PharmaCoNets of Somatostatin (SPCN: 64.11 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Somatostatinhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Somatostatinhsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Somatostatinhsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Somatostatinhsa00220Arginine biosynthesis2.54E-032P05089, P49448ARG1, GLUD2More
Somatostatinhsa00250Alanine, aspartate and glutamate metabolism4.88E-021P49448GLUD2More
Somatostatinhsa00270Cysteine and methionine metabolism1.92E-022Q96RQ9, P40926IL4I1, MDH2More
Somatostatinhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Somatostatinhsa00471D-Glutamine and D-glutamate metabolism1.65E-021P49448GLUD2More
Somatostatinhsa00500Starch and sucrose metabolism9.22E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Somatostatinhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Somatostatinhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Somatostatinhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Somatostatinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Somatostatinhsa00591Linoleic acid metabolism1.29E-031P11712CYP2C9More
Somatostatinhsa00600Sphingolipid metabolism4.50E-021P15289ARSAMore
Somatostatinhsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Somatostatinhsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Somatostatinhsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Somatostatinhsa00910Nitrogen metabolism4.28E-032P22748, P49448CA4, GLUD2More
Somatostatinhsa00970Aminoacyl-tRNA biosynthesis3.94E-064O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Somatostatinhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Somatostatinhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Somatostatinhsa00983Drug metabolism - other enzymes2.16E-033P04183, P32320, P05164TK1, CDA, MPOMore
Somatostatinhsa01100Metabolic pathways2.25E-027Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGLMore
Somatostatinhsa01521EGFR tyrosine kinase inhibitor resistance2.18E-022P49841, Q9NRA1GSK3B, PDGFCMore
Somatostatinhsa01524Platinum drug resistance1.13E-025P10415, Q13489, P78417, P23025, P43246BCL2, BIRC3, GSTO1, XPA, MSH2More
Somatostatinhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Somatostatinhsa03008Ribosome biogenesis in eukaryotes2.60E-035Q9NYH9, P78345, Q9BVP2, O15381, Q9GZY0UTP6, RPP38, GNL3, NVL, NXF2; NXF2BMore
Somatostatinhsa03013RNA transport6.20E-0613O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1More
Somatostatinhsa03020RNA polymerase4.40E-022P24928, P62487POLR2A, POLR2GMore
Somatostatinhsa03040Spliceosome5.79E-037Q14562, O43143, O60508, Q99633, Q13595, Q01130, Q9UMS4DHX8, DHX15, CDC40, PRPF18, TRA2A, SFRS2, PRPF19More
Somatostatinhsa03060Protein export3.28E-021Q15070OXA1LMore
Somatostatinhsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Somatostatinhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Somatostatinhsa04010MAPK signaling pathway4.76E-025Q15283, P21860, Q12933, P01584, O14944RASA2, ERBB3, TRAF2, IL1B, EREGMore
Somatostatinhsa04015Rap1 signaling pathway1.58E-026P20827, P49767, P63261, P25116, P0DP23, P17252EFNA1, VEGFC, ACTG1, F2R, CALM1, PRKCAMore
Somatostatinhsa04020Calcium signaling pathway1.33E-0411Q96DU7, Q08828, Q16566, Q13557, P17252, P21860, O15399, P25116, P0DP23, P23634, P49767ITPKC, ADCY1, CAMK4, CAMK2D, PRKCA, ERBB3, GRIN2D, F2R, CALM1, ATP2B4, VEGFCMore
Somatostatinhsa04022cGMP-PKG signaling pathway2.55E-024P18848, Q8WYR1, P05141, P0DP24ATF4, PIK3R5, SLC25A5, CALM2More
