PharmaCoNets of Secobarbital (SPCN: 11.88 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Secobarbitalhsa00310Lysine degradation1.53E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Secobarbitalhsa00380Tryptophan metabolism4.14E-021Q16613AANATMore
Secobarbitalhsa00500Starch and sucrose metabolism2.86E-022O43451, P46976MGAM, GYG1More
Secobarbitalhsa00562Inositol phosphate metabolism2.54E-034P27987, Q13572, Q96PE3, P42338ITPKB, ITPK1, INPP4A, PIK3CBMore
Secobarbitalhsa00730Thiamine metabolism1.75E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Secobarbitalhsa00770Pantothenate and CoA biosynthesis1.78E-022O95498, O95497VNN2, VNN1More
Secobarbitalhsa01240Biosynthesis of cofactors3.34E-023P05186, Q9Y6K8, O75911ALPL, AK5, DHRS3More
Secobarbitalhsa03008Ribosome biogenesis in eukaryotes4.94E-022P19784, P67870CSNK2A2, CSNK2BMore
Secobarbitalhsa03040Spliceosome3.94E-048Q14562, O43143, O60508, P08579, P26368, Q13595, Q01130, O43447DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS2, PPIHMore
Secobarbitalhsa03050Proteasome1.40E-021P55036PSMD4More
Secobarbitalhsa04014Ras signaling pathway3.62E-025P42338, P49767, P0DP23, P63218, P50151PIK3CB, VEGFC, CALM1, GNG5, GNG10More
Secobarbitalhsa04020Calcium signaling pathway5.15E-058P27987, P21796, Q16566, P30679, O15399, P0DP23, P23634, P49767ITPKB, VDAC1, CAMK4, GNA15, GRIN2D, CALM1, ATP2B4, VEGFCMore
Secobarbitalhsa04024cAMP signaling pathway1.46E-038P63092, P42338, P26678, P0DP23, P23634, P61586, Q16566, O15399GNAS, PIK3CB, PLN, CALM1, ATP2B4, RHOA, CAMK4, GRIN2DMore
Secobarbitalhsa04070Phosphatidylinositol signaling system1.49E-035P0DP23, P42338, Q96PE3, Q13572, P27987CALM1, PIK3CB, INPP4A, ITPK1, ITPKBMore
Secobarbitalhsa04072Phospholipase D signaling pathway2.75E-023P61586, O14986, P63092RHOA, PIP5K1B, GNASMore
Secobarbitalhsa04120Ubiquitin mediated proteolysis6.89E-035Q14145, Q13042, Q13191, Q15751, Q7Z6Z7KEAP1, CDC16, CBLB, HERC1, HUWE1More
Secobarbitalhsa04137Mitophagy - animal2.52E-022P19784, P67870CSNK2A2, CSNK2BMore
Secobarbitalhsa04310Wnt signaling pathway4.17E-033P61586, P19784, P67870RHOA, CSNK2A2, CSNK2BMore
Secobarbitalhsa04371Apelin signaling pathway7.45E-035P63218, P50151, Q13485, Q16566, P0DP23GNG5, GNG10, SMAD4, CAMK4, CALM1More
Secobarbitalhsa04510Focal adhesion4.07E-023O14986, P61586, Q16363PIP5K1B, RHOA, LAMA4More
Secobarbitalhsa04520Adherens junction1.38E-043P19784, P67870, P61586CSNK2A2, CSNK2B, RHOAMore
Secobarbitalhsa04621NOD-like receptor signaling pathway4.31E-024P01375, P59665, P59666, P12838TNF, DEFA1; DEFA1B, DEFA3, DEFA4More
Secobarbitalhsa04640Hematopoietic cell lineage4.27E-024P08514, P14778, P01730, P13765ITGA2B, IL1R1, CD4, HLA-DOBMore
Secobarbitalhsa04659Th17 cell differentiation2.73E-024Q16539, P01730, P13765, P14778MAPK14, CD4, HLA-DOB, IL1R1More
Secobarbitalhsa04664Fc epsilon RI signaling pathway2.32E-023P42338, P07948, P09917PIK3CB, LYN, ALOX5More
Secobarbitalhsa04666Fc gamma R-mediated phagocytosis4.10E-023P07948, P42338, P23528LYN, PIK3CB, CFL1More
Secobarbitalhsa04713Circadian entrainment9.72E-046O15399, P0DP23, P62873, P63218, P50151, P63092GRIN2D, CALM1, GNB1, GNG5, GNG10, GNASMore
Secobarbitalhsa04720Long-term potentiation1.63E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Secobarbitalhsa04723Retrograde endocannabinoid signaling4.94E-022P48169, P62873GABRA4, GNB1More
