PharmaCoNets

PharmaCoNets of Sulfinpyrazone (S_PCN: 92.12 )

Sulfinpyrazone regulated-network (S_DN: 17.35)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Sulfinpyrazone

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Sulfinpyrazone

hsa00071

Fatty acid degradation

3.50E-02

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Sulfinpyrazone

hsa00500

Starch and sucrose metabolism

6.17E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Sulfinpyrazone

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Sulfinpyrazone

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

3.43E-02

Q9NY97

B3GNT2

Sulfinpyrazone

hsa00561

Glycerolipid metabolism

2.51E-02

P51648, P23743

ALDH3A2, DGKA

Sulfinpyrazone

hsa00562

Inositol phosphate metabolism

7.30E-04

P27987, Q96PE3, P19174, P42338

ITPKB, INPP4A, PLCG1, PIK3CB

Sulfinpyrazone

hsa00600

Sphingolipid metabolism

1.98E-03

P07602, Q9BX95, Q13510, Q8TCT0, P15289

PSAP, SGPP1, ASAH1, CERK, ARSA

Sulfinpyrazone

hsa00620

Pyruvate metabolism

2.51E-02

P40925, P51648

MDH1, ALDH3A2

Sulfinpyrazone

hsa00630

Glyoxylate and dicarboxylate metabolism

2.78E-03

P40925, P15104

MDH1, GLUL

Sulfinpyrazone

hsa00730

Thiamine metabolism

2.27E-02

P05186, P24666

ALPL, ACP1

Sulfinpyrazone

hsa00830

Retinol metabolism

1.79E-03

P00325, P11766, Q9BPW9, O75911

ADH1B, ADH5, DHRS9, DHRS3

Sulfinpyrazone

hsa00970

Aminoacyl-tRNA biosynthesis

2.24E-03

O95363, P14868, Q15046

FARS2, DARS, KARS

Sulfinpyrazone

hsa00983

Drug metabolism - other enzymes

1.64E-02

P04183, P32320, P05164

TK1, CDA, MPO

Sulfinpyrazone

hsa01040

Biosynthesis of unsaturated fatty acids

2.92E-02

P22307, Q9H5J4

SCP2, ELOVL6

Sulfinpyrazone

hsa01100

Metabolic pathways

4.12E-02

P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P40925, P23743, P43034, P09917, Q53FZ2

GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, MDH1, DGKA, PAFAH1B1, ALOX5, ACSM3

Sulfinpyrazone

hsa01521

EGFR tyrosine kinase inhibitor resistance

7.30E-04

Q92529, P19174, P42338, Q9NRA1

SHC3, PLCG1, PIK3CB, PDGFC

Sulfinpyrazone

hsa01522

Endocrine resistance

4.48E-02

P22694, Q02750, Q9UM47, P46527

PRKACB, MAP2K1, NOTCH3, CDKN1B

Sulfinpyrazone

hsa01524

Platinum drug resistance

1.79E-02

O15392, P11388

BIRC5, TOP2A

Sulfinpyrazone

hsa03013

RNA transport

7.27E-03

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, TACC3, FXR1

Sulfinpyrazone

hsa03018

RNA degradation

5.00E-02

Q9NQT4

EXOSC5

Sulfinpyrazone

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Sulfinpyrazone

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Sulfinpyrazone

hsa03060

Protein export

1.90E-02

Q15070, O76094

OXA1L, SRP72

Sulfinpyrazone

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Sulfinpyrazone

hsa04012

ErbB signaling pathway

9.49E-03

Q92529, P19174, P42338

SHC3, PLCG1, PIK3CB

Sulfinpyrazone

hsa04014

Ras signaling pathway

1.34E-05

Q02750, P42338, Q92529, P20827, Q15389, Q9NRA1, P49767, Q13009, P17252, Q7LDG7, P21359, P62879, P63218, P50151, P19174, P22694

MAP2K1, PIK3CB, SHC3, EFNA1, ANGPT1, PDGFC, VEGFC, TIAM1, PRKCA, RASGRP2, NF1, GNB2, GNG5, GNG10, PLCG1, PRKACB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13315	ATM	Serine-protein kinase ATM	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	-0.797
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P06746	POLB	DNA polymerase beta	Q92529	SHC3	SHC-transforming protein 3	-0.785
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
Q13315	ATM	Serine-protein kinase ATM	Q15389	ANGPT1	Angiopoietin-1	0.726
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q13315	ATM	Serine-protein kinase ATM	P17252	PRKCA	Protein kinase C alpha type	0.739
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
Q13315	ATM	Serine-protein kinase ATM	P21359	NF1	Neurofibromin	0.762
Q13315	ATM	Serine-protein kinase ATM	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	-0.716
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q13315	ATM	Serine-protein kinase ATM	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.858

