PharmaCoNets of Siponimod (SPCN: 55.94 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Siponimodhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Siponimodhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Siponimodhsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Siponimodhsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Siponimodhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Siponimodhsa00591Linoleic acid metabolism1.29E-031P11712CYP2C9More
Siponimodhsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Siponimodhsa00670One carbon pool by folate3.62E-021P00374DHFRMore
Siponimodhsa00730Thiamine metabolism1.15E-032Q9Y6K8, P24666AK5, ACP1More
Siponimodhsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Siponimodhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Siponimodhsa00790Folate biosynthesis3.62E-021P00374DHFRMore
Siponimodhsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Siponimodhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Siponimodhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Siponimodhsa00983Drug metabolism - other enzymes2.99E-023P04183, P32320, P05164TK1, CDA, MPOMore
Siponimodhsa012102-Oxocarboxylic acid metabolism1.91E-021P50213IDH3AMore
Siponimodhsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Siponimodhsa01522Endocrine resistance4.74E-023P22694, P10415, Q13323PRKACB, BCL2, BIKMore
Siponimodhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Siponimodhsa03013RNA transport8.19E-047Q15287, Q9UBU9, P35658, P63279, P55884, O15371, P20042RNPS1, NXF1, NUP214, UBE2I, EIF3B, EIF3D, EIF2S2More
Siponimodhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Siponimodhsa03040Spliceosome1.81E-0616O43143, O60508, P08579, Q15427, P26368, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, SF3B4, U2AF2, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Siponimodhsa03060Protein export1.43E-022P37108, Q15005SRP14, SPCS2More
Siponimodhsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Siponimodhsa04012ErbB signaling pathway3.74E-023P21860, Q13557, O14944ERBB3, CAMK2D, EREGMore
Siponimodhsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Siponimodhsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Siponimodhsa04020Calcium signaling pathway6.50E-046Q96DU7, P45880, Q13557, P21860, P51828, P23634ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4More
Siponimodhsa04022cGMP-PKG signaling pathway4.72E-024Q99941, P23634, P51828, P45880CREBL1, ATP2B4, ADCY7, VDAC2More
Siponimodhsa04060Cytokine-cytokine receptor interaction2.61E-0210P27930, P08476, P25024, P25025, Q9UBD3, P47992, P01375, P09341, P18510, Q93038IL1R2, INHBA, CXCR1, CXCR2, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25More
Siponimodhsa04061Viral protein interaction with cytokine and cytokine receptor1.87E-026P09341, P25024, P25025, P47992, Q9UBD3, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, TNFMore
Siponimodhsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Siponimodhsa04064NF-kappa B signaling pathway4.09E-038P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Siponimodhsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Siponimodhsa04080Neuroactive ligand-receptor interaction1.66E-058P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2More
Siponimodhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Siponimodhsa04140Autophagy - animal3.75E-034P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Siponimodhsa04141Protein processing in endoplasmic reticulum3.64E-025Q99941, O75460, P11142, Q9H3Z4, P07900CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1More
Siponimodhsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Siponimodhsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Siponimodhsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Siponimodhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Siponimodhsa04261Adrenergic signaling in cardiomyocytes3.98E-024P51828, Q99941, Q13557, P23634ADCY7, CREBL1, CAMK2D, ATP2B4More
Siponimodhsa04330Notch signaling pathway4.34E-022Q92542, P46531NCSTN, NOTCH1More
Siponimodhsa04340Hedgehog signaling pathway7.64E-043P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Siponimodhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Siponimodhsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Siponimodhsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Siponimodhsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Siponimodhsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Siponimodhsa04540Gap junction2.86E-023P22694, P68371, Q14643PRKACB, TUBB2C, ITPR1More
Siponimodhsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Siponimodhsa04612Antigen processing and presentation3.02E-037P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Siponimodhsa04613Neutrophil extracellular trap formation1.81E-0621P11215, O60603, P05164, P08246, Q9UM07, Q13547, P04908, Q93077, P62807, Q16778, O60814, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Siponimodhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Siponimodhsa04650Natural killer cell mediated cytotoxicity4.66E-048P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Siponimodhsa04658Th1 and Th2 cell differentiation1.07E-037Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOBMore
Siponimodhsa04659Th17 cell differentiation9.58E-0413Q04759, P19174, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963PRKCQ, PLCG1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Siponimodhsa04660T cell receptor signaling pathway1.00E-027Q9UDY8, Q04759, P10747, Q08881, P20963, P09693, P01732MALT1, PRKCQ, CD28, ITK, CD247, CD3G, CD8AMore
Siponimodhsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Siponimodhsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Siponimodhsa04668TNF signaling pathway4.74E-023Q99941, P01584, O95429CREBL1, IL1B, BAG4More
Siponimodhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Siponimodhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Siponimodhsa04725Cholinergic synapse3.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Siponimodhsa04750Inflammatory mediator regulation of TRP channels3.74E-023P01584, P51828, Q13557IL1B, ADCY7, CAMK2DMore
Siponimodhsa04911Insulin secretion1.48E-023P51828, Q99941, Q13557ADCY7, CREBL1, CAMK2DMore
Siponimodhsa04913Ovarian steroidogenesis2.72E-022P42330, P22694AKR1C3, PRKACBMore
Siponimodhsa04915Estrogen signaling pathway4.72E-024Q99941, P51828, P07900, P11142CREBL1, ADCY7, HSP90AA1, HSPA8More
Siponimodhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Siponimodhsa04924Renin secretion7.24E-053P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Siponimodhsa04925Aldosterone synthesis and secretion5.19E-034Q99941, P51828, Q13557, P23634CREBL1, ADCY7, CAMK2D, ATP2B4More
Siponimodhsa04927Cortisol synthesis and secretion2.72E-022Q14643, P22694ITPR1, PRKACBMore
Siponimodhsa04928Parathyroid hormone synthesis, secretion and action1.32E-034Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Siponimodhsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Siponimodhsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Siponimodhsa04934Cushing syndrome5.32E-047Q14643, Q99941, P51828, P22694, O15169, Q13557, P04628ITPR1, CREBL1, ADCY7, PRKACB, AXIN1, CAMK2D, WNT1More
Siponimodhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Siponimodhsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Siponimodhsa04970Salivary secretion2.11E-023P07550, P22694, Q14643ADRB2, PRKACB, ITPR1More
Siponimodhsa04971Gastric acid secretion1.48E-023P51828, P15311, Q13557ADCY7, VIL2, CAMK2DMore
Siponimodhsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Siponimodhsa05010Alzheimer disease2.07E-027Q92542, P05496, P12074, O75460, P01584, O15169, P45880NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2More
Siponimodhsa05020Prion disease1.37E-0311P01584, P46531, P11142, Q16718, O14521, P05496, P12074, P45880, P49841, Q99941, Q16539IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, VDAC2, GSK3B, CREBL1, MAPK14More
Siponimodhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Siponimodhsa05034Alcoholism2.72E-056P62879, Q9BTM1, Q93077, P62807, O60814, P68431GNB2, H2AFJ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Siponimodhsa05133Pertussis4.94E-021P0C0L4C4AMore
Siponimodhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Siponimodhsa05146Amoebiasis1.39E-026P09341, P27930, P01375, P05089, P22694, P08311CXCL1, IL1R2, TNF, ARG1, PRKACB, CTSGMore
Siponimodhsa05150Staphylococcus aureus infection1.67E-025P21730, P21462, O75015, P12838, P49913C5AR1, FPR1, FCGR3B, DEFA4, CAMPMore
Siponimodhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Siponimodhsa05200Pathways in cancer1.71E-0320Q13751, P17301, P42338, P08238, P19174, P43246, P84022, Q13485, P20585, Q13547, P30281, P49767, P43657, P62879, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, ITGA2, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, MSH3, HDAC1, CCND3, VEGFC, P2RY5, GNB2, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Siponimodhsa05202Transcriptional misregulation in cancer2.76E-0313Q12778, Q13315, P14780, P27930, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, Q13547, P24522FOXO1, ATM, MMP9, IL1R2, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, HDAC1, GADD45AMore
Siponimodhsa05203Viral carcinogenesis2.93E-033Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Siponimodhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Siponimodhsa05206MicroRNAs in cancer2.97E-036P15311, P21860, P61978, P46531, P63279, P22105VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXBMore
Siponimodhsa05212Pancreatic cancer9.39E-035P42338, P37173, P84022, Q13485, O75293PIK3CB, TGFBR2, SMAD3, SMAD4, GADD45BMore
Siponimodhsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Siponimodhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.84E-025P20963, P09693, O60603, P10747, Q04759CD247, CD3G, TLR2, CD28, PRKCQMore
Siponimodhsa05321Inflammatory bowel disease6.71E-056O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Siponimodhsa05322Systemic lupus erythematosus1.49E-055P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Siponimodhsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Siponimodhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Siponimodhsa05332Graft-versus-host disease5.07E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Siponimodhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Siponimod (SDC: 4.54)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9H228EDG8Sphingosine 1Nonephosphate receptor 5Reported00.09250.05520.10030.2569
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Reported10.14340.38470.2211.0621
Q99527GPER1GNoneprotein coupled estrogen receptor 1Predicted00.02490.12940.21380.485
P49354FNTAProtein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alphaPredicted00.53030.758801.7827
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P00374DHFRDihydrofolate reductasePredicted00.3380.18680.22630.7688
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)