PharmaCoNets

PharmaCoNets of Simvastatin (S_PCN: 81.08 )

Simvastatin regulated-network (S_DN: 14.93)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Simvastatin

hsa00030

Pentose phosphate pathway

1.69E-02

P60891, P37837

PRPS1, TALDO1

Simvastatin

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Simvastatin

hsa00190

Oxidative phosphorylation

3.52E-04

Q16718, Q13488, P36542, O14521

NDUFA5, TCIRG1, ATP5C1, SDHD

Simvastatin

hsa00500

Starch and sucrose metabolism

1.67E-02

O43451, P06737

MGAM, PYGL

Simvastatin

hsa00564

Glycerophospholipid metabolism

1.43E-04

Q9Y259, P23743, P49619, Q3LIE5

CHKB, DGKA, DGKG, ADPRM

Simvastatin

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Simvastatin

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Simvastatin

hsa00630

Glyoxylate and dicarboxylate metabolism

9.21E-03

P40925, P15104

MDH1, GLUL

Simvastatin

hsa00730

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Simvastatin

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Simvastatin

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Simvastatin

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Simvastatin

hsa00983

Drug metabolism - other enzymes

2.44E-02

P32320, P05164

CDA, MPO

Simvastatin

hsa01230

Biosynthesis of amino acids

3.59E-02

P60891, Q99707, P37837

PRPS1, MTR, TALDO1

Simvastatin

hsa03008

Ribosome biogenesis in eukaryotes

1.88E-02

O14980, O60832, Q9BVP2

XPO1, DKC1, GNL3

Simvastatin

hsa03013

RNA transport

1.89E-08

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, P47813, Q14152, O75822, Q14240, Q9BZI7, P23588, Q9Y6A5, Q06787, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, EIF4A2, UPF3B, EIF4B, TACC3, FMR1, FXR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14980	XPO1	Exportin-1	0.799
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14893	GEMIN2	Gem-associated protein 2	0.72
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.844
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.869
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.77
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.849
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.764
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q06787	FMR1	Synaptic functional regulator FMR1	0.863
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.798

Simvastatin

hsa03022

Basal transcription factors

3.50E-02

P20226, O00268, Q15544

TBP, TAF4, TAF11

Simvastatin

hsa03040

Spliceosome

2.58E-05

Q14562, O43143, P08579, O75940, O75494, Q07955, Q01130, P84103, Q13243, P11142, O75643

DHX8, DHX15, SNRPB2, SMNDC1, FUSIP1, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, ASCC3L1