Sulfinpyrazone

hsa04015

Rap1 signaling pathway

2.22E-03

P20827, Q9NRA1, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, PDGFC, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Sulfinpyrazone

hsa04020

Calcium signaling pathway

2.16E-02

P27987, P19174, Q9NRA1, P49767

ITPKB, PLCG1, PDGFC, VEGFC

Sulfinpyrazone

hsa04062

Chemokine signaling pathway

2.01E-04

P09769, P07948, P42338, P19174, Q92529, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1

FGR, LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5

Sulfinpyrazone

hsa04064

NF-kappa B signaling pathway

8.68E-04

Q13489, O00463, Q13546, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, P24522, P09341, Q9UNE0, Q9NQC7

BIRC3, TRAF5, RIPK1, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, GADD45A, CXCL1, EDAR, CYLD

Sulfinpyrazone

hsa04066

HIF-1 signaling pathway

4.48E-02

P17252, Q15389, Q02750, P46527

PRKCA, ANGPT1, MAP2K1, CDKN1B

Sulfinpyrazone

hsa04070

Phosphatidylinositol signaling system

3.19E-04

P19174, P42338, P23743, Q96PE3, P27987

PLCG1, PIK3CB, DGKA, INPP4A, ITPKB

Sulfinpyrazone

hsa04071

Sphingolipid signaling pathway

5.59E-03

P17252, Q9H228, P01375, Q13510, Q13362, Q9BX95, P10415, Q9UQC2

PRKCA, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, BCL2, GAB2

Sulfinpyrazone

hsa04072

Phospholipase D signaling pathway

3.63E-05

P42338, Q92529, Q9UQC2, P19174, Q14344, Q8WYR1, Q08828, P23743, Q9NRA1

PIK3CB, SHC3, GAB2, PLCG1, GNA13, PIK3R5, ADCY1, DGKA, PDGFC

Sulfinpyrazone

hsa04151

PI3K-Akt signaling pathway

9.31E-05

P42338, P43657, O43521, P20827, Q9NRA1, P49767, Q13362, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P23458, Q6ZUJ8, P30281

PIK3CB, P2RY5, BCL2L11, EFNA1, PDGFC, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, JAK1, PIK3AP1, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P42892	ECE1	Endothelin-converting enzyme 1	O43521	BCL2L11	Bcl-2-like protein 11	0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P06746	POLB	DNA polymerase beta	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.859
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P42892	ECE1	Endothelin-converting enzyme 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.733
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P42892	ECE1	Endothelin-converting enzyme 1	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06746	POLB	DNA polymerase beta	O15335	CHAD	Chondroadherin	-0.734
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P42892	ECE1	Endothelin-converting enzyme 1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.797
P42892	ECE1	Endothelin-converting enzyme 1	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.747
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Sulfinpyrazone

