PharmaCoNets of Succinic-acid (SPCN: 9.02 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Succinic-acidhsa00220Arginine biosynthesis1.43E-022P05089, P49448ARG1, GLUD2More
Succinic-acidhsa00250Alanine, aspartate and glutamate metabolism4.51E-021P51649ALDH5A1More
Succinic-acidhsa00531Glycosaminoglycan degradation3.03E-021P15586GNSMore
Succinic-acidhsa01524Platinum drug resistance2.55E-022P04637, P48023TP53, FASLGMore
Succinic-acidhsa03020RNA polymerase4.40E-022P24928, P62487POLR2A, POLR2GMore
Succinic-acidhsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Succinic-acidhsa04068FoxO signaling pathway6.45E-032P48023, Q96BR1FASLG, SGK3More
Succinic-acidhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Succinic-acidhsa04151PI3K-Akt signaling pathway1.60E-0410P62753, P48023, O43521, P04637, P27348, Q8WYR1, P18848, Q96BR1, O00141, Q6ZUJ8RPS6, FASLG, BCL2L11, TP53, YWHAQ, PIK3R5, ATF4, SGK3, SGK, PIK3AP1More
Succinic-acidhsa04210Apoptosis3.63E-023O75460, O43521, P18848ERN1, BCL2L11, ATF4More
Succinic-acidhsa04217Necroptosis5.66E-035P15104, P05141, P01584, P0C0S5, Q9H444GLUL, SLC25A5, IL1B, H2AFZ, CHMP4BMore
Succinic-acidhsa04612Antigen processing and presentation8.21E-035P26715, P26717, Q07444, Q13241, P01732KLRC1, KLRC2, KLRC3, KLRD1, CD8AMore
Succinic-acidhsa04650Natural killer cell mediated cytotoxicity1.37E-0510P06239, P20963, P48023, Q13241, P26718, O14931, P26717, Q07444, Q14953, P26715LCK, CD247, FASLG, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KIR2DS5, KLRC1More
Succinic-acidhsa04658Th1 and Th2 cell differentiation7.09E-057Q04759, P20963, P09693, P06239, P23771, Q9UL17, Q13761PRKCQ, CD247, CD3G, LCK, GATA3, TBX21, RUNX3More
Succinic-acidhsa04659Th17 cell differentiation2.34E-036Q04759, P06239, Q9UL17, P23771, P09693, P20963PRKCQ, LCK, TBX21, GATA3, CD3G, CD247More
Succinic-acidhsa04660T cell receptor signaling pathway8.49E-047Q04759, O95267, Q08881, P20963, P09693, P01732, P06239PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, LCKMore
Succinic-acidhsa04668TNF signaling pathway2.91E-023P18848, P01584, P20333ATF4, IL1B, TNFRSF1BMore
Succinic-acidhsa04722Neurotrophin signaling pathway2.27E-022P48023, P04637FASLG, TP53More
Succinic-acidhsa04932Non-alcoholic fatty liver disease2.05E-035O43521, P18848, O75460, P01584, P13073BCL2L11, ATF4, ERN1, IL1B, COX4I1More
Succinic-acidhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Succinic-acidhsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Succinic-acidhsa05012Parkinson disease3.89E-025P13073, P05141, O75460, P18848, P0DP24COX4I1, SLC25A5, ERN1, ATF4, CALM2More
Succinic-acidhsa05016Huntington disease4.87E-025P13073, P24928, P62487, P05141, O75460COX4I1, POLR2A, POLR2G, SLC25A5, ERN1More
Succinic-acidhsa05022Pathways of neurodegeneration - multiple diseases1.98E-027P13073, O75460, P18848, P05141, P20333, P01584, P0DP24COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2More
Succinic-acidhsa05146Amoebiasis2.73E-024P09341, P05089, P12814, P08311CXCL1, ARG1, ACTN1, CTSGMore
Succinic-acidhsa05160Hepatitis C3.81E-022P04637, P48023TP53, FASLGMore
Succinic-acidhsa05164Influenza A3.48E-022Q9GZY0, P48023NXF2; NXF2B, FASLGMore
Succinic-acidhsa05168Herpes simplex virus 1 infection4.54E-034P04637, Q9GZY0, P48023, P98182TP53, NXF2; NXF2B, FASLG, ZNF200More
Succinic-acidhsa05219Bladder cancer4.51E-021P04637TP53More
Succinic-acidhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.88E-035O95267, P20963, P09693, P06239, Q04759RASGRP1, CD247, CD3G, LCK, PRKCQMore
Succinic-acidhsa05322Systemic lupus erythematosus1.57E-024P08311, P62807, Q16778, P12814CTSG, HIST1H2BC, HIST2H2BE, ACTN1More

Community members of Succinic-acid (SDC: 1.69)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)