Simvastatin

hsa03050

Proteasome

1.21E-02

P28074

PSMB5

Simvastatin

hsa04010

MAPK signaling pathway

1.53E-02

Q9H2K8, Q12933

TAOK3, TRAF2

Simvastatin

hsa04012

ErbB signaling pathway

3.49E-03

P16333, P19174, P01106

NCK1, PLCG1, MYC

Simvastatin

hsa04014

Ras signaling pathway

3.57E-02

P20827, P49767, P17252, P0DP23, P62873, P19174

EFNA1, VEGFC, PRKCA, CALM1, GNB1, PLCG1

Simvastatin

hsa04015

Rap1 signaling pathway

2.98E-02

P20827, P49767, P11215, P0DP23, P17252, P19174

EFNA1, VEGFC, ITGAM, CALM1, PRKCA, PLCG1

Simvastatin

hsa04020

Calcium signaling pathway

4.81E-02

P27987, P17252, P19174, P0DP23, P49767

ITPKB, PRKCA, PLCG1, CALM1, VEGFC

Simvastatin

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.48E-02

P09341, P19875, P25024, P25025, P14784

CXCL1, CXCL2, CXCR1, CXCR2, IL2RB

Simvastatin

hsa04062

Chemokine signaling pathway

1.83E-02

P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151

CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10

Simvastatin

hsa04064

NF-kappa B signaling pathway

2.49E-03

P10415, Q13489, P14778, P29965, P19174, Q04759, Q9UDY8, P06239, Q8WV28, Q13315, P09341, P19875, Q06643

BCL2, BIRC3, IL1R1, CD40LG, PLCG1, PRKCQ, MALT1, LCK, BLNK, ATM, CXCL1, CXCL2, LTB

Simvastatin

hsa04070

Phosphatidylinositol signaling system

1.01E-04

P19174, P0DP23, Q14643, P23743, P49619, P27987, P17252

PLCG1, CALM1, ITPR1, DGKA, DGKG, ITPKB, PRKCA

Simvastatin

hsa04071

Sphingolipid signaling pathway

2.56E-04

P17252, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2, Q12933, Q02156

PRKCA, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2, TRAF2, PRKCE

Simvastatin

hsa04072

Phospholipase D signaling pathway

4.48E-02

P42338, P43657, P25024, P25025, P19174

PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1

Simvastatin

hsa04110

Cell cycle

1.44E-02

P06493, O75293, P30304, P33981, P42773, P01106, Q13547

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1

Simvastatin

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Simvastatin

hsa04145

Phagosome

1.59E-03

Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765

NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOB

Simvastatin

hsa04146

Peroxisome

4.83E-02

O96011, P56589, Q9UKG9, O75521

PEX11B, PEX3, CROT, ECI2

Simvastatin

hsa04151

PI3K-Akt signaling pathway

4.50E-02

P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252

F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCA

Simvastatin

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Simvastatin

hsa04213

Longevity regulating pathway - multiple species

3.85E-02

P42338, Q9Y4H2, P11142, Q13547

PIK3CB, IRS2, HSPA8, HDAC1

Simvastatin

hsa04217

Necroptosis

9.14E-03

P01568, Q13489, P42224, Q6FI13, P10415, O43633, Q08752

IFNA21, BIRC3, STAT1, H2AC18; H2AC19, BCL2, CHMP2A, PPID

Simvastatin

hsa04261

Adrenergic signaling in cardiomyocytes

2.84E-02

P09493, Q13362, P0DP23, P17252, P10415

TPM1, PPP2R5C, CALM1, PRKCA, BCL2

Simvastatin

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Simvastatin

hsa04360

Axon guidance

1.53E-02

P16333, P20827, O95631, P17252, P19174

NCK1, EFNA1, NTN1, PRKCA, PLCG1

Simvastatin

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Simvastatin

hsa04540

Gap junction

1.29E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Simvastatin

hsa04613

Neutrophil extracellular trap formation

2.78E-04

P19174, P17252, P11215, O60603, P08246, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P21462

PLCG1, PRKCA, ITGAM, TLR2, ELA2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, FPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.851
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P17252	PRKCA	Protein kinase C alpha type	-0.706
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P11215	ITGAM	Integrin alpha-M	-0.844
P17252	PRKCA	Protein kinase C alpha type	O60603	TLR2	Toll-like receptor 2	-0.716
P17252	PRKCA	Protein kinase C alpha type	P08246	ELA2	Neutrophil elastase	-0.735
P17252	PRKCA	Protein kinase C alpha type	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.83
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	Q93077	HIST1H2AC	Histone H2A type 1-C	-0.821
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.729
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.729
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	O60814	H2BC12	Histone H2B type 1-K	-0.809
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P17252	PRKCA	Protein kinase C alpha type	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.783
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P14598	NCF1	Neutrophil cytosol factor 1	0.801
P17252	PRKCA	Protein kinase C alpha type	P14598	NCF1	Neutrophil cytosol factor 1	-0.821
P17252	PRKCA	Protein kinase C alpha type	Q15080	NCF4	Neutrophil cytosol factor 4	-0.836
P17252	PRKCA	Protein kinase C alpha type	P21462	FPR1	fMet-Leu-Phe receptor	-0.731