Somatostatinhsa04024cAMP signaling pathway2.84E-025P0DP23, P23634, Q16566, O15399, P25116CALM1, ATP2B4, CAMK4, GRIN2D, F2RMore
Somatostatinhsa04060Cytokine-cytokine receptor interaction3.27E-0415P27930, P08476, Q9UHF4, Q13651, P16871, Q9HBE5, Q9UBD3, P47992, P02775, P01375, P09341, P32248, P51684, P18510, Q93038IL1R2, INHBA, IL20RA, IL10RA, IL7R, IL21R, XCL2, XCL1, PPBP, TNF, CXCL1, CCR7, CCR6, IL1RN, TNFRSF25More
Somatostatinhsa04061Viral protein interaction with cytokine and cytokine receptor2.22E-049P51684, P32248, P09341, P02775, P47992, Q9UBD3, Q13651, Q9UHF4, P01375CCR6, CCR7, CXCL1, PPBP, XCL1, XCL2, IL10RA, IL20RA, TNFMore
Somatostatinhsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Somatostatinhsa04064NF-kappa B signaling pathway3.48E-0815P10415, Q13489, P25963, P51617, O00463, Q13546, P01375, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q13315, P24522, P09341BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, RIPK1, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, ATM, GADD45A, CXCL1More
Somatostatinhsa04066HIF-1 signaling pathway3.40E-023Q09472, P07195, P10415EP300, LDHB, BCL2More
Somatostatinhsa04068FoxO signaling pathway3.52E-021Q96BR1SGK3More
Somatostatinhsa04070Phosphatidylinositol signaling system4.07E-024P0DP23, Q14643, O14732, P17252CALM1, ITPR1, IMPA2, PRKCAMore
Somatostatinhsa04071Sphingolipid signaling pathway3.90E-0910P17252, P21453, Q9H228, P01375, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2More
Somatostatinhsa04080Neuroactive ligand-receptor interaction8.70E-0510P08311, Q15722, P21453, Q9H228, O00398, Q01726, P41968, P21462, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, MC1R, MC3R, FPR1, C5AR1, C3AR1More
Somatostatinhsa04110Cell cycle2.39E-039Q9UBD5, Q9UJX4, P06493, O60566, Q09472, P24522, P04637, P49918, P33981ORC3, ANAPC5, CDK1, BUB1B, EP300, GADD45A, TP53, CDKN1C, TTKMore
Somatostatinhsa04115p53 signaling pathway3.57E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Somatostatinhsa04145Phagosome6.97E-0613O75015, P63261, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P27824, P13765FCGR3B, ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, CANX, HLA-DOBMore
Somatostatinhsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Somatostatinhsa04151PI3K-Akt signaling pathway7.39E-037P62753, O43521, P27348, Q8WYR1, P18848, O00141, Q6ZUJ8RPS6, BCL2L11, YWHAQ, PIK3R5, ATF4, SGK, PIK3AP1More
Somatostatinhsa04152AMPK signaling pathway2.34E-022Q96EB6, P36956SIRT1, SREBF1More
Somatostatinhsa04210Apoptosis1.82E-0616Q13315, P04637, P10415, Q13489, O76075, P25963, P01375, O75460, P24522, Q16548, Q13077, O43521, P43234, Q9UBR2, P18848, Q14643ATM, TP53, BCL2, BIRC3, DFFB, NFKBIA, TNF, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, CTSO, CTSZ, ATF4, ITPR1More
Somatostatinhsa04217Necroptosis5.66E-035P15104, P05141, P01584, P0C0S5, Q9H444GLUL, SLC25A5, IL1B, H2AFZ, CHMP4BMore
Somatostatinhsa04260Cardiac muscle contraction3.76E-021P07951TPM2More
Somatostatinhsa04261Adrenergic signaling in cardiomyocytes3.44E-025Q16537, P0DP23, P17252, P10415, P20020PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Somatostatinhsa04340Hedgehog signaling pathway4.63E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Somatostatinhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Somatostatinhsa04390Hippo signaling pathway1.47E-025P63261, Q13485, Q9UJU2, O43623, Q13489ACTG1, SMAD4, LEF1, SNAI2, BIRC3More