hsa04211

Longevity regulating pathway

1.18E-02

Q12778, Q9UEF7, Q96KQ7

FOXO1, KL, EHMT2

Sulfinpyrazone

hsa04213

Longevity regulating pathway - multiple species

5.62E-04

Q9Y4H2, Q08828, P0DMV8, Q13547

IRS2, ADCY1, HSPA1A, HDAC1

Sulfinpyrazone

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Sulfinpyrazone

hsa04217

Necroptosis

2.93E-02

P01568, Q13489, Q13546

IFNA21, BIRC3, RIPK1

Sulfinpyrazone

hsa04270

Vascular smooth muscle contraction

2.68E-02

Q08828, P35579, P35318

ADCY1, MYH9, ADM

Sulfinpyrazone

hsa04350

TGF-beta signaling pathway

4.88E-02

P37173

TGFBR2

Sulfinpyrazone

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Sulfinpyrazone

hsa04370

VEGF signaling pathway

1.56E-02

P19174, P42338

PLCG1, PIK3CB

Sulfinpyrazone

hsa04371

Apelin signaling pathway

4.48E-04

P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3

Sulfinpyrazone

hsa04380

Osteoclast differentiation

9.58E-05

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA

Sulfinpyrazone

hsa04390

Hippo signaling pathway

2.08E-02

P84022, Q13485, Q13489

SMAD3, SMAD4, BIRC3

Sulfinpyrazone

hsa04510

Focal adhesion

1.55E-02

P42338, O15335, Q9NRA1, P49767, Q92529

PIK3CB, CHAD, PDGFC, VEGFC, SHC3

Sulfinpyrazone

hsa04540

Gap junction

2.03E-02

P17252, P22694, P68371, Q02750

PRKCA, PRKACB, TUBB2C, MAP2K1

Sulfinpyrazone

hsa04611

Platelet activation

1.59E-03

Q9Y490, P42338, Q14344, Q08828, Q8WYR1, P07948

TLN1, PIK3CB, GNA13, ADCY1, PIK3R5, LYN

Sulfinpyrazone

hsa04613

Neutrophil extracellular trap formation

2.00E-03

P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, P58876, Q16778, O60814, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539

ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2BC5, HIST2H2BE, H2BC12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Sulfinpyrazone

hsa04614

Renin-angiotensin system

7.48E-03

P50052, P15144, P08311, O75787

AGTR2, ANPEP, CTSG, ATP6AP2

Sulfinpyrazone

hsa04620

Toll-like receptor signaling pathway

4.16E-02

Q13546, P01568

RIPK1, IFNA21

Sulfinpyrazone

hsa04621

NOD-like receptor signaling pathway

5.00E-03

P23458, P01568, Q9H3M7, Q13489, P43490, Q13546

JAK1, IFNA21, TXNIP, BIRC3, PBEF1, RIPK1

Sulfinpyrazone

hsa04622

RIG-I-like receptor signaling pathway

2.39E-02

P01568, Q13546

IFNA21, RIPK1

Sulfinpyrazone

hsa04623

Cytosolic DNA-sensing pathway

2.20E-03

P01568, Q13546

IFNA21, RIPK1

Sulfinpyrazone

hsa04625

C-type lectin receptor signaling pathway

9.91E-04

Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539

CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14

Sulfinpyrazone

hsa04640

Hematopoietic cell lineage

4.31E-02

P13612, P14778, P27930, P15144, P11836, P09693, P01732, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3G, CD8A, HLA-DOB, TNF, IL1B

Sulfinpyrazone

hsa04650

Natural killer cell mediated cytotoxicity

2.87E-03

P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O14931, O75015, P26717, P26715

TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1

Sulfinpyrazone

hsa04657

IL-17 signaling pathway

9.91E-04

O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Sulfinpyrazone

hsa04658

Th1 and Th2 cell differentiation

1.33E-05

Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P13612	ITGA4	Integrin alpha-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P13612	ITGA4	Integrin alpha-4	Q9UL17	TBX21	T-box transcription factor TBX21	0.822
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P06746	POLB	DNA polymerase beta	Q13761	RUNX3	Runt-related transcription factor 3	0.738
P13612	ITGA4	Integrin alpha-4	Q13761	RUNX3	Runt-related transcription factor 3	0.78

Sulfinpyrazone

hsa04659

Th17 cell differentiation

1.29E-05

P25963, Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458

NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P06746	POLB	DNA polymerase beta	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Sulfinpyrazone

hsa04660

T cell receptor signaling pathway

4.52E-04

P01375, Q04759, O95267, Q08881, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Sulfinpyrazone

