PharmaCoNets of Selegiline (SPCN: 7.43 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Selegilinehsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Selegilinehsa00190Oxidative phosphorylation4.36E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Selegilinehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Selegilinehsa01230Biosynthesis of amino acids3.91E-023P51854, Q99707, P50213TKTL1, MTR, IDH3AMore
Selegilinehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Selegilinehsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Selegilinehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Selegilinehsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Selegilinehsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Selegilinehsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Selegilinehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Selegilinehsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Selegilinehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Selegilinehsa05140Leishmaniasis4.50E-035P14598, O60603, P25963, P29350, Q15080NCF1, TLR2, NFKBIA, PTPN6, NCF4More
Selegilinehsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Selegilinehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Selegilinehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Selegilinehsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore

Community members of Selegiline (SDC: 3.08)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)