Simvastatin

hsa04622

RIG-I-like receptor signaling pathway

2.47E-02

Q12933

TRAF2

Simvastatin

hsa04640

Hematopoietic cell lineage

1.37E-02

P14778, P27930, P11215, P25063, P07766, P01732, P09564

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7

Simvastatin

hsa04650

Natural killer cell mediated cytotoxicity

2.48E-03

P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931

PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3

Simvastatin

hsa04657

IL-17 signaling pathway

1.95E-03

P25963, P08238, Q07955, P49841, P14780, P04141, P01375, P06702

NFKBIA, HSP90AB1, SFRS1, GSK3B, MMP9, CSF2, TNF, S100A9

Simvastatin

hsa04658

Th1 and Th2 cell differentiation

1.30E-09

P25963, Q04759, P07766, P20963, P19174, P01730, P06239, P42224, Q9UL17, P14784, Q9UM47, Q13761

NFKBIA, PRKCQ, CD3E, CD247, PLCG1, CD4, LCK, STAT1, TBX21, IL2RB, NOTCH3, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.734
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P11215	ITGAM	Integrin alpha-M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.769
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.851
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P11215	ITGAM	Integrin alpha-M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.913
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	1
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P11215	ITGAM	Integrin alpha-M	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.844
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.732
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P11215	ITGAM	Integrin alpha-M	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.769
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	0.714
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721
P11215	ITGAM	Integrin alpha-M	Q13761	RUNX3	Runt-related transcription factor 3	-0.828

Simvastatin

hsa04659

Th17 cell differentiation

7.18E-07

P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P14778, Q9UL17, P08238, P07766, P20963

NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, IL1R1, TBX21, HSP90AB1, CD3E, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.734
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.851
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P11215	ITGAM	Integrin alpha-M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.913
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	1
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P11215	ITGAM	Integrin alpha-M	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.844
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.732
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P11215	ITGAM	Integrin alpha-M	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.769
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.783
P11215	ITGAM	Integrin alpha-M	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.78
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P11215	ITGAM	Integrin alpha-M	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.769
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87

