| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
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| Sulfamethizole | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Sulfamethizole | hsa00190 | Oxidative phosphorylation | 8.71E-03 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Sulfamethizole | hsa00565 | Ether lipid metabolism | 4.93E-02 | 1 | Q8N661 | TMEM86B | More | | | Sulfamethizole | hsa00630 | Glyoxylate and dicarboxylate metabolism | 5.34E-03 | 2 | P40925, P15104 | MDH1, GLUL | More | | | Sulfamethizole | hsa02010 | ABC transporters | 4.93E-02 | 1 | Q8IZY2 | ABCA7 | More | | | Sulfamethizole | hsa03013 | RNA transport | 3.98E-02 | 9 | P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5 | NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3 | More | | | Sulfamethizole | hsa03040 | Spliceosome | 4.19E-02 | 5 | Q14562, O60508, P08579, Q01130, O43447 | DHX8, CDC40, SNRPB2, SFRS2, PPIH | More | | | Sulfamethizole | hsa04064 | NF-kappa B signaling pathway | 3.99E-02 | 6 | P10415, Q13489, P29965, Q9UDY8, Q8WV28, Q13315 | BCL2, BIRC3, CD40LG, MALT1, BLNK, ATM | More | | | Sulfamethizole | hsa04070 | Phosphatidylinositol signaling system | 3.47E-02 | 4 | P0DP23, Q14643, P23743, P17252 | CALM1, ITPR1, DGKA, PRKCA | More | | | Sulfamethizole | hsa04071 | Sphingolipid signaling pathway | 1.35E-04 | 8 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2 | More | | | Sulfamethizole | hsa04140 | Autophagy - animal | 3.72E-02 | 5 | P22694, Q14643, P10415, Q9H1Y0, Q04759 | PRKACB, ITPR1, BCL2, ATG5, PRKCQ | More | | | Sulfamethizole | hsa04145 | Phagosome | 1.59E-03 | 7 | Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765 | NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOB | More | | | Sulfamethizole | hsa04146 | Peroxisome | 2.42E-02 | 5 | O43933, P56589, Q9UKG9, O75521, P33121 | PEX1, PEX3, CROT, ECI2, ACSL1 | More | | | Sulfamethizole | hsa04151 | PI3K-Akt signaling pathway | 4.50E-02 | 9 | P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252 | F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCA | More | | | Sulfamethizole | hsa04217 | Necroptosis | 9.14E-03 | 7 | P01568, Q13489, P42224, Q6FI13, P10415, O43633, Q08752 | IFNA21, BIRC3, STAT1, H2AC18; H2AC19, BCL2, CHMP2A, PPID | More | | | Sulfamethizole | hsa04261 | Adrenergic signaling in cardiomyocytes | 2.84E-02 | 5 | P09493, Q13362, P0DP23, P17252, P10415 | TPM1, PPP2R5C, CALM1, PRKCA, BCL2 | More | | | Sulfamethizole | hsa04540 | Gap junction | 1.29E-02 | 4 | P17252, Q13509, P68371, Q14643 | PRKCA, TUBB3, TUBB2C, ITPR1 | More | | | Sulfamethizole | hsa04610 | Complement and coagulation cascades | 2.33E-03 | 1 | P0C0L4 | C4A | More | | | Sulfamethizole | hsa04612 | Antigen processing and presentation | 2.84E-02 | 7 | P13765, P48382, P26715, P26717, Q13241, P01732, P01375 | HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNF | More | | | Sulfamethizole | hsa04613 | Neutrophil extracellular trap formation | 1.74E-04 | 17 | P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539 | PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | | Sulfamethizole | hsa04640 | Hematopoietic cell lineage | 3.58E-02 | 8 | P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375 | ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNF | More | | | Sulfamethizole | hsa04657 | IL-17 signaling pathway | 4.98E-02 | 6 | O00463, Q16539, P14780, Q9UJX4, P80188, P01375 | TRAF5, MAPK14, MMP9, ANAPC5, LCN2, TNF | More | | | Sulfamethizole | hsa04658 | Th1 and Th2 cell differentiation | 1.48E-02 | 7 | Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765 | PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOB | More | | | Sulfamethizole | hsa04660 | T cell receptor signaling pathway | 3.19E-03 | 10 | P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191 | TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB | More | | | Sulfamethizole | hsa04662 | B cell receptor signaling pathway | 1.49E-03 | 5 | P42338, P60033, P07948, P21854, Q8N149 | PIK3CB, CD81, LYN, CD72, LILRA2 | More | | | Sulfamethizole | hsa04664 | Fc epsilon RI signaling pathway | 2.32E-02 | 3 | P42338, P07948, P09917 | PIK3CB, LYN, ALOX5 | More | | | Sulfamethizole | hsa04672 | Intestinal immune network for IgA production | 1.27E-04 | 4 | P29965, P10747, P13765, P13612 | CD40LG, CD28, HLA-DOB, ITGA4 | More | | | Sulfamethizole | hsa04713 | Circadian entrainment | 2.60E-02 | 4 | P0DP23, P17252, P62873, Q14643 | CALM1, PRKCA, GNB1, ITPR1 | More | | | Sulfamethizole | hsa04720 | Long-term potentiation | 3.89E-02 | 3 | P17252, P0DP23, Q14643 | PRKCA, CALM1, ITPR1 | More | | | Sulfamethizole | hsa04723 | Retrograde endocannabinoid signaling | 1.88E-02 | 4 | Q14643, P17252, P62873, Q16718 | ITPR1, PRKCA, GNB1, NDUFA5 | More | | | Sulfamethizole | hsa04724 | Glutamatergic synapse | 5.94E-03 | 4 | O15399, P63218, P50151, P15104 | GRIN2D, GNG5, GNG10, GLUL | More | | | Sulfamethizole | hsa04725 | Cholinergic synapse | 1.90E-03 | 7 | Q14643, P17252, P62873, P63218, P50151, P42338, P10415 | ITPR1, PRKCA, GNB1, GNG5, GNG10, PIK3CB, BCL2 | More | | | Sulfamethizole | hsa04727 | GABAergic synapse | 1.63E-02 | 3 | P63218, P50151, P15104 | GNG5, GNG10, GLUL | More | | | Sulfamethizole | hsa04728 | Dopaminergic synapse | 3.55E-02 | 5 | Q14643, P17252, P62873, Q13362, P0DP23 | ITPR1, PRKCA, GNB1, PPP2R5C, CALM1 | More | | | Sulfamethizole | hsa04744 | Phototransduction | 1.02E-02 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | | | Sulfamethizole | hsa04912 | GnRH signaling pathway | 3.89E-02 | 3 | P17252, Q14643, P0DP23 | PRKCA, ITPR1, CALM1 | More | | | Sulfamethizole | hsa04922 | Glucagon signaling pathway | 3.47E-02 | 4 | Q12778, Q13370, P0DP23, Q14643 | FOXO1, PDE3B, CALM1, ITPR1 | More | | | Sulfamethizole | hsa04924 | Renin secretion | 7.51E-04 | 5 | P22694, P07550, Q14643, Q13370, P0DP23 | PRKACB, ADRB2, ITPR1, PDE3B, CALM1 | More | | | Sulfamethizole | hsa04926 | Relaxin signaling pathway | 5.70E-03 | 5 | P42338, P63218, P50151, P49767, P49407 | PIK3CB, GNG5, GNG10, VEGFC, ARRB1 | More | | | Sulfamethizole | hsa04927 | Cortisol synthesis and secretion | 1.66E-02 | 3 | Q14643, P18848, P22694 | ITPR1, ATF4, PRKACB | More | | | Sulfamethizole | hsa04929 | GnRH secretion | 4.62E-02 | 2 | P42338, P49407 | PIK3CB, ARRB1 | More | | | Sulfamethizole | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.27E-02 | 5 | P42224, P10415, Q12778, P49767, P17252 | STAT1, BCL2, FOXO1, VEGFC, PRKCA | More | | | Sulfamethizole | hsa04940 | Type I diabetes mellitus | 3.64E-02 | 3 | P10747, P13765, P01375 | CD28, HLA-DOB, TNF | More | | | Sulfamethizole | hsa04964 | Proximal tubule bicarbonate reclamation | 4.93E-02 | 1 | P00918 | CA2 | More | | | Sulfamethizole | hsa04966 | Collecting duct acid secretion | 2.07E-03 | 3 | Q13488, P00918, Q9Y666 | TCIRG1, CA2, SLC12A7 | More | | | Sulfamethizole | hsa04970 | Salivary secretion | 4.92E-02 | 4 | P07550, P22694, Q14643, P49913 | ADRB2, PRKACB, ITPR1, CAMP | More | | | Sulfamethizole | hsa05010 | Alzheimer disease | 3.55E-02 | 7 | Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752 | NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPID | More | | | Sulfamethizole | hsa05012 | Parkinson disease | 2.25E-02 | 6 | Q16718, O14521, Q14643, P0DP23, Q13509, P68371 | NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C | More | | | Sulfamethizole | hsa05020 | Prion disease | 1.15E-02 | 7 | Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080 | NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4 | More | | | Sulfamethizole | hsa05022 | Pathways of neurodegeneration - multiple diseases | 4.48E-03 | 10 | Q14643, Q13509, P68371, P10415, Q16718, O14521, Q13561, P17252, Q08752, P0DP23 | ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, PPID, CALM1 | More | | | Sulfamethizole | hsa05131 | Shigellosis | 2.27E-02 | 8 | P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID | More | | | Sulfamethizole | hsa05132 | Salmonella infection | 1.11E-02 | 8 | Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371 | LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C | More | | | Sulfamethizole | hsa05133 | Pertussis | 4.20E-02 | 1 | P0C0L4 | C4A | More | | | Sulfamethizole | hsa05140 | Leishmaniasis | 2.17E-03 | 6 | P14598, P42224, P13765, O60603, P29350, Q15080 | NCF1, STAT1, HLA-DOB, TLR2, PTPN6, NCF4 | More | | | Sulfamethizole | hsa05143 | African trypanosomiasis | 1.31E-02 | 2 | P69905, P68871 | HBA2, HBB | More | | | Sulfamethizole | hsa05144 | Malaria | 6.79E-03 | 6 | P69905, P68871, O60603, P01375, P35443, P26718 | HBA2, HBB, TLR2, TNF, THBS4, KLRK1 | More | | | Sulfamethizole | hsa05145 | Toxoplasmosis | 1.11E-02 | 6 | P10415, Q13489, P42224, P13765, O60603, P29965 | BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG | More | | | Sulfamethizole | hsa05146 | Amoebiasis | 1.48E-02 | 7 | P09341, P27930, P01375, O60603, P05089, P22694, P08311 | CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSG | More | | | Sulfamethizole | hsa05152 | Tuberculosis | 7.93E-04 | 8 | Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8 | TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1 | More | | | Sulfamethizole | hsa05165 | Human papillomavirus infection | 3.10E-02 | 8 | P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315 | ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM | More | | | Sulfamethizole | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 4.73E-02 | 6 | P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2 | IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1 | More | | | Sulfamethizole | hsa05169 | Epstein-Barr virus infection | 3.72E-02 | 6 | Q13547, P42338, P07948, Q13761, O75293, P07766 | HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3E | More | | | Sulfamethizole | hsa05170 | Human immunodeficiency virus 1 infection | 4.67E-03 | 9 | P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5 | GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2 | More | | | Sulfamethizole | hsa05200 | Pathways in cancer | 4.99E-02 | 12 | P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568 | STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21 | More | | | Sulfamethizole | hsa05202 | Transcriptional misregulation in cancer | 1.78E-03 | 16 | Q15532, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P12980, P24522 | SS18, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, LYL1, GADD45A | More | | | Sulfamethizole | hsa05310 | Asthma | 1.66E-02 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Sulfamethizole | hsa05320 | Autoimmune thyroid disease | 1.27E-03 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | | | Sulfamethizole | hsa05321 | Inflammatory bowel disease | 1.14E-03 | 6 | O60603, P01375, P13765, Q14765, Q9UL17, P23771 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3 | More | | | Sulfamethizole | hsa05322 | Systemic lupus erythematosus | 4.18E-03 | 7 | P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431 | ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Sulfamethizole | hsa05323 | Rheumatoid arthritis | 5.62E-04 | 6 | P01375, P13765, Q13488, P10747, P09341, O60603 | TNF, HLA-DOB, TCIRG1, CD28, CXCL1, TLR2 | More | | | Sulfamethizole | hsa05330 | Allograft rejection | 1.62E-02 | 3 | P13765, P29965, P10747 | HLA-DOB, CD40LG, CD28 | More | | | Sulfamethizole | hsa05332 | Graft-versus-host disease | 2.03E-03 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | | Sulfamethizole | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.93E-02 | 1 | P54284 | CACNB3 | More | | | Sulfamethizole | hsa05415 | Diabetic cardiomyopathy | 3.55E-02 | 5 | P17252, P14598, Q15080, Q16718, O14521 | PRKCA, NCF1, NCF4, NDUFA5, SDHD | More | | | Sulfamethizole | hsa05416 | Viral myocarditis | 2.62E-02 | 3 | P13765, P29965, P10747 | HLA-DOB, CD40LG, CD28 | More | |
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