| Spironolactone | hsa00052 | Galactose metabolism | 1.03E-02 | 2 | P06280, O43451 | GLA, MGAM | More | |
| Spironolactone | hsa00500 | Starch and sucrose metabolism | 1.67E-02 | 2 | O43451, P06737 | MGAM, PYGL | More | |
| Spironolactone | hsa00532 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 4.32E-02 | 1 | Q9Y2C2 | UST | More | |
| Spironolactone | hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 3.43E-02 | 1 | Q9NY97 | B3GNT2 | More | |
| Spironolactone | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | |
| Spironolactone | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | |
| Spironolactone | hsa00604 | Glycosphingolipid biosynthesis - ganglio series | 1.34E-02 | 2 | P06865, Q9H4F1 | HEXA, ST6GALNAC4 | More | |
| Spironolactone | hsa00730 | Thiamine metabolism | 5.29E-03 | 2 | P05186, P24666 | ALPL, ACP1 | More | |
| Spironolactone | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 9.14E-03 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | |
| Spironolactone | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | |
| Spironolactone | hsa00983 | Drug metabolism - other enzymes | 2.44E-02 | 2 | P32320, P05164 | CDA, MPO | More | |
| Spironolactone | hsa03010 | Ribosome | 1.03E-02 | 2 | P46777, P50914 | RPL5, RPL14 | More | |
| Spironolactone | hsa03015 | mRNA surveillance pathway | 4.42E-02 | 4 | O60942, O43148, P52298, Q53GS7 | RNGTT, RNMT, NCBP2, GLE1 | More | |
| Spironolactone | hsa04064 | NF-kappa B signaling pathway | 4.58E-03 | 4 | Q13489, Q13546, Q9UDY8, Q9UNE0 | BIRC3, RIPK1, MALT1, EDAR | More | |
| Spironolactone | hsa04071 | Sphingolipid signaling pathway | 1.94E-02 | 3 | Q9H228, P01375, Q9UQC2 | EDG8, TNF, GAB2 | More | |
| Spironolactone | hsa04145 | Phagosome | 2.61E-02 | 5 | P63261, Q15080, P14598, Q13509, P68371 | ACTG1, NCF4, NCF1, TUBB3, TUBB2C | More | |
| Spironolactone | hsa04150 | mTOR signaling pathway | 7.19E-03 | 3 | Q9NQL2, Q13322, Q93098 | RRAGD, GRB10, WNT8B | More | |
| Spironolactone | hsa04210 | Apoptosis | 3.58E-02 | 4 | O76075, P01375, Q9NR28, Q16548 | DFFB, TNF, DIABLO, BCL2A1 | More | |
| Spironolactone | hsa04211 | Longevity regulating pathway | 1.18E-02 | 3 | Q12778, Q9UEF7, Q96KQ7 | FOXO1, KL, EHMT2 | More | |
| Spironolactone | hsa04215 | Apoptosis - multiple species | 1.56E-02 | 2 | Q13489, P10415 | BIRC3, BCL2 | More | |
| Spironolactone | hsa04217 | Necroptosis | 5.94E-04 | 7 | P01568, Q13489, Q13546, P07384, Q6FI13, P10415, O43633 | IFNA21, BIRC3, RIPK1, CAPN1, H2AC18; H2AC19, BCL2, CHMP2A | More | |
| Spironolactone | hsa04340 | Hedgehog signaling pathway | 3.32E-02 | 2 | P49841, P22694 | GSK3B, PRKACB | More | |
| Spironolactone | hsa04390 | Hippo signaling pathway | 2.08E-02 | 3 | P84022, Q13485, Q13489 | SMAD3, SMAD4, BIRC3 | More | |
| Spironolactone | hsa04510 | Focal adhesion | 4.64E-02 | 6 | O75369, Q15942, Q13489, P10415, P49767, P63261 | FLNB, ZYX, BIRC3, BCL2, VEGFC, ACTG1 | More | |
| Spironolactone | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | |
| Spironolactone | hsa04610 | Complement and coagulation cascades | 4.69E-03 | 1 | P0C0L4 | C4A | More | |
| Spironolactone | hsa04613 | Neutrophil extracellular trap formation | 1.73E-02 | 4 | Q93077, P62807, O60814, P68431 | HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | |
| Spironolactone | hsa04620 | Toll-like receptor signaling pathway | 4.16E-02 | 2 | Q13546, P01568 | RIPK1, IFNA21 | More | |
| Spironolactone | hsa04621 | NOD-like receptor signaling pathway | 4.72E-02 | 3 | P01568, Q13489, Q13546 | IFNA21, BIRC3, RIPK1 | More | |
| Spironolactone | hsa04622 | RIG-I-like receptor signaling pathway | 2.39E-02 | 2 | P01568, Q13546 | IFNA21, RIPK1 | More | |
| Spironolactone | hsa04623 | Cytosolic DNA-sensing pathway | 1.78E-04 | 2 | P01568, Q13546 | IFNA21, RIPK1 | More | |
