| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Sertindole | hsa00020 | Citrate cycle (TCA cycle) | 3.41E-02 | 2 | P50213, O14521 | IDH3A, SDHD | More | | | Sertindole | hsa00030 | Pentose phosphate pathway | 3.06E-04 | 3 | P60891, P51854, P37837 | PRPS1, TKTL1, TALDO1 | More | | | Sertindole | hsa00052 | Galactose metabolism | 1.03E-02 | 2 | P06280, O43451 | GLA, MGAM | More | | | Sertindole | hsa00053 | Ascorbate and aldarate metabolism | 4.93E-02 | 1 | P14550 | AKR1A1 | More | | | Sertindole | hsa00071 | Fatty acid degradation | 3.65E-03 | 4 | O75521, P00325, P11766, P33121 | ECI2, ADH1B, ADH5, ACSL1 | More | | | Sertindole | hsa00190 | Oxidative phosphorylation | 2.11E-04 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Sertindole | hsa00220 | Arginine biosynthesis | 7.67E-04 | 1 | P15104 | GLUL | More | | | Sertindole | hsa00230 | Purine metabolism | 6.91E-04 | 3 | P20839, Q16774, Q02153 | IMPDH1, GUK1, GUCY1B3 | More | | | Sertindole | hsa00240 | Pyrimidine metabolism | 2.20E-02 | 3 | P21589, P32320, P04183 | NT5E, CDA, TK1 | More | | | Sertindole | hsa00250 | Alanine, aspartate and glutamate metabolism | 2.42E-02 | 1 | P15104 | GLUL | More | | | Sertindole | hsa00260 | Glycine, serine and threonine metabolism | 1.99E-02 | 1 | P22557 | ALAS2 | More | | | Sertindole | hsa00340 | Histidine metabolism | 4.52E-02 | 1 | O95954 | FTCD | More | | | Sertindole | hsa00350 | Tyrosine metabolism | 3.40E-02 | 1 | P28332 | ADH6 | More | | | Sertindole | hsa00500 | Starch and sucrose metabolism | 6.14E-08 | 3 | O43451, P46976, P06737 | MGAM, GYG1, PYGL | More | | | Sertindole | hsa00520 | Amino sugar and nucleotide sugar metabolism | 1.59E-02 | 3 | Q16222, Q9Y223, P06865 | UAP1, GNE, HEXA | More | | | Sertindole | hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 6.96E-04 | 1 | Q9NY97 | B3GNT2 | More | | | Sertindole | hsa00564 | Glycerophospholipid metabolism | 9.70E-03 | 2 | Q9Y259, P49619 | CHKB, DGKG | More | | | Sertindole | hsa00565 | Ether lipid metabolism | 3.00E-03 | 1 | Q8N661 | TMEM86B | More | | | Sertindole | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Sertindole | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Sertindole | hsa00600 | Sphingolipid metabolism | 2.65E-03 | 3 | Q9BX95, Q06136, P15289 | SGPP1, FVT1, ARSA | More | | | Sertindole | hsa00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | 3.78E-02 | 1 | Q9NY97 | B3GNT2 | More | | | Sertindole | hsa00603 | Glycosphingolipid biosynthesis - globo and isoglobo series | 7.10E-03 | 2 | P06865, O75752 | HEXA, B3GALNT1 | More | | | Sertindole | hsa00640 | Propanoate metabolism | 3.83E-02 | 2 | Q02252, Q9P2R7 | ALDH6A1, SUCLA2 | More | | | Sertindole | hsa00670 | One carbon pool by folate | 1.33E-02 | 2 | P04818, Q99707 | TYMS, MTR | More | | | Sertindole | hsa00730 | Thiamine metabolism | 4.16E-06 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Sertindole | hsa00770 | Pantothenate and CoA biosynthesis | 2.26E-04 | 3 | O95498, O95497, Q9NRN7 | VNN2, VNN1, AASDHPPT | More | | | Sertindole | hsa00785 | Lipoic acid metabolism | 4.32E-02 | 1 | Q9Y234 | LIPT1 | More | | | Sertindole | hsa00790 | Folate biosynthesis | 4.74E-02 | 2 | P07101, P42330 | TH, AKR1C3 | More | | | Sertindole | hsa00830 | Retinol metabolism | 2.20E-02 | 4 | P00325, P11766, Q9BPW9, O75911 | ADH1B, ADH5, DHRS9, DHRS3 | More | | | Sertindole | hsa00910 | Nitrogen metabolism | 2.42E-02 | 1 | P15104 | GLUL | More | | | Sertindole | hsa00970 | Aminoacyl-tRNA biosynthesis | 3.94E-06 | 4 | O95363, P54136, P14868, Q15046 | FARS2, RARS1, DARS, KARS | More | | | Sertindole | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 8.40E-04 | 3 | P78417, P28332, P11712 | GSTO1, ADH6, CYP2C9 | More | | | Sertindole | hsa00982 | Drug metabolism - cytochrome P450 | 8.40E-04 | 3 | P11712, P78417, P28332 | CYP2C9, GSTO1, ADH6 | More | | | Sertindole | hsa00983 | Drug metabolism - other enzymes | 7.78E-04 | 3 | P04183, P32320, P05164 | TK1, CDA, MPO | More | | | Sertindole | hsa01100 | Metabolic pathways | 6.99E-03 | 30 | Q9NR34, Q9Y259, P05089, P32320, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, P49619, O95954, Q9HCC0, P33121, Q02318, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737 | MAN1C1, CHKB, ARG1, CDA, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGL | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9NR34 | MAN1C1 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC | -0.716 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | Q9Y259 | CHKB | Choline/ethanolamine kinase | -0.751 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32320 | CDA | Cytidine deaminase | 0.701 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | Q13956 | PDE6H | Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | 0.703 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P22748 | CA4 | Carbonic anhydrase 4 | 0.767 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P55809 | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | -0.746 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06280 | GLA | Alpha-galactosidase A | 0.714 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 0.849 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43286 | B4GALT5 | Beta-1,4-galactosyltransferase 5 | 0.917 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43451 | MGAM | Maltase-glucoamylase | 0.871 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | 0.901 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24666 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | -0.832 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | P49619 | DGKG | Diacylglycerol kinase gamma | 0.926 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | O95954 | FTCD | Formimidoyltransferase-cyclodeaminase | -0.718 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9HCC0 | MCCC2 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial | -0.782 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P33121 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | 0.886 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | Q02318 | CYP27A1 | Sterol 26-hydroxylase, mitochondrial | -0.879 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P57054 | PIGP | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P | -0.881 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | Q9UBX8 | B4GALT6 | Beta-1,4-galactosyltransferase 6 | 0.869 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UNP4 | ST3GAL5 | Lactosylceramide alpha-2,3-sialyltransferase | -0.819 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.743 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32321 | DCTD | Deoxycytidylate deaminase | -0.748 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | 0.817 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75911 | DHRS3 | Short-chain dehydrogenase/reductase 3 | -0.81 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UHY7 | ENOPH1 | Enolase-phosphatase E1 | -0.737 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.883 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P46976 | GYG1 | Glycogenin-1 | 0.817 | | P11388 | TOP2A | DNA topoisomerase 2-alpha | P35573 | AGL | Glycogen debranching enzyme | 0.759 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06737 | PYGL | Glycogen phosphorylase, liver form | 0.863 |
