PharmaCoNets

PharmaCoNets of Sulfamethoxazole (S_PCN: 66.00 )

Sulfamethoxazole regulated-network (S_DN: 15.42)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Sulfamethoxazole

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Sulfamethoxazole

hsa00190

Oxidative phosphorylation

8.71E-03

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Sulfamethoxazole

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Sulfamethoxazole

hsa00630

Glyoxylate and dicarboxylate metabolism

5.34E-03

P40925, P15104

MDH1, GLUL

Sulfamethoxazole

hsa01524

Platinum drug resistance

4.78E-02

P31751

AKT2

Sulfamethoxazole

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Sulfamethoxazole

hsa03013

RNA transport

3.98E-02

P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Sulfamethoxazole

hsa03040

Spliceosome

4.19E-02

Q14562, O60508, P08579, Q01130, O43447

DHX8, CDC40, SNRPB2, SFRS2, PPIH

Sulfamethoxazole

hsa04014

Ras signaling pathway

7.30E-03

P31751, P0DP23

AKT2, CALM1

Sulfamethoxazole

hsa04015

Rap1 signaling pathway

6.14E-03

P31751, P0DP23

AKT2, CALM1

Sulfamethoxazole

hsa04022

cGMP-PKG signaling pathway

5.07E-03

P31751, P0DP23

AKT2, CALM1

Sulfamethoxazole

hsa04024

cAMP signaling pathway

3.23E-03

P31751, P0DP23

AKT2, CALM1

Sulfamethoxazole

hsa04064

NF-kappa B signaling pathway

3.99E-02

P10415, Q13489, P29965, Q9UDY8, Q8WV28, Q13315

BCL2, BIRC3, CD40LG, MALT1, BLNK, ATM

Sulfamethoxazole

hsa04070

Phosphatidylinositol signaling system

3.47E-02

P0DP23, Q14643, P23743, P17252

CALM1, ITPR1, DGKA, PRKCA

Sulfamethoxazole

hsa04071

Sphingolipid signaling pathway

1.35E-04

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Sulfamethoxazole

hsa04140

Autophagy - animal

3.72E-02

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Sulfamethoxazole

hsa04145

Phagosome

1.59E-03

Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOB

Sulfamethoxazole

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Sulfamethoxazole

hsa04151

PI3K-Akt signaling pathway

4.50E-02

P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252

F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCA

Sulfamethoxazole

hsa04217

Necroptosis

9.14E-03

P01568, Q13489, P42224, Q6FI13, P10415, O43633, Q08752

IFNA21, BIRC3, STAT1, H2AC18; H2AC19, BCL2, CHMP2A, PPID

Sulfamethoxazole

hsa04218

Cellular senescence

3.65E-03

P31751, P0DP23

AKT2, CALM1

Sulfamethoxazole

hsa04261

Adrenergic signaling in cardiomyocytes

4.30E-03

P09493, P31751, Q13362, P0DP23, P17252, P10415

TPM1, AKT2, PPP2R5C, CALM1, PRKCA, BCL2

Sulfamethoxazole

hsa04370

VEGF signaling pathway

3.60E-02

P31751

AKT2

Sulfamethoxazole

hsa04371

Apelin signaling pathway

3.23E-03

P31751, P0DP23

AKT2, CALM1

Sulfamethoxazole

hsa04380

Osteoclast differentiation

2.11E-03

Q9NQC7, P31751

CYLD, AKT2

Sulfamethoxazole

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Sulfamethoxazole

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Sulfamethoxazole

hsa04612

Antigen processing and presentation

2.84E-02

P13765, P48382, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Sulfamethoxazole

hsa04613

Neutrophil extracellular trap formation

1.74E-04

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
Q9UM07	PADI4	Protein-arginine deiminase type-4	O60603	TLR2	Toll-like receptor 2	0.772
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9UM07	PADI4	Protein-arginine deiminase type-4	1
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.707
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15080	NCF4	Neutrophil cytosol factor 4	0.795
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
Q9UM07	PADI4	Protein-arginine deiminase type-4	P20160	AZU1	Azurocidin	0.884
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08311	CTSG	Cathepsin G	0.884
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
Q9UM07	PADI4	Protein-arginine deiminase type-4	P49913	CAMP	Cathelicidin antimicrobial peptide	0.737
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.825
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731
Q9UM07	PADI4	Protein-arginine deiminase type-4	P21462	FPR1	fMet-Leu-Phe receptor	0.733
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767

