PharmaCoNets

PharmaCoNets of Sonidegib (S_PCN: 275.99 )

Sonidegib regulated-network (S_DN: 28.48)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Sonidegib

hsa00030

Pentose phosphate pathway

7.84E-03

P06744, P37837

GPI, TALDO1

Sonidegib

hsa00052

Galactose metabolism

4.27E-02

P06280, O43451

GLA, MGAM

Sonidegib

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Sonidegib

hsa00071

Fatty acid degradation

3.65E-03

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Sonidegib

hsa00190

Oxidative phosphorylation

2.29E-02

Q16718, O14521

NDUFA5, SDHD

Sonidegib

hsa00220

Arginine biosynthesis

1.26E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Sonidegib

hsa00250

Alanine, aspartate and glutamate metabolism

2.42E-02

P15104

GLUL

Sonidegib

hsa00500

Starch and sucrose metabolism

2.38E-06

O43451, P46976, P35573, P06737

MGAM, GYG1, AGL, PYGL

Sonidegib

hsa00510

N-Glycan biosynthesis

3.15E-02

P15907, Q9NR34

ST6GAL1, MAN1C1

Sonidegib

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Sonidegib

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Sonidegib

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

6.96E-04

Q9NY97

B3GNT2

Sonidegib

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Sonidegib

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Sonidegib

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Sonidegib

hsa00600

Sphingolipid metabolism

4.77E-02

Q9BX95, O14494, P06280

SGPP1, PLPP1, GLA

Sonidegib

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Sonidegib

hsa00630

Glyoxylate and dicarboxylate metabolism

5.34E-03

P40925, P15104

MDH1, GLUL

Sonidegib

hsa00670

One carbon pool by folate

3.62E-02

P00374

DHFR

Sonidegib

hsa00730

Thiamine metabolism

1.55E-03

P05186, P24666

ALPL, ACP1

Sonidegib

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Sonidegib

hsa00790

Folate biosynthesis

7.87E-04

P00374, Q92820, P05186, P42330

DHFR, GGH, ALPL, AKR1C3

Sonidegib

hsa00830

Retinol metabolism

2.27E-03

P00325, P11766, P00352, Q9BPW9, O75911

ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3

Sonidegib

hsa00910

Nitrogen metabolism

2.42E-02

P15104

GLUL

Sonidegib

hsa00920

Sulfur metabolism

1.78E-02

Q16762

TST

Sonidegib

hsa00970

Aminoacyl-tRNA biosynthesis

2.93E-05

O95363, P14868, Q15046

FARS2, DARS, KARS

Sonidegib

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Sonidegib

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Sonidegib

hsa00983

Drug metabolism - other enzymes

4.08E-03

P04183, P32320, P05164

TK1, CDA, MPO

Sonidegib

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Sonidegib

hsa01200

Carbon metabolism

7.69E-03

P06744, P37837, P40926

GPI, TALDO1, MDH2

Sonidegib

hsa01210

2-Oxocarboxylic acid metabolism

1.91E-02

P50213

IDH3A

Sonidegib

hsa01230

Biosynthesis of amino acids

5.53E-03

P15104, P37837

GLUL, TALDO1

Sonidegib

hsa01240

Biosynthesis of cofactors

2.95E-02

P13716, P14618

ALAD, PKM2

Sonidegib

hsa01521

EGFR tyrosine kinase inhibitor resistance

3.18E-04

P04049, P08069

RAF1, IGF1R

Sonidegib

hsa01522

Endocrine resistance

1.56E-02

P14780, P22694, P04049, Q9UM47, P08069, P10415, Q13323

MMP9, PRKACB, RAF1, NOTCH3, IGF1R, BCL2, BIK

Sonidegib

hsa01523

Antifolate resistance

2.79E-03

P41440, Q92820, P04818, P01375, P18054

SLC19A1, GGH, TYMS, TNF, ALOX12

Sonidegib

hsa02010

ABC transporters

1.66E-04

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Sonidegib

hsa03013

RNA transport

4.35E-04

P62826, P52298, Q09161, O14893, P61326, Q9UBU9, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, P78345, Q9Y6A5, Q14232

RAN, NCBP2, NCBP1, GEMIN2, MAGOH, NXF1, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, RPP38, TACC3, EIF2B1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P62826	RAN	GTP-binding nuclear protein Ran	0.732
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.956
P08246	ELA2	Neutrophil elastase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.852
P08246	ELA2	Neutrophil elastase	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.732
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O14893	GEMIN2	Gem-associated protein 2	0.925
P08246	ELA2	Neutrophil elastase	O14893	GEMIN2	Gem-associated protein 2	-0.785
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P61326	MAGOH	Protein mago nashi homolog	0.761
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.79
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q7Z3B4	NUP54	Nucleoporin p54	0.854
P08246	ELA2	Neutrophil elastase	Q7Z3B4	NUP54	Nucleoporin p54	-0.723
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.79
P08246	ELA2	Neutrophil elastase	P35658	NUP214	Nuclear pore complex protein Nup214	0.765
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
Q00535	CDK5	Cyclin-dependent-like kinase 5	P68104	EEF1A1	Elongation factor 1-alpha 1	0.721
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.715
P08246	ELA2	Neutrophil elastase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.722
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.793
P08246	ELA2	Neutrophil elastase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.825
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P78345	RPP38	Ribonuclease P protein subunit p38	0.819
P08246	ELA2	Neutrophil elastase	P78345	RPP38	Ribonuclease P protein subunit p38	-0.795
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.891
P08246	ELA2	Neutrophil elastase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.849
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q14232	EIF2B1	Translation initiation factor eIF-2B subunit alpha	0.749

Sonidegib

hsa03020

RNA polymerase

6.21E-04

P30876, P24928, P62487, Q9Y535

POLR2B, POLR2A, POLR2G, POLR3H

Sonidegib

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Sonidegib

hsa03040

Spliceosome

2.92E-06

Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q14562	DHX8	ATP-dependent RNA helicase DHX8	-0.708
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O60508	CDC40	Pre-mRNA-processing factor 17	-0.837
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.835
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Sonidegib

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Sonidegib

hsa03320

PPAR signaling pathway

4.93E-03

Q6PCB7, O00767, Q9UNU6, Q02318

SLC27A1, SCD, CYP8B1, CYP27A1

Sonidegib

hsa03450

Non-homologous end-joining

1.02E-03

P78527, P13010

PRKDC, XRCC5

Sonidegib

hsa04010

MAPK signaling pathway

1.69E-03

P04049, P08069

RAF1, IGF1R

Sonidegib

hsa04012

ErbB signaling pathway

1.82E-02

P04049

RAF1

Sonidegib

hsa04014

Ras signaling pathway

4.22E-04

P04049, P42338, P20827, P49767, P08069, Q13009, Q7LDG7, Q15283, P61586, P62873, P63218, P50151, P19174

RAF1, PIK3CB, EFNA1, VEGFC, IGF1R, TIAM1, RASGRP2, RASA2, RHOA, GNB1, GNG5, GNG10, PLCG1

Sonidegib

hsa04015

Rap1 signaling pathway

1.66E-04

P04049, P20827, P49767, P08069, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P19174