| | Sertindole | hsa01200 | Carbon metabolism | 4.32E-02 | 3 | P51854, P37837, P60891 | TKTL1, TALDO1, PRPS1 | More | | | Sertindole | hsa01210 | 2-Oxocarboxylic acid metabolism | 1.91E-02 | 1 | P50213 | IDH3A | More | | | Sertindole | hsa01212 | Fatty acid metabolism | 4.62E-02 | 2 | P33121, P11310 | ACSL1, ACADM | More | | | Sertindole | hsa01230 | Biosynthesis of amino acids | 1.59E-04 | 6 | P51854, P60891, Q99707, P50213, P15104, P37837 | TKTL1, PRPS1, MTR, IDH3A, GLUL, TALDO1 | More | | | Sertindole | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 3.18E-04 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Sertindole | hsa01522 | Endocrine resistance | 4.47E-04 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Sertindole | hsa01523 | Antifolate resistance | 1.68E-02 | 2 | Q92820, P04818 | GGH, TYMS | More | | | Sertindole | hsa02010 | ABC transporters | 1.11E-05 | 3 | P45844, P08183, Q8IZY2 | ABCG1, ABCB1, ABCA7 | More | | | Sertindole | hsa03010 | Ribosome | 7.34E-03 | 6 | P62753, P62829, P62888, P61927, P61513, P36578 | RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4 | More | | | Sertindole | hsa03013 | RNA transport | 1.67E-05 | 12 | P62826, P38919, Q15287, Q9UBU9, P37198, P35658, P63279, P68104, P55884, O15371, P20042, Q14232 | RAN, EIF4A3, RNPS1, NXF1, NUP62, NUP214, UBE2I, EEF1A1, EIF3B, EIF3D, EIF2S2, EIF2B1 | More | | | Sertindole | hsa03020 | RNA polymerase | 4.91E-06 | 4 | P30876, P24928, P62487, Q9Y535 | POLR2B, POLR2A, POLR2G, POLR3H | More | | | Sertindole | hsa03022 | Basal transcription factors | 3.32E-02 | 2 | O00268, Q15544 | TAF4, TAF11 | More | | | Sertindole | hsa03040 | Spliceosome | 3.98E-02 | 4 | Q15427, P38159, P61978, P11142 | SF3B4, RBMX, HNRPK, HSPA8 | More | | | Sertindole | hsa03050 | Proteasome | 4.78E-02 | 1 | P40306 | PSMB10 | More | | | Sertindole | hsa03060 | Protein export | 1.20E-03 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | | Sertindole | hsa03320 | PPAR signaling pathway | 1.62E-02 | 2 | Q13133, Q02318 | NR1H3, CYP27A1 | More | | | Sertindole | hsa03430 | Mismatch repair | 4.38E-02 | 1 | P20585 | MSH3 | More | | | Sertindole | hsa03450 | Non-homologous end-joining | 1.58E-04 | 3 | Q9NP87, P78527, P13010 | POLM, PRKDC, XRCC5 | More | | | Sertindole | hsa04010 | MAPK signaling pathway | 1.69E-03 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Sertindole | hsa04012 | ErbB signaling pathway | 6.03E-04 | 7 | P21860, P16333, Q13557, P19174, O14944, P01106, P04049 | ERBB3, NCK1, CAMK2D, PLCG1, EREG, MYC, RAF1 | More | | | Sertindole | hsa04014 | Ras signaling pathway | 1.30E-03 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Sertindole | hsa04015 | Rap1 signaling pathway | 2.60E-05 | 4 | P04049, P08069, P06213, O00522 | RAF1, IGF1R, INSR, KRIT1 | More | | | Sertindole | hsa04020 | Calcium signaling pathway | 1.48E-04 | 9 | Q96DU7, Q08828, P45880, Q13557, P21860, P0DP23, P05141, P51828, P23634 | ITPKC, ADCY1, VDAC2, CAMK2D, ERBB3, CALM1, SLC25A5, ADCY7, ATP2B4 | More | | | Sertindole | hsa04022 | cGMP-PKG signaling pathway | 2.17E-04 | 10 | P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP23 | RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM1 | More | | | Sertindole | hsa04024 | cAMP signaling pathway | 1.09E-02 | 5 | Q08828, P51828, P31751, P0DP23, P04049 | ADCY1, ADCY7, AKT2, CALM1, RAF1 | More | | | Sertindole | hsa04060 | Cytokine-cytokine receptor interaction | 3.33E-02 | 8 | P48551, Q9UBD3, P47992, P02775, P09341, P32248, P51684, P01730 | IFNAR2, XCL2, XCL1, PPBP, CXCL1, CCR7, CCR6, CD4 | More | | | Sertindole | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 4.24E-05 | 8 | Q8NHW4, P51684, P32248, P09341, P02775, P47992, Q9UBD3, Q13651 | CCL4L2, CCR6, CCR7, CXCL1, PPBP, XCL1, XCL2, IL10RA | More | | | Sertindole | hsa04062 | Chemokine signaling pathway | 1.77E-03 | 11 | P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P04049, P49841 | CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, RAF1, GSK3B | More | | | Sertindole | hsa04064 | NF-kappa B signaling pathway | 1.95E-06 | 14 | O00463, P14778, P01584, P01375, Q04759, Q13077, Q16548, P06239, Q8WV28, P63279, P24522, Q8NHW4, P09341, Q9NQC7 | TRAF5, IL1R1, IL1B, TNF, PRKCQ, TRAF1, BCL2A1, LCK, BLNK, UBE2I, GADD45A, CCL4L2, CXCL1, CYLD | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.932 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.73 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.875 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q8WV28 | BLNK | B-cell linker protein | -0.704 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q8WV28 | BLNK | B-cell linker protein | -0.816 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.756 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.739 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.825 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.753 |
| | Sertindole | hsa04066 | HIF-1 signaling pathway | 2.16E-02 | 1 | P08069 | IGF1R | More | | | Sertindole | hsa04068 | FoxO signaling pathway | 3.80E-04 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Sertindole | hsa04070 | Phosphatidylinositol signaling system | 5.86E-04 | 6 | P0DP23, O14986, Q86XP1, Q16760, P48426, Q96DU7 | CALM1, PIP5K1B, DGKH, DGKD, PIP4K2A, ITPKC | More | | | Sertindole | hsa04071 | Sphingolipid signaling pathway | 1.14E-04 | 9 | P04049, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2 | RAF1, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2 | More | | | Sertindole | hsa04072 | Phospholipase D signaling pathway | 6.61E-04 | 7 | P04049, P31751, O14986, Q15438, Q08828, P51828, Q16760 | RAF1, AKT2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKD | More | | | Sertindole | hsa04080 | Neuroactive ligand-receptor interaction | 1.97E-02 | 5 | P28472, P21453, Q9H228, P21730, P07550 | GABRB3, S1PR1, EDG8, C5AR1, ADRB2 | More | | | Sertindole | hsa04110 | Cell cycle | 5.39E-07 | 9 | Q9UBD5, P06493, O60566, P78527, Q14683, P30304, P33981, P42773, P01106 | ORC3, CDK1, BUB1B, PRKDC, SMC1A, CDC25A, TTK, CDKN2C, MYC | More | | | Sertindole | hsa04114 | Oocyte meiosis | 2.00E-04 | 11 | Q9Y6D9, P51812, Q02750, P0DP23, P16298, Q17RY0, Q08828, P51828, Q13362, Q14738, P08069 | MAD1L1, RPS6KA3, MAP2K1, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, PPP2R5C, PPP2R5D, IGF1R | More | | | Sertindole | hsa04120 | Ubiquitin mediated proteolysis | 2.51E-03 | 6 | Q14145, Q13042, P62837, Q15751, O95071, P0CG47 | KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBB | More | | | Sertindole | hsa04137 | Mitophagy - animal | 9.52E-03 | 2 | Q07817, P0CG47 | BCL2L1, UBB | More | | | Sertindole | hsa04140 | Autophagy - animal | 2.92E-04 | 11 | P08069, P31751, P04049, Q7L523, Q9NQL2, O75460, Q14643, P10415, Q04759, Q96GC9, Q8TEV9 | IGF1R, AKT2, RAF1, RRAGA, RRAGD, ERN1, ITPR1, BCL2, PRKCQ, TMEM49, SMCR8 | More | | | Sertindole | hsa04141 | Protein processing in endoplasmic reticulum | 3.64E-02 | 5 | Q99941, O75460, P11142, Q9H3Z4, P07900 | CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1 | More | | | Sertindole | hsa04142 | Lysosome | 2.45E-03 | 9 | Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916 | ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2 | More | | | Sertindole | hsa04144 | Endocytosis | 2.89E-03 | 8 | P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4 | HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12 | More | | | Sertindole | hsa04145 | Phagosome | 6.70E-03 | 6 | Q99437, P05164, P78380, P35443, P13765, P25774 | ATP6V0B, MPO, OLR1, THBS4, HLA-DOB, CTSS | More | | | Sertindole | hsa04146 | Peroxisome | 1.43E-02 | 4 | O00623, P56589, Q9UKG9, P33121 | PEX12, PEX3, CROT, ACSL1 | More | | | Sertindole | hsa04150 | mTOR signaling pathway | 5.20E-04 | 2 | P08069, P04049 | IGF1R, RAF1 | More | | | Sertindole | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Sertindole | hsa04210 | Apoptosis | 3.64E-03 | 5 | O76075, P01375, Q9NR28, Q16548, P04049 | DFFB, TNF, DIABLO, BCL2A1, RAF1 | More | | | Sertindole | hsa04211 | Longevity regulating pathway | 5.00E-03 | 5 | P31751, P08069, Q08828, P51828, P18848 | AKT2, IGF1R, ADCY1, ADCY7, ATF4 | More | | | Sertindole | hsa04213 | Longevity regulating pathway - multiple species | 1.01E-03 | 5 | P31751, P08069, Q08828, P51828, P0DMV8 | AKT2, IGF1R, ADCY1, ADCY7, HSPA1A | More | | | Sertindole | hsa04215 | Apoptosis - multiple species | 1.56E-02 | 2 | Q13489, P10415 | BIRC3, BCL2 | More | | | Sertindole | hsa04217 | Necroptosis | 7.97E-06 | 13 | P01375, P01568, P48023, Q13489, Q9NQC7, Q13546, Q14765, P07900, P15104, P01584, Q6FI13, Q99878, Q9H444 | TNF, IFNA21, FASLG, BIRC3, CYLD, RIPK1, STAT4, HSP90AA1, GLUL, IL1B, H2AC18; H2AC19, H2AC14, CHMP4B | More | | | Sertindole | hsa04218 | Cellular senescence | 2.49E-02 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa04261 | Adrenergic signaling in cardiomyocytes | 7.03E-06 | 12 | P07550, Q08828, P51828, P22694, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557, P23634 | ADRB2, ADCY1, ADCY7, PRKACB, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2D, ATP2B4 | More | | | Sertindole | hsa04270 | Vascular smooth muscle contraction | 2.27E-03 | 7 | P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318 | CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADM | More | | | Sertindole | hsa04330 | Notch signaling pathway | 2.46E-03 | 3 | Q92542, P49768, P46531 | NCSTN, PSEN1, NOTCH1 | More | | | Sertindole | hsa04340 | Hedgehog signaling pathway | 4.15E-03 | 4 | P49841, P22694, Q13635, P10415 | GSK3B, PRKACB, PTCH1, BCL2 | More | | | Sertindole | hsa04360 | Axon guidance | 2.49E-02 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa04370 | VEGF signaling pathway | 9.75E-04 | 4 | P16298, Q05397, Q02750, P04049 | PPP3CB, PTK2, MAP2K1, RAF1 | More | | | Sertindole | hsa04371 | Apelin signaling pathway | 1.24E-02 | 5 | P31751, P04049, Q08828, P51828, P0DP23 | AKT2, RAF1, ADCY1, ADCY7, CALM1 | More | | | Sertindole | hsa04380 | Osteoclast differentiation | 1.25E-05 | 14 | Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, P08637, O75015, Q8WV28, P01375, Q15080, P78324 | CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3A, FCGR3B, BLNK, TNF, NCF4, SIRPA | More | | | Sertindole | hsa04390 | Hippo signaling pathway | 3.80E-05 | 8 | P63261, P84022, Q13485, O15105, P04628, Q9UJU2, O43623, Q13489 | ACTG1, SMAD3, SMAD4, SMAD7, WNT1, LEF1, SNAI2, BIRC3 | More | | | Sertindole | hsa04392 | Hippo signaling pathway - multiple species | 3.01E-02 | 1 | Q6V0I7 | FAT4 | More | | | Sertindole | hsa04510 | Focal adhesion | 1.18E-03 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Sertindole | hsa04512 | ECM-receptor interaction | 4.78E-02 | 1 | Q16787 | LAMA3 | More | | | Sertindole | hsa04520 | Adherens junction | 8.29E-03 | 1 | P08069 | IGF1R | More | | | Sertindole | hsa04530 | Tight junction | 3.60E-03 | 5 | P63261, P16989, P56750, Q92974, Q14247 | ACTG1, CSDA, CLDN17, ARHGEF2, CTTN | More | | | Sertindole | hsa04540 | Gap junction | 1.33E-02 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 3.80E-04 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Sertindole | hsa04610 | Complement and coagulation cascades | 4.27E-06 | 1 | P0C0L4 | C4A | More | | | Sertindole | hsa04612 | Antigen processing and presentation | 2.10E-06 | 9 | P13765, P48382, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375 | HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF | More | | | Sertindole | hsa04613 | Neutrophil extracellular trap formation | 1.06E-06 | 23 | P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, P08637, O75015, P21730, P21462, O43315, Q16539 | RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3A, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.813 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.9 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P04908 | H2AC4; H2AC8 | Histone H2A type 1-B/E | 0.734 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0C0S5 | H2AFZ | Histone H2A.Z | 0.785 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.74 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.737 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.913 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.869 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20160 | AZU1 | Azurocidin | 0.734 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08311 | CTSG | Cathepsin G | 0.744 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08311 | CTSG | Cathepsin G | 0.79 | | Q96PH1 | NOX5 | NADPH oxidase 5 | P08637 | FCGR3A | Low affinity immunoglobulin gamma Fc region receptor III-A | 0.833 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.928 | | Q96PH1 | NOX5 | NADPH oxidase 5 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.833 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.983 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.942 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.839 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.912 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O43315 | AQP9 | Aquaporin-9 | -0.764 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O43315 | AQP9 | Aquaporin-9 | 0.934 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O43315 | AQP9 | Aquaporin-9 | 0.837 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 |
