PharmaCoNets of Sirolimus (SPCN: 20.15 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Sirolimushsa00052Galactose metabolism1.12E-042P06280, O43451GLA, MGAMMore
Sirolimushsa00280Valine, leucine and isoleucine degradation3.41E-034P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Sirolimushsa00500Starch and sucrose metabolism3.16E-042O43451, P06737MGAM, PYGLMore
Sirolimushsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Sirolimushsa00730Thiamine metabolism2.53E-052P05186, P24666ALPL, ACP1More
Sirolimushsa00770Pantothenate and CoA biosynthesis1.27E-043O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Sirolimushsa00980Metabolism of xenobiotics by cytochrome P4503.20E-022P78417, P11766GSTO1, ADH5More
Sirolimushsa00982Drug metabolism - cytochrome P4503.20E-022P78417, P11766GSTO1, ADH5More
Sirolimushsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Sirolimushsa01521EGFR tyrosine kinase inhibitor resistance4.26E-033P17252, P04049, Q9NRA1PRKCA, RAF1, PDGFCMore
Sirolimushsa01522Endocrine resistance2.16E-021P04049RAF1More
Sirolimushsa03013RNA transport4.13E-026Q09161, P35658, P47813, Q14152, O75822, P51114NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1More
Sirolimushsa03060Protein export4.22E-022P37108, Q15005SRP14, SPCS2More
Sirolimushsa04010MAPK signaling pathway4.15E-021P04049RAF1More
Sirolimushsa04012ErbB signaling pathway1.82E-021P04049RAF1More
Sirolimushsa04014Ras signaling pathway1.04E-046P04049, Q9NRA1, P49767, P17252, Q14644, P62873RAF1, PDGFC, VEGFC, PRKCA, RASA3, GNB1More
Sirolimushsa04015Rap1 signaling pathway5.45E-056P04049, Q9NRA1, P49767, P25116, P08514, P17252RAF1, PDGFC, VEGFC, F2R, ITGA2B, PRKCAMore
Sirolimushsa04020Calcium signaling pathway2.39E-034P17252, P25116, Q9NRA1, P49767PRKCA, F2R, PDGFC, VEGFCMore
Sirolimushsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Sirolimushsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Sirolimushsa04060Cytokine-cytokine receptor interaction3.62E-024P27930, P14778, P25024, P25025IL1R2, IL1R1, CXCR1, CXCR2More
Sirolimushsa04061Viral protein interaction with cytokine and cytokine receptor2.60E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Sirolimushsa04062Chemokine signaling pathway3.98E-021P04049RAF1More
Sirolimushsa04064NF-kappa B signaling pathway4.09E-035P01584, P67870, P63279, Q8NHW4, Q9NQC7IL1B, CSNK2B, UBE2I, CCL4L2, CYLDMore
Sirolimushsa04068FoxO signaling pathway1.99E-021P04049RAF1More
Sirolimushsa04071Sphingolipid signaling pathway2.50E-038P04049, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2RAF1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Sirolimushsa04072Phospholipase D signaling pathway1.50E-058P04049, Q9UQC2, P25116, P25024, P25025, P17252, P23743, Q9NRA1RAF1, GAB2, F2R, CXCR1, CXCR2, PRKCA, DGKA, PDGFCMore
Sirolimushsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Sirolimushsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Sirolimushsa04140Autophagy - animal2.82E-021P04049RAF1More
Sirolimushsa04150mTOR signaling pathway7.74E-034P04049, Q02750, Q9NQL2, P51812RAF1, MAP2K1, RRAGD, RPS6KA3More
Sirolimushsa04151PI3K-Akt signaling pathway1.71E-036P25116, Q9NRA1, P49767, P62873, P08514, P17252F2R, PDGFC, VEGFC, GNB1, ITGA2B, PRKCAMore
Sirolimushsa04210Apoptosis3.64E-035O76075, P01375, Q9NR28, Q16548, P04049DFFB, TNF, DIABLO, BCL2A1, RAF1More
Sirolimushsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Sirolimushsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Sirolimushsa04218Cellular senescence2.49E-021P04049RAF1More
Sirolimushsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Sirolimushsa04270Vascular smooth muscle contraction2.32E-021P04049RAF1More
Sirolimushsa04340Hedgehog signaling pathway4.15E-034P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Sirolimushsa04360Axon guidance2.49E-021P04049RAF1More
Sirolimushsa04370VEGF signaling pathway1.79E-044P16298, Q05397, Q02750, P04049PPP3CB, PTK2, MAP2K1, RAF1More
Sirolimushsa04371Apelin signaling pathway1.54E-025P63218, P50151, P04049, Q14344, Q13485GNG5, GNG10, RAF1, GNA13, SMAD4More
Sirolimushsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Sirolimushsa04510Focal adhesion1.25E-035P08514, P17252, P04049, Q9NRA1, P49767ITGA2B, PRKCA, RAF1, PDGFC, VEGFCMore
Sirolimushsa04512ECM-receptor interaction3.19E-022P07359, P08514GP1BA, ITGA2BMore
Sirolimushsa04540Gap junction1.78E-044P17252, P68371, P04049, Q9NRA1PRKCA, TUBB2C, RAF1, PDGFCMore
Sirolimushsa04550Signaling pathways regulating pluripotency of stem cells1.99E-021P04049RAF1More
Sirolimushsa04611Platelet activation7.90E-033P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Sirolimushsa04612Antigen processing and presentation3.25E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Sirolimushsa04613Neutrophil extracellular trap formation6.10E-0418P17252, P04049, O60603, P05164, P08246, Q9UM07, Q6FI13, O60814, Q15080, P20160, P08311, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, H2BC12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Sirolimushsa04621NOD-like receptor signaling pathway1.90E-0314Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P59665, P59666, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4More
Sirolimushsa04623Cytosolic DNA-sensing pathway1.54E-022P01584, Q8NHW4IL1B, CCL4L2More
Sirolimushsa04625C-type lectin receptor signaling pathway1.49E-021P04049RAF1More
Sirolimushsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Sirolimushsa04640Hematopoietic cell lineage2.96E-023P07359, P08514, P04141GP1BA, ITGA2B, CSF2More
Sirolimushsa04650Natural killer cell mediated cytotoxicity1.03E-0412P16298, P50591, P01375, O60880, P20963, Q02750, P04049, Q13241, P26718, O75015, P26717, P26715PPP3CB, TNFSF10, TNF, SH2D1A, CD247, MAP2K1, RAF1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Sirolimushsa04657IL-17 signaling pathway5.82E-037O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Sirolimushsa04658Th1 and Th2 cell differentiation1.12E-028Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Sirolimushsa04659Th17 cell differentiation3.17E-023P25963, P84022, Q13485NFKBIA, SMAD3, SMAD4More
Sirolimushsa04660T cell receptor signaling pathway2.18E-0412P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P04049, Q16539, P49841TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, RAF1, MAPK14, GSK3BMore
Sirolimushsa04662B cell receptor signaling pathway9.95E-031P04049RAF1More
Sirolimushsa04664Fc epsilon RI signaling pathway2.19E-033P04141, P17252, P04049CSF2, PRKCA, RAF1More
Sirolimushsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Sirolimushsa04713Circadian entrainment4.51E-022P17252, P62873PRKCA, GNB1More
Sirolimushsa04720Long-term potentiation2.17E-034P16298, P51812, Q02750, P04049PPP3CB, RPS6KA3, MAP2K1, RAF1More
Sirolimushsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Sirolimushsa04723Retrograde endocannabinoid signaling3.83E-022P17252, P62873PRKCA, GNB1More
Sirolimushsa04724Glutamatergic synapse3.09E-033P17252, P62873, Q9NSB8PRKCA, GNB1, HOMER2More
Sirolimushsa04725Cholinergic synapse3.83E-022P17252, P62873PRKCA, GNB1More
Sirolimushsa04726Serotonergic synapse4.07E-044P17252, P62873, P18054, P04049PRKCA, GNB1, ALOX12, RAF1More
