| Selpercatinib | hsa00280 | Valine, leucine and isoleucine degradation | 3.41E-03 | 4 | P55809, Q9HCC0, Q02252, P11310 | OXCT1, MCCC2, ALDH6A1, ACADM | More | |
| Selpercatinib | hsa00600 | Sphingolipid metabolism | 3.76E-02 | 1 | P15289 | ARSA | More | |
| Selpercatinib | hsa00630 | Glyoxylate and dicarboxylate metabolism | 5.34E-03 | 2 | P40925, P15104 | MDH1, GLUL | More | |
| Selpercatinib | hsa00670 | One carbon pool by folate | 1.33E-02 | 2 | P04818, Q99707 | TYMS, MTR | More | |
| Selpercatinib | hsa02010 | ABC transporters | 4.48E-02 | 1 | Q8IZY2 | ABCA7 | More | |
| Selpercatinib | hsa03013 | RNA transport | 4.13E-02 | 6 | Q09161, P35658, P47813, Q14152, O75822, P51114 | NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1 | More | |
| Selpercatinib | hsa03020 | RNA polymerase | 3.00E-02 | 3 | P30876, P24928, P62487 | POLR2B, POLR2A, POLR2G | More | |
| Selpercatinib | hsa03040 | Spliceosome | 4.19E-02 | 5 | Q14562, O60508, P08579, Q01130, O43447 | DHX8, CDC40, SNRPB2, SFRS2, PPIH | More | |
| Selpercatinib | hsa03060 | Protein export | 4.42E-02 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | |
| Selpercatinib | hsa03430 | Mismatch repair | 4.38E-02 | 1 | P20585 | MSH3 | More | |
| Selpercatinib | hsa04012 | ErbB signaling pathway | 1.91E-02 | 3 | P16333, P19174, P01106 | NCK1, PLCG1, MYC | More | |
| Selpercatinib | hsa04015 | Rap1 signaling pathway | 9.14E-03 | 2 | P06213, O00522 | INSR, KRIT1 | More | |
| Selpercatinib | hsa04064 | NF-kappa B signaling pathway | 2.35E-02 | 4 | P01584, P63279, Q8NHW4, Q9NQC7 | IL1B, UBE2I, CCL4L2, CYLD | More | |
| Selpercatinib | hsa04110 | Cell cycle | 2.06E-02 | 6 | Q9UBD5, P06493, Q14683, P30304, P33981, P01106 | ORC3, CDK1, SMC1A, CDC25A, TTK, MYC | More | |
| Selpercatinib | hsa04142 | Lysosome | 1.46E-02 | 7 | P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916 | HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2 | More | |
| Selpercatinib | hsa04144 | Endocytosis | 1.67E-02 | 8 | P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4 | HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12 | More | |
| Selpercatinib | hsa04213 | Longevity regulating pathway - multiple species | 2.82E-02 | 3 | Q08828, P51828, P0DMV8 | ADCY1, ADCY7, HSPA1A | More | |
| Selpercatinib | hsa04270 | Vascular smooth muscle contraction | 6.96E-03 | 6 | P0DP23, Q08828, P51828, P35579, P35749, P35318 | CALM1, ADCY1, ADCY7, MYH9, MYH11, ADM | More | |
| Selpercatinib | hsa04392 | Hippo signaling pathway - multiple species | 3.01E-02 | 1 | Q6V0I7 | FAT4 | More | |
| Selpercatinib | hsa04610 | Complement and coagulation cascades | 1.91E-03 | 1 | P0C0L4 | C4A | More | |
| Selpercatinib | hsa04612 | Antigen processing and presentation | 4.78E-02 | 6 | P48382, P26715, P26717, Q13241, O43908, P01375 | RFX5, KLRC1, KLRC2, KLRD1, KLRC4, TNF | More | |
| Selpercatinib | hsa04621 | NOD-like receptor signaling pathway | 2.27E-02 | 9 | Q9H1Y0, P43490, O00463, Q05823, P01375, P49913, P59665, P59666, P12838 | ATG5, PBEF1, TRAF5, RNASEL, TNF, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4 | More | |
| Selpercatinib | hsa04623 | Cytosolic DNA-sensing pathway | 1.65E-02 | 2 | P01584, Q8NHW4 | IL1B, CCL4L2 | More | |
| Selpercatinib | hsa04650 | Natural killer cell mediated cytotoxicity | 1.25E-02 | 8 | P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715 | TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1 | More | |
| Selpercatinib | hsa04662 | B cell receptor signaling pathway | 1.49E-03 | 5 | P42338, P60033, P07948, P21854, Q8N149 | PIK3CB, CD81, LYN, CD72, LILRA2 | More | |
| Selpercatinib | hsa04664 | Fc epsilon RI signaling pathway | 2.32E-02 | 3 | P42338, P07948, P09917 | PIK3CB, LYN, ALOX5 | More | |