| | Sertindole | hsa04614 | Renin-angiotensin system | 2.74E-02 | 3 | P15144, P08311, O75787 | ANPEP, CTSG, ATP6AP2 | More | | | Sertindole | hsa04620 | Toll-like receptor signaling pathway | 2.54E-03 | 3 | P01584, P31751, Q8NHW4 | IL1B, AKT2, CCL4L2 | More | | | Sertindole | hsa04621 | NOD-like receptor signaling pathway | 1.03E-04 | 16 | P01584, P07900, Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P59665, P59666, P12838 | IL1B, HSP90AA1, MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4 | More | | | Sertindole | hsa04623 | Cytosolic DNA-sensing pathway | 7.92E-08 | 5 | P01584, P01568, Q13546, Q9Y535, Q8NHW4 | IL1B, IFNA21, RIPK1, POLR3H, CCL4L2 | More | | | Sertindole | hsa04625 | C-type lectin receptor signaling pathway | 7.22E-05 | 12 | Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539 | CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14 | More | | | Sertindole | hsa04630 | JAK-STAT signaling pathway | 8.73E-03 | 4 | P31751, P23458, Q13651, P04049 | AKT2, JAK1, IL10RA, RAF1 | More | | | Sertindole | hsa04640 | Hematopoietic cell lineage | 1.22E-02 | 13 | P13612, P14778, P27930, P15144, P11836, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584 | ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1B | More | | | Sertindole | hsa04650 | Natural killer cell mediated cytotoxicity | 6.70E-12 | 13 | P01375, P78314, P06239, O60880, P20963, P04049, Q13241, P26718, P08637, O75015, P26717, Q14953, P26715 | TNF, SH3BP2, LCK, SH2D1A, CD247, RAF1, KLRD1, KLRK1, FCGR3A, FCGR3B, KLRC2, KIR2DS5, KLRC1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P01375 | TNF | Tumor necrosis factor | P01375 | TNF | Tumor necrosis factor | 1 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P01375 | TNF | Tumor necrosis factor | 0.718 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P01375 | TNF | Tumor necrosis factor | -0.755 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.761 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.748 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.718 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.779 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | P01375 | TNF | Tumor necrosis factor | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.717 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.823 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.751 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.788 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.764 | | P01375 | TNF | Tumor necrosis factor | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.727 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.722 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.771 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.727 | | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P01375 | TNF | Tumor necrosis factor | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.769 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.82 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.715 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.701 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.838 | | P01375 | TNF | Tumor necrosis factor | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.754 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.91 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.842 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.81 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.803 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.701 | | Q96PH1 | NOX5 | NADPH oxidase 5 | P08637 | FCGR3A | Low affinity immunoglobulin gamma Fc region receptor III-A | 0.833 | | P01375 | TNF | Tumor necrosis factor | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.838 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.913 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.896 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.81 | | Q96PH1 | NOX5 | NADPH oxidase 5 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.833 | | P01375 | TNF | Tumor necrosis factor | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.814 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.846 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.714 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.721 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.72 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | Q14953 | KIR2DS5 | Killer cell immunoglobulin-like receptor 2DS5 | 0.815 | | P01375 | TNF | Tumor necrosis factor | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.814 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.846 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.714 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.721 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.72 |
| | Sertindole | hsa04657 | IL-17 signaling pathway | 4.84E-07 | 10 | P07900, O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584 | HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 0.709 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.932 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.917 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.75 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | -0.725 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.771 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.83 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.94 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.778 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.721 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.775 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | 0.715 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | 0.888 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P80188 | LCN2 | Neutrophil gelatinase-associated lipocalin | -0.757 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P07550 | ADRB2 | Beta-2 adrenergic receptor | P01375 | TNF | Tumor necrosis factor | -0.755 | | P08183 | ABCB1 | ATP-dependent translocase ABCB1 | P01375 | TNF | Tumor necrosis factor | -0.769 | | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | P01584 | IL1B | Interleukin-1 beta | 0.786 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 |