Sulfamethoxazole

hsa04620

Toll-like receptor signaling pathway

4.78E-02

P31751

AKT2

Sulfamethoxazole

hsa04622

RIG-I-like receptor signaling pathway

1.81E-02

Q9NQC7

CYLD

Sulfamethoxazole

hsa04625

C-type lectin receptor signaling pathway

1.38E-05

Q9NQC7, P31751, P0DP23

CYLD, AKT2, CALM1

Sulfamethoxazole

hsa04640

Hematopoietic cell lineage

3.58E-02

P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375

ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF

Sulfamethoxazole

hsa04657

IL-17 signaling pathway

4.98E-02

O00463, Q16539, P14780, Q9UJX4, P80188, P01375

TRAF5, MAPK14, MMP9, ANAPC5, LCN2, TNF

Sulfamethoxazole

hsa04658

Th1 and Th2 cell differentiation

1.48E-02

Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765

PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOB

Sulfamethoxazole

hsa04660

T cell receptor signaling pathway

3.19E-03

P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191

TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB

Sulfamethoxazole

hsa04662

B cell receptor signaling pathway

1.60E-04

P31751, P42338, P60033, P07948, P21854, Q8N149

AKT2, PIK3CB, CD81, LYN, CD72, LILRA2

Sulfamethoxazole

hsa04664

Fc epsilon RI signaling pathway

4.79E-03

P31751, P42338, P07948, P09917

AKT2, PIK3CB, LYN, ALOX5

Sulfamethoxazole

hsa04672

Intestinal immune network for IgA production

1.27E-04

P29965, P10747, P13765, P13612

CD40LG, CD28, HLA-DOB, ITGA4

Sulfamethoxazole

hsa04713

Circadian entrainment

2.60E-02

P0DP23, P17252, P62873, Q14643

CALM1, PRKCA, GNB1, ITPR1

Sulfamethoxazole

hsa04720

Long-term potentiation

3.89E-02

P17252, P0DP23, Q14643

PRKCA, CALM1, ITPR1

Sulfamethoxazole

hsa04722

Neurotrophin signaling pathway

2.83E-03

P31751, P0DP23

AKT2, CALM1

Sulfamethoxazole

hsa04723

Retrograde endocannabinoid signaling

1.88E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Sulfamethoxazole

hsa04724

Glutamatergic synapse

5.94E-03

O15399, P63218, P50151, P15104

GRIN2D, GNG5, GNG10, GLUL

Sulfamethoxazole

hsa04725

Cholinergic synapse

1.90E-03

Q14643, P17252, P62873, P63218, P50151, P42338, P10415

ITPR1, PRKCA, GNB1, GNG5, GNG10, PIK3CB, BCL2

Sulfamethoxazole

hsa04727

GABAergic synapse

1.63E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Sulfamethoxazole

hsa04728

Dopaminergic synapse

3.09E-03

Q14643, P17252, P62873, P31751, Q13362, P0DP23

ITPR1, PRKCA, GNB1, AKT2, PPP2R5C, CALM1

Sulfamethoxazole

hsa04740

Olfactory transduction

2.41E-02

P0DP23

CALM1

Sulfamethoxazole

hsa04744

Phototransduction

1.74E-03

P62873, P0DP23

GNB1, CALM1

Sulfamethoxazole

hsa04910

Insulin signaling pathway

9.82E-04

P0DP23, P31751

CALM1, AKT2

Sulfamethoxazole

hsa04912

GnRH signaling pathway

3.89E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Sulfamethoxazole

hsa04915

Estrogen signaling pathway

5.07E-03

P31751, P0DP23

AKT2, CALM1

Sulfamethoxazole

hsa04916

Melanogenesis

4.78E-02

P0DP23

CALM1

Sulfamethoxazole

hsa04917

Prolactin signaling pathway

2.41E-02

P31751

AKT2

Sulfamethoxazole

hsa04920

Adipocytokine signaling pathway

4.19E-02

P31751

AKT2

Sulfamethoxazole

hsa04922

Glucagon signaling pathway

2.33E-03

Q12778, P31751, Q13370, P0DP23, Q14643

FOXO1, AKT2, PDE3B, CALM1, ITPR1

Sulfamethoxazole

hsa04923

Regulation of lipolysis in adipocytes

3.01E-02

P31751

AKT2

Sulfamethoxazole

hsa04924

Renin secretion

2.43E-04

P22694, P07550, Q14643, Q13370, P0DP23

PRKACB, ADRB2, ITPR1, PDE3B, CALM1

Sulfamethoxazole

hsa04926

Relaxin signaling pathway

5.70E-03

P42338, P63218, P50151, P49767, P49407

PIK3CB, GNG5, GNG10, VEGFC, ARRB1

Sulfamethoxazole

hsa04927

Cortisol synthesis and secretion

1.66E-02

Q14643, P18848, P22694

ITPR1, ATF4, PRKACB

Sulfamethoxazole

hsa04929

GnRH secretion

3.61E-03

P42338, P31751, P49407