Sirolimushsa04727GABAergic synapse2.06E-022P62873, P17252GNB1, PRKCAMore
Sirolimushsa04730Long-term depression1.08E-023Q14344, P04049, P07948GNA13, RAF1, LYNMore
Sirolimushsa04750Inflammatory mediator regulation of TRP channels4.51E-022P18054, P17252ALOX12, PRKCAMore
Sirolimushsa04810Regulation of actin cytoskeleton5.85E-034P04049, P08514, Q9NRA1, P25116RAF1, ITGA2B, PDGFC, F2RMore
Sirolimushsa04910Insulin signaling pathway2.51E-034P22694, P06737, P04049, P49841PRKACB, PYGL, RAF1, GSK3BMore
Sirolimushsa04912GnRH signaling pathway1.82E-021P04049RAF1More
Sirolimushsa04914Progesterone-mediated oocyte maturation5.89E-034Q17RY0, P51812, Q02750, P04049CPEB4, RPS6KA3, MAP2K1, RAF1More
Sirolimushsa04915Estrogen signaling pathway2.99E-021P04049RAF1More
Sirolimushsa04916Melanogenesis1.33E-021P04049RAF1More
Sirolimushsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Sirolimushsa04918Thyroid hormone synthesis1.14E-022P17252, P27824PRKCA, CANXMore
Sirolimushsa04919Thyroid hormone signaling pathway6.83E-045P49841, P04049, P22694, O60244, Q9NVC6GSK3B, RAF1, PRKACB, MED14, MED17More
Sirolimushsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Sirolimushsa04926Relaxin signaling pathway1.58E-034P62873, P49767, P04049, P17252GNB1, VEGFC, RAF1, PRKCAMore
Sirolimushsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Sirolimushsa04929GnRH secretion4.98E-031P04049RAF1More
Sirolimushsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Sirolimushsa04932Non-alcoholic fatty liver disease6.66E-049P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, O15239TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1More
Sirolimushsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Sirolimushsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Sirolimushsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Sirolimushsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Sirolimushsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Sirolimushsa05010Alzheimer disease2.21E-0210O15239, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P67870, P28070NDUFA1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, CSNK2B, PSMB4More
Sirolimushsa05032Morphine addiction1.20E-036P62873, P63218, P50151, Q07343, P17252, P43250GNB1, GNG5, GNG10, PDE4B, PRKCA, GRK6More
Sirolimushsa05034Alcoholism2.49E-021P04049RAF1More
Sirolimushsa05120Epithelial cell signaling in Helicobacter pylori infection3.73E-022P25024, P25025CXCR1, CXCR2More
Sirolimushsa05130Pathogenic Escherichia coli infection3.65E-023Q14247, P68371, P25116CTTN, TUBB2C, F2RMore
Sirolimushsa05132Salmonella infection6.67E-035P25963, P04049, Q13489, P10415, Q9BQS8NFKBIA, RAF1, BIRC3, BCL2, FYCO1More
Sirolimushsa05140Leishmaniasis1.87E-027P13612, O75015, P13765, O60603, P01375, Q16539, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MAPK14, NCF4More
Sirolimushsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Sirolimushsa05144Malaria3.12E-024P60033, P01375, P35443, P26718CD81, TNF, THBS4, KLRK1More
Sirolimushsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Sirolimushsa05146Amoebiasis3.91E-027P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Sirolimushsa05150Staphylococcus aureus infection8.13E-058P21730, P21462, O75015, Q14532, P59665, P59666, P12838, P49913C5AR1, FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Sirolimushsa05152Tuberculosis3.98E-021P04049RAF1More
Sirolimushsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Sirolimushsa05161Hepatitis B6.38E-045P04049, P25963, Q13485, P10415, P84022RAF1, NFKBIA, SMAD4, BCL2, SMAD3More