hsa04662

B cell receptor signaling pathway

1.52E-03

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Sulfinpyrazone

hsa04664

Fc epsilon RI signaling pathway

1.98E-06

P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917, P20292

TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5, ALOX5AP

Sulfinpyrazone

hsa04666

Fc gamma R-mediated phagocytosis

1.73E-02

P07948, P42338, P19174

LYN, PIK3CB, PLCG1

Sulfinpyrazone

hsa04668

TNF signaling pathway

2.21E-02

P01375, O00463, Q16539, P20749, P14780

TNF, TRAF5, MAPK14, BCL3, MMP9

Sulfinpyrazone

hsa04710

Circadian rhythm

1.67E-02

Q16526, Q9Y478

CRY1, PRKAB1

Sulfinpyrazone

hsa04720

Long-term potentiation

1.09E-02

P17252, P51812, P22694, Q02750

PRKCA, RPS6KA3, PRKACB, MAP2K1

Sulfinpyrazone

hsa04722

Neurotrophin signaling pathway

4.87E-02

P42338, P19174, Q92529

PIK3CB, PLCG1, SHC3

Sulfinpyrazone

hsa04724

Glutamatergic synapse

1.73E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Sulfinpyrazone

hsa04725

Cholinergic synapse

1.24E-03

P22694, P17252, P62879, P63218, P50151, P42338, Q02750

PRKACB, PRKCA, GNB2, GNG5, GNG10, PIK3CB, MAP2K1

Sulfinpyrazone

hsa04726

Serotonergic synapse

2.20E-03

P22694, P17252, P62879, P63218, P50151, P09917, Q02750

PRKACB, PRKCA, GNB2, GNG5, GNG10, ALOX5, MAP2K1

Sulfinpyrazone

hsa04727

GABAergic synapse

5.05E-04

P62879, P63218, P50151, P15104, P22694, O60296, P17252

GNB2, GNG5, GNG10, GLUL, PRKACB, TRAK2, PRKCA

Sulfinpyrazone

hsa04730

Long-term depression

1.56E-02

Q14344, P07948

GNA13, LYN

Sulfinpyrazone

hsa04750

Inflammatory mediator regulation of TRP channels

1.17E-02

P14778, P01584, P51828, P22694, Q16539, Q14643, Q04759, P0DP24

IL1R1, IL1B, ADCY7, PRKACB, MAPK14, ITPR1, PRKCQ, CALM2

Sulfinpyrazone

hsa04910

Insulin signaling pathway

4.11E-02

Q92529, Q13370, P42338

SHC3, PDE3B, PIK3CB

Sulfinpyrazone

hsa04912

GnRH signaling pathway

4.33E-02

P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694

ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB

Sulfinpyrazone

hsa04914

Progesterone-mediated oocyte maturation

2.22E-02

P42338, Q13370, P08238

PIK3CB, PDE3B, HSP90AB1

Sulfinpyrazone

hsa04915

Estrogen signaling pathway

1.63E-04

Q08828, P42338, Q92529, P08238, P0DMV8, P11142, Q15788

ADCY1, PIK3CB, SHC3, HSP90AB1, HSPA1A, HSPA8, NCOA1

Sulfinpyrazone

hsa04919

Thyroid hormone signaling pathway

2.22E-02

P17252, Q02750, P22694, Q12778, Q9UM47

PRKCA, MAP2K1, PRKACB, FOXO1, NOTCH3

Sulfinpyrazone

hsa04920

Adipocytokine signaling pathway

4.31E-02

Q9Y478, Q96RR4

PRKAB1, CAMKK2

Sulfinpyrazone

hsa04921

Oxytocin signaling pathway

3.76E-02

Q08828, Q96RR4, Q8WYR1

ADCY1, CAMKK2, PIK3R5

Sulfinpyrazone

hsa04923

Regulation of lipolysis in adipocytes

3.64E-02

Q13370, P42338

PDE3B, PIK3CB

Sulfinpyrazone

hsa04926

Relaxin signaling pathway

1.31E-03

P42338, P63218, P50151, P49767, Q92529

PIK3CB, GNG5, GNG10, VEGFC, SHC3

Sulfinpyrazone

hsa04928

Parathyroid hormone synthesis, secretion and action

4.48E-02

P22694, Q02750, P17252, Q9Y5Q3

PRKACB, MAP2K1, PRKCA, MAFB

Sulfinpyrazone

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.54E-04

P84022, Q13485, P10415, P42338, P49767, P19174

SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1

Sulfinpyrazone

hsa04935

Growth hormone synthesis, secretion and action

2.78E-02

P19174, P42338, Q92529

PLCG1, PIK3CB, SHC3

Sulfinpyrazone

hsa04970

Salivary secretion

4.22E-02

P22694, P17252, P49913

PRKACB, PRKCA, CAMP

Sulfinpyrazone

hsa04972

Pancreatic secretion

4.73E-02

Q08828, P62491

ADCY1, RAB11A

Sulfinpyrazone

hsa04975

Fat digestion and absorption

9.50E-04

O14494

PLPP1

Sulfinpyrazone

hsa05032

Morphine addiction

2.22E-02

P63218, P50151, Q13370

GNG5, GNG10, PDE3B

Sulfinpyrazone

hsa05034

Alcoholism

2.10E-03

Q13547, P58876, Q16778, O60814

HDAC1, H2BC5, HIST2H2BE, H2BC12

Sulfinpyrazone

hsa05100

Bacterial invasion of epithelial cells

3.64E-02

P42338, Q92529

PIK3CB, SHC3

Sulfinpyrazone

hsa05132

Salmonella infection

5.76E-04

P25963, Q13546, Q13489, P10415, Q9BQS8, O60282, P68371

NFKBIA, RIPK1, BIRC3, BCL2, FYCO1, KIF5C, TUBB2C

Sulfinpyrazone

hsa05140

Leishmaniasis

2.29E-02

P13612, O75015, P23458, P13765, O60603, P01375, P01584, Q16539, Q15080

ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MAPK14, NCF4