PIK3CB, AKT2, ARRB1

Sulfamethoxazole

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.27E-02

P42224, P10415, Q12778, P49767, P17252

STAT1, BCL2, FOXO1, VEGFC, PRKCA

Sulfamethoxazole

hsa04940

Type I diabetes mellitus

3.64E-02

P10747, P13765, P01375

CD28, HLA-DOB, TNF

Sulfamethoxazole

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Sulfamethoxazole

hsa04966

Collecting duct acid secretion

2.07E-03

Q13488, P00918, Q9Y666

TCIRG1, CA2, SLC12A7

Sulfamethoxazole

hsa04970

Salivary secretion

1.31E-02

P07550, P22694, Q14643, P0DP23, P49913

ADRB2, PRKACB, ITPR1, CALM1, CAMP

Sulfamethoxazole

hsa04971

Gastric acid secretion

4.78E-02

P0DP23

CALM1

Sulfamethoxazole

hsa04973

Carbohydrate digestion and absorption

2.41E-02

P31751

AKT2

Sulfamethoxazole

hsa05010

Alzheimer disease

7.72E-03

Q16718, O14521, Q14643, Q00535, P0DP23, Q13509, P68371, P31751, Q08752

NDUFA5, SDHD, ITPR1, CDK5, CALM1, TUBB3, TUBB2C, AKT2, PPID

Sulfamethoxazole

hsa05012

Parkinson disease

2.25E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C

Sulfamethoxazole

hsa05020

Prion disease

1.15E-02

Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4

Sulfamethoxazole

hsa05022

Pathways of neurodegeneration - multiple diseases

4.00E-03

Q14643, Q13509, P68371, P10415, Q16718, O14521, Q13561, P17252, Q00535, Q08752, P0DP23

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, CDK5, PPID, CALM1

Sulfamethoxazole

hsa05030

Cocaine addiction

4.19E-02

Q00535

CDK5

Sulfamethoxazole

hsa05031

Amphetamine addiction

4.78E-02

P0DP23

CALM1

Sulfamethoxazole

hsa05131

Shigellosis

2.27E-02

P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752

H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID

Sulfamethoxazole

hsa05132

Salmonella infection

1.11E-02

Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371

LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Sulfamethoxazole

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Sulfamethoxazole

hsa05140

Leishmaniasis

2.17E-03

P14598, P42224, P13765, O60603, P29350, Q15080

NCF1, STAT1, HLA-DOB, TLR2, PTPN6, NCF4

Sulfamethoxazole

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Sulfamethoxazole

hsa05144

Malaria

6.79E-03

P69905, P68871, O60603, P01375, P35443, P26718

HBA2, HBB, TLR2, TNF, THBS4, KLRK1

Sulfamethoxazole

hsa05145

Toxoplasmosis

1.11E-02

P10415, Q13489, P42224, P13765, O60603, P29965

BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG

Sulfamethoxazole

hsa05146

Amoebiasis

1.48E-02

P09341, P27930, P01375, O60603, P05089, P22694, P08311

CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG

Sulfamethoxazole

hsa05152

Tuberculosis

3.87E-04

Q13488, P0DP23, P42224, O60603, P31751, P10415, P13765, P01568, Q9UDY8

TCIRG1, CALM1, STAT1, TLR2, AKT2, BCL2, HLA-DOB, IFNA21, MALT1

Sulfamethoxazole

hsa05163

Human cytomegalovirus infection

1.21E-02

P31751, P0DP23

AKT2, CALM1

Sulfamethoxazole

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Sulfamethoxazole

hsa05167

Kaposi sarcoma-associated herpesvirus infection

4.53E-03

P01568, P31751, P42224, P62873, Q14643, P0DP23, Q9UJU2

IFNA21, AKT2, STAT1, GNB1, ITPR1, CALM1, LEF1

Sulfamethoxazole

hsa05169

Epstein-Barr virus infection

3.72E-02

Q13547, P42338, P07948, Q13761, O75293, P07766

HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3E

Sulfamethoxazole

hsa05170

Human immunodeficiency virus 1 infection

2.70E-04

P31751, P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5

AKT2, GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2

Sulfamethoxazole

hsa05200

Pathways in cancer

8.38E-03

P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P31751, P25116, P62873, P0DP23, P01568

STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, AKT2, F2R, GNB1, CALM1, IFNA21

