PharmaCoNets of Sufentanil (SPCN: 107.73 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Sufentanilhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Sufentanilhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Sufentanilhsa00071Fatty acid degradation3.65E-034O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Sufentanilhsa00190Oxidative phosphorylation5.12E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Sufentanilhsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Sufentanilhsa00500Starch and sucrose metabolism5.45E-053O43451, P46976, P06737MGAM, GYG1, PYGLMore
Sufentanilhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Sufentanilhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Sufentanilhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Sufentanilhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Sufentanilhsa00730Thiamine metabolism7.19E-042P05186, P24666ALPL, ACP1More
Sufentanilhsa00770Pantothenate and CoA biosynthesis2.26E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Sufentanilhsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Sufentanilhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Sufentanilhsa00970Aminoacyl-tRNA biosynthesis3.94E-064O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Sufentanilhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Sufentanilhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Sufentanilhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Sufentanilhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Sufentanilhsa01522Endocrine resistance4.55E-025P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Sufentanilhsa01524Platinum drug resistance1.13E-025P10415, Q13489, P78417, P23025, P43246BCL2, BIRC3, GSTO1, XPA, MSH2More
Sufentanilhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Sufentanilhsa03008Ribosome biogenesis in eukaryotes1.31E-047Q9NYH9, O14980, O60832, P78345, Q9BVP2, O15381, Q9GZY0UTP6, XPO1, DKC1, RPP38, GNL3, NVL, NXF2; NXF2BMore
Sufentanilhsa03013RNA transport6.49E-1020O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q14240, P23588, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, EIF4A2, EIF4B, TACC3, FXR1More
Sufentanilhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Sufentanilhsa03040Spliceosome6.12E-0411Q14562, O43143, O60508, Q99633, Q15427, P38159, P61978, Q13595, Q01130, Q9UMS4, P11142DHX8, DHX15, CDC40, PRPF18, SF3B4, RBMX, HNRPK, TRA2A, SFRS2, PRPF19, HSPA8More
Sufentanilhsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Sufentanilhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Sufentanilhsa04012ErbB signaling pathway3.74E-023P21860, Q13557, O14944ERBB3, CAMK2D, EREGMore
Sufentanilhsa04015Rap1 signaling pathway1.58E-026P20827, P49767, P63261, P25116, P0DP23, P17252EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCAMore
Sufentanilhsa04020Calcium signaling pathway3.99E-0713Q96DU7, P45880, Q16566, Q13557, P17252, P21860, O15399, P25116, P0DP24, P0DP23, P51828, P23634, P49767ITPKC, VDAC2, CAMK4, CAMK2D, PRKCA, ERBB3, GRIN2D, F2R, CALM2, CALM1, ADCY7, ATP2B4, VEGFCMore
Sufentanilhsa04022cGMP-PKG signaling pathway4.72E-024Q99941, P23634, P51828, P45880CREBL1, ATP2B4, ADCY7, VDAC2More
Sufentanilhsa04024cAMP signaling pathway2.84E-037P51828, P0DP24, P0DP23, P23634, Q16566, O15399, P25116ADCY7, CALM2, CALM1, ATP2B4, CAMK4, GRIN2D, F2RMore
Sufentanilhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Sufentanilhsa04062Chemokine signaling pathway2.43E-0414P25024, P25025, P09341, P19875, P47992, Q9UBD3, P07948, P42338, P19174, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Sufentanilhsa04064NF-kappa B signaling pathway5.77E-0821P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB, CYLDMore
Sufentanilhsa04070Phosphatidylinositol signaling system4.07E-024P0DP23, Q14643, O14732, P17252CALM1, ITPR1, IMPA2, PRKCAMore
Sufentanilhsa04071Sphingolipid signaling pathway9.01E-0812P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2, GAB2More
Sufentanilhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Sufentanilhsa04080Neuroactive ligand-receptor interaction4.72E-028P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1More