Secobarbitalhsa04724Glutamatergic synapse3.78E-035O15399, P63092, P62873, P63218, P50151GRIN2D, GNAS, GNB1, GNG5, GNG10More
Secobarbitalhsa04725Cholinergic synapse5.94E-034P63218, P50151, Q16566, P42338GNG5, GNG10, CAMK4, PIK3CBMore
Secobarbitalhsa04726Serotonergic synapse9.72E-046P63092, P62873, P63218, P50151, P33260, P09917GNAS, GNB1, GNG5, GNG10, CYP2C18, ALOX5More
Secobarbitalhsa04728Dopaminergic synapse4.47E-024P63218, P50151, P0DP23, O00327GNG5, GNG10, CALM1, ARNTLMore
Secobarbitalhsa04925Aldosterone synthesis and secretion3.14E-023P0DP23, Q16566, P23634CALM1, CAMK4, ATP2B4More
Secobarbitalhsa04926Relaxin signaling pathway5.70E-035P42338, P63218, P50151, P49767, P30679PIK3CB, GNG5, GNG10, VEGFC, GNA15More
Secobarbitalhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Secobarbitalhsa04972Pancreatic secretion3.65E-022P63092, P61586GNAS, RHOAMore
Secobarbitalhsa05017Spinocerebellar ataxia5.94E-034Q8TB72, O15399, P42338, P21796PUM2, GRIN2D, PIK3CB, VDAC1More
Secobarbitalhsa05032Morphine addiction9.04E-055P62873, P48169, P78334, P63092, P32298GNB1, GABRA4, GABRE, GNAS, GRK4More
Secobarbitalhsa05034Alcoholism3.62E-025O15399, Q16566, P0DP23, P63218, P50151GRIN2D, CAMK4, CALM1, GNG5, GNG10More
Secobarbitalhsa05142Chagas disease2.26E-023P01375, P30679, P48023TNF, GNA15, FASLGMore
Secobarbitalhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Secobarbitalhsa05150Staphylococcus aureus infection1.83E-023P59665, P59666, P12838DEFA1; DEFA1B, DEFA3, DEFA4More
Secobarbitalhsa05163Human cytomegalovirus infection3.23E-039P42338, P62873, P63218, P50151, P0DP23, P61586, P63092, P30101, P61769PIK3CB, GNB1, GNG5, GNG10, CALM1, RHOA, GNAS, PDIA3, B2MMore
Secobarbitalhsa05167Kaposi sarcoma-associated herpesvirus infection4.19E-025P42338, P63218, P50151, P07948, P0DP23PIK3CB, GNG5, GNG10, LYN, CALM1More
Secobarbitalhsa05170Human immunodeficiency virus 1 infection3.27E-026P42338, P63218, P50151, P0DP23, P30101, P23528PIK3CB, GNG5, GNG10, CALM1, PDIA3, CFL1More
Secobarbitalhsa05171Coronavirus disease - COVID-194.47E-022Q9UHA3, O14786RSL24D1, NRP1More
Secobarbitalhsa05204Chemical carcinogenesis4.62E-022P78417, P33260GSTO1, CYP2C18More
Secobarbitalhsa05214Glioma2.32E-023P0DP23, Q16566, P42338CALM1, CAMK4, PIK3CBMore
Secobarbitalhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Secobarbitalhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Secobarbitalhsa05340Primary immunodeficiency1.58E-023P01730, P11912, Q8WV28CD4, CD79A, BLNKMore

Community members of Secobarbital (SDC: 1.88)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48169GABRA4GammaNoneaminobutyric acid receptor subunit alphaNone4Reported00.32530.5650.15791.4506
O15399GRIN2DGlutamate receptor ionotropic, NMDA 2DReported00.10350.15650.64481.0095
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Predicted00.15590.43870.16951.1248
P48058GRIA4Glutamate receptor 4Predicted00.40370.12090.37480.8184
P78334GABREGammaNoneaminobutyric acid receptor subunit epsilonPredicted00.13940.40970.15791.0469
P28472GABRB3GammaNoneaminobutyric acid receptor subunit betaNone3Predicted00.15590.43870.16951.1248
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)