Sirolimushsa05163Human cytomegalovirus infection1.53E-028P04049, P0DP23, Q8NHW4, Q08828, P23458, P01584, P61073, Q13651RAF1, CALM1, CCL4L2, ADCY1, JAK1, IL1B, CXCR4, IL10RAMore
Sirolimushsa05164Influenza A3.65E-021P04049RAF1More
Sirolimushsa05167Kaposi sarcoma-associated herpesvirus infection4.57E-035P62879, P16298, P04049, Q02750, P0CG47GNB2, PPP3CB, RAF1, MAP2K1, UBBMore
Sirolimushsa05170Human immunodeficiency virus 1 infection1.31E-036P04049, Q02750, P62879, P16298, Q05397, P20333RAF1, MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Sirolimushsa05200Pathways in cancer1.37E-026P08514, P17252, P49767, P25116, P62873, P78417ITGA2B, PRKCA, VEGFC, F2R, GNB1, GSTO1More
Sirolimushsa05202Transcriptional misregulation in cancer3.00E-0213P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Sirolimushsa05205Proteoglycans in cancer8.61E-034Q12955, P04049, Q14247, P17252ANK3, RAF1, CTTN, PRKCAMore
Sirolimushsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Sirolimushsa05210Colorectal cancer1.68E-034P84022, Q13485, P04049, P10415SMAD3, SMAD4, RAF1, BCL2More
Sirolimushsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Sirolimushsa05212Pancreatic cancer3.44E-033P04049, P84022, Q13485RAF1, SMAD3, SMAD4More
Sirolimushsa05213Endometrial cancer4.26E-033O15169, Q02750, P04049AXIN1, MAP2K1, RAF1More
Sirolimushsa05214Glioma9.95E-031P04049RAF1More
Sirolimushsa05215Prostate cancer1.33E-021P04049RAF1More
Sirolimushsa05218Melanoma6.63E-031P04049RAF1More
Sirolimushsa05219Bladder cancer4.98E-031P04049RAF1More
Sirolimushsa05220Chronic myeloid leukemia6.24E-044Q13485, P25963, P84022, P04049SMAD4, NFKBIA, SMAD3, RAF1More
Sirolimushsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Sirolimushsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Sirolimushsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Sirolimushsa05224Breast cancer1.49E-021P04049RAF1More
Sirolimushsa05225Hepatocellular carcinoma1.33E-021P04049RAF1More
Sirolimushsa05226Gastric cancer2.93E-046P04049, Q02750, O15169, P84022, Q13485, P10415RAF1, MAP2K1, AXIN1, SMAD3, SMAD4, BCL2More
Sirolimushsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Sirolimushsa05231Choline metabolism in cancer1.78E-044P04049, Q9NRA1, P23743, P17252RAF1, PDGFC, DGKA, PRKCAMore
Sirolimushsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.66E-021P04049RAF1More
Sirolimushsa05310Asthma2.81E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Sirolimushsa05321Inflammatory bowel disease3.16E-036O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Sirolimushsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Sirolimushsa05332Graft-versus-host disease4.38E-035P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Temsirolimushsa00052Galactose metabolism1.12E-042P06280, O43451GLA, MGAMMore
Temsirolimushsa00280Valine, leucine and isoleucine degradation3.41E-034P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Temsirolimushsa00500Starch and sucrose metabolism3.16E-042O43451, P06737MGAM, PYGLMore
Temsirolimushsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Temsirolimushsa00730Thiamine metabolism2.53E-052P05186, P24666ALPL, ACP1More
Temsirolimushsa00770Pantothenate and CoA biosynthesis5.59E-032O95498, O95497VNN2, VNN1More
Temsirolimushsa00980Metabolism of xenobiotics by cytochrome P4503.20E-022P78417, P11766GSTO1, ADH5More
Temsirolimushsa00982Drug metabolism - cytochrome P4503.20E-022P78417, P11766GSTO1, ADH5More
Temsirolimushsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Temsirolimushsa01521EGFR tyrosine kinase inhibitor resistance2.60E-022P17252, Q9NRA1PRKCA, PDGFCMore