Sulfinpyrazone

hsa05144

Malaria

2.43E-02

P60033, O60603, P01375, P35443, P01584, P26718

CD81, TLR2, TNF, THBS4, IL1B, KLRK1

Sulfinpyrazone

hsa05145

Toxoplasmosis

4.95E-04

P25963, P10415, Q13489, P23458, Q8WYR1, P0DMV8

NFKBIA, BCL2, BIRC3, JAK1, PIK3R5, HSPA1A

Sulfinpyrazone

hsa05146

Amoebiasis

4.25E-02

P01584, P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311

IL1B, CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Sulfinpyrazone

hsa05161

Hepatitis B

8.49E-03

P25963, Q13485, P10415, P84022

NFKBIA, SMAD4, BCL2, SMAD3

Sulfinpyrazone

hsa05162

Measles

2.81E-03

P23458, P14784, P07766, P42338, P0DMV8, P11142

JAK1, IL2RB, CD3E, PIK3CB, HSPA1A, HSPA8

Sulfinpyrazone

hsa05163

Human cytomegalovirus infection

1.10E-03

P42338, P01375, P63218, P50151, Q14344, P49841, P14778, P25025, Q16539, O00463, P30101

PIK3CB, TNF, GNG5, GNG10, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3

Sulfinpyrazone

hsa05165

Human papillomavirus infection

4.71E-03

P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315

CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATM

Sulfinpyrazone

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.14E-02

P42338, P63218, P50151, P19174, P07948

PIK3CB, GNG5, GNG10, PLCG1, LYN

Sulfinpyrazone

hsa05169

Epstein-Barr virus infection

3.34E-02

P42338, P07948, P30101, Q13761, P07766

PIK3CB, LYN, PDIA3, RUNX3, CD3E

Sulfinpyrazone

hsa05170

Human immunodeficiency virus 1 infection

7.03E-03

P42338, P63218, P50151, P30101, P19174, P07766

PIK3CB, GNG5, GNG10, PDIA3, PLCG1, CD3E

Sulfinpyrazone

hsa05200

Pathways in cancer

1.13E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P06746	POLB	DNA polymerase beta	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P06746	POLB	DNA polymerase beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.834
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P06746	POLB	DNA polymerase beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.787
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P06746	POLB	DNA polymerase beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.78
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P06746	POLB	DNA polymerase beta	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06746	POLB	DNA polymerase beta	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.804
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06746	POLB	DNA polymerase beta	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	-0.75
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P06746	POLB	DNA polymerase beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Sulfinpyrazone

hsa05202

Transcriptional misregulation in cancer

2.26E-04

Q12778, Q13315, P17844, P14780, P27930, Q15744, Q16548, P11215, Q13077, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, ATM, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, ITGAM, TRAF1, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13315	ATM	Serine-protein kinase ATM	Q12778	FOXO1	Forkhead box protein O1	0.821
Q13315	ATM	Serine-protein kinase ATM	Q13315	ATM	Serine-protein kinase ATM	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
O15245	SLC22A1	Solute carrier family 22 member 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.711
Q13315	ATM	Serine-protein kinase ATM	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.709
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
O15245	SLC22A1	Solute carrier family 22 member 1	P11215	ITGAM	Integrin alpha-M	0.706
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q13315	ATM	Serine-protein kinase ATM	P46527	CDKN1B	Cyclin-dependent kinase inhibitor 1B	0.708
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
Q13315	ATM	Serine-protein kinase ATM	P05164	MPO	Myeloperoxidase	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
Q13315	ATM	Serine-protein kinase ATM	P08246	ELA2	Neutrophil elastase	-0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
Q13315	ATM	Serine-protein kinase ATM	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
O15245	SLC22A1	Solute carrier family 22 member 1	Q13547	HDAC1	Histone deacetylase 1	-0.711
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
O15245	SLC22A1	Solute carrier family 22 member 1	P12980	LYL1	Protein lyl-1	0.806
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819