RAF1, EFNA1, VEGFC, IGF1R, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PLCG1

Sonidegib

hsa04020

Calcium signaling pathway

4.83E-02

Q08828, P0DP23, P05141, P51828

ADCY1, CALM1, SLC25A5, ADCY7

Sonidegib

hsa04022

cGMP-PKG signaling pathway

3.77E-05

P24844, P04049, P18848, Q8WYR1, P31751, Q08828, P51828, P05141, Q15746, P0DP23

MYL9, RAF1, ATF4, PIK3R5, AKT2, ADCY1, ADCY7, SLC25A5, MYLK, CALM1

Sonidegib

hsa04024

cAMP signaling pathway

5.44E-04

Q08828, P51828, P31751, P0DP23, P04049, P48058, P25116, P24844

ADCY1, ADCY7, AKT2, CALM1, RAF1, GRIA4, F2R, MYL9

Sonidegib

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Sonidegib

hsa04061

Viral protein interaction with cytokine and cytokine receptor

2.92E-06

Q8NHW4, P09341, P19875, P25024, P02775, P25025, P47992, Q9UBD3, Q13651, P14784, P01375

CCL4L2, CXCL1, CXCL2, CXCR1, PPBP, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
O00767	SCD	Stearoyl-CoA desaturase	P09341	CXCL1	Growth-regulated alpha protein	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09341	CXCL1	Growth-regulated alpha protein	-0.927
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.772
O00767	SCD	Stearoyl-CoA desaturase	P02775	PPBP	Platelet basic protein	-0.773
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.754
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P47992	XCL1	Lymphotactin	0.83
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.83
O00767	SCD	Stearoyl-CoA desaturase	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	-0.713
P06239	LCK	Tyrosine-protein kinase Lck	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.881
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783

Sonidegib

hsa04062

Chemokine signaling pathway

7.01E-06

P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P04049, Q8WYR1

CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, RAF1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Sonidegib

hsa04064

NF-kappa B signaling pathway

2.60E-14

P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P10415	BCL2	Apoptosis regulator Bcl-2	0.744
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O00463	TRAF5	TNF receptor-associated factor 5	0.945
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
Q00535	CDK5	Cyclin-dependent-like kinase 5	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.739
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753

Sonidegib

hsa04066

HIF-1 signaling pathway

2.16E-02

P08069

IGF1R

Sonidegib

hsa04068

FoxO signaling pathway

3.80E-04

P04049, P08069

RAF1, IGF1R

Sonidegib

hsa04070

Phosphatidylinositol signaling system

5.86E-04

P0DP23, O14986, Q86XP1, Q16760, P48426, Q96DU7

CALM1, PIP5K1B, DGKH, DGKD, PIP4K2A, ITPKC

Sonidegib

hsa04071

Sphingolipid signaling pathway

3.82E-06

P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415

RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.773
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.799
P08246	ELA2	Neutrophil elastase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.865
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.917
P08246	ELA2	Neutrophil elastase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.847
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942

Sonidegib

hsa04072

Phospholipase D signaling pathway

2.43E-04

P04049, P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760

RAF1, AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD

Sonidegib

hsa04080

Neuroactive ligand-receptor interaction

4.98E-05

P08311, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, Q16581, P07550, P35318

CTSG, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, C3AR1, ADRB2, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P08246	ELA2	Neutrophil elastase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.846
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.777
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.744
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.92
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P43657	P2RY5	Lysophosphatidic acid receptor 6	0.768
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P08246	ELA2	Neutrophil elastase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.793
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.852
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P07550	ADRB2	Beta-2 adrenergic receptor	0.737
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	-0.734

Sonidegib

hsa04110

Cell cycle

1.35E-02

P78527

PRKDC

Sonidegib

hsa04114

Oocyte meiosis

8.43E-05

Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069

MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1R

Sonidegib

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Sonidegib

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Sonidegib

hsa04122

Sulfur relay system

1.78E-02

Q16762

TST

Sonidegib

hsa04136

Autophagy - other

3.53E-02

O94817

ATG12

Sonidegib

hsa04140

Autophagy - animal

9.83E-04

P08069, P31751, P04049, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9

IGF1R, AKT2, RAF1, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8

Sonidegib

hsa04142

Lysosome

3.80E-03

Q99437, P25774, P08962, Q9Y6Q5

ATP6V0B, CTSS, CD63, AP1M2

Sonidegib

hsa04145

Phagosome

2.37E-06

O75015, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774

FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSS

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15080	NCF4	Neutrophil cytosol factor 4	-0.919
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15080	NCF4	Neutrophil cytosol factor 4	-0.74
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14598	NCF1	Neutrophil cytosol factor 1	-0.857
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.846
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P68371	TUBB2C	Tubulin beta-4B chain	-0.783
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
P25774	CTSS	Cathepsin S	Q99437	ATP6V0B	V-type proton ATPase 21 kDa proteolipid subunit c''	0.722
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05164	MPO	Myeloperoxidase	-0.811
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P78380	OLR1	Oxidized low-density lipoprotein receptor 1	-0.702
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35443	THBS4	Thrombospondin-4	-0.755
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35443	THBS4	Thrombospondin-4	-0.903
P08246	ELA2	Neutrophil elastase	P35443	THBS4	Thrombospondin-4	0.871
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P25774	CTSS	Cathepsin S	P25774	CTSS	Cathepsin S	1

Sonidegib

hsa04150

mTOR signaling pathway

5.20E-04

P08069, P04049

IGF1R, RAF1

Sonidegib

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Sonidegib

hsa04152

AMPK signaling pathway

1.99E-02

P08069

IGF1R

Sonidegib

hsa04210

Apoptosis

2.84E-03

Q13315, P10415, Q13489, P25963, P01375, P24522, Q16548, Q13077, Q14643, P04049

ATM, BCL2, BIRC3, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, ITPR1, RAF1

