PharmaCoNets of Sulfadiazine (SPCN: 57.31 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Sulfadiazinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Sulfadiazinehsa00190Oxidative phosphorylation8.71E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Sulfadiazinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Sulfadiazinehsa00630Glyoxylate and dicarboxylate metabolism4.84E-043P40925, P40926, P15104MDH1, MDH2, GLULMore
Sulfadiazinehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Sulfadiazinehsa03013RNA transport3.98E-029P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Sulfadiazinehsa03040Spliceosome1.93E-039Q14562, O60508, P17844, P08579, P51991, P61978, Q01130, P11142, O43447DHX8, CDC40, DDX5, SNRPB2, HNRPA3, HNRPK, SFRS2, HSPA8, PPIHMore
Sulfadiazinehsa04064NF-kappa B signaling pathway3.99E-026P10415, Q13489, P29965, Q9UDY8, Q8WV28, Q13315BCL2, BIRC3, CD40LG, MALT1, BLNK, ATMMore
Sulfadiazinehsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Sulfadiazinehsa04071Sphingolipid signaling pathway1.35E-048P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Sulfadiazinehsa04140Autophagy - animal3.72E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Sulfadiazinehsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Sulfadiazinehsa04145Phagosome1.59E-037Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Sulfadiazinehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Sulfadiazinehsa04151PI3K-Akt signaling pathway1.13E-0316P62753, P25116, P27348, P49767, Q13362, P07900, P62873, P16144, P22105, O60603, P01568, Q99941, P18848, P10415, P17252, O00141RPS6, F2R, YWHAQ, VEGFC, PPP2R5C, HSP90AA1, GNB1, ITGB4, TNXB, TLR2, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGKMore
Sulfadiazinehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Sulfadiazinehsa04217Necroptosis9.14E-037P01568, Q13489, P42224, Q6FI13, P10415, O43633, Q08752IFNA21, BIRC3, STAT1, H2AC18; H2AC19, BCL2, CHMP2A, PPIDMore
Sulfadiazinehsa04261Adrenergic signaling in cardiomyocytes1.73E-039P09493, P51828, Q99941, P18848, Q13362, P0DP23, Q13557, P17252, P10415TPM1, ADCY7, CREBL1, ATF4, PPP2R5C, CALM1, CAMK2D, PRKCA, BCL2More
Sulfadiazinehsa04540Gap junction1.29E-024P17252, Q13509, P68371, Q14643PRKCA, TUBB3, TUBB2C, ITPR1More
Sulfadiazinehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Sulfadiazinehsa04612Antigen processing and presentation2.84E-027P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Sulfadiazinehsa04613Neutrophil extracellular trap formation1.74E-0417P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Sulfadiazinehsa04640Hematopoietic cell lineage3.58E-028P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Sulfadiazinehsa04657IL-17 signaling pathway4.98E-026O00463, Q16539, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, MMP9, ANAPC5, LCN2, TNFMore
Sulfadiazinehsa04658Th1 and Th2 cell differentiation1.48E-027Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOBMore
Sulfadiazinehsa04660T cell receptor signaling pathway3.19E-0310P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLBMore
Sulfadiazinehsa04662B cell receptor signaling pathway1.49E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Sulfadiazinehsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Sulfadiazinehsa04672Intestinal immune network for IgA production1.27E-044P29965, P10747, P13765, P13612CD40LG, CD28, HLA-DOB, ITGA4More
Sulfadiazinehsa04713Circadian entrainment2.60E-024P0DP23, P17252, P62873, Q14643CALM1, PRKCA, GNB1, ITPR1More
Sulfadiazinehsa04714Thermogenesis3.31E-024P51828, P62753, P12074, O15239ADCY7, RPS6, COX6A1, NDUFA1More
Sulfadiazinehsa04720Long-term potentiation3.89E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Sulfadiazinehsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Sulfadiazinehsa04724Glutamatergic synapse5.94E-034O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Sulfadiazinehsa04725Cholinergic synapse1.53E-0410P51828, Q14643, P17252, P62873, P63218, P50151, P18848, Q13557, P42338, P10415ADCY7, ITPR1, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, BCL2More
Sulfadiazinehsa04727GABAergic synapse1.63E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Sulfadiazinehsa04728Dopaminergic synapse4.76E-038Q14643, P17252, P62873, Q99941, P18848, Q13557, Q13362, P0DP23ITPR1, PRKCA, GNB1, CREBL1, ATF4, CAMK2D, PPP2R5C, CALM1More
Sulfadiazinehsa04744Phototransduction1.02E-022P62873, P0DP23GNB1, CALM1More
Sulfadiazinehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Sulfadiazinehsa04912GnRH signaling pathway3.41E-036P17252, P51828, P18848, Q13557, Q14643, P0DP23PRKCA, ADCY7, ATF4, CAMK2D, ITPR1, CALM1More
Sulfadiazinehsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Sulfadiazinehsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Sulfadiazinehsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Sulfadiazinehsa04924Renin secretion7.51E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Sulfadiazinehsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Sulfadiazinehsa04926Relaxin signaling pathway5.00E-048P42338, P63218, P50151, Q99941, P18848, P49767, P51828, P49407PIK3CB, GNG5, GNG10, CREBL1, ATF4, VEGFC, ADCY7, ARRB1More