Sufentanilhsa04114Oocyte meiosis8.69E-034P0DP24, P51828, P27348, Q13362CALM2, ADCY7, YWHAQ, PPP2R5CMore
Sufentanilhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Sufentanilhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Sufentanilhsa04140Autophagy - animal5.09E-035P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Sufentanilhsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Sufentanilhsa04145Phagosome8.81E-0512O75015, P63261, Q15080, P14598, Q13509, P68371, P05164, P78380, O60603, P35443, P27824, P13765FCGR3B, ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, OLR1, TLR2, THBS4, CANX, HLA-DOBMore
Sufentanilhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Sufentanilhsa04213Longevity regulating pathway - multiple species4.41E-034P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Sufentanilhsa04217Necroptosis2.24E-0412P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPIDMore
Sufentanilhsa04261Adrenergic signaling in cardiomyocytes2.23E-0411P51828, Q99941, Q13362, Q16537, P0DP24, P0DP23, Q13557, P17252, P10415, P20020, P23634ADCY7, CREBL1, PPP2R5C, PPP2R5E, CALM2, CALM1, CAMK2D, PRKCA, BCL2, ATP2B1, ATP2B4More
Sufentanilhsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Sufentanilhsa04340Hedgehog signaling pathway4.15E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Sufentanilhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Sufentanilhsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Sufentanilhsa04390Hippo signaling pathway1.47E-025P63261, Q13485, Q9UJU2, O43623, Q13489ACTG1, SMAD4, LEF1, SNAI2, BIRC3More
Sufentanilhsa04510Focal adhesion3.21E-026Q15942, P17252, Q13489, P10415, P49767, P63261ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1More
Sufentanilhsa04520Adherens junction3.36E-024Q13485, Q9UJU2, O43623, P63261SMAD4, LEF1, SNAI2, ACTG1More
Sufentanilhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Sufentanilhsa04540Gap junction4.76E-023P17252, Q13509, P68371PRKCA, TUBB3, TUBB2CMore
Sufentanilhsa04612Antigen processing and presentation1.30E-048P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Sufentanilhsa04613Neutrophil extracellular trap formation8.39E-0928P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P58876, P62807, P33778, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, H2BC3, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Sufentanilhsa04614Renin-angiotensin system7.48E-034P50052, P15144, P08311, O75787AGTR2, ANPEP, CTSG, ATP6AP2More
Sufentanilhsa04621NOD-like receptor signaling pathway2.62E-0211Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Sufentanilhsa04623Cytosolic DNA-sensing pathway3.15E-022P01568, P25963IFNA21, NFKBIAMore
Sufentanilhsa04625C-type lectin receptor signaling pathway8.11E-039Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Sufentanilhsa04640Hematopoietic cell lineage3.83E-0414P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF, IL1BMore
Sufentanilhsa04650Natural killer cell mediated cytotoxicity7.89E-0913P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Sufentanilhsa04657IL-17 signaling pathway3.47E-048O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Sufentanilhsa04658Th1 and Th2 cell differentiation2.42E-0814Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Sufentanilhsa04659Th17 cell differentiation8.78E-0615Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P01584, P07766, P09693, P20963, P23458PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, IL1B, CD3E, CD3G, CD247, JAK1More
Sufentanilhsa04660T cell receptor signaling pathway3.63E-1015P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Sufentanilhsa04666Fc gamma R-mediated phagocytosis1.88E-036O75015, P49006, P06396, O14494, P14598, P17252FCGR3B, MARCKSL1, GSN, PLPP1, NCF1, PRKCAMore
Sufentanilhsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Sufentanilhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Sufentanilhsa04720Long-term potentiation3.70E-045P17252, Q16566, P0DP23, O15399, Q14643PRKCA, CAMK4, CALM1, GRIN2D, ITPR1More