Sonidegib

hsa04211

Longevity regulating pathway

5.00E-03

P31751, P08069, Q08828, P51828, P18848

AKT2, IGF1R, ADCY1, ADCY7, ATF4

Sonidegib

hsa04213

Longevity regulating pathway - multiple species

1.39E-03

P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P11142, Q13547

AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA8, HDAC1

Sonidegib

hsa04215

Apoptosis - multiple species

1.56E-02

Q13489, P10415

BIRC3, BCL2

Sonidegib

hsa04217

Necroptosis

2.34E-02

P01375, P48023, Q14765, Q99878

TNF, FASLG, STAT4, H2AC14

Sonidegib

hsa04218

Cellular senescence

2.49E-02

P04049

RAF1

Sonidegib

hsa04261

Adrenergic signaling in cardiomyocytes

4.98E-04

Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23

ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Sonidegib

hsa04270

Vascular smooth muscle contraction

3.32E-03

Q15746, P24844, P24723, Q04759, Q14643, P04049, P22694, P35318

MYLK, MYL9, PRKCH, PRKCQ, ITPR1, RAF1, PRKACB, ADM

Sonidegib

hsa04340

Hedgehog signaling pathway

3.46E-02

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Sonidegib

hsa04360

Axon guidance

1.51E-02

P16333, P20827, O95631, P42338, P07332, P04049, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, RAF1, PLCG1

Sonidegib

hsa04370

VEGF signaling pathway

2.77E-04

P16298, Q05397, Q02750, P04049

PPP3CB, PTK2, MAP2K1, RAF1

Sonidegib

hsa04371

Apelin signaling pathway

4.80E-04

P63218, P50151, Q8WYR1, P31751, P04049, Q08828, P51828, Q14814, Q14344, Q13485, P84022, P0DP23

GNG5, GNG10, PIK3R5, AKT2, RAF1, ADCY1, ADCY7, MEF2D, GNA13, SMAD4, SMAD3, CALM1

Sonidegib

hsa04380

Osteoclast differentiation

5.22E-06

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.753
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.834
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.885
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P49841	GSK3B	Glycogen synthase kinase-3 beta	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.83
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q8N149	LILRA2	Leukocyte immunoglobulin-like receptor subfamily A member 2	0.743
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78324	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1	0.832

Sonidegib

hsa04390

Hippo signaling pathway

2.17E-03

P63261, P84022, Q13485, O15105, Q13489

ACTG1, SMAD3, SMAD4, SMAD7, BIRC3

Sonidegib

hsa04392

Hippo signaling pathway - multiple species

2.16E-02

Q9UGP4

LIMD1

Sonidegib

hsa04510

Focal adhesion

8.18E-04

P08514, Q15746, P24844, P04049, P08069

ITGA2B, MYLK, MYL9, RAF1, IGF1R

Sonidegib

hsa04512

ECM-receptor interaction

9.97E-04

P07359, P26012, P08514, P16070

GP1BA, ITGB8, ITGA2B, CD44

Sonidegib

hsa04514

Cell adhesion molecules

2.58E-03

P16109, O00501

SELP, CLDN5

Sonidegib

hsa04520

Adherens junction

8.29E-03

P08069

IGF1R

Sonidegib

hsa04530

Tight junction

1.50E-07

Q8TEU7, P63261, P16989, P56750, O00501, Q92974, Q14247, P24844

RAPGEF6, ACTG1, CSDA, CLDN17, CLDN5, ARHGEF2, CTTN, MYL9

Sonidegib

hsa04540

Gap junction

1.33E-02

P04049

RAF1

Sonidegib

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.61E-03

Q13873, P04049, Q02750, P08069, Q86SE9

BMPR2, RAF1, MAP2K1, IGF1R, PCGF5

Sonidegib

hsa04610

Complement and coagulation cascades

1.35E-07

P25116, P00734, P0C0L4, P10909

F2R, F2, C4A, CLU

Sonidegib

hsa04611

Platelet activation

1.59E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Sonidegib

hsa04612

Antigen processing and presentation

3.83E-07

P13765, P48382, P01730, P26715, P26717, Q07444, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P25025	CXCR2	C-X-C chemokine receptor type 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.7
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P48382	RFX5	DNA-binding protein RFX5	0.826
P25025	CXCR2	C-X-C chemokine receptor type 2	P48382	RFX5	DNA-binding protein RFX5	-0.743
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26717	KLRC2	NKG2-C type II integral membrane protein	0.915
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.718
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
P25025	CXCR2	C-X-C chemokine receptor type 2	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.721
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.892
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783

Sonidegib

hsa04613

Neutrophil extracellular trap formation

1.33E-09

P17252, P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778

Sonidegib

hsa04614

Renin-angiotensin system

2.74E-02

P15144, P08311, O75787

ANPEP, CTSG, ATP6AP2

Sonidegib

hsa04620

Toll-like receptor signaling pathway

2.54E-03

P01584, P31751, Q8NHW4

IL1B, AKT2, CCL4L2

Sonidegib

hsa04621

NOD-like receptor signaling pathway

2.68E-04

Q16539, Q14643, P25963, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838

MAPK14, ITPR1, NFKBIA, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4

Sonidegib

hsa04623

Cytosolic DNA-sensing pathway

2.21E-04

P01584, Q9Y535, Q8NHW4

IL1B, POLR3H, CCL4L2

Sonidegib

hsa04625

C-type lectin receptor signaling pathway

8.86E-06

Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539

CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14

Sonidegib

hsa04630

JAK-STAT signaling pathway

8.73E-03

P31751, P23458, Q13651, P04049

AKT2, JAK1, IL10RA, RAF1

Sonidegib

hsa04640

Hematopoietic cell lineage

5.94E-08

P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765, P01375, P01584

ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13612	ITGA4	Integrin alpha-4	0.774
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13612	ITGA4	Integrin alpha-4	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.813
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P15144	ANPEP	Aminopeptidase N	-0.757
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P15144	ANPEP	Aminopeptidase N	-0.765
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P25063	CD24	Signal transducer CD24	-0.839
Q13547	HDAC1	Histone deacetylase 1	P25063	CD24	Signal transducer CD24	-0.706
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P25063	CD24	Signal transducer CD24	-0.838
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.892
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
Q13547	HDAC1	Histone deacetylase 1	P09564	CD7	T-cell antigen CD7	0.738
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Sonidegib

hsa04650

Natural killer cell mediated cytotoxicity

4.71E-13

P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715

PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q05397	PTK2	Focal adhesion kinase 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.919
Q05397	PTK2	Focal adhesion kinase 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.849
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P25025	CXCR2	C-X-C chemokine receptor type 2	P78314	SH3BP2	SH3 domain-binding protein 2	0.748
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60880	SH2D1A	SH2 domain-containing protein 1A	0.862
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O60880	SH2D1A	SH2 domain-containing protein 1A	0.922
P25025	CXCR2	C-X-C chemokine receptor type 2	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q05397	PTK2	Focal adhesion kinase 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.898
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13241	KLRD1	Natural killer cells antigen CD94	-0.715
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26718	KLRK1	NKG2-D type II integral membrane protein	0.922
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26718	KLRK1	NKG2-D type II integral membrane protein	0.858
P25025	CXCR2	C-X-C chemokine receptor type 2	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.842
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.716
P25025	CXCR2	C-X-C chemokine receptor type 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.913
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26717	KLRC2	NKG2-C type II integral membrane protein	0.943
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26717	KLRC2	NKG2-C type II integral membrane protein	0.915
P25025	CXCR2	C-X-C chemokine receptor type 2	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.714
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q07444	KLRC3	NKG2-E type II integral membrane protein	0.718
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P25025	CXCR2	C-X-C chemokine receptor type 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.714