| | Sertindole | hsa04658 | Th1 and Th2 cell differentiation | 1.07E-07 | 11 | Q04759, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P13765, P23458 | PRKCQ, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOB, JAK1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | P07305 | H1-0 | Histone H1.0 | Q04759 | PRKCQ | Protein kinase C theta type | -0.706 | | P32249 | GPR183 | G-protein coupled receptor 183 | Q04759 | PRKCQ | Protein kinase C theta type | 0.71 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P32249 | GPR183 | G-protein coupled receptor 183 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.864 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | | P32249 | GPR183 | G-protein coupled receptor 183 | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.713 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | P07305 | H1-0 | Histone H1.0 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.716 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.777 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.861 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.747 | | P07305 | H1-0 | Histone H1.0 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.772 | | P32249 | GPR183 | G-protein coupled receptor 183 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.927 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.808 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.714 | | P07305 | H1-0 | Histone H1.0 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.859 | | P32249 | GPR183 | G-protein coupled receptor 183 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.845 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 |
| | Sertindole | hsa04659 | Th17 cell differentiation | 1.37E-06 | 15 | P25963, Q04759, Q16539, P01730, P06239, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P09693, P20963, P23458 | NFKBIA, PRKCQ, MAPK14, CD4, LCK, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, CD3G, CD247, JAK1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.728 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | P07305 | H1-0 | Histone H1.0 | Q04759 | PRKCQ | Protein kinase C theta type | -0.706 | | P32249 | GPR183 | G-protein coupled receptor 183 | Q04759 | PRKCQ | Protein kinase C theta type | 0.71 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.901 | | P32249 | GPR183 | G-protein coupled receptor 183 | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.713 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | P07305 | H1-0 | Histone H1.0 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.716 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P06239 | LCK | Tyrosine-protein kinase Lck | -0.709 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | | P07305 | H1-0 | Histone H1.0 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.859 | | P32249 | GPR183 | G-protein coupled receptor 183 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.845 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.731 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.909 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.73 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | | P07305 | H1-0 | Histone H1.0 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.772 | | P32249 | GPR183 | G-protein coupled receptor 183 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.927 | | O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.769 | | O75469 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.721 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | | P32249 | GPR183 | G-protein coupled receptor 183 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.864 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.734 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.703 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 |
| | Sertindole | hsa04660 | T cell receptor signaling pathway | 8.93E-08 | 13 | P01375, Q9UDY8, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, P04049, Q16539, P49841 | TNF, MALT1, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01375 | TNF | Tumor necrosis factor | 0.897 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P01375 | TNF | Tumor necrosis factor | 0.718 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.767 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q04759 | PRKCQ | Protein kinase C theta type | -0.787 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.852 | | P14780 | MMP9 | Matrix metalloproteinase-9 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.792 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.716 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.866 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.855 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.746 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.736 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.745 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.722 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.771 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.719 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.77 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.781 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.742 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.722 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.803 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.793 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.719 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.734 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P06239 | LCK | Tyrosine-protein kinase Lck | -0.779 | | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.778 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.889 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.795 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.75 | | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.861 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.823 |