Somatostatinhsa04510Focal adhesion3.21E-026Q15942, P17252, Q13489, P10415, P49767, P63261ZYX, PRKCA, BIRC3, BCL2, VEGFC, ACTG1More
Somatostatinhsa04520Adherens junction3.36E-024Q13485, Q9UJU2, O43623, P63261SMAD4, LEF1, SNAI2, ACTG1More
Somatostatinhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Somatostatinhsa04540Gap junction4.76E-023P17252, Q13509, P68371PRKCA, TUBB3, TUBB2CMore
Somatostatinhsa04610Complement and coagulation cascades1.29E-052P00734, P0C0L4F2, C4AMore
Somatostatinhsa04612Antigen processing and presentation8.57E-078P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Somatostatinhsa04613Neutrophil extracellular trap formation1.46E-1124P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, Q6FI13, Q93077, P62807, P33778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC3, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Somatostatinhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Somatostatinhsa04621NOD-like receptor signaling pathway3.10E-0311Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4More
Somatostatinhsa04625C-type lectin receptor signaling pathway4.80E-026Q9ULY5, P20749, Q14643, P01375, Q13191, Q16539CLEC4E, BCL3, ITPR1, TNF, CBLB, MAPK14More
Somatostatinhsa04640Hematopoietic cell lineage3.26E-0310P13612, P14778, P27930, P15144, P11836, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Somatostatinhsa04650Natural killer cell mediated cytotoxicity3.86E-0910P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Somatostatinhsa04657IL-17 signaling pathway1.92E-048O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNFMore
Somatostatinhsa04658Th1 and Th2 cell differentiation5.24E-059Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOBMore
Somatostatinhsa04659Th17 cell differentiation5.04E-0410Q04759, Q16539, P06239, P13765, P14778, Q9HBE5, Q9UL17, P23771, P09693, P20963PRKCQ, MAPK14, LCK, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, CD3G, CD247More
Somatostatinhsa04660T cell receptor signaling pathway6.64E-0814P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Somatostatinhsa04666Fc gamma R-mediated phagocytosis2.22E-024P49006, P06396, P14598, P17252MARCKSL1, GSN, NCF1, PRKCAMore
Somatostatinhsa04668TNF signaling pathway1.17E-0413P01375, Q12933, O00463, Q13489, P25963, Q99941, P18848, P01584, P20749, Q13077, P14780, P20333, O95429TNF, TRAF2, TRAF5, BIRC3, NFKBIA, CREBL1, ATF4, IL1B, BCL3, TRAF1, MMP9, TNFRSF1B, BAG4More
Somatostatinhsa04670Leukocyte transendothelial migration4.20E-027P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXKMore
Somatostatinhsa04713Circadian entrainment4.25E-023Q13557, Q02153, Q08828CAMK2D, GUCY1B3, ADCY1More
Somatostatinhsa04720Long-term potentiation3.70E-045P17252, Q16566, P0DP23, O15399, Q14643PRKCA, CAMK4, CALM1, GRIN2D, ITPR1More
Somatostatinhsa04723Retrograde endocannabinoid signaling1.75E-025Q14643, P17252, P22694, Q16539, Q16718ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5More
Somatostatinhsa04725Cholinergic synapse3.86E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Somatostatinhsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Somatostatinhsa04750Inflammatory mediator regulation of TRP channels4.25E-023P01584, Q08828, Q13557IL1B, ADCY1, CAMK2DMore
Somatostatinhsa04911Insulin secretion2.23E-023Q08828, Q99941, Q13557ADCY1, CREBL1, CAMK2DMore
Somatostatinhsa04912GnRH signaling pathway5.61E-056P17252, Q16539, Q9Y6R4, Q14643, P0DP23, P22694PRKCA, MAPK14, MAP3K4, ITPR1, CALM1, PRKACBMore
Somatostatinhsa04915Estrogen signaling pathway2.25E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Somatostatinhsa04916Melanogenesis2.46E-035P0DP23, Q9UJU2, P17252, P49841, Q01726CALM1, LEF1, PRKCA, GSK3B, MC1RMore
Somatostatinhsa04918Thyroid hormone synthesis2.91E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Somatostatinhsa04920Adipocytokine signaling pathway5.72E-035P25963, P33121, Q04759, Q9Y4H2, P01375NFKBIA, ACSL1, PRKCQ, IRS2, TNFMore
Somatostatinhsa04921Oxytocin signaling pathway4.19E-024P0DP23, P17252, Q16566, P63261CALM1, PRKCA, CAMK4, ACTG1More
Somatostatinhsa04925Aldosterone synthesis and secretion2.90E-046Q14643, P0DP23, P17252, Q16566, P20020, P23634ITPR1, CALM1, PRKCA, CAMK4, ATP2B1, ATP2B4More
Somatostatinhsa04927Cortisol synthesis and secretion7.04E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Somatostatinhsa04928Parathyroid hormone synthesis, secretion and action1.65E-036Q14643, P22694, P23771, P17252, P18848, P10415ITPR1, PRKACB, GATA3, PRKCA, ATF4, BCL2More
Somatostatinhsa04932Non-alcoholic fatty liver disease3.49E-048O43521, P18848, O75460, Q12933, P01584, P13073, P12074, O15239BCL2L11, ATF4, ERN1, TRAF2, IL1B, COX4I1, COX6A1, NDUFA1More
Somatostatinhsa04933AGE-RAGE signaling pathway in diabetic complications3.36E-024Q13485, P10415, P49767, P17252SMAD4, BCL2, VEGFC, PRKCAMore
Somatostatinhsa04934Cushing syndrome6.07E-034Q99941, Q08828, O15169, Q13557CREBL1, ADCY1, AXIN1, CAMK2DMore
Somatostatinhsa04964Proximal tubule bicarbonate reclamation4.21E-043P22748, P00918, P49448CA4, CA2, GLUD2More
Somatostatinhsa04966Collecting duct acid secretion2.32E-033P02730, P00918, Q9Y666SLC4A1, CA2, SLC12A7More
Somatostatinhsa04970Salivary secretion1.38E-047P22694, Q14643, P20020, P23634, P17252, P0DP23, P49913PRKACB, ITPR1, ATP2B1, ATP2B4, PRKCA, CALM1, CAMPMore
Somatostatinhsa04971Gastric acid secretion4.76E-023P17252, P63261, P0DP23PRKCA, ACTG1, CALM1More
Somatostatinhsa04972Pancreatic secretion1.00E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Somatostatinhsa04978Mineral absorption3.94E-022P23634, Q9BXS9ATP2B4, SLC26A6More
Somatostatinhsa05010Alzheimer disease9.91E-0413Q92542, O15239, P05496, P13073, P12074, O75460, P0DP24, P01584, Q12933, P18848, O15169, P05141, P43686NCSTN, NDUFA1, ATP5G1, COX4I1, COX6A1, ERN1, CALM2, IL1B, TRAF2, ATF4, AXIN1, SLC25A5, PSMC4More
Somatostatinhsa05012Parkinson disease3.80E-0311P62987, O15239, P13073, P12074, P05496, P05141, O75460, P18848, P43686, P0DP24, Q13557UBA52, NDUFA1, COX4I1, COX6A1, ATP5G1, SLC25A5, ERN1, ATF4, PSMC4, CALM2, CAMK2DMore
Somatostatinhsa05014Amyotrophic lateral sclerosis3.90E-0314O15399, P10415, O15239, P12074, P05496, Q13509, P68371, Q12933, P43686, Q53GS7, P37198, P35658, P63261, Q9GZY0GRIN2D, BCL2, NDUFA1, COX6A1, ATP5G1, TUBB3, TUBB2C, TRAF2, PSMC4, GLE1, NUP62, NUP214, ACTG1, NXF2; NXF2BMore
Somatostatinhsa05016Huntington disease4.87E-025P13073, P24928, P62487, P05141, O75460COX4I1, POLR2A, POLR2G, SLC25A5, ERN1More
Somatostatinhsa05020Prion disease2.99E-027P01584, P46531, O15239, P05496, P12074, P43686, Q99941IL1B, NOTCH1, NDUFA1, ATP5G1, COX6A1, PSMC4, CREBL1More
Somatostatinhsa05022Pathways of neurodegeneration - multiple diseases5.59E-0415O15239, P13073, P12074, P05496, O75460, P18848, Q12933, P05141, P20333, O15169, P01584, P0DP24, Q13557, P62987, P43686NDUFA1, COX4I1, COX6A1, ATP5G1, ERN1, ATF4, TRAF2, SLC25A5, TNFRSF1B, AXIN1, IL1B, CALM2, CAMK2D, UBA52, PSMC4More