Sonidegib

hsa04657

IL-17 signaling pathway

1.69E-05

O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14780	MMP9	Matrix metalloproteinase-9	0.778
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14780	MMP9	Matrix metalloproteinase-9	0.75
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.715
P14780	MMP9	Matrix metalloproteinase-9	P80188	LCN2	Neutrophil gelatinase-associated lipocalin	0.888
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Sonidegib

hsa04658

Th1 and Th2 cell differentiation

4.65E-16

Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q04759	PRKCQ	Protein kinase C theta type	0.869
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q14765	STAT4	Signal transducer and activator of transcription 4	0.821
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.878
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UL17	TBX21	T-box transcription factor TBX21	0.858
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13761	RUNX3	Runt-related transcription factor 3	0.702

Sonidegib

hsa04659

Th17 cell differentiation

1.59E-12

P25963, Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458

NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q04759	PRKCQ	Protein kinase C theta type	0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UL17	TBX21	T-box transcription factor TBX21	0.858
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.878
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.769
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Sonidegib

hsa04660

T cell receptor signaling pathway

1.35E-14

P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.721
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q04759	PRKCQ	Protein kinase C theta type	0.803
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q04759	PRKCQ	Protein kinase C theta type	0.869
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.925
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P25025	CXCR2	C-X-C chemokine receptor type 2	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	1
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.808
P25025	CXCR2	C-X-C chemokine receptor type 2	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.881
P25025	CXCR2	C-X-C chemokine receptor type 2	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.813
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.731
P25025	CXCR2	C-X-C chemokine receptor type 2	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.803
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.892
P25025	CXCR2	C-X-C chemokine receptor type 2	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.722
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.811
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.795
P25025	CXCR2	C-X-C chemokine receptor type 2	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.719
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P06239	LCK	Tyrosine-protein kinase Lck	0.774
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P06239	LCK	Tyrosine-protein kinase Lck	0.769
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P25025	CXCR2	C-X-C chemokine receptor type 2	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.889
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75
P25025	CXCR2	C-X-C chemokine receptor type 2	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.861

Sonidegib

hsa04662

B cell receptor signaling pathway

1.17E-05

P42338, P60033, P07948, P21854, Q8N149, P04049

PIK3CB, CD81, LYN, CD72, LILRA2, RAF1

Sonidegib

hsa04664

Fc epsilon RI signaling pathway

3.96E-05

P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917

TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5

Sonidegib

hsa04666

Fc gamma R-mediated phagocytosis

3.41E-02

O75015, P04049, P06396, O14494, P14598, P17252

FCGR3B, RAF1, GSN, PLPP1, NCF1, PRKCA

Sonidegib

hsa04668

TNF signaling pathway

1.83E-03

P01375, O00463, Q13489, Q16539, P25963, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, MAPK14, NFKBIA, BCL3, TRAF1, MMP9

Sonidegib

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Sonidegib

hsa04710

Circadian rhythm

2.43E-02

O15516

CLOCK

Sonidegib

hsa04713

Circadian entrainment

4.54E-02

P0DP23, Q08828, P51828

CALM1, ADCY1, ADCY7

Sonidegib

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Sonidegib

hsa04720

Long-term potentiation

7.58E-04

P16298, P0DP23, P51812, P18848, Q08828, Q02750, P04049

PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1

Sonidegib

hsa04722

Neurotrophin signaling pathway

7.10E-03

P04049, P49841, O43524, P48023

RAF1, GSK3B, FOXO3, FASLG

Sonidegib

hsa04723

Retrograde endocannabinoid signaling

2.68E-02

P48169, P62873

GABRA4, GNB1

Sonidegib

hsa04724

Glutamatergic synapse

4.83E-04

P48058, O15399, P63218, P50151, P15104, Q9NSB8

GRIA4, GRIN2D, GNG5, GNG10, GLUL, HOMER2

Sonidegib

hsa04725

Cholinergic synapse

1.34E-03

Q08828, P51828, P63218, P50151, P18848, P42338, P31751

ADCY1, ADCY7, GNG5, GNG10, ATF4, PIK3CB, AKT2

Sonidegib

hsa04726

Serotonergic synapse

1.33E-02

P04049

RAF1

Sonidegib

hsa04727

GABAergic synapse

3.28E-03

P62873, P63218, P50151, P48169, P15104

GNB1, GNG5, GNG10, GABRA4, GLUL

Sonidegib

hsa04728

Dopaminergic synapse

7.83E-03

P31751, P18848, Q13362, Q14738, P0DP23

AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1

Sonidegib

hsa04730

Long-term depression

1.25E-04

P08069, P04049

IGF1R, RAF1

Sonidegib

hsa04742

Taste transduction

4.80E-02

P48169

GABRA4

Sonidegib

hsa04750

Inflammatory mediator regulation of TRP channels

1.30E-05

P14778, P01584, Q08828, P51828, P22694, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23

IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1

Sonidegib

hsa04810

Regulation of actin cytoskeleton

3.52E-04

P24844, Q15746, P04049, P08514, P25116

MYL9, MYLK, RAF1, ITGA2B, F2R

Sonidegib

hsa04910

Insulin signaling pathway

1.49E-02

P04049

RAF1

Sonidegib

hsa04911

Insulin secretion

2.40E-02

Q08828, P51828, P18848

ADCY1, ADCY7, ATF4

Sonidegib

hsa04912

GnRH signaling pathway

1.73E-03

Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P04049

ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, RAF1

Sonidegib

hsa04913

Ovarian steroidogenesis

1.16E-02

P08069

IGF1R

Sonidegib

hsa04914

Progesterone-mediated oocyte maturation

2.97E-04

P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049

IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1

Sonidegib

hsa04915

Estrogen signaling pathway

5.83E-03

P04049, P18848, Q08828, P51828, P31751, P0DP23

RAF1, ATF4, ADCY1, ADCY7, AKT2, CALM1

Sonidegib

hsa04916

Melanogenesis

4.54E-03

P0DP23, Q08828, P51828, P04049

CALM1, ADCY1, ADCY7, RAF1

Sonidegib

hsa04917

Prolactin signaling pathway

6.63E-03

P04049

RAF1

Sonidegib

hsa04919

Thyroid hormone signaling pathway

1.82E-02

P04049

RAF1

Sonidegib

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Sonidegib

hsa04921

Oxytocin signaling pathway

8.19E-04

Q15746, P04049, P24844, Q8WYR1

MYLK, RAF1, MYL9, PIK3R5

Sonidegib

hsa04922

Glucagon signaling pathway

4.18E-02

P14618, P06737

PKM2, PYGL

Sonidegib

hsa04923

Regulation of lipolysis in adipocytes

2.89E-04

Q08828, P51828, P07550, P42338, Q9Y4H2, P31751

ADCY1, ADCY7, ADRB2, PIK3CB, IRS2, AKT2

Sonidegib

hsa04924

Renin secretion

2.32E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Sonidegib

hsa04925

Aldosterone synthesis and secretion

9.86E-03

P18848, Q08828, P51828, P0DP23

ATF4, ADCY1, ADCY7, CALM1

Sonidegib

hsa04926

Relaxin signaling pathway

1.26E-04

P31751, P42338, P63218, P50151, P18848, P49767, Q08828, P51828, P04049, P49407

AKT2, PIK3CB, GNG5, GNG10, ATF4, VEGFC, ADCY1, ADCY7, RAF1, ARRB1

Sonidegib

hsa04927

Cortisol synthesis and secretion

1.59E-02

P18848, Q08828, P51828

ATF4, ADCY1, ADCY7

Sonidegib

hsa04928

Parathyroid hormone synthesis, secretion and action

1.99E-02

P04049

RAF1

Sonidegib

hsa04929

GnRH secretion

3.50E-03

P42338, P49407, P04049

PIK3CB, ARRB1, RAF1

Sonidegib

hsa04932

Non-alcoholic fatty liver disease

5.67E-05

P31751, P01375, P49841, P18848, P48023, O75460, P01584, Q16718, O95298, O14521

AKT2, TNF, GSK3B, ATF4, FASLG, ERN1, IL1B, NDUFA5, NDUFC2, SDHD

Sonidegib

hsa04933

AGE-RAGE signaling pathway in diabetic complications

2.11E-03

P84022, Q13485, P10415, P42338, P49767, P19174

SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1

Sonidegib

hsa04934

Cushing syndrome

4.54E-02

P18848, Q08828, P51828

ATF4, ADCY1, ADCY7

Sonidegib

hsa04935

Growth hormone synthesis, secretion and action

5.00E-03

Q08828, P51828, P04049, P18848, P31751

ADCY1, ADCY7, RAF1, ATF4, AKT2

Sonidegib

hsa04940

Type I diabetes mellitus

2.61E-03

P10747, P48023, P13765, P01375

CD28, FASLG, HLA-DOB, TNF

Sonidegib

hsa04961

Endocrine and other factor-regulated calcium reabsorption

2.68E-02

P20020, Q9UEF7, P17252

ATP2B1, KL, PRKCA

Sonidegib

hsa04964

Proximal tubule bicarbonate reclamation

2.17E-03

P00918

CA2

Sonidegib

hsa04966

Collecting duct acid secretion

2.17E-03

P00918

CA2

Sonidegib

hsa04970

Salivary secretion

2.40E-03

Q08828, P51828, P22694, Q14643, P17252, P0DP23, P49913

ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM1, CAMP

Sonidegib

hsa04971

Gastric acid secretion

2.54E-03

Q08828, P51828, P15311, P0DP23

ADCY1, ADCY7, VIL2, CALM1

Sonidegib

hsa04972

Pancreatic secretion

2.68E-02

Q14643, P20020, P17252

ITPR1, ATP2B1, PRKCA

Sonidegib

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Sonidegib

hsa04975

Fat digestion and absorption

3.43E-02

O14494

PLPP1

Sonidegib

hsa04976

Bile secretion

9.77E-04

O43315, Q08828, P51828, P08183, Q14032

AQP9, ADCY1, ADCY7, ABCB1, BAAT

Sonidegib

hsa05010

Alzheimer disease

4.94E-03

O95298, Q00535, O75460, P0DP23, P01584, P18848, P31751, P05141, P28070

NDUFC2, CDK5, ERN1, CALM1, IL1B, ATF4, AKT2, SLC25A5, PSMB4

Sonidegib

hsa05014

Amyotrophic lateral sclerosis

7.70E-03

Q13509, Q9UJW0, P03950, Q09161

TUBB3, DCTN4, ANG, NCBP1

Sonidegib

hsa05016

Huntington disease

2.24E-02

O95298, P24928, P30876, P62487, P05141, O75460, P28070

NDUFC2, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4

Sonidegib

hsa05017

Spinocerebellar ataxia

3.94E-02

O75460, P31751, P28070, P05141

ERN1, AKT2, PSMB4, SLC25A5

Sonidegib

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Sonidegib

hsa05022

Pathways of neurodegeneration - multiple diseases

4.63E-04

P49841, Q16718, O95298, O14521, Q8TEV9, O75460, P18848, Q13561, P05141, Q16539, Q00535, P01584, Q08752, P0DP23, P28070

GSK3B, NDUFA5, NDUFC2, SDHD, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, MAPK14, CDK5, IL1B, PPID, CALM1, PSMB4

Sonidegib

hsa05032

Morphine addiction

1.42E-02

P62873, P48169

GNB1, GABRA4

Sonidegib

hsa05033

Nicotine addiction

2.43E-02

P48169

GABRA4

Sonidegib

hsa05034

Alcoholism

1.89E-05

P62879, P04049, Q9BTM1, Q93077, P62807, O60814, P68431

GNB2, RAF1, H2AFJ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Sonidegib

hsa05100

Bacterial invasion of epithelial cells

2.85E-02

Q14141, Q05397, Q96JJ3

SEPT6, PTK2, ELMO2

Sonidegib

hsa05110

Vibrio cholerae infection

4.78E-02

Q99437

ATP6V0B

Sonidegib

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.96E-04

Q16539, P09341, P19875, P19174, P25024, P25025

MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Sonidegib

hsa05130

Pathogenic Escherichia coli infection

2.51E-02

Q14247, O00501, P25116

CTTN, CLDN5, F2R

Sonidegib

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Sonidegib

hsa05132

Salmonella infection

2.48E-06

P51617, P25963, P01375, P04049, Q9UJU2, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q9UJW0, Q13509, P68371

IRAK1, NFKBIA, TNF, RAF1, LEF1, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, DCTN4, TUBB3, TUBB2C