| Selpercatinib | hsa04724 | Glutamatergic synapse | 5.94E-03 | 4 | O15399, P63218, P50151, P15104 | GRIN2D, GNG5, GNG10, GLUL | More | |
| Selpercatinib | hsa04725 | Cholinergic synapse | 4.10E-02 | 3 | P63218, P50151, P42338 | GNG5, GNG10, PIK3CB | More | |
| Selpercatinib | hsa04727 | GABAergic synapse | 1.63E-02 | 3 | P63218, P50151, P15104 | GNG5, GNG10, GLUL | More | |
| Selpercatinib | hsa04750 | Inflammatory mediator regulation of TRP channels | 4.01E-02 | 4 | P01584, Q08828, P51828, P0DP23 | IL1B, ADCY1, ADCY7, CALM1 | More | |
| Selpercatinib | hsa04913 | Ovarian steroidogenesis | 2.52E-02 | 1 | P06213 | INSR | More | |
| Selpercatinib | hsa04915 | Estrogen signaling pathway | 3.17E-02 | 5 | Q08828, P51828, P0DMV8, P0DP23, Q15788 | ADCY1, ADCY7, HSPA1A, CALM1, NCOA1 | More | |
| Selpercatinib | hsa04923 | Regulation of lipolysis in adipocytes | 3.76E-02 | 1 | P06213 | INSR | More | |
| Selpercatinib | hsa04926 | Relaxin signaling pathway | 5.70E-03 | 5 | P42338, P63218, P50151, P49767, P49407 | PIK3CB, GNG5, GNG10, VEGFC, ARRB1 | More | |
| Selpercatinib | hsa04929 | GnRH secretion | 4.62E-02 | 2 | P42338, P49407 | PIK3CB, ARRB1 | More | |
| Selpercatinib | hsa04930 | Type II diabetes mellitus | 3.14E-02 | 1 | P06213 | INSR | More | |
| Selpercatinib | hsa04932 | Non-alcoholic fatty liver disease | 1.39E-02 | 6 | O43521, O75460, P01584, P13073, P12074, O95298 | BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFC2 | More | |
| Selpercatinib | hsa04960 | Aldosterone-regulated sodium reabsorption | 3.14E-02 | 1 | P06213 | INSR | More | |
| Selpercatinib | hsa04964 | Proximal tubule bicarbonate reclamation | 4.48E-02 | 1 | P00918 | CA2 | More | |
| Selpercatinib | hsa04966 | Collecting duct acid secretion | 4.48E-02 | 1 | P00918 | CA2 | More | |
| Selpercatinib | hsa04970 | Salivary secretion | 4.78E-02 | 3 | Q08828, P51828, P0DP23 | ADCY1, ADCY7, CALM1 | More | |
| Selpercatinib | hsa04976 | Bile secretion | 4.78E-02 | 3 | Q08828, P51828, Q14032 | ADCY1, ADCY7, BAAT | More | |
| Selpercatinib | hsa05016 | Huntington disease | 2.46E-02 | 9 | O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232 | NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12 | More | |
| Selpercatinib | hsa05022 | Pathways of neurodegeneration - multiple diseases | 2.95E-02 | 2 | Q06055, O15020 | ATP5G2, SPTBN2 | More | |
| Selpercatinib | hsa05133 | Pertussis | 3.51E-02 | 1 | P0C0L4 | C4A | More | |
| Selpercatinib | hsa05134 | Legionellosis | 2.82E-02 | 3 | P01584, Q9NR31, P0DMV8 | IL1B, SAR1A, HSPA1A | More | |
| Selpercatinib | hsa05144 | Malaria | 3.12E-02 | 4 | P60033, P01375, P35443, P26718 | CD81, TNF, THBS4, KLRK1 | More | |
| Selpercatinib | hsa05150 | Staphylococcus aureus infection | 1.01E-05 | 10 | P0C0L4, P21730, P21462, O75015, P13646, Q14532, P59665, P59666, P12838, P49913 | C4A, C5AR1, FPR1, FCGR3B, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP | More | |
| Selpercatinib | hsa05162 | Measles | 3.18E-02 | 4 | P23458, P0DMV8, P01584, Q9NP90 | JAK1, HSPA1A, IL1B, RAB9B | More | |
| Selpercatinib | hsa05163 | Human cytomegalovirus infection | 3.31E-02 | 7 | P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651 | CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RA | More | |
| Selpercatinib | hsa05169 | Epstein-Barr virus infection | 3.72E-02 | 6 | Q13547, P42338, P07948, Q13761, O75293, P07766 | HDAC1, PIK3CB, LYN, RUNX3, GADD45B, CD3E | More | |
| Selpercatinib | hsa05231 | Choline metabolism in cancer | 2.60E-02 | 3 | Q9Y259, P19174, P49619 | CHKB, PLCG1, DGKG | More | |
| Selpercatinib | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.48E-02 | 1 | P54284 | CACNB3 | More | |
| Selpercatinib | hsa05414 | Dilated cardiomyopathy | 4.55E-02 | 2 | P54284, P26678 | CACNB3, PLN | More | |
