PharmaCoNets of Sulfadoxine (SPCN: 20.61 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Sulfadoxinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Sulfadoxinehsa00220Arginine biosynthesis1.21E-021P15104GLULMore
Sulfadoxinehsa00230Purine metabolism4.02E-022P31350, P21589RRM2, NT5EMore
Sulfadoxinehsa00240Pyrimidine metabolism2.54E-043P31350, P21589, P04818RRM2, NT5E, TYMSMore
Sulfadoxinehsa00250Alanine, aspartate and glutamate metabolism2.42E-021P15104GLULMore
Sulfadoxinehsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Sulfadoxinehsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Sulfadoxinehsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Sulfadoxinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Sulfadoxinehsa00630Glyoxylate and dicarboxylate metabolism9.21E-032P40925, P15104MDH1, GLULMore
Sulfadoxinehsa00670One carbon pool by folate3.62E-021P00374DHFRMore
Sulfadoxinehsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Sulfadoxinehsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Sulfadoxinehsa00910Nitrogen metabolism2.42E-021P15104GLULMore
Sulfadoxinehsa01230Biosynthesis of amino acids5.53E-032P15104, P37837GLUL, TALDO1More
Sulfadoxinehsa01523Antifolate resistance6.06E-032Q92820, P04818GGH, TYMSMore
Sulfadoxinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Sulfadoxinehsa03040Spliceosome1.08E-027Q14562, O43143, O60508, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, SFRS1, SFRS2, SFRS5, HSPA8More
Sulfadoxinehsa04014Ras signaling pathway8.66E-037Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Sulfadoxinehsa04062Chemokine signaling pathway1.59E-039P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIAMore
Sulfadoxinehsa04070Phosphatidylinositol signaling system2.93E-024P19174, P0DP23, P23743, P27987PLCG1, CALM1, DGKA, ITPKBMore
Sulfadoxinehsa04110Cell cycle2.34E-023P06493, O60566, P33981CDK1, BUB1B, TTKMore
Sulfadoxinehsa04115p53 signaling pathway3.34E-022P31350, P06493RRM2, CDK1More
Sulfadoxinehsa04141Protein processing in endoplasmic reticulum8.60E-036P30101, P60604, P11142, P08238, Q9H173, Q9UNL2PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3More
Sulfadoxinehsa04142Lysosome2.64E-022Q99437, P25774ATP6V0B, CTSSMore
Sulfadoxinehsa04145Phagosome2.53E-038P11215, P14598, Q71U36, Q13509, P68371, Q13488, Q99437, P25774ITGAM, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, ATP6V0B, CTSSMore
Sulfadoxinehsa04371Apelin signaling pathway7.95E-047P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1More
Sulfadoxinehsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Sulfadoxinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Sulfadoxinehsa04623Cytosolic DNA-sensing pathway2.59E-022P01568, P25963IFNA21, NFKBIAMore
Sulfadoxinehsa04650Natural killer cell mediated cytotoxicity4.40E-026P78314, P06239, O60880, P20963, P26718, O75015SH3BP2, LCK, SH2D1A, CD247, KLRK1, FCGR3BMore
Sulfadoxinehsa04658Th1 and Th2 cell differentiation9.73E-036P20963, P09693, Q16539, P06239, Q9UL17, P13765CD247, CD3G, MAPK14, LCK, TBX21, HLA-DOBMore
Sulfadoxinehsa04659Th17 cell differentiation2.50E-0413P25963, Q16539, P19174, P06239, P42224, P14784, P13765, P14778, Q9UL17, P84022, P08238, P09693, P20963NFKBIA, MAPK14, PLCG1, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, SMAD3, HSP90AB1, CD3G, CD247More
Sulfadoxinehsa04664Fc epsilon RI signaling pathway6.97E-034P04141, P07948, P19174, P09917CSF2, LYN, PLCG1, ALOX5More
Sulfadoxinehsa04713Circadian entrainment2.18E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Sulfadoxinehsa04724Glutamatergic synapse1.57E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Sulfadoxinehsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Sulfadoxinehsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Sulfadoxinehsa04730Long-term depression4.86E-022Q14344, P07948GNA13, LYNMore
Sulfadoxinehsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Sulfadoxinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Sulfadoxinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Sulfadoxinehsa05012Parkinson disease1.77E-026P60604, P19174, P0DP23, Q71U36, Q13509, P68371UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Sulfadoxinehsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Sulfadoxinehsa05034Alcoholism2.79E-022P62879, Q9BTM1GNB2, H2AFJMore
Sulfadoxinehsa05110Vibrio cholerae infection4.78E-021Q99437ATP6V0BMore
Sulfadoxinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.08E-024P25963, Q13488, P19174, P07948NFKBIA, TCIRG1, PLCG1, LYNMore
Sulfadoxinehsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Sulfadoxinehsa05132Salmonella infection2.75E-027P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Sulfadoxinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Sulfadoxinehsa05134Legionellosis4.75E-023P25963, P11215, P11142NFKBIA, ITGAM, HSPA8More
Sulfadoxinehsa05140Leishmaniasis4.82E-024P14598, P11215, P42224, P25963NCF1, ITGAM, STAT1, NFKBIAMore
Sulfadoxinehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Sulfadoxinehsa05144Malaria1.44E-036P60033, P69905, P68871, O60603, P35443, P26718CD81, HBA2, HBB, TLR2, THBS4, KLRK1More
Sulfadoxinehsa05152Tuberculosis4.16E-022Q99437, P25774ATP6V0B, CTSSMore
Sulfadoxinehsa05163Human cytomegalovirus infection2.56E-038P25963, P62873, P63218, P50151, P0DP23, Q14344, P30101, P01568NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, PDIA3, IFNA21More
Sulfadoxinehsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Sulfadoxinehsa05168Herpes simplex virus 1 infection3.79E-029P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189More
Sulfadoxinehsa05169Epstein-Barr virus infection4.41E-028P13765, Q13547, O00463, Q16539, P24522, O60603, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, GADD45A, TLR2, CD3G, CD247More
Sulfadoxinehsa05170Human immunodeficiency virus 1 infection1.19E-028P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Sulfadoxinehsa05200Pathways in cancer2.14E-0417P17301, P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P62879, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784ITGA2, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNB2, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Sulfadoxinehsa05212Pancreatic cancer4.75E-023P42224, P84022, O75293STAT1, SMAD3, GADD45BMore
Sulfadoxinehsa05214Glioma4.75E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Sulfadoxinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.03E-025P20963, P09693, P06239, O60603, Q16539CD247, CD3G, LCK, TLR2, MAPK14More
Sulfadoxinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Sulfadoxine (SDC: 2.66)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P04818TYMSThymidylate synthasePredicted10.45530.27060.18930.9582
P00374DHFRDihydrofolate reductasePredicted00.3380.18680.22630.7688
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)