Sulfamethoxazole

hsa05202

Transcriptional misregulation in cancer

1.78E-03

Q15532, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P12980, P24522

SS18, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
Q9UM07	PADI4	Protein-arginine deiminase type-4	P14780	MMP9	Matrix metalloproteinase-9	0.9
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
Q9UM07	PADI4	Protein-arginine deiminase type-4	P27930	IL1R2	Interleukin-1 receptor type 2	0.721
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.772
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q16548	BCL2A1	Bcl-2-related protein A1	0.776
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	P35226	BMI1	Polycomb complex protein BMI-1	-0.716
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
Q9UM07	PADI4	Protein-arginine deiminase type-4	P05164	MPO	Myeloperoxidase	0.909
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12838	DEFA4	Neutrophil defensin 4	0.882
Q9UM07	PADI4	Protein-arginine deiminase type-4	P08246	ELA2	Neutrophil elastase	0.889
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
Q9UM07	PADI4	Protein-arginine deiminase type-4	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.85
Q9UM07	PADI4	Protein-arginine deiminase type-4	P12980	LYL1	Protein lyl-1	0.702
Q9UM07	PADI4	Protein-arginine deiminase type-4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.859
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769

Sulfamethoxazole

hsa05211

Renal cell carcinoma

4.78E-02

P31751

AKT2

Sulfamethoxazole

hsa05212

Pancreatic cancer

4.78E-02

P31751

AKT2

Sulfamethoxazole

hsa05213

Endometrial cancer

3.60E-02

P31751

AKT2

Sulfamethoxazole

hsa05214

Glioma

5.75E-04

P0DP23, P31751

CALM1, AKT2

Sulfamethoxazole

hsa05218

Melanoma

3.01E-02

P31751

AKT2

Sulfamethoxazole

hsa05220

Chronic myeloid leukemia

4.19E-02

P31751

AKT2

Sulfamethoxazole

hsa05221

Acute myeloid leukemia

4.19E-02

P31751

AKT2

Sulfamethoxazole

hsa05222

Small cell lung cancer

4.78E-02

P31751

AKT2

Sulfamethoxazole

hsa05223

Non-small cell lung cancer

2.41E-02

P31751

AKT2

Sulfamethoxazole

hsa05226

Gastric cancer

3.60E-02

P31751

AKT2

Sulfamethoxazole

hsa05230

Central carbon metabolism in cancer

4.78E-02

P31751

AKT2

Sulfamethoxazole

hsa05310

Asthma

1.66E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Sulfamethoxazole

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Sulfamethoxazole

hsa05321

Inflammatory bowel disease

1.14E-03

O60603, P01375, P13765, Q14765, Q9UL17, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3

Sulfamethoxazole

hsa05322

Systemic lupus erythematosus

4.18E-03

P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431

ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Sulfamethoxazole

hsa05323

Rheumatoid arthritis

5.62E-04

P01375, P13765, Q13488, P10747, P09341, O60603

TNF, HLA-DOB, TCIRG1, CD28, CXCL1, TLR2

Sulfamethoxazole

hsa05330

Allograft rejection

1.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Sulfamethoxazole

hsa05332

Graft-versus-host disease

2.03E-03

P13765, P10747, P01375, P26715, Q13241

HLA-DOB, CD28, TNF, KLRC1, KLRD1

Sulfamethoxazole

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Sulfamethoxazole

hsa05415

Diabetic cardiomyopathy

3.55E-02

P17252, P14598, Q15080, Q16718, O14521

PRKCA, NCF1, NCF4, NDUFA5, SDHD

Sulfamethoxazole

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Sulfamethoxazole

hsa05418

Fluid shear stress and atherosclerosis

3.65E-03

P31751, P0DP23

AKT2, CALM1

Community members of Sulfamethoxazole (S_DC: 4.28)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

PADI4

ProteinNonearginine deiminase typeNone4

Predicted

0.1488

0.2778

0.4267

1.0567

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P17252

PRKCA

Protein kinase C alpha type

Predicted

0.1409

0.6948

2.4601

P31751

AKT2

RACNonebeta serine/threonineNoneprotein kinase

Predicted

0.4662

0.4856

2.2044

P22748

CA4

Carbonic anhydrase 4

Predicted

0.0056

0.8267

0.1609

1.8171

PharmaCoNets of Sulfamethoxazole (SPCN: 66.00 )

Sulfamethoxazole regulated-network (SDN: 15.42)

Community members of Sulfamethoxazole (SDC: 4.28)

PharmaCoNets of Sulfamethoxazole (S_PCN: 66.00 )

Sulfamethoxazole regulated-network (S_DN: 15.42)

Community members of Sulfamethoxazole (S_DC: 4.28)