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
Q9UHI8	ADAMTS1	A disintegrin and metalloproteinase with thrombospondin motifs 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.815
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P25963	NFKBIA	NF-kappa-B inhibitor alpha	-0.728
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.825
P08246	ELA2	Neutrophil elastase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.771
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.708
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	P10415	BCL2	Apoptosis regulator Bcl-2	0.742
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O75369	FLNB	Filamin-B	-0.746
Q9UHI8	ADAMTS1	A disintegrin and metalloproteinase with thrombospondin motifs 1	O75369	FLNB	Filamin-B	-0.757
P08246	ELA2	Neutrophil elastase	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.724
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
O75469	NR1I2	Nuclear receptor subfamily 1 group I member 2	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.722
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.924
P08246	ELA2	Neutrophil elastase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	-0.949
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13561	DCTN2	Dynactin subunit 2	-0.809
P08246	ELA2	Neutrophil elastase	Q13561	DCTN2	Dynactin subunit 2	0.78
Q9UHI8	ADAMTS1	A disintegrin and metalloproteinase with thrombospondin motifs 1	Q9UJW0	DCTN4	Dynactin subunit 4	0.832
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.846
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
Q9UHI8	ADAMTS1	A disintegrin and metalloproteinase with thrombospondin motifs 1	Q13509	TUBB3	Tubulin beta-3 chain	-0.72
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P68371	TUBB2C	Tubulin beta-4B chain	-0.783

Sonidegib

hsa05133

Pertussis

2.60E-04

P0DP23, P0C0L4

CALM1, C4A

Sonidegib

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Sonidegib

hsa05135

Yersinia infection

3.29E-02

Q05397, P51812, Q02750, Q96JJ3

PTK2, RPS6KA3, MAP2K1, ELMO2

Sonidegib

hsa05140

Leishmaniasis

2.84E-08

P13612, O75015, P14598, P23458, P13765, O60603, P25963, P01375, P01584, P49006, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, MARCKSL1, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13612	ITGA4	Integrin alpha-4	0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.778
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15080	NCF4	Neutrophil cytosol factor 4	-0.74
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945

Sonidegib

hsa05143

African trypanosomiasis

1.11E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Sonidegib

hsa05144

Malaria

1.34E-05

P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1

Sonidegib

hsa05145

Toxoplasmosis

8.84E-04

P51617, P25963, P01375, P10415, Q13489, P28068, P13765, Q16787, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DMB, HLA-DOB, LAMA3, TLR2

Sonidegib

hsa05146

Amoebiasis

2.38E-10

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P09341	CXCL1	Growth-regulated alpha protein	-0.802
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P09341	CXCL1	Growth-regulated alpha protein	-0.927
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.813
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05089	ARG1	Arginase-1	-0.868
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P05089	ARG1	Arginase-1	-0.905
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.873
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.894
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12814	ACTN1	Alpha-actinin-1	-0.76
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08311	CTSG	Cathepsin G	-0.866
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898

Sonidegib

hsa05150

Staphylococcus aureus infection

2.68E-03

P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, P49913

C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, CAMP

Sonidegib

hsa05152

Tuberculosis

3.52E-05

P04049, Q13488, Q99437, O75015, P48382, P25208, O60603, P01375, P10415, P13765, P25774, P01568, P49913, Q9UDY8, P51617

RAF1, TCIRG1, ATP6V0B, FCGR3B, RFX5, NFYB, TLR2, TNF, BCL2, HLA-DOB, CTSS, IFNA21, CAMP, MALT1, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	-0.716
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
P25774	CTSS	Cathepsin S	Q99437	ATP6V0B	V-type proton ATPase 21 kDa proteolipid subunit c''	0.722
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P48382	RFX5	DNA-binding protein RFX5	0.797
P08246	ELA2	Neutrophil elastase	P48382	RFX5	DNA-binding protein RFX5	-0.895
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P25208	NFYB	Nuclear transcription factor Y subunit beta	0.742
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P25774	CTSS	Cathepsin S	P25774	CTSS	Cathepsin S	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P01568	IFNA21	Interferon alpha-21	0.716
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	1
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734

Sonidegib

hsa05160

Hepatitis C

1.98E-04

P60033, O00501, P29728, P04049, P49841, P01375, P48023, P01106

CD81, CLDN5, OAS2, RAF1, GSK3B, TNF, FASLG, MYC

Sonidegib

hsa05161

Hepatitis B

2.67E-04

P17252, P04049, P14780, P25963, Q13485, P01375, P10415, P84022, P51617, O60603, Q14765

PRKCA, RAF1, MMP9, NFKBIA, SMAD4, TNF, BCL2, SMAD3, IRAK1, TLR2, STAT4

Sonidegib

hsa05163

Human cytomegalovirus infection

5.62E-06

P31751, P04049, P01375, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463

AKT2, RAF1, TNF, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q00535	CDK5	Cyclin-dependent-like kinase 5	P31751	AKT2	RAC-beta serine/threonine-protein kinase	0.726
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	P01375	TNF	Tumor necrosis factor	0.732
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.728
Q00535	CDK5	Cyclin-dependent-like kinase 5	P0DP23	CALM1	Calmodulin-1	0.857
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q8NHW4	CCL4L2	C-C motif chemokine 4-like	0.756
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q08828	ADCY1	Adenylate cyclase type 1	0.796
Q00535	CDK5	Cyclin-dependent-like kinase 5	P51828	ADCY7	Adenylate cyclase type 7	0.726
Q00535	CDK5	Cyclin-dependent-like kinase 5	P23458	JAK1	Tyrosine-protein kinase JAK1	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.78
P49841	GSK3B	Glycogen synthase kinase-3 beta	P49841	GSK3B	Glycogen synthase kinase-3 beta	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P49841	GSK3B	Glycogen synthase kinase-3 beta	P14778	IL1R1	Interleukin-1 receptor type 1	0.778
Q00535	CDK5	Cyclin-dependent-like kinase 5	P01584	IL1B	Interleukin-1 beta	0.735
Q00535	CDK5	Cyclin-dependent-like kinase 5	Q13651	IL10RA	Interleukin-10 receptor subunit alpha	0.786
Q16539	MAPK14	Mitogen-activated protein kinase 14	P25025	CXCR2	C-X-C chemokine receptor type 2	0.889
P49841	GSK3B	Glycogen synthase kinase-3 beta	P25025	CXCR2	C-X-C chemokine receptor type 2	0.861
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P49841	GSK3B	Glycogen synthase kinase-3 beta	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.78
Q00535	CDK5	Cyclin-dependent-like kinase 5	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	P04637	TP53	Cellular tumor antigen p53	-0.823
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P49841	GSK3B	Glycogen synthase kinase-3 beta	O00463	TRAF5	TNF receptor-associated factor 5	-0.734

Sonidegib

hsa05164

Influenza A

1.49E-02

P31751, P01584, P23458, P05141, P04049, Q9UBU9

AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1

Sonidegib

hsa05165

Human papillomavirus infection

2.01E-02

Q16787, Q02930, Q13315

LAMA3, CREB5, ATM

Sonidegib

hsa05166

Human T-cell leukemia virus 1 infection

5.15E-03

P23458, P05141, P62826, Q08828, P51828, P18848, Q02930, P31751, P28068, Q13315

JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, CREB5, AKT2, HLA-DMB, ATM