Somatostatinhsa05031Amphetamine addiction1.49E-024O15399, P0DP23, Q16566, P17252GRIN2D, CALM1, CAMK4, PRKCAMore
Somatostatinhsa05034Alcoholism3.90E-044Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Somatostatinhsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Somatostatinhsa05130Pathogenic Escherichia coli infection1.45E-022Q06124, O95487PTPN11, SEC24BMore
Somatostatinhsa05131Shigellosis3.34E-0211P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPFMore
Somatostatinhsa05132Salmonella infection3.70E-0516P51617, P25963, P01375, Q9UJU2, P63261, Q13546, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, P51808, Q13561, Q13509, P68371IRAK1, NFKBIA, TNF, LEF1, ACTG1, RIPK1, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3, TUBB2CMore
Somatostatinhsa05133Pertussis1.79E-044P0DP23, P23528, P09871, P0C0L4CALM1, CFL1, C1S, C4AMore
Somatostatinhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Somatostatinhsa05140Leishmaniasis2.91E-0511P13612, O75015, P14598, P13765, O60603, P25963, P01375, P49006, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, MAPK14, IRAK1, NCF4More
Somatostatinhsa05143African trypanosomiasis1.74E-032P69905, P68871HBA2, HBBMore
Somatostatinhsa05144Malaria5.88E-077P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Somatostatinhsa05145Toxoplasmosis3.07E-027P51617, P25963, P01375, P10415, Q13489, P13765, O60603IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2More
Somatostatinhsa05146Amoebiasis3.14E-069P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Somatostatinhsa05152Tuberculosis1.64E-0411Q13488, O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, Q16539, P51617TCIRG1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, MAPK14, IRAK1More
Somatostatinhsa05161Hepatitis B2.33E-028P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4More
Somatostatinhsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Somatostatinhsa05168Herpes simplex virus 1 infection1.94E-029Q9UKJ0, P01568, Q9GZY0, Q01130, Q13489, Q13398, Q03923, Q9UDV6, P10415PILRB, IFNA21, NXF2; NXF2B, SFRS2, BIRC3, ZNF211, ZNF85, ZNF212, BCL2More
Somatostatinhsa05169Epstein-Barr virus infection2.15E-0310P13765, Q92769, P04637, Q13546, P10415, P24522, O60603, P29728, P51617, P09693HLA-DOB, HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, OAS2, IRAK1, CD3GMore
Somatostatinhsa05170Human immunodeficiency virus 1 infection2.45E-0516P0DP23, P01375, P17252, Q13546, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P09693, P10415, Q13619, Q93034, Q9Y6Q5CALM1, TNF, PRKCA, RIPK1, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, CD3G, BCL2, CUL4A, CUL5, AP1M2More
Somatostatinhsa05200Pathways in cancer2.37E-0318P04637, Q9UJU2, P17252, Q09472, P43246, Q13485, P14923, P10415, Q13489, Q13077, P49767, P25116, O95267, P78417, P24522, P0DP23, P01568, P16871TP53, LEF1, PRKCA, EP300, MSH2, SMAD4, JUP, BCL2, BIRC3, TRAF1, VEGFC, F2R, RASGRP1, GSTO1, GADD45A, CALM1, IFNA21, IL7RMore
Somatostatinhsa05202Transcriptional misregulation in cancer1.74E-1323Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Somatostatinhsa05203Viral carcinogenesis2.93E-033Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Somatostatinhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Somatostatinhsa05210Colorectal cancer2.41E-024P10415, P04637, Q9UJU2, P24522BCL2, TP53, LEF1, GADD45AMore
Somatostatinhsa05211Renal cell carcinoma3.76E-021Q06124PTPN11More
Somatostatinhsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Somatostatinhsa05213Endometrial cancer1.91E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Somatostatinhsa05214Glioma8.71E-045P0DP23, Q16566, P17252, P04637, P24522CALM1, CAMK4, PRKCA, TP53, GADD45AMore
Somatostatinhsa05215Prostate cancer1.94E-024P10415, Q9UJU2, Q09472, P04637BCL2, LEF1, EP300, TP53More
Somatostatinhsa05216Thyroid cancer2.42E-043Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Somatostatinhsa05217Basal cell carcinoma1.56E-033Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Somatostatinhsa05222Small cell lung cancer1.93E-037Q13489, P10415, P25963, Q13077, O00463, P04637, P24522BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, TP53, GADD45AMore
Somatostatinhsa05224Breast cancer4.32E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Somatostatinhsa05226Gastric cancer8.86E-035Q9UJU2, P04637, P24522, P14923, P10415LEF1, TP53, GADD45A, JUP, BCL2More
Somatostatinhsa05230Central carbon metabolism in cancer4.04E-022P07195, P04637LDHB, TP53More
Somatostatinhsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore
Somatostatinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.34E-025O95267, P20963, P09693, P06239, Q04759RASGRP1, CD247, CD3G, LCK, PRKCQMore
Somatostatinhsa05310Asthma1.00E-043P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Somatostatinhsa05321Inflammatory bowel disease9.19E-107O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Somatostatinhsa05322Systemic lupus erythematosus4.36E-0614P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P12814, P05455ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ACTN1, SSBMore
Somatostatinhsa05323Rheumatoid arthritis2.72E-024P01375, P13765, P09341, O60603TNF, HLA-DOB, CXCL1, TLR2More
Somatostatinhsa05332Graft-versus-host disease1.16E-075P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Somatostatinhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Somatostatinhsa05418Fluid shear stress and atherosclerosis2.49E-0311Q16539, P78417, P10599, P14780, P01375, P63261, P10415, P14778, P27930, P0DP23, Q92974MAPK14, GSTO1, TXN, MMP9, TNF, ACTG1, BCL2, IL1R1, IL1R2, CALM1, ARHGEF2More

Community members of Somatostatin (SDC: 3.59)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P08311CTSGCathepsin GPredicted00.49490.18740.64781.2701
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
P08246ELA2Neutrophil elastasePredicted10.4960.68440.71322.33
P24158PRTN3MyeloblastinPredicted10.05160.051100.1281
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
P61073CXCR4CNoneXNoneC chemokine receptor type 4Predicted10.28230.40180.6481.5927
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P32248CCR7CNoneC chemokine receptor type 7Predicted10.13910.04610.33040.4922
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P32302CXCR5CNoneXNoneC chemokine receptor type 5Predicted00.24550.04590.33040.545
Q15722LTB4RLeukotriene B4 receptor 1Predicted00.06770.219900.4736
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P46091GPR1ChemerinNonelike receptor 2Predicted00.24760.137200.3982
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
Q9HB89NMUR1NeuromedinNoneU receptor 1Predicted00.00240.30300.6072
Q15743GPR68Ovarian cancer GNoneprotein coupled receptor 1Predicted00.06580.013700.0602
Q99527GPER1GNoneprotein coupled estrogen receptor 1Predicted00.02490.12940.21380.485
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)