Simvastatin

hsa04660

T cell receptor signaling pathway

4.50E-04

Q04759, P42338, P19174, P16333, P07766, P20963, P01730, P01732, Q13191, P06239

PRKCQ, PIK3CB, PLCG1, NCK1, CD3E, CD247, CD4, CD8A, CBLB, LCK

Simvastatin

hsa04664

Fc epsilon RI signaling pathway

4.75E-02

P07948, P19174, P09917

LYN, PLCG1, ALOX5

Simvastatin

hsa04672

Intestinal immune network for IgA production

3.76E-03

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Simvastatin

hsa04713

Circadian entrainment

2.60E-02

P0DP23, P17252, P62873, Q14643

CALM1, PRKCA, GNB1, ITPR1

Simvastatin

hsa04720

Long-term potentiation

3.89E-02

P17252, P0DP23, Q14643

PRKCA, CALM1, ITPR1

Simvastatin

hsa04722

Neurotrophin signaling pathway

9.39E-03

Q05655, P52566

PRKCD, ARHGDIB

Simvastatin

hsa04723

Retrograde endocannabinoid signaling

1.88E-02

Q14643, P17252, P62873, Q16718

ITPR1, PRKCA, GNB1, NDUFA5

Simvastatin

hsa04725

Cholinergic synapse

1.88E-02

Q14643, P17252, P62873, P10415

ITPR1, PRKCA, GNB1, BCL2

Simvastatin

hsa04727

GABAergic synapse

3.40E-02

P63218, P50151, P15104

GNG5, GNG10, GLUL

Simvastatin

hsa04728

Dopaminergic synapse

3.55E-02

Q14643, P17252, P62873, Q13362, P0DP23

ITPR1, PRKCA, GNB1, PPP2R5C, CALM1

Simvastatin

hsa04744

Phototransduction

9.81E-05

P62873, P0DP23

GNB1, CALM1

Simvastatin

hsa04750

Inflammatory mediator regulation of TRP channels

7.24E-03

P14778, P19174, P42338, P24723, Q04759

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ

Simvastatin

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Simvastatin

hsa04912

GnRH signaling pathway

3.89E-02

P17252, Q14643, P0DP23

PRKCA, ITPR1, CALM1

Simvastatin

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Simvastatin

hsa04922

Glucagon signaling pathway

3.47E-02

Q12778, Q13370, P0DP23, Q14643

FOXO1, PDE3B, CALM1, ITPR1

Simvastatin

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Simvastatin

hsa04924

Renin secretion

8.71E-03

Q14643, Q13370, P0DP23

ITPR1, PDE3B, CALM1

Simvastatin

hsa04930

Type II diabetes mellitus

9.83E-04

Q05655, Q02156

PRKCD, PRKCE

Simvastatin

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Simvastatin

hsa04933

AGE-RAGE signaling pathway in diabetic complications

1.27E-02

P42224, P10415, Q12778, P49767, P17252

STAT1, BCL2, FOXO1, VEGFC, PRKCA

Simvastatin

hsa04966

Collecting duct acid secretion

2.86E-02

Q13488, Q9Y666

TCIRG1, SLC12A7

Simvastatin

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Simvastatin

hsa04974

Protein digestion and absorption

2.47E-02

Q7Z2H8

SLC36A1

Simvastatin

hsa04976

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Simvastatin

hsa05010

Alzheimer disease

3.55E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPID

Simvastatin

hsa05012

Parkinson disease

2.25E-02

Q16718, O14521, Q14643, P0DP23, Q13509, P68371

NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C

Simvastatin

hsa05014

Amyotrophic lateral sclerosis

2.72E-02

P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629

TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7

Simvastatin

hsa05017

Spinocerebellar ataxia

2.43E-02

P28074

PSMB5

Simvastatin

hsa05020

Prion disease

1.15E-02

Q16718, O14521, Q14643, Q13509, P68371, P14598, Q15080

NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, NCF1, NCF4

Simvastatin

hsa05022

Pathways of neurodegeneration - multiple diseases

4.48E-03

Q14643, Q13509, P68371, P10415, Q16718, O14521, Q13561, P17252, Q08752, P0DP23

ITPR1, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, DCTN2, PRKCA, PPID, CALM1

Simvastatin

hsa05034

Alcoholism

1.90E-05

Q13547, P0DP23, P62873, P63218, P50151, Q93077, P62807, O60814, P68431

HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Simvastatin

hsa05110

Vibrio cholerae infection

1.51E-02

Q13488, P17252, P19174

TCIRG1, PRKCA, PLCG1

Simvastatin

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P25025

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Simvastatin

hsa05131

Shigellosis

4.98E-04

Q12933, P68431, Q05655, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752, P07737

TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1

Simvastatin

hsa05132

Salmonella infection

6.68E-03

Q9UJU2, P84095, Q13489, P10415, P07737, O60603, Q9BQS8, Q13561, Q13509, P68371

LEF1, RHOG, BIRC3, BCL2, PFN1, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Simvastatin

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Simvastatin

hsa05140

Leishmaniasis

7.47E-05

P14598, P11215, P42224, P13765, O60603, P25963, P29350, Q15080

NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, PTPN6, NCF4

Simvastatin

hsa05145

Toxoplasmosis

1.16E-03

P10415, Q13489, P42224, P13765, P09917, Q13751, P11142, O60603, P29965, Q13651

BCL2, BIRC3, STAT1, HLA-DOB, ALOX5, LAMB3, HSPA8, TLR2, CD40LG, IL10RA

Simvastatin

hsa05146

Amoebiasis

2.21E-04

P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814

CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1

Simvastatin

hsa05150

Staphylococcus aureus infection

4.02E-03

P21462, O75015, Q14532, P59665, P59666, P12838

FPR1, FCGR3B, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4

Simvastatin

hsa05152

Tuberculosis

7.93E-04

Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8

TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1

Simvastatin

hsa05165

Human papillomavirus infection

3.10E-02

P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315

ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATM

Simvastatin

hsa05167

Kaposi sarcoma-associated herpesvirus infection

6.61E-04

P01568, P42224, P25963, P62873, P63218, P50151, P19174, Q14643, P07948, P01106, P04141, P0DP23, Q9UJU2

IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, ITPR1, LYN, MYC, CSF2, CALM1, LEF1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	1
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P11215	ITGAM	Integrin alpha-M	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.844
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.734
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.84
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11215	ITGAM	Integrin alpha-M	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.819
P11215	ITGAM	Integrin alpha-M	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.746
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.851
P11215	ITGAM	Integrin alpha-M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.913
P17252	PRKCA	Protein kinase C alpha type	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.786
P11215	ITGAM	Integrin alpha-M	P07948	LYN	Tyrosine-protein kinase Lyn	0.746
P11215	ITGAM	Integrin alpha-M	P01106	MYC	Myc proto-oncogene protein	-0.743
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P04141	CSF2	Granulocyte-macrophage colony-stimulating factor	-0.738
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P0DP23	CALM1	Calmodulin-1	0.775
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881