Sulfadiazinehsa04927Cortisol synthesis and secretion6.33E-045Q14643, Q99941, P18848, P51828, P22694ITPR1, CREBL1, ATF4, ADCY7, PRKACBMore
Sulfadiazinehsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Sulfadiazinehsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Sulfadiazinehsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Sulfadiazinehsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Sulfadiazinehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Sulfadiazinehsa04940Type I diabetes mellitus3.64E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Sulfadiazinehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Sulfadiazinehsa04966Collecting duct acid secretion2.07E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Sulfadiazinehsa04970Salivary secretion4.92E-024P07550, P22694, Q14643, P49913ADRB2, PRKACB, ITPR1, CAMPMore
Sulfadiazinehsa05010Alzheimer disease3.55E-027Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPIDMore
Sulfadiazinehsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Sulfadiazinehsa05020Prion disease1.15E-027Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4More
Sulfadiazinehsa05022Pathways of neurodegeneration - multiple diseases4.48E-0310Q14643, Q13509, P68371, P10415, Q16718, O14521, Q13561, P17252, Q08752, P0DP23ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, PPID, CALM1More
Sulfadiazinehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Sulfadiazinehsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Sulfadiazinehsa05131Shigellosis2.27E-028P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Sulfadiazinehsa05132Salmonella infection1.11E-028Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Sulfadiazinehsa05133Pertussis4.20E-021P0C0L4C4AMore
Sulfadiazinehsa05140Leishmaniasis2.17E-036P14598, P42224, P13765, O60603, P29350, Q15080NCF1, STAT1, HLA-DOB, TLR2, PTPN6, NCF4More
Sulfadiazinehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Sulfadiazinehsa05144Malaria6.79E-036P69905, P68871, O60603, P01375, P35443, P26718HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Sulfadiazinehsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Sulfadiazinehsa05146Amoebiasis1.48E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Sulfadiazinehsa05152Tuberculosis7.93E-048Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Sulfadiazinehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Sulfadiazinehsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Sulfadiazinehsa05167Kaposi sarcoma-associated herpesvirus infection4.73E-026P01568, P42224, P62873, Q14643, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, ITPR1, CALM1, LEF1More
Sulfadiazinehsa05169Epstein-Barr virus infection3.72E-026Q13547, P42338, P07948, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3EMore
Sulfadiazinehsa05170Human immunodeficiency virus 1 infection4.67E-039P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2More
Sulfadiazinehsa05200Pathways in cancer4.99E-0212P42224, Q9UJU2, P17252, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P0DP23, P01568STAT1, LEF1, PRKCA, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, CALM1, IFNA21More
Sulfadiazinehsa05202Transcriptional misregulation in cancer1.78E-0316Q15532, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P12980, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, LYL1, GADD45AMore
Sulfadiazinehsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Sulfadiazinehsa05310Asthma1.66E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Sulfadiazinehsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Sulfadiazinehsa05321Inflammatory bowel disease1.14E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Sulfadiazinehsa05322Systemic lupus erythematosus4.18E-037P08246, P09871, P10747, P13765, P29965, Q6FI13, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Sulfadiazinehsa05323Rheumatoid arthritis5.62E-046P01375, P13765, Q13488, P10747, P09341, O60603TNF, HLA-DOB, TCIRG1, CD28, CXCL1, TLR2More
Sulfadiazinehsa05330Allograft rejection1.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Sulfadiazinehsa05332Graft-versus-host disease2.03E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Sulfadiazinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Sulfadiazinehsa05415Diabetic cardiomyopathy3.55E-025P17252, P14598, Q15080, Q16718, O14521PRKCA, NCF1, NCF4, NDUFA5, SDHDMore
Sulfadiazinehsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More

Community members of Sulfadiazine (SDC: 4.27)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q9UM07PADI4ProteinNonearginine deiminase typeNone4Predicted10.14880.27780.42671.0567
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)