PharmaCoNets of Streptomycin (SPCN: 2.98 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Streptomycinhsa04071Sphingolipid signaling pathway1.94E-026P21453, Q9H228, P01375, Q13362, Q9BX95, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Streptomycinhsa04140Autophagy - animal3.72E-025P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Streptomycinhsa04612Antigen processing and presentation2.84E-027P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Streptomycinhsa04613Neutrophil extracellular trap formation4.94E-0211O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, P49913, P21730, P21462TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1More
Streptomycinhsa04640Hematopoietic cell lineage3.58E-028P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Streptomycinhsa04658Th1 and Th2 cell differentiation1.48E-027Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOBMore
Streptomycinhsa04660T cell receptor signaling pathway3.19E-0310P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLBMore
Streptomycinhsa04672Intestinal immune network for IgA production1.66E-023P10747, P13765, P13612CD28, HLA-DOB, ITGA4More
Streptomycinhsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Streptomycinhsa04927Cortisol synthesis and secretion1.66E-023Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Streptomycinhsa04940Type I diabetes mellitus3.64E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Streptomycinhsa04970Salivary secretion4.92E-024P07550, P22694, Q14643, P49913ADRB2, PRKACB, ITPR1, CAMPMore
Streptomycinhsa05144Malaria4.92E-024O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Streptomycinhsa05146Amoebiasis1.48E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Streptomycinhsa05202Transcriptional misregulation in cancer3.71E-0211P14780, P27930, Q15744, Q16548, P35226, P05164, P12838, P08246, Q9C0K0, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, BMI1, MPO, DEFA4, ELA2, BCL11B, LYL1, GADD45AMore
Streptomycinhsa05310Asthma1.66E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Streptomycinhsa05321Inflammatory bowel disease1.14E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Streptomycinhsa05323Rheumatoid arthritis1.58E-025P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Streptomycinhsa05332Graft-versus-host disease2.03E-035P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More

Community members of Streptomycin (SDC: 1.06)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9UM07PADI4ProteinNonearginine deiminase typeNone4Reported10.14880.27780.42671.0567
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)