PharmaCoNets of Stavudine (SPCN: 54.17 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Stavudinehsa00030Pentose phosphate pathway8.97E-031P11413G6PDMore
Stavudinehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Stavudinehsa00240Pyrimidine metabolism8.44E-044P31350, P21589, P32320, P04183RRM2, NT5E, CDA, TK1More
Stavudinehsa00480Glutathione metabolism1.35E-021P11413G6PDMore
Stavudinehsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Stavudinehsa00561Glycerolipid metabolism2.51E-022P51648, P23743ALDH3A2, DGKAMore
Stavudinehsa00562Inositol phosphate metabolism7.30E-044P27987, Q96PE3, P19174, P42338ITPKB, INPP4A, PLCG1, PIK3CBMore
Stavudinehsa00620Pyruvate metabolism2.51E-022P40925, P51648MDH1, ALDH3A2More
Stavudinehsa00630Glyoxylate and dicarboxylate metabolism2.78E-032P40925, P15104MDH1, GLULMore
Stavudinehsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Stavudinehsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Stavudinehsa00983Drug metabolism - other enzymes3.83E-044P04183, P32320, P31350, P05164TK1, CDA, RRM2, MPOMore
Stavudinehsa01100Metabolic pathways4.12E-0212P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P40925, P23743, P43034, P09917, Q53FZ2GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, MDH1, DGKA, PAFAH1B1, ALOX5, ACSM3More
Stavudinehsa01200Carbon metabolism2.91E-021P11413G6PDMore
Stavudinehsa01521EGFR tyrosine kinase inhibitor resistance7.30E-044Q92529, P19174, P42338, Q9NRA1SHC3, PLCG1, PIK3CB, PDGFCMore
Stavudinehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Stavudinehsa03020RNA polymerase3.22E-033P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Stavudinehsa04010MAPK signaling pathway1.53E-022Q9H2K8, Q12933TAOK3, TRAF2More
Stavudinehsa04012ErbB signaling pathway9.49E-033Q92529, P19174, P42338SHC3, PLCG1, PIK3CBMore
Stavudinehsa04014Ras signaling pathway2.29E-047P42338, Q92529, Q9NRA1, P49767, P63218, P50151, P19174PIK3CB, SHC3, PDGFC, VEGFC, GNG5, GNG10, PLCG1More
Stavudinehsa04015Rap1 signaling pathway3.91E-024Q9NRA1, P49767, P42338, P19174PDGFC, VEGFC, PIK3CB, PLCG1More
Stavudinehsa04020Calcium signaling pathway2.16E-024P27987, P19174, Q9NRA1, P49767ITPKB, PLCG1, PDGFC, VEGFCMore
Stavudinehsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Stavudinehsa04062Chemokine signaling pathway4.35E-036P07948, P42338, P19174, Q92529, P63218, P50151LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10More
Stavudinehsa04064NF-kappa B signaling pathway1.98E-037P10415, P51617, Q04759, Q9UDY8, Q13315, P24522, P09341BCL2, IRAK1, PRKCQ, MALT1, ATM, GADD45A, CXCL1More
Stavudinehsa04070Phosphatidylinositol signaling system3.19E-045P19174, P42338, P23743, Q96PE3, P27987PLCG1, PIK3CB, DGKA, INPP4A, ITPKBMore
Stavudinehsa04071Sphingolipid signaling pathway4.14E-032Q12933, Q02156TRAF2, PRKCEMore
Stavudinehsa04072Phospholipase D signaling pathway1.85E-046P42338, Q92529, P19174, Q14344, P23743, Q9NRA1PIK3CB, SHC3, PLCG1, GNA13, DGKA, PDGFCMore
Stavudinehsa04115p53 signaling pathway3.35E-035P24522, Q13315, P31350, O95067, P10415GADD45A, ATM, RRM2, CCNB2, BCL2More
Stavudinehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Stavudinehsa04145Phagosome1.73E-036Q15080, P68371, P05164, P78380, P35443, P13765NCF4, TUBB2C, MPO, OLR1, THBS4, HLA-DOBMore
Stavudinehsa04151PI3K-Akt signaling pathway6.21E-0515P62753, P42338, O43521, P27348, Q9NRA1, P49767, P08238, Q8WYR1, P63218, P50151, O15335, P14784, P18848, O00141, Q6ZUJ8RPS6, PIK3CB, BCL2L11, YWHAQ, PDGFC, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, IL2RB, ATF4, SGK, PIK3AP1More
Stavudinehsa04210Apoptosis3.63E-023O75460, O43521, P18848ERN1, BCL2L11, ATF4More
Stavudinehsa04217Necroptosis8.73E-067P07900, P15104, P05141, P01584, P0C0S5, Q13557, Q9H444HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D, CHMP4BMore
Stavudinehsa04370VEGF signaling pathway1.56E-022P19174, P42338PLCG1, PIK3CBMore
Stavudinehsa04371Apelin signaling pathway1.24E-024P63218, P50151, Q13370, Q14344GNG5, GNG10, PDE3B, GNA13More
Stavudinehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Stavudinehsa04510Focal adhesion1.55E-025P42338, O15335, Q9NRA1, P49767, Q92529PIK3CB, CHAD, PDGFC, VEGFC, SHC3More
Stavudinehsa04611Platelet activation4.11E-023P42338, Q14344, P07948PIK3CB, GNA13, LYNMore
Stavudinehsa04612Antigen processing and presentation4.72E-024P13765, P48382, P26715, P26717HLA-DOB, RFX5, KLRC1, KLRC2More
Stavudinehsa04622RIG-I-like receptor signaling pathway2.47E-021Q12933TRAF2More
Stavudinehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Stavudinehsa04657IL-17 signaling pathway1.14E-037P07900, O00463, Q16539, P49841, P14780, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, MMP9, TNF, IL1BMore
Stavudinehsa04658Th1 and Th2 cell differentiation1.01E-024P07766, P19174, P14784, Q13761CD3E, PLCG1, IL2RB, RUNX3More
Stavudinehsa04659Th17 cell differentiation2.16E-024P19174, P14784, P08238, P07766PLCG1, IL2RB, HSP90AB1, CD3EMore
Stavudinehsa04662B cell receptor signaling pathway2.78E-023P42338, P07948, Q8N149PIK3CB, LYN, LILRA2More
Stavudinehsa04664Fc epsilon RI signaling pathway1.34E-047P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5More
Stavudinehsa04666Fc gamma R-mediated phagocytosis1.73E-023P07948, P42338, P19174LYN, PIK3CB, PLCG1More
Stavudinehsa04668TNF signaling pathway1.56E-038P01375, O00463, Q16539, P18848, P01584, P20749, P14780, P20333TNF, TRAF5, MAPK14, ATF4, IL1B, BCL3, MMP9, TNFRSF1BMore
Stavudinehsa04722Neurotrophin signaling pathway4.87E-023P42338, P19174, Q92529PIK3CB, PLCG1, SHC3More
Stavudinehsa04724Glutamatergic synapse1.73E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Stavudinehsa04725Cholinergic synapse1.73E-023P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Stavudinehsa04726Serotonergic synapse3.41E-023P63218, P50151, P09917GNG5, GNG10, ALOX5More
Stavudinehsa04727GABAergic synapse6.57E-033P63218, P50151, P15104GNG5, GNG10, GLULMore
Stavudinehsa04730Long-term depression1.56E-022Q14344, P07948GNA13, LYNMore
Stavudinehsa04910Insulin signaling pathway4.11E-023Q92529, Q13370, P42338SHC3, PDE3B, PIK3CBMore
Stavudinehsa04914Progesterone-mediated oocyte maturation2.22E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Stavudinehsa04915Estrogen signaling pathway4.76E-034P42338, Q92529, P08238, P11142PIK3CB, SHC3, HSP90AB1, HSPA8More
Stavudinehsa04923Regulation of lipolysis in adipocytes3.64E-022Q13370, P42338PDE3B, PIK3CBMore
Stavudinehsa04926Relaxin signaling pathway1.31E-035P42338, P63218, P50151, P49767, Q92529PIK3CB, GNG5, GNG10, VEGFC, SHC3More
Stavudinehsa04930Type II diabetes mellitus2.47E-021Q02156PRKCEMore
Stavudinehsa04932Non-alcoholic fatty liver disease5.73E-056O43521, P18848, O75460, P01584, P13073, O15239BCL2L11, ATF4, ERN1, IL1B, COX4I1, NDUFA1More
Stavudinehsa04933AGE-RAGE signaling pathway in diabetic complications4.11E-023P42338, P49767, P19174PIK3CB, VEGFC, PLCG1More
Stavudinehsa04935Growth hormone synthesis, secretion and action2.78E-023P19174, P42338, Q92529PLCG1, PIK3CB, SHC3More
Stavudinehsa04974Protein digestion and absorption2.47E-021Q7Z2H8SLC36A1More
Stavudinehsa05010Alzheimer disease2.78E-026P13073, O75460, P0DP24, P01584, P18848, P05141COX4I1, ERN1, CALM2, IL1B, ATF4, SLC25A5More
Stavudinehsa05012Parkinson disease2.77E-037O15239, P13073, P05141, O75460, P18848, P0DP24, Q13557NDUFA1, COX4I1, SLC25A5, ERN1, ATF4, CALM2, CAMK2DMore
Stavudinehsa05016Huntington disease4.33E-037O15239, P13073, P24928, P30876, P62487, P05141, O75460NDUFA1, COX4I1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1More
Stavudinehsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Stavudinehsa05022Pathways of neurodegeneration - multiple diseases2.20E-039O15239, P13073, O75460, P18848, P05141, P20333, P01584, P0DP24, Q13557NDUFA1, COX4I1, ERN1, ATF4, SLC25A5, TNFRSF1B, IL1B, CALM2, CAMK2DMore
Stavudinehsa05032Morphine addiction2.22E-023P63218, P50151, Q13370GNG5, GNG10, PDE3BMore
Stavudinehsa05100Bacterial invasion of epithelial cells3.64E-022P42338, Q92529PIK3CB, SHC3More
Stavudinehsa05131Shigellosis1.65E-022Q12933, Q02156TRAF2, PRKCEMore
Stavudinehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Stavudinehsa05150Staphylococcus aureus infection1.91E-024Q14532, P59665, P59666, P49913KRT32, DEFA1; DEFA1B, DEFA3, CAMPMore
Stavudinehsa05152Tuberculosis1.95E-025P48382, P10415, P13765, Q9UDY8, P51617RFX5, BCL2, HLA-DOB, MALT1, IRAK1More
Stavudinehsa05162Measles4.15E-036P14784, P07766, P42338, P11142, P01584, Q9NP90IL2RB, CD3E, PIK3CB, HSPA8, IL1B, RAB9BMore
Stavudinehsa05163Human cytomegalovirus infection1.10E-0311P42338, P01375, P63218, P50151, Q14344, P49841, P14778, P25025, Q16539, O00463, P30101PIK3CB, TNF, GNG5, GNG10, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3More
Stavudinehsa05167Kaposi sarcoma-associated herpesvirus infection1.14E-025P42338, P63218, P50151, P19174, P07948PIK3CB, GNG5, GNG10, PLCG1, LYNMore
Stavudinehsa05168Herpes simplex virus 1 infection4.79E-028P25963, Q07955, Q01130, Q9Y2A4, P51522, P17038, P52738, O75820NFKBIA, SFRS1, SFRS2, ZNF443, ZNF83, ZNF43, ZNF140, ZNF189More
Stavudinehsa05169Epstein-Barr virus infection3.34E-025P42338, P07948, P30101, Q13761, P07766PIK3CB, LYN, PDIA3, RUNX3, CD3EMore
Stavudinehsa05170Human immunodeficiency virus 1 infection7.03E-036P42338, P63218, P50151, P30101, P19174, P07766PIK3CB, GNG5, GNG10, PDIA3, PLCG1, CD3EMore
Stavudinehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Stavudinehsa05200Pathways in cancer3.05E-028P42338, P08238, P19174, P49767, P63218, P50151, Q14344, P14784PIK3CB, HSP90AB1, PLCG1, VEGFC, GNG5, GNG10, GNA13, IL2RBMore
Stavudinehsa05202Transcriptional misregulation in cancer3.11E-027Q13315, P14923, Q15744, P05164, P08246, Q9C0K0, P24522ATM, JUP, CEBPE, MPO, ELA2, BCL11B, GADD45AMore
Stavudinehsa05214Glioma9.49E-033Q92529, P42338, P19174SHC3, PIK3CB, PLCG1More
Stavudinehsa05215Prostate cancer4.87E-023Q9NRA1, P08238, P42338PDGFC, HSP90AB1, PIK3CBMore
Stavudinehsa05218Melanoma3.64E-022Q9NRA1, P42338PDGFC, PIK3CBMore
Stavudinehsa05221Acute myeloid leukemia3.29E-023P14923, Q15744, P05164JUP, CEBPE, MPOMore
Stavudinehsa05230Central carbon metabolism in cancer1.12E-021P11413G6PDMore
Stavudinehsa05231Choline metabolism in cancer1.17E-034P42338, Q9NRA1, P19174, P23743PIK3CB, PDGFC, PLCG1, DGKAMore
Stavudinehsa05310Asthma3.01E-022P13765, P12724HLA-DOB, RNASE3More
Stavudinehsa05415Diabetic cardiomyopathy7.11E-035P05141, O15239, P13073, Q13557, P11413SLC25A5, NDUFA1, COX4I1, CAMK2D, G6PDMore
Stavudinehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Stavudine (SDC: 3.92)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P04183TK1Thymidine kinase, cytosolicPredicted00.27170.16370.16530.6286
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P11413G6PDGlucoseNone6Nonephosphate 1NonedehydrogenasePredicted10.44350.63690.29291.7884
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P06746POLBDNA polymerase betaPredicted00.45730.18680.48561.0878
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)