Sonidegib

hsa05167

Kaposi sarcoma-associated herpesvirus infection

3.15E-02

P04049

RAF1

Sonidegib

hsa05169

Epstein-Barr virus infection

5.94E-04

P13765, P01106, Q13547, O00463, P42338, P07948, Q13761, P24522, O75293, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, CD3E, CD3G, CD247

Sonidegib

hsa05170

Human immunodeficiency virus 1 infection

2.39E-05

P04049, P62873, P01375, P17252, Q13546, O00463, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5

RAF1, GNB1, TNF, PRKCA, RIPK1, TRAF5, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.701
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P17252	PRKCA	Protein kinase C alpha type	0.769
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13546	RIPK1	Receptor-interacting serine/threonine-protein kinase 1	-0.769
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.823
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P01568	IFNA21	Interferon alpha-21	0.716
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	0.741
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	O60603	TLR2	Toll-like receptor 2	-0.862
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	O95067	CCNB2	G2/mitotic-specific cyclin-B2	0.711
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P10415	BCL2	Apoptosis regulator Bcl-2	0.94
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13619	CUL4A	Cullin-4A	-0.707
P08246	ELA2	Neutrophil elastase	Q93034	CUL5	Cullin-5	-0.744
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	-0.946
P08246	ELA2	Neutrophil elastase	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.811

Sonidegib

hsa05200

Pathways in cancer

1.71E-03

Q13751, P17301, P42338, P08238, P19174, P43246, P84022, Q13485, P20585, Q13547, P30281, P49767, P43657, P62879, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, ITGA2, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, MSH3, HDAC1, CCND3, VEGFC, P2RY5, GNB2, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P00374	DHFR	Dihydrofolate reductase	P17301	ITGA2	Integrin alpha-2	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P00374	DHFR	Dihydrofolate reductase	P20585	MSH3	DNA mismatch repair protein Msh3	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P00374	DHFR	Dihydrofolate reductase	P62879	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.721
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Sonidegib

hsa05202

Transcriptional misregulation in cancer

2.93E-12

Q12778, Q15532, Q13315, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q12778	FOXO1	Forkhead box protein O1	0.777
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q15532	SS18	Protein SSXT	0.763
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13315	ATM	Serine-protein kinase ATM	0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13315	ATM	Serine-protein kinase ATM	0.752
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14780	MMP9	Matrix metalloproteinase-9	-0.767
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P14780	MMP9	Matrix metalloproteinase-9	-0.855
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P14780	MMP9	Matrix metalloproteinase-9	-0.869
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P27930	IL1R2	Interleukin-1 receptor type 2	-0.727
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P27930	IL1R2	Interleukin-1 receptor type 2	-0.813
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P14923	JUP	Junction plakoglobin	0.845
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.833
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	-0.844
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q16548	BCL2A1	Bcl-2-related protein A1	-0.877
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.762
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.794
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q13077	TRAF1	TNF receptor-associated factor 1	0.754
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13077	TRAF1	TNF receptor-associated factor 1	0.83
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P08069	IGF1R	Insulin-like growth factor 1 receptor	P08069	IGF1R	Insulin-like growth factor 1 receptor	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P35226	BMI1	Polycomb complex protein BMI-1	0.805
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P35226	BMI1	Polycomb complex protein BMI-1	0.76
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P05164	MPO	Myeloperoxidase	-0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P05164	MPO	Myeloperoxidase	-0.811
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P05164	MPO	Myeloperoxidase	-0.867
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P12838	DEFA4	Neutrophil defensin 4	-0.86
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12838	DEFA4	Neutrophil defensin 4	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	P08246	ELA2	Neutrophil elastase	-0.896
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P08246	ELA2	Neutrophil elastase	-0.782
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08246	ELA2	Neutrophil elastase	-0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.787
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.9
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.822
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13547	HDAC1	Histone deacetylase 1	0.83
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12980	LYL1	Protein lyl-1	-0.73
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.75
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.787

Sonidegib

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Sonidegib

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Sonidegib

hsa05205

Proteoglycans in cancer

2.64E-03

Q13009, Q14643, O75369, P04049, P14780, P17252, O60603, P08069, P04628, Q13635, P08962

TIAM1, ITPR1, FLNB, RAF1, MMP9, PRKCA, TLR2, IGF1R, WNT1, PTCH1, CD63

Sonidegib

hsa05206

MicroRNAs in cancer

3.15E-02

P04049

RAF1

Sonidegib

hsa05210

Colorectal cancer

1.68E-03

P84022, Q13485, P04049, P10415

SMAD3, SMAD4, RAF1, BCL2

Sonidegib

hsa05211

Renal cell carcinoma

1.16E-02

P04049

RAF1

Sonidegib

hsa05212

Pancreatic cancer

6.15E-05

P42338, P31751, P04049, Q15311, P23458, P84022, Q13485, O75293

PIK3CB, AKT2, RAF1, RALBP1, JAK1, SMAD3, SMAD4, GADD45B

Sonidegib

hsa05213

Endometrial cancer

9.95E-03

P04049

RAF1

Sonidegib

hsa05214

Glioma

9.08E-05

P08069, P04049

IGF1R, RAF1

Sonidegib

hsa05215

Prostate cancer

1.65E-04

P08069, P04049

IGF1R, RAF1

Sonidegib

hsa05217

Basal cell carcinoma

3.50E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Sonidegib

hsa05218

Melanoma

3.85E-05

P08069, P04049

IGF1R, RAF1

Sonidegib

hsa05219

Bladder cancer

5.65E-03

P14780, P04637, P04049

MMP9, TP53, RAF1

Sonidegib

hsa05220

Chronic myeloid leukemia

1.61E-04

Q13547, Q13485, P25963, P84022, P42338, P04049, O75293

HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, RAF1, GADD45B

Sonidegib

hsa05221

Acute myeloid leukemia

8.29E-03

P04049

RAF1

Sonidegib

hsa05222

Small cell lung cancer

2.38E-03

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Sonidegib

hsa05223

Non-small cell lung cancer

6.63E-03

P04049

RAF1

Sonidegib

hsa05224

Breast cancer

2.75E-03

P04049, P08069, P49841, Q92837, P04637, P24522

RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45A

Sonidegib

hsa05225

Hepatocellular carcinoma

1.65E-04

P04049, P08069

RAF1, IGF1R

Sonidegib

hsa05226

Gastric cancer

1.25E-03

P04049, P84022, Q13485, P10415

RAF1, SMAD3, SMAD4, BCL2

Sonidegib

hsa05230

Central carbon metabolism in cancer

9.95E-03

P04049

RAF1

Sonidegib

hsa05231

Choline metabolism in cancer

5.74E-03

P04049, P31751, Q16760, O14986

RAF1, AKT2, DGKD, PIP5K1B

Sonidegib

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.99E-06

P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, Q04759, Q16539, P01730

PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, PRKCQ, MAPK14, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746