Simvastatin

hsa05168

Herpes simplex virus 1 infection

4.39E-02

P25963, P42224, Q07955, Q01130, Q13243, Q13398, Q03923, O75820, Q9UDV6

NFKBIA, STAT1, SFRS1, SFRS2, SFRS5, ZNF211, ZNF85, ZNF189, ZNF212

Simvastatin

hsa05169

Epstein-Barr virus infection

1.43E-02

P01106, Q13547, P07948, P30101, Q13761, O75293, P42224, P07766

MYC, HDAC1, LYN, PDIA3, RUNX3, GADD45B, STAT1, CD3E

Simvastatin

hsa05170

Human immunodeficiency virus 1 infection

4.67E-03

P62873, P0DP23, P17252, Q14643, P01568, O60603, Q13315, P10415, Q9Y6Q5

GNB1, CALM1, PRKCA, ITPR1, IFNA21, TLR2, ATM, BCL2, AP1M2

Simvastatin

hsa05200

Pathways in cancer

1.76E-04

Q13751, P08238, P42224, P25963, P19174, P01106, Q9UJU2, P17252, P43246, P20585, Q13547, P14923, P10415, Q13489, P49767, Q12778, P25116, P62873, P63218, P50151, Q9UM47, P78417, O75293, P0DP23, P01568, P14784

LAMB3, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, PRKCA, MSH2, MSH3, HDAC1, JUP, BCL2, BIRC3, VEGFC, FOXO1, F2R, GNB1, GNG5, GNG10, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P11215	ITGAM	Integrin alpha-M	Q13751	LAMB3	Laminin subunit beta-3	0.779
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.783
P11215	ITGAM	Integrin alpha-M	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.78
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	1
P17252	PRKCA	Protein kinase C alpha type	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.706
P11215	ITGAM	Integrin alpha-M	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.844
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.734
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.851
P11215	ITGAM	Integrin alpha-M	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.913
P11215	ITGAM	Integrin alpha-M	P01106	MYC	Myc proto-oncogene protein	-0.743
P17252	PRKCA	Protein kinase C alpha type	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.881
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P17252	PRKCA	Protein kinase C alpha type	-0.706
P17252	PRKCA	Protein kinase C alpha type	P17252	PRKCA	Protein kinase C alpha type	1
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P43246	MSH2	DNA mismatch repair protein Msh2	0.789
P11215	ITGAM	Integrin alpha-M	P43246	MSH2	DNA mismatch repair protein Msh2	-0.712
P11215	ITGAM	Integrin alpha-M	P20585	MSH3	DNA mismatch repair protein Msh3	-0.703
P11215	ITGAM	Integrin alpha-M	Q13547	HDAC1	Histone deacetylase 1	-0.751
P17252	PRKCA	Protein kinase C alpha type	P14923	JUP	Junction plakoglobin	0.761
P17252	PRKCA	Protein kinase C alpha type	P10415	BCL2	Apoptosis regulator Bcl-2	0.844
P17252	PRKCA	Protein kinase C alpha type	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.849
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P49767	VEGFC	Vascular endothelial growth factor C	-0.754
P17252	PRKCA	Protein kinase C alpha type	P49767	VEGFC	Vascular endothelial growth factor C	0.719
P11215	ITGAM	Integrin alpha-M	P49767	VEGFC	Vascular endothelial growth factor C	0.711
P17252	PRKCA	Protein kinase C alpha type	Q12778	FOXO1	Forkhead box protein O1	0.863
P17252	PRKCA	Protein kinase C alpha type	P25116	F2R	Proteinase-activated receptor 1	0.857
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.84
P17252	PRKCA	Protein kinase C alpha type	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	-0.852
P11215	ITGAM	Integrin alpha-M	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.819
P11215	ITGAM	Integrin alpha-M	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.746
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	Q9UM47	NOTCH3	Neurogenic locus notch homolog protein 3	0.714
P11215	ITGAM	Integrin alpha-M	P78417	GSTO1	Glutathione S-transferase omega-1	0.728
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.802
P11215	ITGAM	Integrin alpha-M	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.712
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P0DP23	CALM1	Calmodulin-1	0.775
P17252	PRKCA	Protein kinase C alpha type	P0DP23	CALM1	Calmodulin-1	-0.776
P17252	PRKCA	Protein kinase C alpha type	P01568	IFNA21	Interferon alpha-21	0.733
P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.732
P11215	ITGAM	Integrin alpha-M	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.769