| | Sertindole | hsa04662 | B cell receptor signaling pathway | 9.95E-03 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa04664 | Fc epsilon RI signaling pathway | 1.16E-02 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa04666 | Fc gamma R-mediated phagocytosis | 4.07E-03 | 3 | P08637, O75015, P04049 | FCGR3A, FCGR3B, RAF1 | More | | | Sertindole | hsa04668 | TNF signaling pathway | 4.29E-03 | 7 | P01375, Q99941, P18848, P19875, P01584, P14780, O95429 | TNF, CREBL1, ATF4, CXCL2, IL1B, MMP9, BAG4 | More | | | Sertindole | hsa04710 | Circadian rhythm | 4.40E-02 | 1 | O15516 | CLOCK | More | | | Sertindole | hsa04713 | Circadian entrainment | 4.54E-02 | 3 | P0DP23, Q08828, P51828 | CALM1, ADCY1, ADCY7 | More | | | Sertindole | hsa04714 | Thermogenesis | 9.00E-04 | 4 | Q16539, P33121, Q16718, O14521 | MAPK14, ACSL1, NDUFA5, SDHD | More | | | Sertindole | hsa04720 | Long-term potentiation | 1.33E-03 | 7 | P16298, P0DP23, P51812, P18848, Q08828, Q02750, P04049 | PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1 | More | | | Sertindole | hsa04721 | Synaptic vesicle cycle | 1.80E-02 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | | Sertindole | hsa04722 | Neurotrophin signaling pathway | 7.10E-03 | 4 | P04049, P49841, O43524, P48023 | RAF1, GSK3B, FOXO3, FASLG | More | | | Sertindole | hsa04725 | Cholinergic synapse | 1.39E-02 | 4 | Q08828, P51828, P18848, P31751 | ADCY1, ADCY7, ATF4, AKT2 | More | | | Sertindole | hsa04726 | Serotonergic synapse | 1.33E-02 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa04728 | Dopaminergic synapse | 8.02E-04 | 11 | P14416, P63218, P50151, P31751, P49841, P18848, Q16539, P49407, Q13362, Q14738, P0DP23 | DRD2, GNG5, GNG10, AKT2, GSK3B, ATF4, MAPK14, ARRB1, PPP2R5C, PPP2R5D, CALM1 | More | | | Sertindole | hsa04730 | Long-term depression | 1.25E-04 | 2 | P08069, P04049 | IGF1R, RAF1 | More | | | Sertindole | hsa04740 | Olfactory transduction | 2.52E-02 | 1 | Q9H255 | OR51E2 | More | | | Sertindole | hsa04742 | Taste transduction | 1.01E-02 | 1 | P30939 | HTR1F | More | | | Sertindole | hsa04750 | Inflammatory mediator regulation of TRP channels | 7.39E-06 | 11 | P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, Q14643, Q04759, P0DP24, P0DP23 | IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, ITPR1, PRKCQ, CALM2, CALM1 | More | | | Sertindole | hsa04810 | Regulation of actin cytoskeleton | 3.81E-02 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa04910 | Insulin signaling pathway | 2.51E-03 | 4 | P22694, P06737, P04049, P49841 | PRKACB, PYGL, RAF1, GSK3B | More | | | Sertindole | hsa04911 | Insulin secretion | 8.29E-04 | 5 | Q08828, P51828, Q99941, P18848, Q13557 | ADCY1, ADCY7, CREBL1, ATF4, CAMK2D | More | | | Sertindole | hsa04912 | GnRH signaling pathway | 1.73E-03 | 10 | Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P04049 | ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, RAF1 | More | | | Sertindole | hsa04913 | Ovarian steroidogenesis | 5.67E-04 | 4 | P42330, P22694, P06213, P08069 | AKR1C3, PRKACB, INSR, IGF1R | More | | | Sertindole | hsa04914 | Progesterone-mediated oocyte maturation | 1.02E-03 | 6 | P08069, Q17RY0, Q9Y6D9, P51812, Q02750, P04049 | IGF1R, CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1 | More | | | Sertindole | hsa04915 | Estrogen signaling pathway | 1.02E-04 | 11 | P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788 | RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1 | More | | | Sertindole | hsa04916 | Melanogenesis | 4.54E-03 | 4 | P0DP23, Q08828, P51828, P04049 | CALM1, ADCY1, ADCY7, RAF1 | More | | | Sertindole | hsa04917 | Prolactin signaling pathway | 6.63E-03 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa04919 | Thyroid hormone signaling pathway | 6.83E-04 | 5 | P49841, P04049, P22694, O60244, Q9NVC6 | GSK3B, RAF1, PRKACB, MED14, MED17 | More | | | Sertindole | hsa04921 | Oxytocin signaling pathway | 2.32E-02 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa04923 | Regulation of lipolysis in adipocytes | 7.59E-04 | 4 | Q08828, P51828, P06213, P31751 | ADCY1, ADCY7, INSR, AKT2 | More | | | Sertindole | hsa04924 | Renin secretion | 4.04E-02 | 2 | P22694, P07550 | PRKACB, ADRB2 | More | | | Sertindole | hsa04925 | Aldosterone synthesis and secretion | 1.35E-04 | 7 | Q99941, P18848, Q08828, P51828, P0DP23, Q13557, P23634 | CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2D, ATP2B4 | More | | | Sertindole | hsa04926 | Relaxin signaling pathway | 4.96E-04 | 8 | P31751, P18848, P22694, P14780, Q08828, P51828, P04049, P30679 | AKT2, ATF4, PRKACB, MMP9, ADCY1, ADCY7, RAF1, GNA15 | More | | | Sertindole | hsa04927 | Cortisol synthesis and secretion | 7.43E-04 | 4 | P18848, Q08828, P51828, P22694 | ATF4, ADCY1, ADCY7, PRKACB | More | | | Sertindole | hsa04928 | Parathyroid hormone synthesis, secretion and action | 1.99E-02 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa04929 | GnRH secretion | 4.98E-03 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa04930 | Type II diabetes mellitus | 3.14E-02 | 1 | P06213 | INSR | More | | | Sertindole | hsa04931 | Insulin resistance | 1.94E-02 | 3 | P01375, P49841, P06737 | TNF, GSK3B, PYGL | More | | | Sertindole | hsa04932 | Non-alcoholic fatty liver disease | 2.89E-07 | 14 | P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521 | AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHD | More | | | Sertindole | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 1.25E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | | | Sertindole | hsa04934 | Cushing syndrome | 4.83E-04 | 6 | Q99941, P18848, Q08828, P51828, O15169, Q13557 | CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2D | More | | | Sertindole | hsa04935 | Growth hormone synthesis, secretion and action | 5.00E-03 | 5 | Q08828, P51828, P04049, P18848, P31751 | ADCY1, ADCY7, RAF1, ATF4, AKT2 | More | | | Sertindole | hsa04940 | Type I diabetes mellitus | 1.87E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Sertindole | hsa04960 | Aldosterone-regulated sodium reabsorption | 7.59E-03 | 2 | O00141, P06213 | SGK, INSR | More | | | Sertindole | hsa04962 | Vasopressin-regulated water reabsorption | 1.80E-02 | 2 | P62491, P46459 | RAB11A, NSF | More | | | Sertindole | hsa04964 | Proximal tubule bicarbonate reclamation | 2.17E-03 | 1 | P00918 | CA2 | More | | | Sertindole | hsa04966 | Collecting duct acid secretion | 1.06E-04 | 3 | P02730, P00918, Q9Y666 | SLC4A1, CA2, SLC12A7 | More | | | Sertindole | hsa04970 | Salivary secretion | 1.04E-04 | 6 | P07550, Q08828, P51828, P22694, P0DP23, P49913 | ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMP | More | | | Sertindole | hsa04971 | Gastric acid secretion | 9.27E-05 | 5 | Q08828, P51828, P15311, P0DP23, Q13557 | ADCY1, ADCY7, VIL2, CALM1, CAMK2D | More | | | Sertindole | hsa04973 | Carbohydrate digestion and absorption | 2.41E-02 | 1 | P13866 | SLC5A1 | More | | | Sertindole | hsa04975 | Fat digestion and absorption | 3.43E-02 | 1 | O14494 | PLPP1 | More | | | Sertindole | hsa04976 | Bile secretion | 2.12E-06 | 7 | O43315, Q08828, P51828, P22694, P08183, P13866, Q14032 | AQP9, ADCY1, ADCY7, PRKACB, ABCB1, SLC5A1, BAAT | More | | | Sertindole | hsa05010 | Alzheimer disease | 3.34E-04 | 14 | Q92542, O95298, P05496, P12074, Q00535, O75460, P0DP23, P01584, P18848, O15169, P31751, P05141, P45880, P28070 | NCSTN, NDUFC2, ATP5G1, COX6A1, CDK5, ERN1, CALM1, IL1B, ATF4, AXIN1, AKT2, SLC25A5, VDAC2, PSMB4 | More | | | Sertindole | hsa05016 | Huntington disease | 1.76E-03 | 10 | O95298, P13073, P12074, P24928, P30876, P62487, P05141, O75460, P28070, O00232 | NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12 | More | | | Sertindole | hsa05017 | Spinocerebellar ataxia | 3.94E-02 | 4 | O75460, P31751, P28070, P05141 | ERN1, AKT2, PSMB4, SLC25A5 | More | | | Sertindole | hsa05020 | Prion disease | 1.01E-04 | 13 | P01584, P46531, P11142, Q16718, O14521, P05496, P12074, Q92736, P45880, O60282, P49841, Q99941, Q16539 | IL1B, NOTCH1, HSPA8, NDUFA5, SDHD, ATP5G1, COX6A1, RYR2, VDAC2, KIF5C, GSK3B, CREBL1, MAPK14 | More | | | Sertindole | hsa05022 | Pathways of neurodegeneration - multiple diseases | 1.73E-04 | 17 | P49841, Q16718, O95298, O14521, Q06055, Q8TEV9, O75460, P18848, Q13561, P05141, Q16539, Q00535, P01584, Q08752, O15020, P0DP23, P28070 | GSK3B, NDUFA5, NDUFC2, SDHD, ATP5G2, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, MAPK14, CDK5, IL1B, PPID, SPTBN2, CALM1, PSMB4 | More | | | Sertindole | hsa05031 | Amphetamine addiction | 4.32E-02 | 3 | P22694, P18848, Q13547 | PRKACB, ATF4, HDAC1 | More | | | Sertindole | hsa05034 | Alcoholism | 2.78E-04 | 5 | P04049, Q93077, P62807, O60814, P68431 | RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Sertindole | hsa05100 | Bacterial invasion of epithelial cells | 4.54E-02 | 3 | Q14141, Q05397, Q96JJ3 | SEPT6, PTK2, ELMO2 | More | | | Sertindole | hsa05110 | Vibrio cholerae infection | 4.78E-02 | 1 | Q99437 | ATP6V0B | More | | | Sertindole | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.85E-03 | 5 | Q16539, P09341, P25024, P25025, P07948 | MAPK14, CXCL1, CXCR1, CXCR2, LYN | More | | | Sertindole | hsa05131 | Shigellosis | 2.93E-02 | 6 | Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q13315 | RRAGD, UBB, SEPT6, ELMO2, PTK2, ATM | More | | | Sertindole | hsa05132 | Salmonella infection | 5.66E-06 | 12 | P25963, P04049, Q9UJU2, O00471, Q13546, Q13489, P10415, Q9BQS8, Q13561, O60282, Q13509, P68371 | NFKBIA, RAF1, LEF1, EXOC5, RIPK1, BIRC3, BCL2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2C | More | | | Sertindole | hsa05133 | Pertussis | 3.02E-03 | 1 | P0C0L4 | C4A | More | | | Sertindole | hsa05134 | Legionellosis | 2.82E-02 | 3 | P01584, Q9NR31, P0DMV8 | IL1B, SAR1A, HSPA1A | More | | | Sertindole | hsa05135 | Yersinia infection | 4.65E-02 | 5 | P13612, P06239, Q16539, P01375, P49841 | ITGA4, LCK, MAPK14, TNF, GSK3B | More | | | Sertindole | hsa05140 | Leishmaniasis | 1.20E-06 | 14 | P13612, P08637, O75015, P14598, P23458, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, Q15080 | ITGA4, FCGR3A, FCGR3B, NCF1, JAK1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, NCF4 | More | | | Sertindole | hsa05143 | African trypanosomiasis | 7.50E-04 | 4 | P01375, P69905, P68871, P48023 | TNF, HBA2, HBB, FASLG | More | | | Sertindole | hsa05144 | Malaria | 6.65E-09 | 8 | P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718 | CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1 | More | | | Sertindole | hsa05145 | Toxoplasmosis | 2.78E-02 | 3 | P25963, P10415, Q13489 | NFKBIA, BCL2, BIRC3 | More | | | Sertindole | hsa05146 | Amoebiasis | 8.54E-05 | 11 | P01584, P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P08311 | IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, CTSG | More | | | Sertindole | hsa05150 | Staphylococcus aureus infection | 1.39E-06 | 11 | P0C0L4, P21730, P21462, P08637, O75015, P13646, Q14532, P59665, P59666, P12838, P49913 | C4A, C5AR1, FPR1, FCGR3A, FCGR3B, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP | More | | | Sertindole | hsa05152 | Tuberculosis | 4.65E-03 | 3 | P04049, Q99437, P25774 | RAF1, ATP6V0B, CTSS | More | | | Sertindole | hsa05160 | Hepatitis C | 1.40E-03 | 5 | P60033, P04049, P49841, P01375, P48023 | CD81, RAF1, GSK3B, TNF, FASLG | More | | | Sertindole | hsa05161 | Hepatitis B | 6.38E-04 | 5 | P04049, P25963, Q13485, P10415, P84022 | RAF1, NFKBIA, SMAD4, BCL2, SMAD3 | More | | | Sertindole | hsa05162 | Measles | 3.18E-02 | 4 | P23458, P0DMV8, P01584, Q9NP90 | JAK1, HSPA1A, IL1B, RAB9B | More | | | Sertindole | hsa05163 | Human cytomegalovirus infection | 6.47E-07 | 20 | P31751, P04049, P01375, P63218, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463 | AKT2, RAF1, TNF, GNG5, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 0.726 | | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P01375 | TNF | Tumor necrosis factor | 0.718 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.727 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.743 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.728 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P0DP23 | CALM1 | Calmodulin-1 | 0.857 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.756 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.796 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.726 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 1 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.842 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.823 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.857 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P01584 | IL1B | Interleukin-1 beta | 0.735 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.799 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.786 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.889 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.929 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.795 | | Q00535 | CDK5 | Cyclin-dependent-like kinase 5 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.748 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.788 |
