytocin signaling pathway4.19E-024P0DP23, P17252, Q16566, P63261CALM1, PRKCA, CAMK4, ACTG1More
Sulindachsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Sulindachsa04923Regulation of lipolysis in adipocytes5.15E-033Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Sulindachsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Sulindachsa04925Aldosterone synthesis and secretion1.84E-047P18848, Q08828, P51828, P0DP23, P17252, Q16566, P23634ATF4, ADCY1, ADCY7, CALM1, PRKCA, CAMK4, ATP2B4More
Sulindachsa04926Relaxin signaling pathway2.46E-024P31751, P18848, Q08828, P51828AKT2, ATF4, ADCY1, ADCY7More
Sulindachsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Sulindachsa04928Parathyroid hormone synthesis, secretion and action4.10E-035Q14643, P22694, P23771, P17252, P10415ITPR1, PRKACB, GATA3, PRKCA, BCL2More
Sulindachsa04932Non-alcoholic fatty liver disease2.99E-047P31751, P18848, O75460, P01584, P13073, O15239, O95298AKT2, ATF4, ERN1, IL1B, COX4I1, NDUFA1, NDUFC2More
Sulindachsa04933AGE-RAGE signaling pathway in diabetic complications3.36E-024Q13485, P10415, P49767, P17252SMAD4, BCL2, VEGFC, PRKCAMore
Sulindachsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Sulindachsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Sulindachsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Sulindachsa04970Salivary secretion1.38E-035Q08828, P51828, P23634, P17252, P0DP23ADCY1, ADCY7, ATP2B4, PRKCA, CALM1More
Sulindachsa04971Gastric acid secretion4.13E-046Q08828, P51828, P17252, P15311, P63261, P0DP23ADCY1, ADCY7, PRKCA, VIL2, ACTG1, CALM1More
Sulindachsa04976Bile secretion1.59E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Sulindachsa04978Mineral absorption3.94E-022P23634, Q9BXS9ATP2B4, SLC26A6More
Sulindachsa05010Alzheimer disease4.94E-039O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4More
Sulindachsa05012Parkinson disease1.59E-039O15239, P13073, P05141, P21796, P60604, P18848, Q13557, Q71U36, Q13509NDUFA1, COX4I1, SLC25A5, VDAC1, UBE2G2, ATF4, CAMK2D, TUBA1A, TUBB3More
Sulindachsa05014Amyotrophic lateral sclerosis4.31E-027O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2BMore
Sulindachsa05016Huntington disease2.14E-039O15239, O95298, P13073, P24928, P30876, P62487, P05141, O75460, P28070NDUFA1, NDUFC2, COX4I1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4More
Sulindachsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Sulindachsa05020Prion disease3.30E-0410P13591, P01584, P11142, O15239, P13073, P18848, P05141, P21796, Q71U36, Q13509NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5, VDAC1, TUBA1A, TUBB3More
Sulindachsa05022Pathways of neurodegeneration - multiple diseases1.89E-0417Q71U36, Q13509, O15239, O95298, P13073, Q8TEV9, P21796, O75460, P18848, P05141, Q00535, P04628, P01584, P0DP23, Q13557, P28070, P60604TUBA1A, TUBB3, NDUFA1, NDUFC2, COX4I1, SMCR8, VDAC1, ERN1, ATF4, SLC25A5, CDK5, WNT1, IL1B, CALM1, CAMK2D, PSMB4, UBE2G2More
Sulindachsa05031Amphetamine addiction1.49E-024O15399, P0DP23, Q16566, P17252GRIN2D, CALM1, CAMK4, PRKCAMore
Sulindachsa05120Epithelial cell signaling in Helicobacter pylori infection2.45E-024Q16539, P09341, P25024, P25025MAPK14, CXCL1, CXCR1, CXCR2More
Sulindachsa05132Salmonella infection4.98E-026Q9UJU2, P63261, Q13489, P10415, Q13509, P68371LEF1, ACTG1, BIRC3, BCL2, TUBB3, TUBB2CMore
Sulindachsa05133Pertussis1.60E-035P0DP23, P10145, P23528, P09871, P0C0L4CALM1, IL8, CFL1, C1S, C4AMore
Sulindachsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Sulindachsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Sulindachsa05146Amoebiasis4.73E-048P09341, P14778, P27930, O60603, P42338, P05089, P12814, P08311CXCL1, IL1R1, IL1R2, TLR2, PIK3CB, ARG1, ACTN1, CTSGMore
Sulindachsa05152Tuberculosis1.26E-028Q13488, O75015, P48382, O60603, P10415, P13765, Q9UDY8, Q16539TCIRG1, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, MALT1, MAPK14More
Sulindachsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Sulindachsa05163Human cytomegalovirus infection4.02E-0617P31751, P01375, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463AKT2, TNF, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5More
Sulindachsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Sulindachsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Sulindachsa05168Herpes simplex virus 1 infection1.94E-029Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2More
Sulindachsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Sulindachsa05200Pathways in cancer1.51E-0212Q9UJU2, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P25116, P78417, P0DP23, P01568LEF1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, F2R, GSTO1, CALM1, IFNA21More
Sulindachsa05202Transcriptional misregulation in cancer2.67E-0414Q12778, Q15532, Q13315, P41732, P14780, P27930, Q16548, Q13489, O15550, P35226, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, BCL2A1, BIRC3, UTX, BMI1, MPO, ELA2, BCL11B, GADD45AMore
Sulindachsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Sulindachsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Sulindachsa05212Pancreatic cancer4.00E-034P31751, Q15311, P23458, P37173AKT2, RALBP1, JAK1, TGFBR2More
Sulindachsa05214Glioma3.55E-023P0DP23, Q16566, P17252CALM1, CAMK4, PRKCAMore
Sulindachsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Sulindachsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Sulindachsa05231Choline metabolism in cancer3.38E-023P31751, Q16760, O14986AKT2, DGKD, PIP5K1BMore
Sulindachsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.70E-0411P42338, O95267, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, P01730PIK3CB, RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, CD4More
Sulindachsa05321Inflammatory bowel disease1.66E-045O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Sulindachsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Sulindachsa05332Graft-versus-host disease1.16E-044P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Sulindachsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore
Sulindachsa05418Fluid shear stress and atherosclerosis9.76E-0613Q16539, Q14145, P78417, P10599, P14780, P01375, P63261, P04637, P10415, P14778, P27930, P0DP23, Q92974MAPK14, KEAP1, GSTO1, TXN, MMP9, TNF, ACTG1, TP53, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2More

Community members of Sulindac (SDC: 3.11)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P15121AKR1B1AldoNoneketo reductase family 1 member B1Reported10.56830.6290.2141.7562
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P14550AKR1A1AldoNoneketo reductase family 1 member A1Predicted10.30560.06210.17370.4508
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
Q15131CDK10CyclinNonedependent kinase 10Predicted00.36120.032300.2453
P46091GPR1ChemerinNonelike receptor 2Predicted00.24760.137200.3982
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
Q15722LTB4RLeukotriene B4 receptor 1Predicted00.06770.219900.4736
O15529GPR42GNoneprotein coupled receptor 42Predicted10.01270.016200.0388
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
AKR1B1P15121IC50374