PharmaCoNets of Sitagliptin (SPCN: 7.67 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Sitagliptinhsa00230Purine metabolism4.48E-022Q08828, P51828ADCY1, ADCY7More
Sitagliptinhsa00270Cysteine and methionine metabolism1.92E-022Q96RQ9, P40926IL4I1, MDH2More
Sitagliptinhsa00830Retinol metabolism3.19E-021P00325ADH1BMore
Sitagliptinhsa01522Endocrine resistance6.51E-033Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Sitagliptinhsa04010MAPK signaling pathway4.76E-025Q15283, P21860, Q12933, P01584, O14944RASA2, ERBB3, TRAF2, IL1B, EREGMore
Sitagliptinhsa04015Rap1 signaling pathway3.69E-045P15498, Q08828, P51828, P31751, P0DP23VAV1, ADCY1, ADCY7, AKT2, CALM1More
Sitagliptinhsa04020Calcium signaling pathway1.75E-036Q96DU7, Q08828, Q13557, P21860, P0DP23, P51828ITPKC, ADCY1, CAMK2D, ERBB3, CALM1, ADCY7More
Sitagliptinhsa04022cGMP-PKG signaling pathway2.66E-034P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Sitagliptinhsa04024cAMP signaling pathway6.94E-055Q08828, P51828, P31751, P0DP23, P15498ADCY1, ADCY7, AKT2, CALM1, VAV1More
Sitagliptinhsa04062Chemokine signaling pathway7.23E-034P15498, Q08828, P51828, P31751VAV1, ADCY1, ADCY7, AKT2More
Sitagliptinhsa04071Sphingolipid signaling pathway1.94E-026Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2More
Sitagliptinhsa04072Phospholipase D signaling pathway1.67E-023P31751, Q08828, P51828AKT2, ADCY1, ADCY7More
Sitagliptinhsa04114Oocyte meiosis1.67E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Sitagliptinhsa04211Longevity regulating pathway6.51E-033P31751, Q08828, P51828AKT2, ADCY1, ADCY7More
Sitagliptinhsa04213Longevity regulating pathway - multiple species2.91E-033P31751, Q08828, P51828AKT2, ADCY1, ADCY7More
Sitagliptinhsa04261Adrenergic signaling in cardiomyocytes2.17E-034Q08828, P51828, P31751, P0DP23ADCY1, ADCY7, AKT2, CALM1More
Sitagliptinhsa04270Vascular smooth muscle contraction9.93E-033P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Sitagliptinhsa04340Hedgehog signaling pathway1.80E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Sitagliptinhsa04371Apelin signaling pathway1.09E-034P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Sitagliptinhsa04380Osteoclast differentiation6.51E-033Q9NQC7, P23458, P31751CYLD, JAK1, AKT2More
Sitagliptinhsa04540Gap junction3.73E-022Q08828, P51828ADCY1, ADCY7More
Sitagliptinhsa04611Platelet activation5.11E-033P31751, Q08828, P51828AKT2, ADCY1, ADCY7More
Sitagliptinhsa04625C-type lectin receptor signaling pathway3.91E-033Q9NQC7, P31751, P0DP23CYLD, AKT2, CALM1More
Sitagliptinhsa04630JAK-STAT signaling pathway2.91E-033P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Sitagliptinhsa04662B cell receptor signaling pathway2.41E-022P31751, P15498AKT2, VAV1More
Sitagliptinhsa04664Fc epsilon RI signaling pathway2.41E-022P31751, P15498AKT2, VAV1More
Sitagliptinhsa04668TNF signaling pathway1.26E-024Q12933, Q99941, P01584, O95429TRAF2, CREBL1, IL1B, BAG4More
Sitagliptinhsa04713Circadian entrainment5.31E-045P0DP23, Q13557, Q02153, Q08828, P51828CALM1, CAMK2D, GUCY1B3, ADCY1, ADCY7More
Sitagliptinhsa04720Long-term potentiation3.73E-022P0DP23, Q08828CALM1, ADCY1More
Sitagliptinhsa04723Retrograde endocannabinoid signaling4.48E-022Q08828, P51828ADCY1, ADCY7More
Sitagliptinhsa04724Glutamatergic synapse3.73E-022Q08828, P51828ADCY1, ADCY7More
Sitagliptinhsa04725Cholinergic synapse5.11E-033Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Sitagliptinhsa04750Inflammatory mediator regulation of TRP channels7.11E-045P01584, Q08828, P51828, Q13557, P0DP23IL1B, ADCY1, ADCY7, CAMK2D, CALM1More
Sitagliptinhsa04910Insulin signaling pathway3.04E-022P0DP23, P31751CALM1, AKT2More
Sitagliptinhsa04911Insulin secretion1.32E-034Q08828, P51828, Q99941, Q13557ADCY1, ADCY7, CREBL1, CAMK2DMore
Sitagliptinhsa04912GnRH signaling pathway5.11E-033Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Sitagliptinhsa04913Ovarian steroidogenesis1.85E-022Q08828, P51828ADCY1, ADCY7More
Sitagliptinhsa04914Progesterone-mediated oocyte maturation6.51E-033Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Sitagliptinhsa04915Estrogen signaling pathway2.66E-034Q08828, P51828, P31751, P0DP23ADCY1, ADCY7, AKT2, CALM1More