Temsirolimushsa03013RNA transport4.13E-026Q09161, P35658, P47813, Q14152, O75822, P51114NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1More
Temsirolimushsa03060Protein export4.22E-022P37108, Q15005SRP14, SPCS2More
Temsirolimushsa04014Ras signaling pathway5.92E-045Q9NRA1, P49767, P17252, Q14644, P62873PDGFC, VEGFC, PRKCA, RASA3, GNB1More
Temsirolimushsa04015Rap1 signaling pathway4.88E-045Q9NRA1, P49767, P25116, P08514, P17252PDGFC, VEGFC, F2R, ITGA2B, PRKCAMore
Temsirolimushsa04020Calcium signaling pathway2.39E-034P17252, P25116, Q9NRA1, P49767PRKCA, F2R, PDGFC, VEGFCMore
Temsirolimushsa04060Cytokine-cytokine receptor interaction3.62E-024P27930, P14778, P25024, P25025IL1R2, IL1R1, CXCR1, CXCR2More
Temsirolimushsa04061Viral protein interaction with cytokine and cytokine receptor2.60E-023Q8NHW4, P61073, Q13651CCL4L2, CXCR4, IL10RAMore
Temsirolimushsa04064NF-kappa B signaling pathway4.09E-035P01584, P67870, P63279, Q8NHW4, Q9NQC7IL1B, CSNK2B, UBE2I, CCL4L2, CYLDMore
Temsirolimushsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Temsirolimushsa04072Phospholipase D signaling pathway6.69E-057Q9UQC2, P25116, P25024, P25025, P17252, P23743, Q9NRA1GAB2, F2R, CXCR1, CXCR2, PRKCA, DGKA, PDGFCMore
Temsirolimushsa04151PI3K-Akt signaling pathway1.71E-036P25116, Q9NRA1, P49767, P62873, P08514, P17252F2R, PDGFC, VEGFC, GNB1, ITGA2B, PRKCAMore
Temsirolimushsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Temsirolimushsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Temsirolimushsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Temsirolimushsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Temsirolimushsa04371Apelin signaling pathway4.39E-024P63218, P50151, Q14344, Q13485GNG5, GNG10, GNA13, SMAD4More
Temsirolimushsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Temsirolimushsa04510Focal adhesion8.11E-034P08514, P17252, Q9NRA1, P49767ITGA2B, PRKCA, PDGFC, VEGFCMore
Temsirolimushsa04512ECM-receptor interaction3.19E-022P07359, P08514GP1BA, ITGA2BMore
Temsirolimushsa04540Gap junction2.29E-033P17252, P68371, Q9NRA1PRKCA, TUBB2C, PDGFCMore
Temsirolimushsa04611Platelet activation7.90E-033P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Temsirolimushsa04613Neutrophil extracellular trap formation2.31E-024P17252, O60814, P08514, P07359PRKCA, H2BC12, ITGA2B, GP1BAMore
Temsirolimushsa04623Cytosolic DNA-sensing pathway1.54E-022P01584, Q8NHW4IL1B, CCL4L2More
Temsirolimushsa04640Hematopoietic cell lineage2.96E-023P07359, P08514, P04141GP1BA, ITGA2B, CSF2More
Temsirolimushsa04657IL-17 signaling pathway3.31E-023P49841, P14780, P01375GSK3B, MMP9, TNFMore
Temsirolimushsa04659Th17 cell differentiation3.17E-023P25963, P84022, Q13485NFKBIA, SMAD3, SMAD4More
Temsirolimushsa04664Fc epsilon RI signaling pathway2.60E-022P04141, P17252CSF2, PRKCAMore
Temsirolimushsa04713Circadian entrainment4.51E-022P17252, P62873PRKCA, GNB1More
Temsirolimushsa04723Retrograde endocannabinoid signaling3.83E-022P17252, P62873PRKCA, GNB1More
Temsirolimushsa04724Glutamatergic synapse3.09E-033P17252, P62873, Q9NSB8PRKCA, GNB1, HOMER2More
Temsirolimushsa04725Cholinergic synapse3.83E-022P17252, P62873PRKCA, GNB1More
Temsirolimushsa04726Serotonergic synapse6.44E-033P17252, P62873, P18054PRKCA, GNB1, ALOX12More
Temsirolimushsa04727GABAergic synapse2.06E-022P62873, P17252GNB1, PRKCAMore
Temsirolimushsa04730Long-term depression3.20E-022Q14344, P07948GNA13, LYNMore
Temsirolimushsa04750Inflammatory mediator regulation of TRP channels4.51E-022P18054, P17252ALOX12, PRKCAMore
