PharmaCoNets of Salsalate (SPCN: 44.21 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Salsalatehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Salsalatehsa00190Oxidative phosphorylation1.29E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Salsalatehsa00280Valine, leucine and isoleucine degradation1.63E-044P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Salsalatehsa00340Histidine metabolism4.52E-021O95954FTCDMore
Salsalatehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Salsalatehsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Salsalatehsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Salsalatehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Salsalatehsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Salsalatehsa00630Glyoxylate and dicarboxylate metabolism7.59E-032P40925, P15104MDH1, GLULMore
Salsalatehsa00970Aminoacyl-tRNA biosynthesis2.76E-032O95363, Q15046FARS2, KARSMore
Salsalatehsa01100Metabolic pathways2.25E-027Q9Y259, Q13956, P49619, O95954, Q02318, Q9UBX8, P35573CHKB, PDE6H, DGKG, FTCD, CYP27A1, B4GALT6, AGLMore
Salsalatehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Salsalatehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Salsalatehsa03013RNA transport4.13E-026Q09161, P35658, P47813, Q14152, O75822, P51114NCBP1, NUP214, EIF1AX, EIF3A, EIF3J, FXR1More
Salsalatehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Salsalatehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Salsalatehsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Salsalatehsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Salsalatehsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Salsalatehsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Salsalatehsa04062Chemokine signaling pathway1.30E-0313P25024, P25025, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q7LDG7, Q13009, Q8WYR1CXCR1, CXCR2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, RASGRP2, TIAM1, PIK3R5More
Salsalatehsa04064NF-kappa B signaling pathway4.09E-038P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Salsalatehsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Salsalatehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Salsalatehsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Salsalatehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Salsalatehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Salsalatehsa04145Phagosome4.79E-0310P60709, Q15075, Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765ACTB, EEA1, NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Salsalatehsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Salsalatehsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Salsalatehsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Salsalatehsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Salsalatehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Salsalatehsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Salsalatehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Salsalatehsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Salsalatehsa04613Neutrophil extracellular trap formation6.74E-0313O60603, P05164, P08246, Q9UM07, P04908, Q93077, P68431, Q15080, P20160, P08311, P21730, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, C5AR1, AQP9, MAPK14More
Salsalatehsa04650Natural killer cell mediated cytotoxicity2.96E-026O60880, P20963, Q13241, P26718, P26717, P26715SH2D1A, CD247, KLRD1, KLRK1, KLRC2, KLRC1More
Salsalatehsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Salsalatehsa04658Th1 and Th2 cell differentiation4.12E-0511Q04759, P07766, P20963, P09693, P01730, P06239, Q14765, P23771, Q9UL17, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, CD4, LCK, STAT4, GATA3, TBX21, HLA-DOB, RUNX3More
Salsalatehsa04659Th17 cell differentiation2.59E-0515Q04759, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963PRKCQ, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Salsalatehsa04660T cell receptor signaling pathway1.00E-027Q9UDY8, Q04759, P10747, Q08881, P20963, P09693, P01732MALT1, PRKCQ, CD28, ITK, CD247, CD3G, CD8AMore
Salsalatehsa04662B cell receptor signaling pathway1.00E-035P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Salsalatehsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Salsalatehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Salsalatehsa04727GABAergic synapse2.62E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Salsalatehsa04730Long-term depression4.05E-022Q14344, P07948GNA13, LYNMore
Salsalatehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Salsalatehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Salsalatehsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Salsalatehsa04932Non-alcoholic fatty liver disease9.01E-047P49841, P18848, P01584, P13073, O15239, Q16718, O14521GSK3B, ATF4, IL1B, COX4I1, NDUFA1, NDUFA5, SDHDMore
Salsalatehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Salsalatehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Salsalatehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Salsalatehsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Salsalatehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Salsalatehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Salsalatehsa05020Prion disease3.73E-0411P13591, P01584, P11142, O15239, Q16718, O14521, P13073, P18848, P05141, P49841, Q16539NCAM1, IL1B, HSPA8, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, SLC25A5, GSK3B, MAPK14More
Salsalatehsa05022Pathways of neurodegeneration - multiple diseases1.47E-0312P49841, O15239, Q16718, O14521, P13073, P18848, Q13561, P05141, Q16539, P01584, Q08752, Q13557GSK3B, NDUFA1, NDUFA5, SDHD, COX4I1, ATF4, DCTN2, SLC25A5, MAPK14, IL1B, PPID, CAMK2DMore
Salsalatehsa05110Vibrio cholerae infection4.50E-034Q13488, P17252, P19174, P60709TCIRG1, PRKCA, PLCG1, ACTBMore
Salsalatehsa05120Epithelial cell signaling in Helicobacter pylori infection4.95E-023P25024, P25025, P07948CXCR1, CXCR2, LYNMore
Salsalatehsa05133Pertussis4.20E-021P0C0L4C4AMore
Salsalatehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Salsalatehsa05140Leishmaniasis4.75E-025P14598, P42224, P25963, P29350, Q15080NCF1, STAT1, NFKBIA, PTPN6, NCF4More
Salsalatehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Salsalatehsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Salsalatehsa05150Staphylococcus aureus infection2.44E-024P21462, Q14532, P59665, P59666FPR1, KRT32, DEFA1; DEFA1B, DEFA3More
Salsalatehsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Salsalatehsa05163Human cytomegalovirus infection2.46E-026P63218, P50151, Q14344, P14778, P25025, P30101GNG5, GNG10, GNA13, IL1R1, CXCR2, PDIA3More
Salsalatehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Salsalatehsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Salsalatehsa05202Transcriptional misregulation in cancer2.90E-029Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45AMore
Salsalatehsa05212Pancreatic cancer3.94E-024P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Salsalatehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Salsalatehsa05223Non-small cell lung cancer3.99E-024P17252, O43524, P19174, O75293PRKCA, FOXO3, PLCG1, GADD45BMore
Salsalatehsa05231Choline metabolism in cancer4.00E-036Q9Y259, P19174, P23743, P49619, O14494, P17252CHKB, PLCG1, DGKA, DGKG, PLPP1, PRKCAMore
Salsalatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.84E-025P20963, P09693, O60603, P10747, Q04759CD247, CD3G, TLR2, CD28, PRKCQMore
Salsalatehsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Salsalatehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Salsalatehsa05332Graft-versus-host disease3.45E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Salsalatehsa05340Primary immunodeficiency4.95E-023P01730, P07766, P06239CD4, CD3E, LCKMore
Salsalatehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Salsalatehsa05415Diabetic cardiomyopathy3.22E-0412P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q16539, P49841, Q13557, P04406PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, GSK3B, CAMK2D, GAPDHMore

Community members of Salsalate (SDC: 3.96)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P26358DNMT1DNAPredicted00.34040.28090.26590.998
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P29350PTPN6TyrosineNoneprotein phosphatase nonNonereceptor type 6Predicted10.28070.24590.56831.2004
Q15046KARSLysineNoneNonetRNA ligasePredicted00.10330.0580.00270.1702
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)