| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
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| Sulfametopyrazine | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Sulfametopyrazine | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Sulfametopyrazine | hsa00630 | Glyoxylate and dicarboxylate metabolism | 5.34E-03 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Sulfametopyrazine | hsa02010 | ABC transporters | 4.93E-02 | 1 | Q8IZY2 | ABCA7 | More | | | Sulfametopyrazine | hsa03040 | Spliceosome | 4.19E-02 | 5 | Q14562, O60508, P08579, Q01130, O43447 | DHX8, CDC40, SNRPB2, SFRS2, PPIH | More | | | Sulfametopyrazine | hsa04071 | Sphingolipid signaling pathway | 1.94E-02 | 6 | P21453, Q9H228, P01375, Q13362, Q9BX95, P10415 | S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2 | More | | | Sulfametopyrazine | hsa04114 | Oocyte meiosis | 1.33E-02 | 4 | P51812, Q02750, P16298, Q17RY0 | RPS6KA3, MAP2K1, PPP3CB, CPEB4 | More | | | Sulfametopyrazine | hsa04140 | Autophagy - animal | 3.72E-02 | 5 | P22694, Q14643, P10415, Q9H1Y0, Q04759 | PRKACB, ITPR1, BCL2, ATG5, PRKCQ | More | | | Sulfametopyrazine | hsa04150 | mTOR signaling pathway | 3.60E-02 | 3 | Q02750, Q9NQL2, P51812 | MAP2K1, RRAGD, RPS6KA3 | More | | | Sulfametopyrazine | hsa04370 | VEGF signaling pathway | 2.68E-03 | 3 | P16298, Q05397, Q02750 | PPP3CB, PTK2, MAP2K1 | More | | | Sulfametopyrazine | hsa04610 | Complement and coagulation cascades | 2.33E-03 | 1 | P0C0L4 | C4A | More | | | Sulfametopyrazine | hsa04612 | Antigen processing and presentation | 2.84E-02 | 7 | P13765, P48382, P26715, P26717, Q13241, P01732, P01375 | HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNF | More | | | Sulfametopyrazine | hsa04613 | Neutrophil extracellular trap formation | 4.94E-02 | 11 | O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, P49913, P21730, P21462 | TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1 | More | | | Sulfametopyrazine | hsa04640 | Hematopoietic cell lineage | 3.58E-02 | 8 | P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375 | ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF | More | | | Sulfametopyrazine | hsa04650 | Natural killer cell mediated cytotoxicity | 2.94E-02 | 3 | P16298, P50591, Q02750 | PPP3CB, TNFSF10, MAP2K1 | More | | | Sulfametopyrazine | hsa04658 | Th1 and Th2 cell differentiation | 1.48E-02 | 7 | Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765 | PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOB | More | | | Sulfametopyrazine | hsa04660 | T cell receptor signaling pathway | 3.19E-03 | 10 | P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191 | TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB | More | | | Sulfametopyrazine | hsa04662 | B cell receptor signaling pathway | 1.49E-03 | 5 | P42338, P60033, P07948, P21854, Q8N149 | PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Sulfametopyrazine | hsa04664 | Fc epsilon RI signaling pathway | 2.32E-02 | 3 | P42338, P07948, P09917 | PIK3CB, LYN, ALOX5 | More | | | Sulfametopyrazine | hsa04672 | Intestinal immune network for IgA production | 1.66E-02 | 3 | P10747, P13765, P13612 | CD28, HLA-DOB, ITGA4 | More | | | Sulfametopyrazine | hsa04720 | Long-term potentiation | 1.38E-02 | 3 | P16298, P51812, Q02750 | PPP3CB, RPS6KA3, MAP2K1 | More | | | Sulfametopyrazine | hsa04724 | Glutamatergic synapse | 5.94E-03 | 4 | O15399, P63218, P50151, P15104 | GRIN2D, GNG5, GNG10, GLUL | More | | | Sulfametopyrazine | hsa04725 | Cholinergic synapse | 4.10E-02 | 3 | P63218, P50151, P42338 | GNG5, GNG10, PIK3CB | More | | | Sulfametopyrazine | hsa04727 | GABAergic synapse | 1.63E-02 | 3 | P63218, P50151, P15104 | GNG5, GNG10, GLUL | More | | | Sulfametopyrazine | hsa04914 | Progesterone-mediated oocyte maturation | 2.94E-02 | 3 | Q17RY0, P51812, Q02750 | CPEB4, RPS6KA3, MAP2K1 | More | | | Sulfametopyrazine | hsa04924 | Renin secretion | 3.64E-02 | 3 | P22694, P07550, Q14643 | PRKACB, ADRB2, ITPR1 | More | | | Sulfametopyrazine | hsa04926 | Relaxin signaling pathway | 5.70E-03 | 5 | P42338, P63218, P50151, P49767, P49407 | PIK3CB, GNG5, GNG10, VEGFC, ARRB1 | More | | | Sulfametopyrazine | hsa04927 | Cortisol synthesis and secretion | 1.66E-02 | 3 | Q14643, P18848, P22694 | ITPR1, ATF4, PRKACB | More | | | Sulfametopyrazine | hsa04929 | GnRH secretion | 4.62E-02 | 2 | P42338, P49407 | PIK3CB, ARRB1 | More | | | Sulfametopyrazine | hsa04940 | Type I diabetes mellitus | 3.64E-02 | 3 | P10747, P13765, P01375 | CD28, HLA-DOB, TNF | More | | | Sulfametopyrazine | hsa04964 | Proximal tubule bicarbonate reclamation | 4.93E-02 | 1 | P00918 | CA2 | More | | | Sulfametopyrazine | hsa04966 | Collecting duct acid secretion | 4.93E-02 | 1 | P00918 | CA2 | More | | | Sulfametopyrazine | hsa04970 | Salivary secretion | 4.92E-02 | 4 | P07550, P22694, Q14643, P49913 | ADRB2, PRKACB, ITPR1, CAMP | More | | | Sulfametopyrazine | hsa05133 | Pertussis | 4.20E-02 | 1 | P0C0L4 | C4A | More | | | Sulfametopyrazine | hsa05143 | African trypanosomiasis | 1.31E-02 | 2 | P69905, P68871 | HBA2, HBB | More | | | Sulfametopyrazine | hsa05144 | Malaria | 6.79E-03 | 6 | P69905, P68871, O60603, P01375, P35443, P26718 | HBA2, HBB, TLR2, TNF, THBS4, KLRK1 | More | | | Sulfametopyrazine | hsa05146 | Amoebiasis | 1.48E-02 | 7 | P09341, P27930, P01375, O60603, P05089, P22694, P08311 | CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG | More | | | Sulfametopyrazine | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 1.94E-02 | 4 | P62879, P16298, Q02750, P0CG47 | GNB2, PPP3CB, MAP2K1, UBB | More | | | Sulfametopyrazine | hsa05169 | Epstein-Barr virus infection | 3.72E-02 | 6 | Q13547, P42338, P07948, Q13761, O75293, P07766 | HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3E | More | | | Sulfametopyrazine | hsa05170 | Human immunodeficiency virus 1 infection | 6.02E-03 | 5 | Q02750, P62879, P16298, Q05397, P20333 | MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B | More | | | Sulfametopyrazine | hsa05202 | Transcriptional misregulation in cancer | 3.71E-02 | 11 | P14780, P27930, Q15744, Q16548, P35226, P05164, P12838, P08246, Q9C0K0, P12980, P24522 | MMP9, IL1R2, CEBPE, BCL2A1, BMI1, MPO, DEFA4, ELA2, BCL11B, LYL1, GADD45A | More | | | Sulfametopyrazine | hsa05213 | Endometrial cancer | 3.79E-02 | 2 | O15169, Q02750 | AXIN1, MAP2K1 | More | | | Sulfametopyrazine | hsa05226 | Gastric cancer | 3.79E-02 | 2 | Q02750, O15169 | MAP2K1, AXIN1 | More | | | Sulfametopyrazine | hsa05310 | Asthma | 1.66E-02 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Sulfametopyrazine | hsa05321 | Inflammatory bowel disease | 1.14E-03 | 6 | O60603, P01375, P13765, Q14765, Q9UL17, P23771 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3 | More | | | Sulfametopyrazine | hsa05323 | Rheumatoid arthritis | 1.58E-02 | 5 | P01375, P13765, P10747, P09341, O60603 | TNF, HLA-DOB, CD28, CXCL1, TLR2 | More | | | Sulfametopyrazine | hsa05332 | Graft-versus-host disease | 2.03E-03 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | | Sulfametopyrazine | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.93E-02 | 1 | P54284 | CACNB3 | More | |
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