Sufentanilhsa04721Synaptic vesicle cycle3.15E-022Q13488, P31645TCIRG1, SLC6A4More
Sufentanilhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Sufentanilhsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Sufentanilhsa04750Inflammatory mediator regulation of TRP channels4.09E-0512P14778, P01584, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24IL1R1, IL1B, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2More
Sufentanilhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Sufentanilhsa04911Insulin secretion1.48E-023P51828, Q99941, Q13557ADCY7, CREBL1, CAMK2DMore
Sufentanilhsa04912GnRH signaling pathway5.11E-038P17252, P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694PRKCA, ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACBMore
Sufentanilhsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Sufentanilhsa04916Melanogenesis3.55E-023P0DP23, Q9UJU2, P17252CALM1, LEF1, PRKCAMore
Sufentanilhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Sufentanilhsa04921Oxytocin signaling pathway4.19E-024P0DP23, P17252, Q16566, P63261CALM1, PRKCA, CAMK4, ACTG1More
Sufentanilhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Sufentanilhsa04925Aldosterone synthesis and secretion3.08E-0710Q14643, Q99941, P51828, P0DP24, P0DP23, P17252, Q16566, Q13557, P20020, P23634ITPR1, CREBL1, ADCY7, CALM2, CALM1, PRKCA, CAMK4, CAMK2D, ATP2B1, ATP2B4More
Sufentanilhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Sufentanilhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Sufentanilhsa04933AGE-RAGE signaling pathway in diabetic complications3.36E-024Q13485, P10415, P49767, P17252SMAD4, BCL2, VEGFC, PRKCAMore
Sufentanilhsa04934Cushing syndrome3.48E-034Q99941, P51828, O15169, Q13557CREBL1, ADCY7, AXIN1, CAMK2DMore
Sufentanilhsa04940Type I diabetes mellitus2.61E-034P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Sufentanilhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Sufentanilhsa04966Collecting duct acid secretion3.15E-022P02730, Q9Y666SLC4A1, SLC12A7More
Sufentanilhsa04970Salivary secretion1.24E-057P51828, Q14643, P20020, P23634, P17252, P0DP24, P0DP23ADCY7, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM2, CALM1More
Sufentanilhsa04971Gastric acid secretion1.87E-036P51828, P17252, P15311, P63261, P0DP23, Q13557ADCY7, PRKCA, VIL2, ACTG1, CALM1, CAMK2DMore
Sufentanilhsa04972Pancreatic secretion2.53E-046Q14643, P20020, P23634, P17252, P51828, P62491ITPR1, ATP2B1, ATP2B4, PRKCA, ADCY7, RAB11AMore
Sufentanilhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Sufentanilhsa04976Bile secretion1.67E-033O43315, P22694, P08183AQP9, PRKACB, ABCB1More
Sufentanilhsa04978Mineral absorption3.94E-022P23634, Q9BXS9ATP2B4, SLC26A6More
Sufentanilhsa05010Alzheimer disease2.07E-027Q92542, P05496, P12074, O75460, P01584, O15169, P45880NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2More
Sufentanilhsa05014Amyotrophic lateral sclerosis4.31E-027O15399, P10415, Q13509, P68371, Q53GS7, P63261, Q9GZY0GRIN2D, BCL2, TUBB3, TUBB2C, GLE1, ACTG1, NXF2; NXF2BMore
Sufentanilhsa05020Prion disease1.37E-0311P01584, P46531, P11142, Q16718, O14521, P05496, P12074, P45880, P49841, Q99941, Q16539IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, VDAC2, GSK3B, CREBL1, MAPK14More
Sufentanilhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Sufentanilhsa05031Amphetamine addiction1.49E-024O15399, P0DP23, Q16566, P17252GRIN2D, CALM1, CAMK4, PRKCAMore
Sufentanilhsa05034Alcoholism2.05E-057Q13547, Q93077, P58876, P62807, Q16778, O60814, P68431HDAC1, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Sufentanilhsa05120Epithelial cell signaling in Helicobacter pylori infection2.62E-047Q16539, P09341, P19875, P19174, P25024, P25025, P07948MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, LYNMore
Sufentanilhsa05132Salmonella infection2.12E-0413P51617, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371IRAK1, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2CMore
Sufentanilhsa05133Pertussis2.52E-023P0DP23, P23528, P09871CALM1, CFL1, C1SMore
Sufentanilhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Sufentanilhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Sufentanilhsa05140Leishmaniasis2.24E-0815P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4More
Sufentanilhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Sufentanilhsa05144Malaria5.01E-066P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Sufentanilhsa05146Amoebiasis1.61E-0613P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Sufentanilhsa05150Staphylococcus aureus infection9.78E-049P21730, P21462, O75015, P13765, Q16581, Q14532, P59665, P59666, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Sufentanilhsa05152Tuberculosis8.54E-039O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Sufentanilhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Sufentanilhsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Sufentanilhsa05168Herpes simplex virus 1 infection4.23E-0520Q9UKJ0, P25963, P01568, Q05823, Q9GZY0, P42224, Q07955, Q01130, Q13243, Q13489, Q9Y2A4, Q13398, P51522, Q9HCX3, P17038, Q03923, P52738, O75820, Q9UDV6, P10415PILRB, NFKBIA, IFNA21, RNASEL, NXF2; NXF2B, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, ZNF443, ZNF211, ZNF83, ZNF304, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Sufentanilhsa05169Epstein-Barr virus infection2.54E-028Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3GMore
Sufentanilhsa05170Human immunodeficiency virus 1 infection6.54E-039P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2More
Sufentanilhsa05200Pathways in cancer1.51E-0212Q9UJU2, P17252, P43246, Q13485, P14923, P10415, Q13489, P49767, P25116, P78417, P0DP23, P01568LEF1, PRKCA, MSH2, SMAD4, JUP, BCL2, BIRC3, VEGFC, F2R, GSTO1, CALM1, IFNA21More
Sufentanilhsa05202Transcriptional misregulation in cancer1.09E-0622Q12778, Q15532, Q13315, P17844, P14780, P27930, P14923, Q15744, Q16548, P11215, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, ITGAM, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Sufentanilhsa05203Viral carcinogenesis1.22E-036Q13547, Q15283, P58876, P62807, Q16778, O60814HDAC1, RASA2, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12More
Sufentanilhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Sufentanilhsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Sufentanilhsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Sufentanilhsa05214Glioma8.71E-045P0DP23, Q16566, P17252, P04637, P24522CALM1, CAMK4, PRKCA, TP53, GADD45AMore
Sufentanilhsa05216Thyroid cancer1.85E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Sufentanilhsa05217Basal cell carcinoma4.48E-035Q13635, P49841, Q9UJU2, P04637, P24522PTCH1, GSK3B, LEF1, TP53, GADD45AMore
Sufentanilhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.58E-0311P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14More
Sufentanilhsa05310Asthma3.25E-053P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Sufentanilhsa05321Inflammatory bowel disease6.37E-098O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Sufentanilhsa05322Systemic lupus erythematosus9.10E-0615O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P58876, P62807, Q16778, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, H2BC5, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Sufentanilhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Sufentanilhsa05332Graft-versus-host disease1.41E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Sufentanilhsa05415Diabetic cardiomyopathy4.54E-048P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDHMore
Sufentanilhsa05418Fluid shear stress and atherosclerosis2.49E-0311Q16539, P78417, P10599, P14780, P01375, P63261, P10415, P14778, P27930, P0DP23, Q92974MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2More

Community members of Sufentanil (SDC: 6.32)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
O15245SLC22A1Solute carrier family 22 member 1Predicted00.014910.02192.0294
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
P09960LTA4HLeukotriene ANone4 hydrolasePredicted00.2770.95190.15652.1988
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P46091GPR1ChemerinNonelike receptor 2Predicted00.24760.137200.3982
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)