PharmaCoNets of Saquinavir (SPCN: 32.02 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Saquinavirhsa00052Galactose metabolism1.03E-022P06280, O43451GLA, MGAMMore
Saquinavirhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Saquinavirhsa00072Synthesis and degradation of ketone bodies2.78E-021Q01581HMGCS1More
Saquinavirhsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Saquinavirhsa00500Starch and sucrose metabolism1.67E-022O43451, P06737MGAM, PYGLMore
Saquinavirhsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Saquinavirhsa00520Amino sugar and nucleotide sugar metabolism2.24E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Saquinavirhsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Saquinavirhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Saquinavirhsa00730Thiamine metabolism5.29E-032P05186, P24666ALPL, ACP1More
Saquinavirhsa00750Vitamin B6 metabolism3.56E-021O00764PDXKMore
Saquinavirhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Saquinavirhsa00785Lipoic acid metabolism4.57E-021Q9Y234LIPT1More
Saquinavirhsa00900Terpenoid backbone biosynthesis1.40E-021Q01581HMGCS1More
Saquinavirhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Saquinavirhsa012102-Oxocarboxylic acid metabolism3.56E-021P50213IDH3AMore
Saquinavirhsa01521EGFR tyrosine kinase inhibitor resistance2.18E-022P49841, Q9NRA1GSK3B, PDGFCMore
Saquinavirhsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Saquinavirhsa03008Ribosome biogenesis in eukaryotes2.99E-022P78345, Q9BVP2RPP38, GNL3More
Saquinavirhsa03013RNA transport5.01E-0312P52298, O14893, P61326, P38919, P37198, Q7Z3B4, P35658, Q14152, P55884, O75822, P78345, Q9Y6A5NCBP2, GEMIN2, MAGOH, EIF4A3, NUP62, NUP54, NUP214, EIF3A, EIF3B, EIF3J, RPP38, TACC3More
Saquinavirhsa04015Rap1 signaling pathway3.07E-024P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Saquinavirhsa04071Sphingolipid signaling pathway1.53E-037Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Saquinavirhsa04080Neuroactive ligand-receptor interaction4.15E-022Q01726, P41968MC1R, MC3RMore
Saquinavirhsa04114Oocyte meiosis3.27E-023Q9UJX4, P30260, Q16539ANAPC5, CDC27, MAPK14More
Saquinavirhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Saquinavirhsa04144Endocytosis4.10E-023O75351, P62491, Q14161VPS4B, RAB11A, GIT2More
Saquinavirhsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Saquinavirhsa04210Apoptosis4.07E-038P04637, O76075, P01375, Q9NR28, P24522, Q16548, P43234, P42575TP53, DFFB, TNF, DIABLO, GADD45A, BCL2A1, CTSO, CASP2More
Saquinavirhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Saquinavirhsa04330Notch signaling pathway2.77E-022Q92542, P49768NCSTN, PSEN1More
Saquinavirhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Saquinavirhsa04360Axon guidance1.66E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Saquinavirhsa04390Hippo signaling pathway2.30E-023P63261, P04628, O43623ACTG1, WNT1, SNAI2More
Saquinavirhsa04550Signaling pathways regulating pluripotency of stem cells1.96E-023P04628, P40189, P14653WNT1, IL6ST, HOXB1More
Saquinavirhsa04610Complement and coagulation cascades1.29E-052P00734, P0C0L4F2, C4AMore
Saquinavirhsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Saquinavirhsa04613Neutrophil extracellular trap formation7.32E-0313O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Saquinavirhsa04630JAK-STAT signaling pathway4.43E-023P48551, P40189, Q06124IFNAR2, IL6ST, PTPN11More
Saquinavirhsa04657IL-17 signaling pathway6.64E-037O00463, Q16539, P49841, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, MMP9, ANAPC5, LCN2, TNFMore
Saquinavirhsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Saquinavirhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Saquinavirhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Saquinavirhsa04914Progesterone-mediated oocyte maturation1.46E-023Q9UJX4, P30260, Q16539ANAPC5, CDC27, MAPK14More
Saquinavirhsa04916Melanogenesis2.18E-022P49841, Q01726GSK3B, MC1RMore
Saquinavirhsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Saquinavirhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Saquinavirhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Saquinavirhsa04932Non-alcoholic fatty liver disease2.74E-023P01375, P49841, P48023TNF, GSK3B, FASLGMore
Saquinavirhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Saquinavirhsa04962Vasopressin-regulated water reabsorption1.80E-022P62491, P46459RAB11A, NSFMore
Saquinavirhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Saquinavirhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Saquinavirhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Saquinavirhsa05133Pertussis2.64E-032P0DP23, P0C0L4CALM1, C4AMore
Saquinavirhsa05143African trypanosomiasis1.11E-044P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Saquinavirhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Saquinavirhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Saquinavirhsa05202Transcriptional misregulation in cancer1.45E-0212Q15532, P41732, P14780, P27930, P14923, Q16548, Q13077, O15550, P35226, P05164, P08246, P24522SS18, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, TRAF1, UTX, BMI1, MPO, ELA2, GADD45AMore
Saquinavirhsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Saquinavirhsa05216Thyroid cancer2.72E-022P04637, P24522TP53, GADD45AMore
Saquinavirhsa05217Basal cell carcinoma4.79E-022P04637, P24522TP53, GADD45AMore
Saquinavirhsa05218Melanoma2.72E-022P04637, P24522TP53, GADD45AMore
Saquinavirhsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Saquinavirhsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Saquinavirhsa05330Allograft rejection1.76E-034P13765, P29965, P48023, P01375HLA-DOB, CD40LG, FASLG, TNFMore
Saquinavirhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Saquinavirhsa05412Arrhythmogenic right ventricular cardiomyopathy2.77E-034P54284, P14923, P08514, Q9UJU2CACNB3, JUP, ITGA2B, LEF1More
Saquinavirhsa05416Viral myocarditis2.18E-034P13765, P29965, P10747, P63261HLA-DOB, CD40LG, CD28, ACTG1More

Community members of Saquinavir (SDC: 4.52)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q01726MC1RMelanocyteNonestimulating hormone receptorPredicted10.0470.23750.0110.5095
P41968MC3RMelanocortin receptor 3Predicted10.22350.263700.6392
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P07384CAPN1CalpainNone1 catalytic subunitPredicted00.0230.14890.60380.9131
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P04637TP53Cellular tumor antigen p53Predicted10.10040.041711.1336
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
P49768PSEN1PresenilinNone1Predicted10.26770.65990.33081.7845
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)