PharmaCoNets of Sibutramine (SPCN: 8.87 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Sibutraminehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Sibutraminehsa00604Glycosphingolipid biosynthesis - ganglio series2.87E-033P06865, O15466, Q9H4F1HEXA, ST8SIA5, ST6GALNAC4More
Sibutraminehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Sibutraminehsa01240Biosynthesis of cofactors2.52E-022Q9BQB6, P14550VKORC1, AKR1A1More
Sibutraminehsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Sibutraminehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Sibutraminehsa03050Proteasome1.21E-021P28074PSMB5More
Sibutraminehsa03410Base excision repair2.52E-022P49005, P29372POLD2, MPGMore
Sibutraminehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Sibutraminehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Sibutraminehsa04610Complement and coagulation cascades2.78E-031P0C0L4C4AMore
Sibutraminehsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Sibutraminehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Sibutraminehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Sibutraminehsa04932Non-alcoholic fatty liver disease2.44E-035P01375, P49841, P48023, Q16718, O14521TNF, GSK3B, FASLG, NDUFA5, SDHDMore
Sibutraminehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Sibutraminehsa04966Collecting duct acid secretion1.68E-022P02730, P00918SLC4A1, CA2More
Sibutraminehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Sibutraminehsa05017Spinocerebellar ataxia2.43E-021P28074PSMB5More
Sibutraminehsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Sibutraminehsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Sibutraminehsa05133Pertussis4.94E-021P0C0L4C4AMore
Sibutraminehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Sibutraminehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Sibutraminehsa05218Melanoma1.07E-023P09619, Q9GZP0, Q02750PDGFRB, PDGFD, MAP2K1More
Sibutraminehsa05231Choline metabolism in cancer9.39E-034Q02750, P09619, Q9GZP0, O15245MAP2K1, PDGFRB, PDGFD, SLC22A1More
Sibutraminehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Sibutraminehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Sibutraminehsa05412Arrhythmogenic right ventricular cardiomyopathy3.10E-023Q8IZS8, P54284, P13612CACNA2D3, CACNB3, ITGA4More
Sibutraminehsa05414Dilated cardiomyopathy2.11E-024Q8IZS8, P54284, P13612, P26678CACNA2D3, CACNB3, ITGA4, PLNMore
Sibutraminehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Sibutramine (SDC: 2.74)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P31645SLC6A4SodiumNonedependent serotonin transporterReported00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P30531SLC6A1SodiumNone and chlorideNonedependent GABA transporter 1Predicted10.08890.52020.10471.1894
P48029SLC6A8SodiumNone and chlorideNonedependent creatine transporter 1Predicted10.21610.232800.5737
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)