Simvastatin

hsa05203

Viral carcinogenesis

6.58E-03

P07948, P29083, Q13547, Q15283, P12814, P62807, O60814

LYN, GTF2E1, HDAC1, RASA2, ACTN1, HIST1H2BC, H2BC12

Simvastatin

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Simvastatin

hsa05206

MicroRNAs in cancer

4.49E-03

P30304, P09493, P01106, Q9Y4H2, Q9UM47, Q13547, P20827, P17252, P19174

CDC25A, TPM1, MYC, IRS2, NOTCH3, HDAC1, EFNA1, PRKCA, PLCG1

Simvastatin

hsa05214

Glioma

7.66E-03

P0DP23, P17252, P19174, O75293

CALM1, PRKCA, PLCG1, GADD45B

Simvastatin

hsa05223

Non-small cell lung cancer

4.24E-02

P19174, Q9HC35, O75293

PLCG1, EML4, GADD45B

Simvastatin

hsa05231

Choline metabolism in cancer

5.78E-06

O15245, Q9Y259, P19174, P23743, P49619, P17252

SLC22A1, CHKB, PLCG1, DGKA, DGKG, PRKCA

Simvastatin

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

4.41E-05

P42338, P19174, P07766, P20963, P06239, P42224, Q04759, Q9HC35, P01730

PIK3CB, PLCG1, CD3E, CD247, LCK, STAT1, PRKCQ, EML4, CD4

Simvastatin

hsa05320

Autoimmune thyroid disease

1.27E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Simvastatin

hsa05322

Systemic lupus erythematosus

4.80E-06

P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431

ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Simvastatin

hsa05323

Rheumatoid arthritis

1.29E-02

P13765, Q13488, P10747, O60603

HLA-DOB, TCIRG1, CD28, TLR2

Simvastatin

hsa05330

Allograft rejection

1.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Simvastatin

hsa05340

Primary immunodeficiency

4.24E-02

P01730, P07766, P06239

CD4, CD3E, LCK

Simvastatin

hsa05415

Diabetic cardiomyopathy

3.55E-02

P17252, P14598, Q15080, Q16718, O14521

PRKCA, NCF1, NCF4, NDUFA5, SDHD

Simvastatin

hsa05416

Viral myocarditis

2.62E-02

P13765, P29965, P10747

HLA-DOB, CD40LG, CD28

Community members of Simvastatin (S_DC: 5.43)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

HDAC2

Histone deacetylase 2

Reported

0.0473

0.986

3.0097

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

Q96EB6

SIRT1

NADNonedependent protein deacetylase sirtuinNone1

Predicted

0.2865

0.4571

0.5784

1.6358

P28074

PSMB5

Proteasome subunit beta typeNone5

Predicted

0.2839

0.4723

0.5439

1.6305

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P30304

CDC25A

MNonephase inducer phosphatase 1

Predicted

0.1795

0.2347

0.4274

0.9865

P42224

STAT1

Signal transducer and activator of transcription 1Nonealpha/beta

Predicted

0.2245

0.0425

1.1973

P17252

PRKCA

Protein kinase C alpha type

Predicted

0.1409

0.6948

2.4601

Q02156

PRKCE

Protein kinase C epsilon type

Predicted

0.1175

0.5287

0.5377

1.6539

Q05655

PRKCD

Protein kinase C delta type

Predicted

0.0816

0.4194

0.6544

1.5339

Q13547

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P11215

ITGAM

Integrin alphaNoneM

Predicted

0.1888

0.0113

0.896

1.013

PharmaCoNets of Simvastatin (SPCN: 81.08 )

Simvastatin regulated-network (SDN: 14.93)

Community members of Simvastatin (SDC: 5.43)

PharmaCoNets of Simvastatin (S_PCN: 81.08 )

Simvastatin regulated-network (S_DN: 14.93)

Community members of Simvastatin (S_DC: 5.43)