Sulfinpyrazone

hsa05203

Viral carcinogenesis

6.44E-03

Q13547, P58876, Q16778, O60814

HDAC1, H2BC5, HIST2H2BE, H2BC12

Sulfinpyrazone

hsa05206

MicroRNAs in cancer

3.66E-02

P46527, Q9UM47, P16070, Q13315, P17252, Q02750

CDKN1B, NOTCH3, CD44, ATM, PRKCA, MAP2K1

Sulfinpyrazone

hsa05210

Colorectal cancer

1.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Sulfinpyrazone

hsa05212

Pancreatic cancer

9.87E-04

P42338, P37173, P84022, Q13485, O75293

PIK3CB, TGFBR2, SMAD3, SMAD4, GADD45B

Sulfinpyrazone

hsa05214

Glioma

9.49E-03

Q92529, P42338, P19174

SHC3, PIK3CB, PLCG1

Sulfinpyrazone

hsa05215

Prostate cancer

4.87E-02

Q9NRA1, P08238, P42338

PDGFC, HSP90AB1, PIK3CB

Sulfinpyrazone

hsa05217

Basal cell carcinoma

3.50E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Sulfinpyrazone

hsa05218

Melanoma

3.64E-02

Q9NRA1, P42338

PDGFC, PIK3CB

Sulfinpyrazone

hsa05220

Chronic myeloid leukemia

1.44E-03

Q13547, Q13485, P25963, P84022, P42338, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45B

Sulfinpyrazone

hsa05222

Small cell lung cancer

1.50E-02

Q13489, P10415, P25963

BIRC3, BCL2, NFKBIA

Sulfinpyrazone

hsa05226

Gastric cancer

2.78E-02

P84022, Q13485, P10415

SMAD3, SMAD4, BCL2

Sulfinpyrazone

hsa05231

Choline metabolism in cancer

1.17E-03

P42338, Q9NRA1, P19174, P23743

PIK3CB, PDGFC, PLCG1, DGKA

Sulfinpyrazone

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.10E-02

O95267, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539

RASGRP1, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14

Sulfinpyrazone

hsa05321

Inflammatory bowel disease

1.21E-02

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B

Sulfinpyrazone

hsa05322

Systemic lupus erythematosus

1.18E-02

P58876, Q16778, O60814

H2BC5, HIST2H2BE, H2BC12

Sulfinpyrazone

hsa05418

Fluid shear stress and atherosclerosis

1.08E-03

Q16539, Q14145, P10599, P14780, P01375, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2

Community members of Sulfinpyrazone (S_DC: 5.31)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

NR1I2

Nuclear receptor subfamily 1 group I member 2

Reported

0.0315

0.9493

1.9143

P08235

NR3C2

Mineralocorticoid receptor

Predicted

0.1855

0.0137

2.1064

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

P21462

FPR1

fMetNoneLeuNonePhe receptor

Predicted

0.1205

0.3492

0.4378

1.1964

P13612

ITGA4

Integrin alphaNone4

Predicted

0.1165

0.2386

0.6862

1.2217

P50052

AGTR2

TypeNone2 angiotensin II receptor

Predicted

0.0604

0.4365

0.1541

1.0572

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

Q13133

NR1H3

Oxysterols receptor LXRNonealpha

Predicted

0.0162

0.439

0.2086

1.0947

Q13315

ATM

SerineNoneprotein kinase ATM

Predicted

0.7747

0.2014

0.9391

1.7293

P06746

POLB

DNA polymerase beta

Predicted

0.4573

0.1868

0.4856

1.0878

P43490

PBEF1

Nicotinamide phosphoribosyltransferase

Predicted

0.4423

0.7064

0.238

1.872

P42892

ECE1

EndothelinNoneconverting enzyme 1

Predicted

0.4853

0.0922

0.4269

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

O15164

TRIM24

Transcription intermediary factor 1Nonealpha

Predicted

0.2807

0.1055

0.3514

O15245

SLC22A1

Solute carrier family 22 member 1

Predicted

0.0149

0.0219

2.0294

P10826

RARB

Retinoic acid receptor beta

Predicted

0.0094

0.3466

0.3005

0.9983

PharmaCoNets of Sulfinpyrazone (SPCN: 92.12 )

Sulfinpyrazone regulated-network (SDN: 17.35)

Community members of Sulfinpyrazone (SDC: 5.31)

PharmaCoNets of Sulfinpyrazone (S_PCN: 92.12 )

Sulfinpyrazone regulated-network (S_DN: 17.35)

Community members of Sulfinpyrazone (S_DC: 5.31)