Sonidegib

hsa05310

Asthma

1.87E-07

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Sonidegib

hsa05321

Inflammatory bowel disease

5.09E-12

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	O60603	TLR2	Toll-like receptor 2	-0.714
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q14765	STAT4	Signal transducer and activator of transcription 4	0.904
P08246	ELA2	Neutrophil elastase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.783
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q14765	STAT4	Signal transducer and activator of transcription 4	0.821
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9UL17	TBX21	T-box transcription factor TBX21	0.884
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q9UL17	TBX21	T-box transcription factor TBX21	0.858
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.784
P08246	ELA2	Neutrophil elastase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.724
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.878
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q9HBE5	IL21R	Interleukin-21 receptor	0.713

Sonidegib

hsa05322

Systemic lupus erythematosus

2.48E-06

O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455

FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.716
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08246	ELA2	Neutrophil elastase	-0.742
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P08311	CTSG	Cathepsin G	-0.898
P11712	CYP2C9	Cytochrome P450 2C9	P09871	C1S	Complement C1s subcomponent	0.702
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.712
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P12814	ACTN1	Alpha-actinin-1	-0.76
P22894	MMP8	Neutrophil collagenase	P05455	SSB	Lupus La protein	-0.725
P08246	ELA2	Neutrophil elastase	P05455	SSB	Lupus La protein	-0.717

Sonidegib

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Sonidegib

hsa05332

Graft-versus-host disease

2.02E-09

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.85
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.734
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P01375	TNF	Tumor necrosis factor	-0.79
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P01375	TNF	Tumor necrosis factor	-0.783
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.943
P08246	ELA2	Neutrophil elastase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.775
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.915
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
Q08881	ITK	Tyrosine-protein kinase ITK/TSK	Q13241	KLRD1	Natural killer cells antigen CD94	0.852
P08246	ELA2	Neutrophil elastase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.7
Q92630	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q13241	KLRD1	Natural killer cells antigen CD94	0.941

Sonidegib

hsa05340

Primary immunodeficiency

2.19E-02

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Sonidegib

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

2.17E-03

P54284

CACNB3

Sonidegib

hsa05414

Dilated cardiomyopathy

2.60E-03

P54284, P09493, P26678

CACNB3, TPM1, PLN

Sonidegib

hsa05415

Diabetic cardiomyopathy

1.28E-02

Q16718, O14521, Q16539, P49841

NDUFA5, SDHD, MAPK14, GSK3B

Sonidegib

hsa05418

Fluid shear stress and atherosclerosis

1.26E-04

Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930

MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2

Community members of Sonidegib (S_DC: 9.69)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

O00767

SCD

StearoylNoneCoA desaturase

Predicted

0.1686

0.187

0.1997

0.6581

O14684

PTGES

Prostaglandin E synthase

Predicted

0.4531

0.6358

0.1565

1.6547

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P61586

RHOA

Transforming protein RhoA

Predicted

0.3541

0.0689

1.3149

P25025

CXCR2

CNoneXNoneC chemokine receptor type 2

Predicted

0.0278

0.5189

0.4494

1.5011

P43490

PBEF1

Nicotinamide phosphoribosyltransferase

Predicted

0.4423

0.7064

0.238

1.872

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P49841

GSK3B

Glycogen synthase kinaseNone3 beta

Predicted

0.1678

3.0839

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

P42338

PIK3CB

Phosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoform

Predicted

0.0447

0.9416

2.9055

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P09619

PDGFRB

PlateletNonederived growth factor receptor beta

Predicted

0.0496

0.9444

0.7408

2.6543

Q08881

ITK

TyrosineNoneprotein kinase ITK/TSK

Predicted

0.1635

0.5545

0.422

1.6127

Q9P1W9

PIM2

Serine/threonineNoneprotein kinase pimNone2

Predicted

0.1267

0.7674

0.2638

1.8619

Q92630

DYRK2

Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2

Predicted

0.1779

0.3494

0.7877

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

Q9UDY8

MALT1

MucosaNoneassociated lymphoid tissue lymphoma translocation protein 1

Predicted

0.0516

0.147

0.5592

0.8789

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

O75469

NR1I2

Nuclear receptor subfamily 1 group I member 2

Predicted

0.0315

0.9493

1.9143

Q02763

TEK

AngiopoietinNone1 receptor

Predicted

0.3206

0.6236

0.4304

1.8379

P08069

IGF1R

InsulinNonelike growth factor 1 receptor

Predicted

0.2082

0.9561

0.9883

3.0047

Q00535

CDK5

CyclinNonedependentNonelike kinase 5

Predicted

0.1992

0.6633

0.2994

1.7256

P25774

CTSS

Cathepsin S

Predicted

0.3185

0.4932

0.5168

1.6625

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P13866

SLC5A1

Sodium/glucose cotransporter 1

Predicted

0.3719

0.1105

0.105

0.512

P14780

MMP9

Matrix metalloproteinaseNone9

Predicted

0.1696

0.8424

0.7315

2.5012

Q9UHI8

ADAMTS1

A disintegrin and metalloproteinase with thrombospondin motifs 1

Predicted

0.0983

0.0054

0.0599

P22894

MMP8

Neutrophil collagenase

Predicted

0.1061

0.357

0.767

P10619

CTSA

Lysosomal protective protein

Predicted

0.1226

0.1531

0.1901

0.5575

P08514

ITGA2B

Integrin alphaNoneIIb

Predicted

0.0782

0.3248

0.779

1.4677

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

P07947

YES1

TyrosineNoneprotein kinase Yes

Predicted

0.1212

0.4345

0.165

1.0947

P04049

RAF1

RAF protoNoneoncogene serine/threonineNoneprotein kinase

Predicted

0.557

0.7572

2.7929

P78527

PRKDC

DNANonedependent protein kinase catalytic subunit

Predicted

0.178

0.1944

0.2496

0.7273

Q05397

PTK2

Focal adhesion kinase 1

Predicted

0.2153

0.5864

0.9713

2.2518

P00374

DHFR

Dihydrofolate reductase

Predicted

0.338

0.1868

0.2263

0.7688

PharmaCoNets of Sonidegib (SPCN: 275.99 )

Sonidegib regulated-network (SDN: 28.48)

Community members of Sonidegib (SDC: 9.69)

PharmaCoNets of Sonidegib (S_PCN: 275.99 )

Sonidegib regulated-network (S_DN: 28.48)

Community members of Sonidegib (S_DC: 9.69)