| | Sertindole | hsa05164 | Influenza A | 1.49E-02 | 6 | P31751, P01584, P23458, P05141, P04049, Q9UBU9 | AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1 | More | | | Sertindole | hsa05166 | Human T-cell leukemia virus 1 infection | 3.90E-02 | 7 | P23458, P05141, P62826, Q08828, P51828, P18848, P31751 | JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2 | More | | | Sertindole | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 3.15E-02 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa05168 | Herpes simplex virus 1 infection | 4.64E-03 | 17 | O00463, O60603, P25963, Q05823, Q07955, Q01130, Q16629, Q9Y2A4, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415 | TRAF5, TLR2, NFKBIA, RNASEL, SFRS1, SFRS2, SFRS7, ZNF443, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2 | More | | | Sertindole | hsa05169 | Epstein-Barr virus infection | 5.26E-03 | 12 | P13765, Q13547, P04637, O00463, P10415, Q16539, P24522, P48551, O60603, P29728, P09693, P20963 | HLA-DOB, HDAC1, TP53, TRAF5, BCL2, MAPK14, GADD45A, IFNAR2, TLR2, OAS2, CD3G, CD247 | More | | | Sertindole | hsa05170 | Human immunodeficiency virus 1 infection | 1.21E-02 | 6 | P04049, Q02750, P62879, P16298, Q05397, Q13315 | RAF1, MAP2K1, GNB2, PPP3CB, PTK2, ATM | More | | | Sertindole | hsa05171 | Coronavirus disease - COVID-19 | 3.18E-03 | 7 | P01584, P62753, P36578, P62888, P61927, P61513, P62829 | IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23 | More | | | Sertindole | hsa05202 | Transcriptional misregulation in cancer | 5.62E-05 | 17 | P17844, P14780, P27930, Q15744, Q16548, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522 | DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | 0.863 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.94 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P14780 | MMP9 | Matrix metalloproteinase-9 | 1 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.851 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.921 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.758 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.89 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P05164 | MPO | Myeloperoxidase | 0.812 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.784 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.858 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P08246 | ELA2 | Neutrophil elastase | 0.859 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.783 | | P14780 | MMP9 | Matrix metalloproteinase-9 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.752 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.919 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.812 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12980 | LYL1 | Protein lyl-1 | 0.784 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P12980 | LYL1 | Protein lyl-1 | 0.716 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | | P14780 | MMP9 | Matrix metalloproteinase-9 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.765 |
| | Sertindole | hsa05203 | Viral carcinogenesis | 4.85E-02 | 3 | Q15283, P62807, O60814 | RASA2, HIST1H2BC, H2BC12 | More | | | Sertindole | hsa05204 | Chemical carcinogenesis | 1.48E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | | | Sertindole | hsa05205 | Proteoglycans in cancer | 2.86E-03 | 7 | P04049, P14780, P01375, P08069, P23588, Q13635, P22694 | RAF1, MMP9, TNF, IGF1R, EIF4B, PTCH1, PRKACB | More | | | Sertindole | hsa05206 | MicroRNAs in cancer | 6.19E-04 | 7 | P15311, P21860, P61978, P46531, P63279, P22105, P04049 | VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB, RAF1 | More | | | Sertindole | hsa05210 | Colorectal cancer | 1.68E-03 | 4 | P84022, Q13485, P04049, P10415 | SMAD3, SMAD4, RAF1, BCL2 | More | | | Sertindole | hsa05211 | Renal cell carcinoma | 1.16E-02 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa05212 | Pancreatic cancer | 2.95E-04 | 6 | P31751, P04049, Q15311, P23458, P84022, Q13485 | AKT2, RAF1, RALBP1, JAK1, SMAD3, SMAD4 | More | | | Sertindole | hsa05213 | Endometrial cancer | 7.11E-03 | 4 | Q9UJU2, P04049, P04637, P24522 | LEF1, RAF1, TP53, GADD45A | More | | | Sertindole | hsa05214 | Glioma | 9.46E-04 | 5 | P08069, Q16566, P04049, P04637, P24522 | IGF1R, CAMK4, RAF1, TP53, GADD45A | More | | | Sertindole | hsa05215 | Prostate cancer | 1.65E-04 | 2 | P08069, P04049 | IGF1R, RAF1 | More | | | Sertindole | hsa05216 | Thyroid cancer | 1.35E-02 | 3 | Q9UJU2, P04637, P24522 | LEF1, TP53, GADD45A | More | | | Sertindole | hsa05217 | Basal cell carcinoma | 1.34E-04 | 6 | Q13635, P04628, P49841, Q9UJU2, P04637, P24522 | PTCH1, WNT1, GSK3B, LEF1, TP53, GADD45A | More | | | Sertindole | hsa05218 | Melanoma | 3.85E-05 | 2 | P08069, P04049 | IGF1R, RAF1 | More | | | Sertindole | hsa05219 | Bladder cancer | 5.65E-03 | 3 | P14780, P04637, P04049 | MMP9, TP53, RAF1 | More | | | Sertindole | hsa05220 | Chronic myeloid leukemia | 6.24E-04 | 4 | Q13485, P25963, P84022, P04049 | SMAD4, NFKBIA, SMAD3, RAF1 | More | | | Sertindole | hsa05221 | Acute myeloid leukemia | 8.29E-03 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa05222 | Small cell lung cancer | 1.36E-03 | 4 | Q16787, Q13489, P10415, P25963 | LAMA3, BIRC3, BCL2, NFKBIA | More | | | Sertindole | hsa05223 | Non-small cell lung cancer | 6.63E-03 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa05224 | Breast cancer | 2.75E-03 | 6 | P04049, P08069, P49841, Q92837, P04637, P24522 | RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45A | More | | | Sertindole | hsa05225 | Hepatocellular carcinoma | 1.65E-04 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Sertindole | hsa05226 | Gastric cancer | 1.78E-04 | 8 | P04049, Q9UJU2, P04637, P24522, P84022, Q13485, P14923, P10415 | RAF1, LEF1, TP53, GADD45A, SMAD3, SMAD4, JUP, BCL2 | More | | | Sertindole | hsa05230 | Central carbon metabolism in cancer | 9.95E-03 | 1 | P04049 | RAF1 | More | | | Sertindole | hsa05231 | Choline metabolism in cancer | 2.66E-05 | 7 | P04049, P31751, Q9Y259, P19174, P49619, Q16760, O14986 | RAF1, AKT2, CHKB, PLCG1, DGKG, DGKD, PIP5K1B | More | | | Sertindole | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 1.95E-04 | 10 | O95267, P20963, P09693, P06239, P04049, P23458, O60603, Q04759, Q16539, P01730 | RASGRP1, CD247, CD3G, LCK, RAF1, JAK1, TLR2, PRKCQ, MAPK14, CD4 | More | | | Sertindole | hsa05310 | Asthma | 1.64E-03 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Sertindole | hsa05321 | Inflammatory bowel disease | 1.12E-05 | 7 | O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B | More | | | Sertindole | hsa05322 | Systemic lupus erythematosus | 1.13E-05 | 7 | P08637, O75015, P09871, Q93077, P62807, O60814, P68431 | FCGR3A, FCGR3B, C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Sertindole | hsa05330 | Allograft rejection | 2.72E-02 | 2 | P48023, P01375 | FASLG, TNF | More | | | Sertindole | hsa05332 | Graft-versus-host disease | 1.36E-04 | 5 | P13765, P48023, P01375, P26715, Q13241 | HLA-DOB, FASLG, TNF, KLRC1, KLRD1 | More | | | Sertindole | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 2.17E-03 | 1 | P54284 | CACNB3 | More | | | Sertindole | hsa05414 | Dilated cardiomyopathy | 4.55E-02 | 2 | P54284, P26678 | CACNB3, PLN | More | | | Sertindole | hsa05415 | Diabetic cardiomyopathy | 1.09E-03 | 6 | Q15080, Q16718, O14521, Q16539, P49841, P14780 | NCF4, NDUFA5, SDHD, MAPK14, GSK3B, MMP9 | More | | | Sertindole | hsa05418 | Fluid shear stress and atherosclerosis | 2.64E-03 | 7 | Q16539, P10599, P14780, P01375, P04637, P14778, P27930 | MAPK14, TXN, MMP9, TNF, TP53, IL1R1, IL1R2 | More | |
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