Temsirolimushsa04810Regulation of actin cytoskeleton2.06E-023P08514, Q9NRA1, P25116ITGA2B, PDGFC, F2RMore
Temsirolimushsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Temsirolimushsa04918Thyroid hormone synthesis1.14E-022P17252, P27824PRKCA, CANXMore
Temsirolimushsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Temsirolimushsa04926Relaxin signaling pathway1.14E-023P62873, P49767, P17252GNB1, VEGFC, PRKCAMore
Temsirolimushsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Temsirolimushsa04932Non-alcoholic fatty liver disease1.24E-026O43521, O75460, P01584, P13073, P12074, O15239BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA1More
Temsirolimushsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Temsirolimushsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Temsirolimushsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Temsirolimushsa05010Alzheimer disease2.21E-0210O15239, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P67870, P28070NDUFA1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, CSNK2B, PSMB4More
Temsirolimushsa05032Morphine addiction1.20E-036P62873, P63218, P50151, Q07343, P17252, P43250GNB1, GNG5, GNG10, PDE4B, PRKCA, GRK6More
Temsirolimushsa05120Epithelial cell signaling in Helicobacter pylori infection3.73E-022P25024, P25025CXCR1, CXCR2More
Temsirolimushsa05130Pathogenic Escherichia coli infection3.65E-023Q14247, P68371, P25116CTTN, TUBB2C, F2RMore
Temsirolimushsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Temsirolimushsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Temsirolimushsa05150Staphylococcus aureus infection2.44E-024P21462, Q14532, P59665, P59666FPR1, KRT32, DEFA1; DEFA1B, DEFA3More
Temsirolimushsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Temsirolimushsa05163Human cytomegalovirus infection2.89E-027P0DP23, Q8NHW4, Q08828, P23458, P01584, P61073, Q13651CALM1, CCL4L2, ADCY1, JAK1, IL1B, CXCR4, IL10RAMore
Temsirolimushsa05200Pathways in cancer1.37E-026P08514, P17252, P49767, P25116, P62873, P78417ITGA2B, PRKCA, VEGFC, F2R, GNB1, GSTO1More
Temsirolimushsa05205Proteoglycans in cancer4.43E-023Q12955, Q14247, P17252ANK3, CTTN, PRKCAMore
Temsirolimushsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Temsirolimushsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Temsirolimushsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Temsirolimushsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Temsirolimushsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Temsirolimushsa05231Choline metabolism in cancer2.29E-033Q9NRA1, P23743, P17252PDGFC, DGKA, PRKCAMore

Community members of Sirolimus (SDC: 2.25)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1AReported10.4320.269500.7551
P26358DNMT1DNAPredicted00.34040.28090.26590.998
P68106FKBP1BPeptidylNoneprolyl cisNonetrans isomerase FKBP1BPredicted00.08140.038100.1169
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
Q53EL6PDCD4Programmed cell death protein 4Predicted00.38990.06530.32020.6457
Q13451FKBP5PeptidylNoneprolyl cisNonetrans isomerase FKBP5Predicted00.22890.05860.14230.374
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P11511CYP19A1AromatasePredicted00.815610.15882.5666
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P68106FKBP1BPeptidylNoneprolyl cisNonetrans isomerase FKBP1BPredicted00.08140.038100.1169
P01375TNFTumor necrosis factorPredicted10.18650.55112.1953
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
FKBP1AP62942IC500.45
FKBP1AP62942IC500.6
FKBP1AP62942IC501.1
FKBP1AP62942Ki0.2
FKBP1AP62942Ki1