Sitagliptinhsa04916Melanogenesis1.41E-033P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Sitagliptinhsa04918Thyroid hormone synthesis4.48E-022Q08828, P51828ADCY1, ADCY7More
Sitagliptinhsa04921Oxytocin signaling pathway1.42E-023P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Sitagliptinhsa04923Regulation of lipolysis in adipocytes2.69E-043Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Sitagliptinhsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Sitagliptinhsa04925Aldosterone synthesis and secretion3.91E-033Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Sitagliptinhsa04926Relaxin signaling pathway8.11E-033P31751, Q08828, P51828AKT2, ADCY1, ADCY7More
Sitagliptinhsa04927Cortisol synthesis and secretion1.85E-022Q08828, P51828ADCY1, ADCY7More
Sitagliptinhsa04932Non-alcoholic fatty liver disease4.44E-024Q12933, P01584, P12074, O15239TRAF2, IL1B, COX6A1, NDUFA1More
Sitagliptinhsa04934Cushing syndrome5.31E-045Q99941, Q08828, P51828, O15169, Q13557CREBL1, ADCY1, ADCY7, AXIN1, CAMK2DMore
Sitagliptinhsa04935Growth hormone synthesis, secretion and action6.51E-033Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Sitagliptinhsa04970Salivary secretion9.02E-043Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Sitagliptinhsa04971Gastric acid secretion1.41E-033Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Sitagliptinhsa04972Pancreatic secretion2.41E-022Q08828, P51828ADCY1, ADCY7More
Sitagliptinhsa04976Bile secretion1.85E-022Q08828, P51828ADCY1, ADCY7More
Sitagliptinhsa05010Alzheimer disease1.23E-028Q92542, O15239, P05496, P12074, P01584, Q12933, O15169, P43686NCSTN, NDUFA1, ATP5G1, COX6A1, IL1B, TRAF2, AXIN1, PSMC4More
Sitagliptinhsa05012Parkinson disease3.53E-026P62987, O15239, P12074, P05496, P43686, Q13557UBA52, NDUFA1, COX6A1, ATP5G1, PSMC4, CAMK2DMore
Sitagliptinhsa05014Amyotrophic lateral sclerosis2.99E-027O15239, P12074, P05496, Q12933, P43686, P37198, P35658NDUFA1, COX6A1, ATP5G1, TRAF2, PSMC4, NUP62, NUP214More
Sitagliptinhsa05020Prion disease2.99E-027P01584, P46531, O15239, P05496, P12074, P43686, Q99941IL1B, NOTCH1, NDUFA1, ATP5G1, COX6A1, PSMC4, CREBL1More
Sitagliptinhsa05022Pathways of neurodegeneration - multiple diseases9.10E-039O15239, P12074, P05496, Q12933, O15169, P01584, Q13557, P62987, P43686NDUFA1, COX6A1, ATP5G1, TRAF2, AXIN1, IL1B, CAMK2D, UBA52, PSMC4More
Sitagliptinhsa05032Morphine addiction2.41E-022Q08828, P51828ADCY1, ADCY7More
Sitagliptinhsa05135Yersinia infection2.24E-023Q14161, P15498, P31751GIT2, VAV1, AKT2More
Sitagliptinhsa05142Chagas disease4.48E-022Q08828, P31751ADCY1, AKT2More
Sitagliptinhsa05144Malaria4.92E-024O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Sitagliptinhsa05145Toxoplasmosis1.67E-023P23458, P31751, Q13651JAK1, AKT2, IL10RAMore
Sitagliptinhsa05152Tuberculosis9.49E-034P0DP23, P23458, P31751, Q13651CALM1, JAK1, AKT2, IL10RAMore
Sitagliptinhsa05163Human cytomegalovirus infection2.17E-046P31751, P0DP23, Q08828, P51828, P23458, Q13651AKT2, CALM1, ADCY1, ADCY7, JAK1, IL10RAMore
Sitagliptinhsa05164Influenza A3.67E-023P31751, P23458, Q9UBU9AKT2, JAK1, NXF1More
Sitagliptinhsa05166Human T-cell leukemia virus 1 infection3.02E-024P23458, Q08828, P51828, P31751JAK1, ADCY1, ADCY7, AKT2More
Sitagliptinhsa05167Kaposi sarcoma-associated herpesvirus infection2.24E-023P31751, P23458, P0DP23AKT2, JAK1, CALM1More
Sitagliptinhsa05168Herpes simplex virus 1 infection2.09E-024Q9UBU9, P23458, P31751, Q6NUN9NXF1, JAK1, AKT2, ZNF746More
Sitagliptinhsa05200Pathways in cancer1.65E-025P23458, P31751, Q08828, P51828, P0DP23JAK1, AKT2, ADCY1, ADCY7, CALM1More
Sitagliptinhsa05212Pancreatic cancer2.41E-022P31751, P23458AKT2, JAK1More
Sitagliptinhsa05214Glioma1.85E-022P0DP23, P31751CALM1, AKT2More
Sitagliptinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.48E-022P31751, P23458AKT2, JAK1More
Sitagliptinhsa05321Inflammatory bowel disease4.92E-024O60603, P01375, Q14765, Q9UL17TLR2, TNF, STAT4, TBX21More
Sitagliptinhsa05332Graft-versus-host disease1.80E-024P10747, P01375, P26715, Q13241CD28, TNF, KLRC1, KLRD1More
Sitagliptinhsa05414Dilated cardiomyopathy4.48E-022Q08828, P51828ADCY1, ADCY7More

Community members of Sitagliptin (SDC: 0.72)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
P12955PEPDXaaNonePro dipeptidasePredicted00.33850.018800.2068
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)