PharmaCoNets of Streptozocin (SPCN: 1.45 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Streptozocinhsa00500Starch and sucrose metabolism2.21E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Streptozocinhsa01230Biosynthesis of amino acids3.99E-024P60891, P05089, P15104, P37837PRPS1, ARG1, GLUL, TALDO1More
Streptozocinhsa03060Protein export7.08E-032P37108, Q15005SRP14, SPCS2More
Streptozocinhsa04060Cytokine-cytokine receptor interaction2.05E-0211P27930, P14778, P26842, Q13651, P25024, P25025, Q9UBD3, P47992, P09341, P18510, P01730IL1R2, IL1R1, CD27, IL10RA, CXCR1, CXCR2, XCL2, XCL1, CXCL1, IL1RN, CD4More
Streptozocinhsa04061Viral protein interaction with cytokine and cytokine receptor3.04E-026P09341, P25024, P25025, P47992, Q9UBD3, Q13651CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RAMore
Streptozocinhsa04062Chemokine signaling pathway6.90E-0310P25024, P25025, P09341, P47992, Q9UBD3, P07948, P63218, P50151, Q08881, P49841CXCR1, CXCR2, CXCL1, XCL1, XCL2, LYN, GNG5, GNG10, ITK, GSK3BMore
Streptozocinhsa04064NF-kappa B signaling pathway2.10E-028O00463, P14778, Q04759, Q16548, P07948, P06239, P24522, P09341TRAF5, IL1R1, PRKCQ, BCL2A1, LYN, LCK, GADD45A, CXCL1More
Streptozocinhsa04115p53 signaling pathway2.26E-021P49815TSC2More
Streptozocinhsa04217Necroptosis1.71E-024P23458, Q9NQC7, P15104, O75351JAK1, CYLD, GLUL, VPS4BMore
Streptozocinhsa04640Hematopoietic cell lineage3.31E-039P13612, P14778, P27930, P11836, P07766, P09693, P01732, P01730, P13765ITGA4, IL1R1, IL1R2, MS4A1, CD3E, CD3G, CD8A, CD4, HLA-DOBMore
Streptozocinhsa04650Natural killer cell mediated cytotoxicity3.23E-027P78314, P06239, O60880, P20963, Q13241, P26718, O75015SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3BMore
Streptozocinhsa04658Th1 and Th2 cell differentiation1.64E-0611Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, P23771, Q9UL17, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, GATA3, TBX21, HLA-DOB, RUNX3More
Streptozocinhsa04659Th17 cell differentiation2.83E-0511Q04759, Q16539, P01730, P06239, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, CD4, LCK, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Streptozocinhsa04660T cell receptor signaling pathway2.18E-0512Q04759, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841PRKCQ, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Streptozocinhsa04662B cell receptor signaling pathway2.57E-025P49841, P60033, P07948, P21854, Q8N149GSK3B, CD81, LYN, CD72, LILRA2More
Streptozocinhsa04724Glutamatergic synapse1.08E-023P51828, P62873, P15104ADCY7, GNB1, GLULMore
Streptozocinhsa04727GABAergic synapse2.32E-023P51828, P62873, P15104ADCY7, GNB1, GLULMore
Streptozocinhsa04910Insulin signaling pathway4.05E-021P49815TSC2More
Streptozocinhsa04919Thyroid hormone signaling pathway4.93E-021P49815TSC2More
Streptozocinhsa04973Carbohydrate digestion and absorption1.81E-021P22732SLC2A5More
Streptozocinhsa05120Epithelial cell signaling in Helicobacter pylori infection7.16E-035Q16539, P09341, P25024, P25025, P07948MAPK14, CXCL1, CXCR1, CXCR2, LYNMore
Streptozocinhsa05135Yersinia infection1.66E-026P13612, P06239, Q16539, P49841, P01730, P01732ITGA4, LCK, MAPK14, GSK3B, CD4, CD8AMore
Streptozocinhsa05163Human cytomegalovirus infection8.17E-039P63218, P50151, P49841, P14778, Q13651, P25025, Q16539, O00463, P30101GNG5, GNG10, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5, PDIA3More
Streptozocinhsa05169Epstein-Barr virus infection1.68E-0312P13765, Q13547, O00463, Q16539, P07948, P30101, Q13761, P24522, P29728, P07766, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, LYN, PDIA3, RUNX3, GADD45A, OAS2, CD3E, CD3G, CD247More
Streptozocinhsa05170Human immunodeficiency virus 1 infection3.84E-029P63218, P50151, O00463, P30101, P01730, Q16539, P07766, P09693, P20963GNG5, GNG10, TRAF5, PDIA3, CD4, MAPK14, CD3E, CD3G, CD247More
Streptozocinhsa05231Choline metabolism in cancer4.05E-021P49815TSC2More
Streptozocinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer9.92E-048O95267, P07766, P20963, P09693, P06239, Q04759, Q16539, P01730RASGRP1, CD3E, CD247, CD3G, LCK, PRKCQ, MAPK14, CD4More
Streptozocinhsa05340Primary immunodeficiency3.99E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore

Community members of Streptozocin (SDC: 0.36)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
O60502MGEA5Protein ONoneGlcNAcaseReported00.51010.04550.10570.4517
P11169SLC2A3Solute carrier family 2, facilitated glucose transporter member 3Predicted00.13570.065800.1995
P22732SLC2A5Solute carrier family 2, facilitated glucose transporter member 5Predicted00.34730.00790.00630.1958
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)