PharmaCoNets of Sparfloxacin (SPCN: 18.43 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Sparfloxacinhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Sparfloxacinhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Sparfloxacinhsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Sparfloxacinhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Sparfloxacinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Sparfloxacinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Sparfloxacinhsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Sparfloxacinhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Sparfloxacinhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Sparfloxacinhsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Sparfloxacinhsa01100Metabolic pathways2.25E-027Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGLMore
Sparfloxacinhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Sparfloxacinhsa04064NF-kappa B signaling pathway1.60E-028P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Sparfloxacinhsa04071Sphingolipid signaling pathway2.96E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Sparfloxacinhsa04080Neuroactive ligand-receptor interaction3.22E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1More
Sparfloxacinhsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Sparfloxacinhsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Sparfloxacinhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Sparfloxacinhsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Sparfloxacinhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Sparfloxacinhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Sparfloxacinhsa04612Antigen processing and presentation3.21E-026P13765, P48382, P26715, P26717, Q13241, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8AMore
Sparfloxacinhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Sparfloxacinhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Sparfloxacinhsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Sparfloxacinhsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Sparfloxacinhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Sparfloxacinhsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Sparfloxacinhsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Sparfloxacinhsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Sparfloxacinhsa04927Cortisol synthesis and secretion8.60E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Sparfloxacinhsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Sparfloxacinhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Sparfloxacinhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Sparfloxacinhsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Sparfloxacinhsa05202Transcriptional misregulation in cancer1.77E-0211Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Sparfloxacinhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Sparfloxacinhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Sparfloxacinhsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore
Sparfloxacinhsa05321Inflammatory bowel disease2.29E-024P13765, Q14765, P23771, Q9HBE5HLA-DOB, STAT4, GATA3, IL21RMore
Sparfloxacinhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Sparfloxacinhsa05332Graft-versus-host disease7.89E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Sparfloxacinhsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Sparfloxacin (SDC: 3.80)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11388TOP2ADNA topoisomerase 2NonealphaReported00.19920.46590.19271.2242
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)