| Spironolactone | hsa04657 | IL-17 signaling pathway | 3.31E-02 | 3 | P49841, P14780, P01375 | GSK3B, MMP9, TNF | More | |
| Spironolactone | hsa04659 | Th17 cell differentiation | 3.17E-02 | 3 | P25963, P84022, Q13485 | NFKBIA, SMAD3, SMAD4 | More | |
| Spironolactone | hsa04710 | Circadian rhythm | 1.67E-02 | 2 | Q16526, Q9Y478 | CRY1, PRKAB1 | More | |
| Spironolactone | hsa04910 | Insulin signaling pathway | 2.35E-02 | 3 | P22694, P06737, P49841 | PRKACB, PYGL, GSK3B | More | |
| Spironolactone | hsa04919 | Thyroid hormone signaling pathway | 7.11E-03 | 4 | P49841, P22694, O60244, Q9NVC6 | GSK3B, PRKACB, MED14, MED17 | More | |
| Spironolactone | hsa04920 | Adipocytokine signaling pathway | 4.31E-02 | 2 | Q9Y478, Q96RR4 | PRKAB1, CAMKK2 | More | |
| Spironolactone | hsa04931 | Insulin resistance | 1.94E-02 | 3 | P01375, P49841, P06737 | TNF, GSK3B, PYGL | More | |
| Spironolactone | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.25E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | |
| Spironolactone | hsa04975 | Fat digestion and absorption | 9.50E-04 | 1 | O14494 | PLPP1 | More | |
| Spironolactone | hsa04976 | Bile secretion | 2.44E-02 | 2 | P22694, P08183 | PRKACB, ABCB1 | More | |
| Spironolactone | hsa05022 | Pathways of neurodegeneration - multiple diseases | 2.69E-02 | 8 | O15399, Q13509, P68371, P10415, Q13561, P07384, P04628, P0DP23 | GRIN2D, TUBB3, TUBB2C, BCL2, DCTN2, CAPN1, WNT1, CALM1 | More | |
| Spironolactone | hsa05034 | Alcoholism | 2.89E-03 | 4 | Q93077, P62807, O60814, P68431 | HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | |
| Spironolactone | hsa05132 | Salmonella infection | 2.14E-05 | 11 | P25963, P63261, Q13546, Q13489, P10415, O75369, Q9BQS8, Q13561, O60282, Q13509, P68371 | NFKBIA, ACTG1, RIPK1, BIRC3, BCL2, FLNB, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C | More | |
| Spironolactone | hsa05145 | Toxoplasmosis | 2.78E-02 | 3 | P25963, P10415, Q13489 | NFKBIA, BCL2, BIRC3 | More | |
| Spironolactone | hsa05150 | Staphylococcus aureus infection | 4.36E-02 | 2 | P0C0L4, P13646 | C4A, KRT13 | More | |
| Spironolactone | hsa05161 | Hepatitis B | 8.49E-03 | 4 | P25963, Q13485, P10415, P84022 | NFKBIA, SMAD4, BCL2, SMAD3 | More | |
| Spironolactone | hsa05168 | Herpes simplex virus 1 infection | 1.17E-02 | 10 | Q9UKJ0, Q06124, P01568, Q01130, Q13489, Q13398, Q9NR11, Q03923, Q9UDV6, P10415 | PILRB, PTPN11, IFNA21, SFRS2, BIRC3, ZNF211, ZNF302, ZNF85, ZNF212, BCL2 | More | |
| Spironolactone | hsa05203 | Viral carcinogenesis | 4.85E-02 | 3 | Q15283, P62807, O60814 | RASA2, HIST1H2BC, H2BC12 | More | |
| Spironolactone | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | |
| Spironolactone | hsa05210 | Colorectal cancer | 1.78E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | |
| Spironolactone | hsa05212 | Pancreatic cancer | 3.52E-02 | 2 | P84022, Q13485 | SMAD3, SMAD4 | More | |
| Spironolactone | hsa05214 | Glioma | 4.10E-02 | 2 | P09619, Q02750 | PDGFRB, MAP2K1 | More | |
| Spironolactone | hsa05218 | Melanoma | 1.34E-02 | 2 | P09619, Q02750 | PDGFRB, MAP2K1 | More | |
| Spironolactone | hsa05220 | Chronic myeloid leukemia | 1.25E-02 | 3 | Q13485, P25963, P84022 | SMAD4, NFKBIA, SMAD3 | More | |
| Spironolactone | hsa05222 | Small cell lung cancer | 1.50E-02 | 3 | Q13489, P10415, P25963 | BIRC3, BCL2, NFKBIA | More | |
| Spironolactone | hsa05226 | Gastric cancer | 2.78E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | |
| Spironolactone | hsa05230 | Central carbon metabolism in cancer | 4.10E-02 | 2 | P09619, Q02750 | PDGFRB, MAP2K1 | More | |
| Spironolactone | hsa05322 | Systemic lupus erythematosus | 1.31E-04 | 5 | P09871, Q93077, P62807, O60814, P68431 | C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | |
