PharmaCoNets

PharmaCoNets of Sacubitril (S_PCN: 145.57 )

Sacubitril regulated-network (S_DN: 23.18)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Sacubitril

hsa00030

Pentose phosphate pathway

1.69E-02

P60891, P37837

PRPS1, TALDO1

Sacubitril

hsa00040

Pentose and glucuronate interconversions

9.59E-03

P15121, P14550

AKR1B1, AKR1A1

Sacubitril

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Sacubitril

hsa00061

Fatty acid biosynthesis

4.83E-02

P33121

ACSL1

Sacubitril

hsa00100

Steroid biosynthesis

4.70E-02

P35610

SOAT1

Sacubitril

hsa00190

Oxidative phosphorylation

3.97E-04

Q16718, Q13488, P36542, O14521

NDUFA5, TCIRG1, ATP5C1, SDHD

Sacubitril

hsa00220

Arginine biosynthesis

1.54E-02

P05089, P49448

ARG1, GLUD2

Sacubitril

hsa00230

Purine metabolism

1.81E-02

P20839, Q02153

IMPDH1, GUCY1B3

Sacubitril

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Sacubitril

hsa00500

Starch and sucrose metabolism

2.74E-03

O43451, P46976, P35557, P06737

MGAM, GYG1, GCK, PYGL

Sacubitril

hsa00512

Mucin type O-glycan biosynthesis

1.22E-02

O95395, Q8N4A0

GCNT3, GALNT4

Sacubitril

hsa00513

Various types of N-glycan biosynthesis

4.83E-02

Q9NR34

MAN1C1

Sacubitril

hsa00520

Amino sugar and nucleotide sugar metabolism

2.24E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Sacubitril

hsa00524

Neomycin, kanamycin and gentamicin biosynthesis

4.70E-02

P35557

GCK

Sacubitril

hsa00561

Glycerolipid metabolism

7.94E-03

P15121, P14550, Q86XP1

AKR1B1, AKR1A1, DGKH

Sacubitril

hsa00564

Glycerophospholipid metabolism

1.97E-02

P48651, Q9Y6K0, P35790

PTDSS1, CEPT1, CHKA

Sacubitril

hsa00565

Ether lipid metabolism

3.00E-03

Q8N661

TMEM86B

Sacubitril

hsa00591

Linoleic acid metabolism

4.83E-02

P11712

CYP2C9

Sacubitril

hsa00600

Sphingolipid metabolism

2.68E-02

P07602, Q13510

PSAP, ASAH1

Sacubitril

hsa00630

Glyoxylate and dicarboxylate metabolism

1.32E-02

P40925, P15104

MDH1, GLUL

Sacubitril

hsa00730

Thiamine metabolism

3.79E-02

P05186, P24666

ALPL, ACP1

Sacubitril

hsa00750

Vitamin B6 metabolism

3.56E-02

O00764

PDXK

Sacubitril

hsa00770

Pantothenate and CoA biosynthesis

1.15E-02

O95498, Q9NRN7

VNN2, AASDHPPT

Sacubitril

hsa00830

Retinol metabolism

4.70E-03

P00325, O75911, P11712

ADH1B, DHRS3, CYP2C9

Sacubitril

hsa00860

Porphyrin and chlorophyll metabolism

1.69E-02

P36551, P30043

CPOX, BLVRB

Sacubitril

hsa00910

Nitrogen metabolism

2.93E-02

P22748, P49448

CA4, GLUD2

Sacubitril

hsa00983

Drug metabolism - other enzymes

1.91E-04

P04183, P32320, P05164

TK1, CDA, MPO

Sacubitril

hsa01210

2-Oxocarboxylic acid metabolism

3.56E-02

P50213

IDH3A

Sacubitril

hsa01230

Biosynthesis of amino acids

3.59E-02

P60891, Q99707, P37837

PRPS1, MTR, TALDO1

Sacubitril

hsa01522

Endocrine resistance

4.55E-02

P14780, P22694, Q9UM47, P10415, Q13323

MMP9, PRKACB, NOTCH3, BCL2, BIK

Sacubitril

hsa01524

Platinum drug resistance

4.42E-02

P10415, Q13489, P23025

BCL2, BIRC3, XPA

Sacubitril

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Sacubitril

hsa03008

Ribosome biogenesis in eukaryotes

6.80E-05

Q9NYH9, O14980, O60832, P78345, Q9BVP2, Q9GZY0

UTP6, XPO1, DKC1, RPP38, GNL3, NXF2; NXF2B

Sacubitril

hsa03010

Ribosome

2.08E-04

P30050, P40429, P62906, P62917, P46777, Q9H0U6, P36578, P50914, P05386, P62249, P23396

RPL12, RPL13A, RPL10A, RPL8, RPL5, MRPL18, RPL4, RPL14, RPLP1, RPS16, RPS3

Sacubitril

hsa03013

RNA transport

5.12E-10

O14980, P52298, Q09161, O14893, P61326, P38919, Q9GZY0, P37198, Q7Z3B4, P35658, P47813, Q14152, P55884, O75822, P78345, Q14240, Q9BZI7, P23588, Q9Y6A5, Q06787, P51114, Q53GS7

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, EIF4A3, NXF2; NXF2B, NUP62, NUP54, NUP214, EIF1AX, EIF3A, EIF3B, EIF3J, RPP38, EIF4A2, UPF3B, EIF4B, TACC3, FMR1, FXR1, GLE1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14980	XPO1	Exportin-1	0.799
Q92769	HDAC2	Histone deacetylase 2	O14980	XPO1	Exportin-1	0.75
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.915
Q92769	HDAC2	Histone deacetylase 2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.766
P08246	ELA2	Neutrophil elastase	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.852
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
P08246	ELA2	Neutrophil elastase	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	-0.732
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14893	GEMIN2	Gem-associated protein 2	0.72
Q92769	HDAC2	Histone deacetylase 2	O14893	GEMIN2	Gem-associated protein 2	0.734
P08246	ELA2	Neutrophil elastase	O14893	GEMIN2	Gem-associated protein 2	-0.785
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P61326	MAGOH	Protein mago nashi homolog	0.764
Q92769	HDAC2	Histone deacetylase 2	P61326	MAGOH	Protein mago nashi homolog	0.812
P49768	PSEN1	Presenilin-1	P38919	EIF4A3	Eukaryotic initiation factor 4A-III	0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9GZY0	NXF2; NXF2B	Nuclear RNA export factor 2	0.746
P49768	PSEN1	Presenilin-1	P37198	NUP62	Nuclear pore glycoprotein p62	-0.716
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q92769	HDAC2	Histone deacetylase 2	Q7Z3B4	NUP54	Nucleoporin p54	0.775
P08246	ELA2	Neutrophil elastase	Q7Z3B4	NUP54	Nucleoporin p54	-0.723
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
P49768	PSEN1	Presenilin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.768
Q92769	HDAC2	Histone deacetylase 2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.729
P08246	ELA2	Neutrophil elastase	P35658	NUP214	Nuclear pore complex protein Nup214	0.765
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P47813	EIF1AX	Eukaryotic translation initiation factor 1A, X-chromosomal	0.844
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.869
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.707
Q92769	HDAC2	Histone deacetylase 2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.719
P08246	ELA2	Neutrophil elastase	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.722
P49768	PSEN1	Presenilin-1	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.71
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.77
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.788
P08246	ELA2	Neutrophil elastase	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.825
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P78345	RPP38	Ribonuclease P protein subunit p38	0.869
P08246	ELA2	Neutrophil elastase	P78345	RPP38	Ribonuclease P protein subunit p38	-0.795
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.849
Q92769	HDAC2	Histone deacetylase 2	Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.79
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q9BZI7	UPF3B	Regulator of nonsense transcripts 3B	0.764
Q92769	HDAC2	Histone deacetylase 2	P23588	EIF4B	Eukaryotic translation initiation factor 4B	0.767
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.815
Q92769	HDAC2	Histone deacetylase 2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.758
P08246	ELA2	Neutrophil elastase	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.849
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q06787	FMR1	Synaptic functional regulator FMR1	0.863
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P51114	FXR1	Fragile X mental retardation syndrome-related protein 1	0.798
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q53GS7	GLE1	mRNA export factor GLE1	-0.723

Sacubitril

hsa03015

mRNA surveillance pathway

9.78E-03

O43148, Q16537, P61326, Q9GZY0, P52298, Q53GS7

RNMT, PPP2R5E, MAGOH, NXF2; NXF2B, NCBP2, GLE1

Sacubitril

hsa03022

Basal transcription factors

3.50E-02

P20226, O00268, Q15544

TBP, TAF4, TAF11

Sacubitril

hsa03030

DNA replication

1.48E-02

P49005, P33993, P15927

POLD2, MCM7, RPA2

Sacubitril

hsa03040

Spliceosome

4.19E-04

Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142, O43447, O75643

DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIH, ASCC3L1

Sacubitril

hsa03060

Protein export

1.90E-02

Q15070, O76094

OXA1L, SRP72

Sacubitril

hsa04012

ErbB signaling pathway

1.34E-02

P16333, P19174, P42338, P01106

NCK1, PLCG1, PIK3CB, MYC

Sacubitril

hsa04014

Ras signaling pathway

2.92E-04

P42338, P20827, Q9NRA1, P49767, Q13009, P0DP23, P62873, P63218, P50151, P19174

PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1

Sacubitril

hsa04015

Rap1 signaling pathway

4.69E-04

P20827, Q9NRA1, P49767, P11215, P25116, Q8TEU7, Q13009, P42338, P0DP23, P08514, P19174

EFNA1, PDGFC, VEGFC, ITGAM, F2R, RAPGEF6, TIAM1, PIK3CB, CALM1, ITGA2B, PLCG1

Sacubitril

hsa04020

Calcium signaling pathway

8.05E-05

P27987, Q96DU7, P21796, Q13557, P21860, P19174, P0DP23, P05141, P12236, P26678, P63092, Q9NRA1, P49767

ITPKB, ITPKC, VDAC1, CAMK2D, ERBB3, PLCG1, CALM1, SLC25A5, SLC25A6, PLN, GNAS, PDGFC, VEGFC

Sacubitril

hsa04022

cGMP-PKG signaling pathway

2.71E-04

P24844, P61586, P26678, Q99941, P18848, Q8WYR1, P05141, P12236, Q15746

MYL9, RHOA, PLN, CREBL1, ATF4, PIK3R5, SLC25A5, SLC25A6, MYLK

Sacubitril

hsa04024

cAMP signaling pathway

1.40E-02

P48058, P25116, P24844

GRIA4, F2R, MYL9

Sacubitril

hsa04060

Cytokine-cytokine receptor interaction

5.39E-03

P27930, P08476, Q13651, Q9HBE5, Q9UBD3, P47992, P01375, P09341, P18510, Q93038

IL1R2, INHBA, IL10RA, IL21R, XCL2, XCL1, TNF, CXCL1, IL1RN, TNFRSF25

Sacubitril

hsa04061

Viral protein interaction with cytokine and cytokine receptor

4.81E-03

P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375

CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNF

Sacubitril

hsa04062

Chemokine signaling pathway

2.81E-05

P25024, P25025, P09341, P19875, P07948, P42338, P19174, P62873, P63218, P50151, P43250, Q13009, P14598, P42224, P25963

CXCR1, CXCR2, CXCL1, CXCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIA

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.803
Q13547	HDAC1	Histone deacetylase 1	P25025	CXCR2	C-X-C chemokine receptor type 2	-0.719
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
Q13547	HDAC1	Histone deacetylase 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.864
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
Q13547	HDAC1	Histone deacetylase 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.716
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P43250	GRK6	G protein-coupled receptor kinase 6	-0.775
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	-0.748
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711

Sacubitril

hsa04064

NF-kappa B signaling pathway

2.46E-13

P10415, Q13489, P25963, P51617, O00463, P14778, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P24522, P09341, P19875, Q06643

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, GADD45A, CXCL1, CXCL2, LTB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P24158	PRTN3	Myeloblastin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.787
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.832
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P24158	PRTN3	Myeloblastin	O00463	TRAF5	TNF receptor-associated factor 5	-0.8
P22894	MMP8	Neutrophil collagenase	O00463	TRAF5	TNF receptor-associated factor 5	-0.867
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P08311	CTSG	Cathepsin G	O00463	TRAF5	TNF receptor-associated factor 5	-0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00463	TRAF5	TNF receptor-associated factor 5	0.717
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P24158	PRTN3	Myeloblastin	Q04759	PRKCQ	Protein kinase C theta type	-0.845
P22894	MMP8	Neutrophil collagenase	Q04759	PRKCQ	Protein kinase C theta type	-0.756
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P24158	PRTN3	Myeloblastin	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.733
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q16548	BCL2A1	Bcl-2-related protein A1	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q8WV28	BLNK	B-cell linker protein	-0.746
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P24158	PRTN3	Myeloblastin	P09341	CXCL1	Growth-regulated alpha protein	0.751
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09341	CXCL1	Growth-regulated alpha protein	-0.789
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	Q06643	LTB	Lymphotoxin-beta	0.74

Sacubitril

hsa04070

Phosphatidylinositol signaling system

1.12E-02

P19174, P0DP23, P42338, P23743, P27987

PLCG1, CALM1, PIK3CB, DGKA, ITPKB

Sacubitril

hsa04071

Sphingolipid signaling pathway

3.24E-15

P17252, P21453, Q9H228, P01375, Q13510, Q13362, Q16537, Q9BX95, Q16539, P04637, P10415, Q9UQC2, P01042

PRKCA, S1PR1, EDG8, TNF, ASAH1, PPP2R5C, PPP2R5E, SGPP1, MAPK14, TP53, BCL2, GAB2, KNG1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P24158	PRTN3	Myeloblastin	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.82
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
Q15722	LTB4R	Leukotriene B4 receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.832
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P24158	PRTN3	Myeloblastin	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.904
P14780	MMP9	Matrix metalloproteinase-9	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.901
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.733
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
P15144	ANPEP	Aminopeptidase N	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P15144	ANPEP	Aminopeptidase N	P01375	TNF	Tumor necrosis factor	0.878
P42892	ECE1	Endothelin-converting enzyme 1	Q13510	ASAH1	Acid ceramidase	0.748
P06737	PYGL	Glycogen phosphorylase, liver form	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.716
P24158	PRTN3	Myeloblastin	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.756
P14780	MMP9	Matrix metalloproteinase-9	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.828
P22894	MMP8	Neutrophil collagenase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.834
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.773
P08246	ELA2	Neutrophil elastase	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.865
P15144	ANPEP	Aminopeptidase N	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P42892	ECE1	Endothelin-converting enzyme 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.733
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q16537	PPP2R5E	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform	0.718
P06737	PYGL	Glycogen phosphorylase, liver form	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.781
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.884
P14780	MMP9	Matrix metalloproteinase-9	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.869
P22894	MMP8	Neutrophil collagenase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.879
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.884
P08246	ELA2	Neutrophil elastase	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.847
P15144	ANPEP	Aminopeptidase N	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.708
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P24158	PRTN3	Myeloblastin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.787
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q15722	LTB4R	Leukotriene B4 receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.865
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.706
P15144	ANPEP	Aminopeptidase N	P10415	BCL2	Apoptosis regulator Bcl-2	-0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.822
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.708
P15144	ANPEP	Aminopeptidase N	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.783
P42892	ECE1	Endothelin-converting enzyme 1	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.894
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P01042	KNG1	Kininogen-1	-0.773

Sacubitril

hsa04072

Phospholipase D signaling pathway

1.10E-03

P42338, Q9UQC2, P43657, P25024, P25025, P19174, Q14344, Q8WYR1, Q08828, P23743, Q9NRA1

PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, GNA13, PIK3R5, ADCY1, DGKA, PDGFC

Sacubitril

hsa04080

Neuroactive ligand-receptor interaction

1.40E-09

P08311, P00734, Q15722, P21453, Q9H228, O00398, Q96G91, P25116, P21462, P21730, Q16581, P07550, P01042, P35318

CTSG, F2, LTB4R, S1PR1, EDG8, P2RY10, P2RY11, F2R, FPR1, C5AR1, C3AR1, ADRB2, KNG1, ADM

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P24158	PRTN3	Myeloblastin	P08311	CTSG	Cathepsin G	0.914
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P43005	SLC1A1	Excitatory amino acid transporter 3	P00734	F2	Prothrombin	0.702
P06737	PYGL	Glycogen phosphorylase, liver form	Q15722	LTB4R	Leukotriene B4 receptor 1	0.863
P24158	PRTN3	Myeloblastin	Q15722	LTB4R	Leukotriene B4 receptor 1	0.829
P22894	MMP8	Neutrophil collagenase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.882
P08246	ELA2	Neutrophil elastase	Q15722	LTB4R	Leukotriene B4 receptor 1	0.846
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15722	LTB4R	Leukotriene B4 receptor 1	-0.891
P24158	PRTN3	Myeloblastin	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.82
P22894	MMP8	Neutrophil collagenase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.721
P08246	ELA2	Neutrophil elastase	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.725
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
P24158	PRTN3	Myeloblastin	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.904
P22894	MMP8	Neutrophil collagenase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.787
P08246	ELA2	Neutrophil elastase	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.797
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P24158	PRTN3	Myeloblastin	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.707
P22894	MMP8	Neutrophil collagenase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.831
P08246	ELA2	Neutrophil elastase	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.793
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	O00398	P2RY10	Putative P2Y purinoceptor 10	-0.786
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O00398	P2RY10	Putative P2Y purinoceptor 10	0.704
P43005	SLC1A1	Excitatory amino acid transporter 3	Q96G91	P2RY11	P2Y purinoceptor 11	0.765
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P25116	F2R	Proteinase-activated receptor 1	-0.791
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P24158	PRTN3	Myeloblastin	P21462	FPR1	fMet-Leu-Phe receptor	0.73
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P24158	PRTN3	Myeloblastin	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.738
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.808
P24158	PRTN3	Myeloblastin	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.753
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P07550	ADRB2	Beta-2 adrenergic receptor	0.735
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P01042	KNG1	Kininogen-1	-0.773
P06737	PYGL	Glycogen phosphorylase, liver form	P35318	ADM	Pro-adrenomedullin [Cleaved into: Adrenomedullin	0.727

Sacubitril

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Sacubitril

hsa04120

Ubiquitin mediated proteolysis

2.51E-03

Q14145, Q13042, P62837, Q15751, O95071, P0CG47

KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBB

Sacubitril

hsa04136

Autophagy - other

5.92E-03

O94817, Q9H1Y0

ATG12, ATG5

Sacubitril

hsa04137

Mitophagy - animal

9.52E-03

Q07817, P0CG47

BCL2L1, UBB

Sacubitril

hsa04140

Autophagy - animal

3.94E-03

P22694, Q14643, P10415, Q9H1Y0, Q04759

PRKACB, ITPR1, BCL2, ATG5, PRKCQ

Sacubitril

hsa04144

Endocytosis

4.10E-02

O75351, P62491, Q14161

VPS4B, RAB11A, GIT2

Sacubitril

hsa04145

Phagosome

2.08E-09

O75015, P63261, Q15080, P14598, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P13765

FCGR3B, ACTG1, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, HLA-DOB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P24158	PRTN3	Myeloblastin	Q15080	NCF4	Neutrophil cytosol factor 4	0.815
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.918
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
P22894	MMP8	Neutrophil collagenase	Q13509	TUBB3	Tubulin beta-3 chain	0.707
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.717
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P24158	PRTN3	Myeloblastin	P78380	OLR1	Oxidized low-density lipoprotein receptor 1	0.736
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P24158	PRTN3	Myeloblastin	P35443	THBS4	Thrombospondin-4	0.935
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P35443	THBS4	Thrombospondin-4	-0.744
P22894	MMP8	Neutrophil collagenase	P35443	THBS4	Thrombospondin-4	0.876
Q15722	LTB4R	Leukotriene B4 receptor 1	P35443	THBS4	Thrombospondin-4	0.855
P08246	ELA2	Neutrophil elastase	P35443	THBS4	Thrombospondin-4	0.871
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P35443	THBS4	Thrombospondin-4	-0.906
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q15722	LTB4R	Leukotriene B4 receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.792
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795

Sacubitril

hsa04146

Peroxisome

4.83E-02

O96011, P56589, Q9UKG9, O75521

PEX11B, PEX3, CROT, ECI2

Sacubitril

hsa04151

PI3K-Akt signaling pathway

3.37E-05

P42338, P21860, P01106, O43521, P27348, P20827, O14944, Q9NRA1, P49767, Q13362, P07900, P08238, Q15831, Q8WYR1, P62873, P63218, P50151, O15335, P22105, P14784, P23458, P01568, Q99941, P18848, Q6ZUJ8, O95988

PIK3CB, ERBB3, MYC, BCL2L11, YWHAQ, EFNA1, EREG, PDGFC, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, STK11, PIK3R5, GNB1, GNG5, GNG10, CHAD, TNXB, IL2RB, JAK1, IFNA21, CREBL1, ATF4, PIK3AP1, TCL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40926	MDH2	Malate dehydrogenase, mitochondrial	P21860	ERBB3	Receptor tyrosine-protein kinase erbB-3	-0.731
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P42892	ECE1	Endothelin-converting enzyme 1	O43521	BCL2L11	Bcl-2-like protein 11	0.736
P40926	MDH2	Malate dehydrogenase, mitochondrial	P27348	YWHAQ	14-3-3 protein theta	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P20827	EFNA1	Ephrin-A1	-0.743
P40926	MDH2	Malate dehydrogenase, mitochondrial	O14944	EREG	Proepiregulin [Cleaved into: Epiregulin	-0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q9NRA1	PDGFC	Platelet-derived growth factor C	-0.702
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49767	VEGFC	Vascular endothelial growth factor C	-0.778
P42892	ECE1	Endothelin-converting enzyme 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.733
P40926	MDH2	Malate dehydrogenase, mitochondrial	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.718
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q15831	STK11	Serine/threonine-protein kinase STK11	0.731
P42892	ECE1	Endothelin-converting enzyme 1	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.725
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O15335	CHAD	Chondroadherin	-0.704
P40926	MDH2	Malate dehydrogenase, mitochondrial	P22105	TNXB	Tenascin-X	0.802
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
P42892	ECE1	Endothelin-converting enzyme 1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.797
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P40926	MDH2	Malate dehydrogenase, mitochondrial	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.802
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P42892	ECE1	Endothelin-converting enzyme 1	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.747
P40926	MDH2	Malate dehydrogenase, mitochondrial	O95988	TCL1B	T-cell leukemia/lymphoma protein 1B	0.719

Sacubitril

hsa04210

Apoptosis

1.26E-04

Q13315, P10415, Q13489, O76075, P25963, P01375, P24522, Q16548, Q13077, P43234, P18848, Q14643

ATM, BCL2, BIRC3, DFFB, NFKBIA, TNF, GADD45A, BCL2A1, TRAF1, CTSO, ATF4, ITPR1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
P24158	PRTN3	Myeloblastin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.787
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P24158	PRTN3	Myeloblastin	O76075	DFFB	DNA fragmentation factor subunit beta	-0.747
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O76075	DFFB	DNA fragmentation factor subunit beta	0.748
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P24158	PRTN3	Myeloblastin	P43234	CTSO	Cathepsin O	-0.722
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P43234	CTSO	Cathepsin O	0.701
P24158	PRTN3	Myeloblastin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.743
P24158	PRTN3	Myeloblastin	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.766
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	0.873

Sacubitril

hsa04213

Longevity regulating pathway - multiple species

1.36E-03

P42338, Q9Y4H2, Q08828, P0DMV8, P11142, Q13547

PIK3CB, IRS2, ADCY1, HSPA1A, HSPA8, HDAC1

Sacubitril

hsa04215

Apoptosis - multiple species

3.01E-02

Q13489, P10415

BIRC3, BCL2

Sacubitril

hsa04217

Necroptosis

2.24E-04

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, Q6FI13, Q99878, Q93077, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP2A, PPID

Sacubitril

hsa04261

Adrenergic signaling in cardiomyocytes

3.12E-02

P63092, Q99941, P18848, P26678, Q13557

GNAS, CREBL1, ATF4, PLN, CAMK2D

Sacubitril

hsa04270

Vascular smooth muscle contraction

2.56E-03

Q15746, P24844, Q08828, P35579, P35318

MYLK, MYL9, ADCY1, MYH9, ADM

Sacubitril

hsa04330

Notch signaling pathway

2.77E-02

Q92542, P49768

NCSTN, PSEN1

Sacubitril

hsa04340

Hedgehog signaling pathway

5.20E-07

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Sacubitril

hsa04360

Axon guidance

1.90E-03

P16333, P20827, O95631, P42338, P23528, P19174, Q06124

NCK1, EFNA1, NTN1, PIK3CB, CFL1, PLCG1, PTPN11

Sacubitril

hsa04371

Apelin signaling pathway

2.41E-03

P62873, P63218, P50151, Q13370, Q14814, Q14344, P0DP23

GNB1, GNG5, GNG10, PDE3B, MEF2D, GNA13, CALM1

Sacubitril

hsa04380

Osteoclast differentiation

1.81E-02

Q9UQC2, Q16539, Q8WV28, Q15080

GAB2, MAPK14, BLNK, NCF4

Sacubitril

hsa04390

Hippo signaling pathway

2.30E-02

P63261, P04628, O43623

ACTG1, WNT1, SNAI2

Sacubitril

hsa04510

Focal adhesion

4.41E-03

P16144, P08514, Q15746, P24844, Q15942, Q13489, P10415

ITGB4, ITGA2B, MYLK, MYL9, ZYX, BIRC3, BCL2

Sacubitril

hsa04512

ECM-receptor interaction

2.44E-02

P07359, P08514

GP1BA, ITGA2B

Sacubitril

hsa04514

Cell adhesion molecules

4.65E-02

P16109, O00501

SELP, CLDN5

Sacubitril

hsa04530

Tight junction

7.42E-04

Q8TEU7, O00501, Q14247, P24844

RAPGEF6, CLDN5, CTTN, MYL9

Sacubitril

hsa04540

Gap junction

3.53E-02

P17252, Q13509, P68371, Q14643

PRKCA, TUBB3, TUBB2C, ITPR1

Sacubitril

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.96E-02

P04628, P40189, P14653

WNT1, IL6ST, HOXB1

Sacubitril

hsa04610

Complement and coagulation cascades

3.36E-10

P25116, P01042, P00734, P0C0L4, P10909, P05107, Q16581

F2R, KNG1, F2, C4A, CLU, ITGB2, C3AR1

Sacubitril

hsa04611

Platelet activation

1.55E-06

P25116, Q9Y490, P08514, Q15746, Q08828, Q8WYR1, P07359

F2R, TLN1, ITGA2B, MYLK, ADCY1, PIK3R5, GP1BA

Sacubitril

hsa04612

Antigen processing and presentation

3.57E-06

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P24158	PRTN3	Myeloblastin	P48382	RFX5	DNA-binding protein RFX5	-0.87
P14780	MMP9	Matrix metalloproteinase-9	P48382	RFX5	DNA-binding protein RFX5	-0.874
P08311	CTSG	Cathepsin G	P48382	RFX5	DNA-binding protein RFX5	-0.794
P24158	PRTN3	Myeloblastin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P24158	PRTN3	Myeloblastin	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.77
P14780	MMP9	Matrix metalloproteinase-9	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P24158	PRTN3	Myeloblastin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.732
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P14780	MMP9	Matrix metalloproteinase-9	O43908	KLRC4	NKG2-F type II integral membrane protein	-0.792
P24158	PRTN3	Myeloblastin	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.767
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733

Sacubitril

hsa04613

Neutrophil extracellular trap formation

1.14E-12

P42338, P19174, P17252, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q6FI13, P62807, Q93079, P21796, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, P63261, O43315, Q16539

PIK3CB, PLCG1, PRKCA, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, H2AC18; H2AC19, HIST1H2BC, H2BC9, VDAC1, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, ACTG1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P17252	PRKCA	Protein kinase C alpha type	0.807
P22894	MMP8	Neutrophil collagenase	P17252	PRKCA	Protein kinase C alpha type	-0.759
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P11215	ITGAM	Integrin alpha-M	-0.877
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P24158	PRTN3	Myeloblastin	P08246	ELA2	Neutrophil elastase	0.894
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P24158	PRTN3	Myeloblastin	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.873
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.771
P14780	MMP9	Matrix metalloproteinase-9	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.9
P22894	MMP8	Neutrophil collagenase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.877
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.799
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P24158	PRTN3	Myeloblastin	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.713
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	-0.859
P14780	MMP9	Matrix metalloproteinase-9	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.74
P22894	MMP8	Neutrophil collagenase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.909
Q15722	LTB4R	Leukotriene B4 receptor 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.833
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.703
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q93079	H2BC9	Histone H2B type 1-H	0.756
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P21796	VDAC1	Voltage-dependent anion-selective channel protein 1	0.72
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14598	NCF1	Neutrophil cytosol factor 1	0.755
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
P24158	PRTN3	Myeloblastin	Q15080	NCF4	Neutrophil cytosol factor 4	0.815
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.918
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P24158	PRTN3	Myeloblastin	P20160	AZU1	Azurocidin	0.942
P14780	MMP9	Matrix metalloproteinase-9	P20160	AZU1	Azurocidin	0.734
P22894	MMP8	Neutrophil collagenase	P20160	AZU1	Azurocidin	0.824
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P24158	PRTN3	Myeloblastin	P08311	CTSG	Cathepsin G	0.914
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P22894	MMP8	Neutrophil collagenase	P08311	CTSG	Cathepsin G	0.8
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P24158	PRTN3	Myeloblastin	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.738
P14780	MMP9	Matrix metalloproteinase-9	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.942
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q15722	LTB4R	Leukotriene B4 receptor 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.875
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P24158	PRTN3	Myeloblastin	P21462	FPR1	fMet-Leu-Phe receptor	0.73
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P21462	FPR1	fMet-Leu-Phe receptor	-0.723
P14780	MMP9	Matrix metalloproteinase-9	P21462	FPR1	fMet-Leu-Phe receptor	0.912
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
Q15722	LTB4R	Leukotriene B4 receptor 1	P21462	FPR1	fMet-Leu-Phe receptor	0.888
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
P14780	MMP9	Matrix metalloproteinase-9	O43315	AQP9	Aquaporin-9	0.837
Q15722	LTB4R	Leukotriene B4 receptor 1	O43315	AQP9	Aquaporin-9	0.79
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721

Sacubitril

hsa04620

Toll-like receptor signaling pathway

4.00E-02

P01568, P42224, P25963, P42338

IFNA21, STAT1, NFKBIA, PIK3CB

Sacubitril

hsa04621

NOD-like receptor signaling pathway

2.29E-06

Q16539, Q14643, P23458, P25963, Q9H3M7, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P12838

MAPK14, ITPR1, JAK1, NFKBIA, TXNIP, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P06737	PYGL	Glycogen phosphorylase, liver form	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.804
P14780	MMP9	Matrix metalloproteinase-9	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.81
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P42892	ECE1	Endothelin-converting enzyme 1	P23458	JAK1	Tyrosine-protein kinase JAK1	0.797
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P42892	ECE1	Endothelin-converting enzyme 1	Q9H3M7	TXNIP	Thioredoxin-interacting protein	0.747
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P06737	PYGL	Glycogen phosphorylase, liver form	P10599	TXN	Thioredoxin	0.764
P14780	MMP9	Matrix metalloproteinase-9	P10599	TXN	Thioredoxin	0.713
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H1Y0	ATG5	Autophagy protein 5	-0.73
P14780	MMP9	Matrix metalloproteinase-9	Q9H1Y0	ATG5	Autophagy protein 5	-0.895
P08246	ELA2	Neutrophil elastase	Q9H1Y0	ATG5	Autophagy protein 5	-0.759
P06737	PYGL	Glycogen phosphorylase, liver form	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.912
P14780	MMP9	Matrix metalloproteinase-9	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.94
P08246	ELA2	Neutrophil elastase	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.702
P42892	ECE1	Endothelin-converting enzyme 1	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.815
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P14780	MMP9	Matrix metalloproteinase-9	O00463	TRAF5	TNF receptor-associated factor 5	-0.917
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P14780	MMP9	Matrix metalloproteinase-9	P10415	BCL2	Apoptosis regulator Bcl-2	-0.765
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P14780	MMP9	Matrix metalloproteinase-9	Q05823	RNASEL	2-5A-dependent ribonuclease	0.73
P08246	ELA2	Neutrophil elastase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.734
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P06737	PYGL	Glycogen phosphorylase, liver form	P09341	CXCL1	Growth-regulated alpha protein	0.74
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709

Sacubitril

hsa04622

RIG-I-like receptor signaling pathway

1.36E-02

Q12933, P10145

TRAF2, IL8

Sacubitril

hsa04623

Cytosolic DNA-sensing pathway

1.85E-03

P01568, P25963

IFNA21, NFKBIA

Sacubitril

hsa04625

C-type lectin receptor signaling pathway

2.17E-02

Q9ULY5, P42224, P25963, P42338, P0DP23

CLEC4E, STAT1, NFKBIA, PIK3CB, CALM1

Sacubitril

hsa04630

JAK-STAT signaling pathway

4.43E-02

P48551, P40189, Q06124

IFNAR2, IL6ST, PTPN11

Sacubitril

hsa04640

Hematopoietic cell lineage

2.01E-03

P14778, P27930, P11215, P25063, P07766, P09693, P01732, P09564, P13765, P01375

IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNF

Sacubitril

hsa04650

Natural killer cell mediated cytotoxicity

1.91E-08

P19174, P01375, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, P26717, P26715

PLCG1, TNF, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, KLRC2, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P24158	PRTN3	Myeloblastin	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.816
Q13547	HDAC1	Histone deacetylase 1	O60880	SH2D1A	SH2 domain-containing protein 1A	0.786
P08311	CTSG	Cathepsin G	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.92
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60880	SH2D1A	SH2 domain-containing protein 1A	0.869
P24158	PRTN3	Myeloblastin	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.729
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P24158	PRTN3	Myeloblastin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.732
P13612	ITGA4	Integrin alpha-4	Q13241	KLRD1	Natural killer cells antigen CD94	0.814
Q13547	HDAC1	Histone deacetylase 1	Q13241	KLRD1	Natural killer cells antigen CD94	0.807
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863
P24158	PRTN3	Myeloblastin	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.76
P13612	ITGA4	Integrin alpha-4	P26718	KLRK1	NKG2-D type II integral membrane protein	0.818
Q13547	HDAC1	Histone deacetylase 1	P26718	KLRK1	NKG2-D type II integral membrane protein	0.772
P08311	CTSG	Cathepsin G	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.875
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26718	KLRK1	NKG2-D type II integral membrane protein	0.762
P13612	ITGA4	Integrin alpha-4	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.729
Q13547	HDAC1	Histone deacetylase 1	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.735
P24158	PRTN3	Myeloblastin	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.77
P13612	ITGA4	Integrin alpha-4	P26717	KLRC2	NKG2-C type II integral membrane protein	0.772
P08311	CTSG	Cathepsin G	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.867
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26717	KLRC2	NKG2-C type II integral membrane protein	0.853
P24158	PRTN3	Myeloblastin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P13612	ITGA4	Integrin alpha-4	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.772
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853

Sacubitril

hsa04657

IL-17 signaling pathway

8.22E-05

O00463, Q16539, P49841, P09341, P14780, P80188, P01375

TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF

Sacubitril

hsa04658

Th1 and Th2 cell differentiation

5.71E-15

P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, P42224, Q14765, P42226, P23771, Q9UL17, P14784, P13765, Q13761

NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT1, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P13612	ITGA4	Integrin alpha-4	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.764
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P13612	ITGA4	Integrin alpha-4	Q9UL17	TBX21	T-box transcription factor TBX21	0.822
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
P13612	ITGA4	Integrin alpha-4	Q13761	RUNX3	Runt-related transcription factor 3	0.78
Q13547	HDAC1	Histone deacetylase 1	Q13761	RUNX3	Runt-related transcription factor 3	0.884

Sacubitril

hsa04659

Th17 cell differentiation

2.33E-08

P25963, Q04759, Q16539, P19174, P06239, P42224, P42226, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P08238, P07766, P09693, P20963

NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT1, STAT6, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.912
Q13547	HDAC1	Histone deacetylase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.816
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
Q13547	HDAC1	Histone deacetylase 1	Q9UL17	TBX21	T-box transcription factor TBX21	0.817
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Sacubitril

hsa04660

T cell receptor signaling pathway

6.51E-12

P01375, P25963, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P14780	MMP9	Matrix metalloproteinase-9	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.767
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P14780	MMP9	Matrix metalloproteinase-9	Q04759	PRKCQ	Protein kinase C theta type	-0.787
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P14780	MMP9	Matrix metalloproteinase-9	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.792
P13612	ITGA4	Integrin alpha-4	O95267	RASGRP1	RAS guanyl-releasing protein 1	0.834
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P14780	MMP9	Matrix metalloproteinase-9	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.855
P13612	ITGA4	Integrin alpha-4	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
P08311	CTSG	Cathepsin G	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P13612	ITGA4	Integrin alpha-4	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.729
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
P14780	MMP9	Matrix metalloproteinase-9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.745
P13612	ITGA4	Integrin alpha-4	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.768
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P14780	MMP9	Matrix metalloproteinase-9	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.719
P13612	ITGA4	Integrin alpha-4	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.85
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P14780	MMP9	Matrix metalloproteinase-9	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.742
P13612	ITGA4	Integrin alpha-4	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.7
Q13547	HDAC1	Histone deacetylase 1	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.816
P08311	CTSG	Cathepsin G	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
P14780	MMP9	Matrix metalloproteinase-9	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.793
P13612	ITGA4	Integrin alpha-4	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.83
Q13547	HDAC1	Histone deacetylase 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.806
P13612	ITGA4	Integrin alpha-4	P06239	LCK	Tyrosine-protein kinase Lck	0.732
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
P14780	MMP9	Matrix metalloproteinase-9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.75

Sacubitril

hsa04662

B cell receptor signaling pathway

1.12E-02

P25963, P42338, P07948, P21854, Q8N149

NFKBIA, PIK3CB, LYN, CD72, LILRA2

Sacubitril

hsa04664

Fc epsilon RI signaling pathway

1.74E-03

P42338, Q9UQC2, P07948, P19174, P09917, P20292

PIK3CB, GAB2, LYN, PLCG1, ALOX5, ALOX5AP

Sacubitril

hsa04666

Fc gamma R-mediated phagocytosis

7.22E-05

O75015, P07948, P42338, P19174, P23528, P49006, P06396, O14494, P14598, P17252

FCGR3B, LYN, PIK3CB, PLCG1, CFL1, MARCKSL1, GSN, PLPP1, NCF1, PRKCA

Sacubitril

hsa04668

TNF signaling pathway

2.59E-02

P01375, O00463, Q13489, P25963, P20749, Q13077, P14780

TNF, TRAF5, BIRC3, NFKBIA, BCL3, TRAF1, MMP9

Sacubitril

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Sacubitril

hsa04713

Circadian entrainment

4.00E-02

P0DP23, P62873, P63218, P50151

CALM1, GNB1, GNG5, GNG10

Sacubitril

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Sacubitril

hsa04722

Neurotrophin signaling pathway

3.27E-02

P49841, O43524, P48023

GSK3B, FOXO3, FASLG

Sacubitril

hsa04723

Retrograde endocannabinoid signaling

1.75E-02

Q14643, P17252, P22694, Q16539, Q16718

ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5

Sacubitril

hsa04724

Glutamatergic synapse

3.15E-03

P48058, P62873, P63218, P50151, P15104, Q9NSB8

GRIA4, GNB1, GNG5, GNG10, GLUL, HOMER2

Sacubitril

hsa04725

Cholinergic synapse

2.78E-03

P22694, Q14643, P62873, P63218, P50151, P18848, P42338, P10415

PRKACB, ITPR1, GNB1, GNG5, GNG10, ATF4, PIK3CB, BCL2

Sacubitril

hsa04727

GABAergic synapse

8.14E-03

P62873, P63218, P50151, P15104

GNB1, GNG5, GNG10, GLUL

Sacubitril

hsa04744

Phototransduction

1.32E-02

P62873, P0DP23

GNB1, CALM1

Sacubitril

hsa04750

Inflammatory mediator regulation of TRP channels

8.12E-04

P14778, P19174, P42338, P24723, Q04759, P0DP23

IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1

Sacubitril

hsa04810

Regulation of actin cytoskeleton

4.38E-04

P12814, P24844, Q15746, Q13009, P42338, P08514, P11215, Q14344, Q9NRA1, P25116

ACTN1, MYL9, MYLK, TIAM1, PIK3CB, ITGA2B, ITGAM, GNA13, PDGFC, F2R

Sacubitril

hsa04911

Insulin secretion

4.47E-03

P63092, Q99941, P18848, Q13557

GNAS, CREBL1, ATF4, CAMK2D

Sacubitril

hsa04912

GnRH signaling pathway

3.14E-03

P17252, Q16539, Q9Y6R4, Q14643, P22694

PRKCA, MAPK14, MAP3K4, ITPR1, PRKACB

Sacubitril

hsa04914

Progesterone-mediated oocyte maturation

4.00E-02

P42338, Q13370, P30304, P08238

PIK3CB, PDE3B, CDC25A, HSP90AB1

Sacubitril

hsa04915

Estrogen signaling pathway

2.07E-03

P14780, P22694, P18848, Q08828, P0DMV8, Q14643, Q15788, P10415

MMP9, PRKACB, ATF4, ADCY1, HSPA1A, ITPR1, NCOA1, BCL2

Sacubitril

hsa04918

Thyroid hormone synthesis

2.91E-02

P22694, P18848, Q14643

PRKACB, ATF4, ITPR1

Sacubitril

hsa04920

Adipocytokine signaling pathway

4.49E-02

P25963, P33121, Q04759, P01375

NFKBIA, ACSL1, PRKCQ, TNF

Sacubitril

hsa04921

Oxytocin signaling pathway

6.84E-04

Q15746, Q08828, P24844, Q96RR4, Q8WYR1

MYLK, ADCY1, MYL9, CAMKK2, PIK3R5

Sacubitril

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Sacubitril

hsa04923

Regulation of lipolysis in adipocytes

2.24E-02

P07550, P42338, Q9Y4H2

ADRB2, PIK3CB, IRS2

Sacubitril

hsa04924

Renin secretion

8.55E-04

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Sacubitril

hsa04925

Aldosterone synthesis and secretion

1.68E-02

Q99941, P18848, P63092, Q13557

CREBL1, ATF4, GNAS, CAMK2D

Sacubitril

hsa04926

Relaxin signaling pathway

8.74E-03

P25963, P42338, P62873, P63218, P50151, P49767

NFKBIA, PIK3CB, GNB1, GNG5, GNG10, VEGFC

Sacubitril

hsa04927

Cortisol synthesis and secretion

5.54E-04

Q14643, Q99941, P18848, P63092, P22694

ITPR1, CREBL1, ATF4, GNAS, PRKACB

Sacubitril

hsa04928

Parathyroid hormone synthesis, secretion and action

1.60E-05

Q14643, P63092, P22694, P23771, P17252, P61586, Q99941, P18848, P10415

ITPR1, GNAS, PRKACB, GATA3, PRKCA, RHOA, CREBL1, ATF4, BCL2

Sacubitril

hsa04932

Non-alcoholic fatty liver disease

2.74E-02

P01375, P49841, P48023

TNF, GSK3B, FASLG

Sacubitril

hsa04934

Cushing syndrome

1.37E-03

Q99941, P18848, P63092, O15169, Q13557

CREBL1, ATF4, GNAS, AXIN1, CAMK2D

Sacubitril

hsa04940

Type I diabetes mellitus

2.61E-03

P10747, P48023, P13765, P01375

CD28, FASLG, HLA-DOB, TNF

Sacubitril

hsa04950

Maturity onset diabetes of the young

4.70E-02

P35557

GCK

Sacubitril

hsa04962

Vasopressin-regulated water reabsorption

1.80E-02

P62491, P46459

RAB11A, NSF

Sacubitril

hsa04964

Proximal tubule bicarbonate reclamation

2.74E-03

P22748, P00918, P49448

CA4, CA2, GLUD2

Sacubitril

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Sacubitril

hsa04970

Salivary secretion

4.49E-02

P22694, Q14643, P17252, P49913

PRKACB, ITPR1, PRKCA, CAMP

Sacubitril

hsa04972

Pancreatic secretion

4.89E-03

Q14643, P20020, P17252, Q08828, P62491

ITPR1, ATP2B1, PRKCA, ADCY1, RAB11A

Sacubitril

hsa04973

Carbohydrate digestion and absorption

1.29E-02

O43451, P42338

MGAM, PIK3CB

Sacubitril

hsa05010

Alzheimer disease

1.36E-02

Q92542, O15239, P05496, P18848, O15169, P05141, P12236, P43686, P62195

NCSTN, NDUFA1, ATP5G1, ATF4, AXIN1, SLC25A5, SLC25A6, PSMC4, PSMC5

Sacubitril

hsa05012

Parkinson disease

5.04E-04

O15239, P05496, P05141, P12236, P21796, P60604, P63092, P18848, P43686, P62195, P19174, P0DP23, Q13557, Q71U36, Q13509

NDUFA1, ATP5G1, SLC25A5, SLC25A6, VDAC1, UBE2G2, GNAS, ATF4, PSMC4, PSMC5, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3

Sacubitril

hsa05014

Amyotrophic lateral sclerosis

3.98E-03

P01375, P20333, O15239, Q16718, O14521, P36542, P05496, P18848, P43686, P62195, P51991, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629

TNF, TNFRSF1B, NDUFA1, NDUFA5, SDHD, ATP5C1, ATP5G1, ATF4, PSMC4, PSMC5, HNRPA3, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P01375	TNF	Tumor necrosis factor	-0.76
P40926	MDH2	Malate dehydrogenase, mitochondrial	P20333	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B	0.772
P40926	MDH2	Malate dehydrogenase, mitochondrial	O15239	NDUFA1	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	0.747
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q16718	NDUFA5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	0.733
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O14521	SDHD	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	0.702
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P36542	ATP5C1	ATP synthase subunit gamma, mitochondrial	0.792
P40926	MDH2	Malate dehydrogenase, mitochondrial	P05496	ATP5G1	ATP synthase F(0) complex subunit C1, mitochondrial	0.718
P40926	MDH2	Malate dehydrogenase, mitochondrial	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.781
P40926	MDH2	Malate dehydrogenase, mitochondrial	P43686	PSMC4	26S proteasome regulatory subunit 6B	0.835
P40926	MDH2	Malate dehydrogenase, mitochondrial	P62195	PSMC5	26S proteasome regulatory subunit 8	0.721
P40926	MDH2	Malate dehydrogenase, mitochondrial	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.802
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P09651	HNRNPA1	Heterogeneous nuclear ribonucleoprotein A1	0.801
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q7Z3B4	NUP54	Nucleoporin p54	0.883
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P35658	NUP214	Nuclear pore complex protein Nup214	-0.708
P40926	MDH2	Malate dehydrogenase, mitochondrial	P35658	NUP214	Nuclear pore complex protein Nup214	-0.845
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P43243	MATR3	Matrin-3	0.724
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.771
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q16629	SFRS7	Serine/arginine-rich splicing factor 7	0.801

Sacubitril

hsa05020

Prion disease

1.15E-02

P46531, O15239, P05496, P18848, P05141, P12236, P43686, P62195, Q99941

NOTCH1, NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, PSMC4, PSMC5, CREBL1

Sacubitril

hsa05022

Pathways of neurodegeneration - multiple diseases

1.57E-02

O15239, P05496, P18848, P05141, P12236, P20333, O15169, Q13557, P43686, P62195

NDUFA1, ATP5G1, ATF4, SLC25A5, SLC25A6, TNFRSF1B, AXIN1, CAMK2D, PSMC4, PSMC5

Sacubitril

hsa05030

Cocaine addiction

2.40E-02

P63092, Q99941, P18848

GNAS, CREBL1, ATF4

Sacubitril

hsa05031

Amphetamine addiction

4.47E-03

Q13557, P63092, Q99941, P18848

CAMK2D, GNAS, CREBL1, ATF4

Sacubitril

hsa05032

Morphine addiction

7.60E-03

P62873, P63218, P50151, Q13370, P43250

GNB1, GNG5, GNG10, PDE3B, GRK6

Sacubitril

hsa05034

Alcoholism

6.32E-03

Q13547, P0DP23, P62873, P63218, P50151, P62807, Q93079

HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2BC, H2BC9

Sacubitril

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.78E-03

P09341, P19875, P19174, P25024, P25025

CXCL1, CXCL2, PLCG1, CXCR1, CXCR2

Sacubitril

hsa05130

Pathogenic Escherichia coli infection

2.51E-02

Q14247, O00501, P25116

CTTN, CLDN5, F2R

Sacubitril

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Sacubitril

hsa05132

Salmonella infection

2.03E-04

P51617, P25963, P01375, P08238, Q9UJU2, P01106, P63261, P42338, Q13489, P10415, O75369, Q96A32, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754

IRAK1, NFKBIA, TNF, HSP90AB1, LEF1, MYC, ACTG1, PIK3CB, BIRC3, BCL2, FLNB, MYLPF, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P08238	HSP90AB1	Heat shock protein HSP 90-beta	0.926
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	0.787
P08246	ELA2	Neutrophil elastase	Q9UJU2	LEF1	Lymphoid enhancer-binding factor 1	-0.771
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P63261	ACTG1	Actin, cytoplasmic 2	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P10415	BCL2	Apoptosis regulator Bcl-2	0.859
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75369	FLNB	Filamin-B	0.769
P08246	ELA2	Neutrophil elastase	Q96A32	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform	0.724
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	0.737
P08246	ELA2	Neutrophil elastase	Q9BQS8	FYCO1	FYVE and coiled-coil domain-containing protein 1	-0.949
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13561	DCTN2	Dynactin subunit 2	-0.862
P08246	ELA2	Neutrophil elastase	Q13561	DCTN2	Dynactin subunit 2	0.78
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q71U36	TUBA1A	Tubulin alpha-1A chain	-0.804
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13509	TUBB3	Tubulin beta-3 chain	-0.782
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13509	TUBB3	Tubulin beta-3 chain	0.777
P08246	ELA2	Neutrophil elastase	Q13509	TUBB3	Tubulin beta-3 chain	0.724
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P68371	TUBB2C	Tubulin beta-4B chain	-0.726
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P49754	VPS41	Vacuolar protein sorting-associated protein 41 homolog	0.807

Sacubitril

hsa05133

Pertussis

6.74E-06

P05107, P0DP23, P10145, P0C0L4

ITGB2, CALM1, IL8, C4A

Sacubitril

hsa05134

Legionellosis

1.29E-02

P11215, P11142, P09341, P19875

ITGAM, HSPA8, CXCL1, CXCL2

Sacubitril

hsa05140

Leishmaniasis

2.62E-08

P13612, O75015, P14598, P42224, P13765, O60603, P25963, P01375, P29350, P49006, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14780	MMP9	Matrix metalloproteinase-9	P13612	ITGA4	Integrin alpha-4	-0.7
P14780	MMP9	Matrix metalloproteinase-9	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.928
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14598	NCF1	Neutrophil cytosol factor 1	-0.708
P22894	MMP8	Neutrophil collagenase	P14598	NCF1	Neutrophil cytosol factor 1	0.74
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.75
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.756
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O60603	TLR2	Toll-like receptor 2	-0.797
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P49006	MARCKSL1	MARCKS-related protein	0.706
P14780	MMP9	Matrix metalloproteinase-9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.778
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.708
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	-0.89
P14780	MMP9	Matrix metalloproteinase-9	Q15080	NCF4	Neutrophil cytosol factor 4	0.869
P22894	MMP8	Neutrophil collagenase	Q15080	NCF4	Neutrophil cytosol factor 4	0.963
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q15080	NCF4	Neutrophil cytosol factor 4	0.719

Sacubitril

hsa05143

African trypanosomiasis

6.53E-06

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Sacubitril

hsa05144

Malaria

1.79E-06

P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718

HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1

Sacubitril

hsa05145

Toxoplasmosis

8.39E-05

P51617, P25963, Q16539, P01375, P10415, Q13489, P23458, P13765, Q8WYR1, P0DMV8, O60603

IRAK1, NFKBIA, MAPK14, TNF, BCL2, BIRC3, JAK1, HLA-DOB, PIK3R5, HSPA1A, TLR2

Sacubitril

hsa05146

Amoebiasis

3.73E-08

P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311

CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24158	PRTN3	Myeloblastin	P09341	CXCL1	Growth-regulated alpha protein	0.751
P14780	MMP9	Matrix metalloproteinase-9	P09341	CXCL1	Growth-regulated alpha protein	0.771
Q13547	HDAC1	Histone deacetylase 1	P09341	CXCL1	Growth-regulated alpha protein	-0.736
P08311	CTSG	Cathepsin G	P09341	CXCL1	Growth-regulated alpha protein	0.877
Q13547	HDAC1	Histone deacetylase 1	P19875	CXCL2	C-X-C motif chemokine 2	-0.862
Q13547	HDAC1	Histone deacetylase 1	P14778	IL1R1	Interleukin-1 receptor type 1	-0.854
P24158	PRTN3	Myeloblastin	P27930	IL1R2	Interleukin-1 receptor type 2	0.735
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q13547	HDAC1	Histone deacetylase 1	P27930	IL1R2	Interleukin-1 receptor type 2	-0.837
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
Q13547	HDAC1	Histone deacetylase 1	P11215	ITGAM	Integrin alpha-M	-0.751
P24158	PRTN3	Myeloblastin	P05089	ARG1	Arginase-1	0.834
P14780	MMP9	Matrix metalloproteinase-9	P05089	ARG1	Arginase-1	0.881
Q13547	HDAC1	Histone deacetylase 1	P05089	ARG1	Arginase-1	-0.769
P08311	CTSG	Cathepsin G	P05089	ARG1	Arginase-1	0.931
P24158	PRTN3	Myeloblastin	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.792
P14780	MMP9	Matrix metalloproteinase-9	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.826
P08311	CTSG	Cathepsin G	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.847
Q13547	HDAC1	Histone deacetylase 1	P12814	ACTN1	Alpha-actinin-1	-0.887
P08311	CTSG	Cathepsin G	P12814	ACTN1	Alpha-actinin-1	0.708
P24158	PRTN3	Myeloblastin	P08311	CTSG	Cathepsin G	0.914
P14780	MMP9	Matrix metalloproteinase-9	P08311	CTSG	Cathepsin G	0.79
P08311	CTSG	Cathepsin G	P08311	CTSG	Cathepsin G	1

Sacubitril

hsa05150

Staphylococcus aureus infection

6.19E-06

P0C0L4, P21730, P21462, O75015, P13765, Q16581, Q14532, P05107, P59665, P59666, P12838, P49913

C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT32, ITGB2, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43005	SLC1A1	Excitatory amino acid transporter 3	P0C0L4	C4A	Complement C4-A	0.703
P43005	SLC1A1	Excitatory amino acid transporter 3	P0C0L4	C4A	Complement C4-A	0.703
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
P22894	MMP8	Neutrophil collagenase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.756
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P21462	FPR1	fMet-Leu-Phe receptor	-0.779
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
P22894	MMP8	Neutrophil collagenase	P21462	FPR1	fMet-Leu-Phe receptor	0.88
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	-0.82
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
P06737	PYGL	Glycogen phosphorylase, liver form	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.808
P22894	MMP8	Neutrophil collagenase	Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	0.746
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	Q14532	KRT32	Keratin, type I cuticular Ha2	-0.735
P43005	SLC1A1	Excitatory amino acid transporter 3	P05107	ITGB2	Integrin beta-2	0.793
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P59665	DEFA1; DEFA1B	Neutrophil defensin 1	-0.821
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P59666	DEFA3	Neutrophil defensin 3	-0.821
Q96EB6	SIRT1	NAD-dependent protein deacetylase sirtuin-1	P12838	DEFA4	Neutrophil defensin 4	-0.714
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7

Sacubitril

hsa05152

Tuberculosis

5.68E-07

Q13488, O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, Q16539, P51617

TCIRG1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, MAPK14, IRAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.717
P08246	ELA2	Neutrophil elastase	Q13488	TCIRG1	V-type proton ATPase 116 kDa subunit a 3	0.71
P22894	MMP8	Neutrophil collagenase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.734
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
P24158	PRTN3	Myeloblastin	P48382	RFX5	DNA-binding protein RFX5	-0.87
P22894	MMP8	Neutrophil collagenase	P48382	RFX5	DNA-binding protein RFX5	-0.926
Q15722	LTB4R	Leukotriene B4 receptor 1	P48382	RFX5	DNA-binding protein RFX5	-0.779
P08246	ELA2	Neutrophil elastase	P48382	RFX5	DNA-binding protein RFX5	-0.895
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P48382	RFX5	DNA-binding protein RFX5	-0.78
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P24158	PRTN3	Myeloblastin	P10415	BCL2	Apoptosis regulator Bcl-2	-0.787
P22894	MMP8	Neutrophil collagenase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.959
Q15722	LTB4R	Leukotriene B4 receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.865
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P10415	BCL2	Apoptosis regulator Bcl-2	-0.706
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q15722	LTB4R	Leukotriene B4 receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.792
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.756
P22894	MMP8	Neutrophil collagenase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.7
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P24158	PRTN3	Myeloblastin	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.733
P22894	MMP8	Neutrophil collagenase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.891
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.843
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.708
P22894	MMP8	Neutrophil collagenase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.744
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734

Sacubitril

hsa05160

Hepatitis C

1.27E-02

P60033, P49841, P01375, P48023

CD81, GSK3B, TNF, FASLG

Sacubitril

hsa05161

Hepatitis B

2.33E-02

P17252, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Sacubitril

hsa05162

Measles

1.13E-03

P01568, P25963, P23458, P42224, P14784, P07766, P42338, P0DMV8, P11142

IFNA21, NFKBIA, JAK1, STAT1, IL2RB, CD3E, PIK3CB, HSPA1A, HSPA8

Sacubitril

hsa05163

Human cytomegalovirus infection

4.19E-04

P42338, P25963, P62873, P63218, P50151, P0DP23, Q14344, P01106, P30101, P01568

PIK3CB, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, MYC, PDIA3, IFNA21

Sacubitril

hsa05167

Kaposi sarcoma-associated herpesvirus infection

7.49E-05

P01568, P42224, P25963, P42338, P62873, P63218, P50151, P19174, P07948, P01106, P0DP23

IFNA21, STAT1, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, PLCG1, LYN, MYC, CALM1

Sacubitril

hsa05168

Herpes simplex virus 1 infection

6.47E-04

P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P09960	LTA4H	Leukotriene A-4 hydrolase	P01568	IFNA21	Interferon alpha-21	-0.764
P09960	LTA4H	Leukotriene A-4 hydrolase	Q05823	RNASEL	2-5A-dependent ribonuclease	0.752
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.866
P09960	LTA4H	Leukotriene A-4 hydrolase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	0.732
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	0.835
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.908
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	0.819
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.721
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13398	ZNF211	Zinc finger protein 211	0.891
P09960	LTA4H	Leukotriene A-4 hydrolase	Q13398	ZNF211	Zinc finger protein 211	0.729
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9HCX3	ZNF304	Zinc finger protein 304	-0.746
P09960	LTA4H	Leukotriene A-4 hydrolase	P52738	ZNF140	Zinc finger protein 140	-0.724
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75820	ZNF189	Zinc finger protein 189	-0.749
P09960	LTA4H	Leukotriene A-4 hydrolase	O75820	ZNF189	Zinc finger protein 189	-0.722
P09960	LTA4H	Leukotriene A-4 hydrolase	Q9UDV6	ZNF212	Zinc finger protein 212	0.824

Sacubitril

hsa05169

Epstein-Barr virus infection

3.41E-04

P13765, P01106, Q13547, O00463, P25963, P16070, P10415, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, P42224, Q8WV28, P01568, P01375, O60603, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, NFKBIA, CD44, BCL2, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, STAT1, BLNK, IFNA21, TNF, TLR2, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01106	MYC	Myc proto-oncogene protein	0.719
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13547	HDAC1	Histone deacetylase 1	0.701
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P06737	PYGL	Glycogen phosphorylase, liver form	P16070	CD44	CD44 antigen	0.803
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07948	LYN	Tyrosine-protein kinase Lyn	-0.852
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P40925	MDH1	Malate dehydrogenase, cytoplasmic	Q13761	RUNX3	Runt-related transcription factor 3	0.804
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P40925	MDH1	Malate dehydrogenase, cytoplasmic	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	-0.847
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728

Sacubitril

hsa05170

Human immunodeficiency virus 1 infection

1.22E-05

P42338, P62873, P63218, P50151, P0DP23, P01375, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, O95067, P19174, P07766, P10415, Q13619, Q93034, Q9Y6Q5

PIK3CB, GNB1, GNG5, GNG10, CALM1, TNF, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, CCNB2, PLCG1, CD3E, BCL2, CUL4A, CUL5, AP1M2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P62873	GNB1	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.764
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.846
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.799
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P0DP23	CALM1	Calmodulin-1	0.826
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P30101	PDIA3	Protein disulfide-isomerase A3	0.896
P08246	ELA2	Neutrophil elastase	Q14643	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1	-0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P01568	IFNA21	Interferon alpha-21	-0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08246	ELA2	Neutrophil elastase	O95067	CCNB2	G2/mitotic-specific cyclin-B2	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13619	CUL4A	Cullin-4A	-0.707
P08246	ELA2	Neutrophil elastase	Q93034	CUL5	Cullin-5	-0.744
P08246	ELA2	Neutrophil elastase	Q9Y6Q5	AP1M2	AP-1 complex subunit mu-2	0.811

Sacubitril

hsa05200

Pathways in cancer

1.82E-03

P42338, P08238, P42224, P25963, P19174, P01106, P43246, Q13547, P49767, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784

PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, MSH2, HDAC1, VEGFC, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB

Sacubitril

hsa05202

Transcriptional misregulation in cancer

7.31E-17

Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, Q15652, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P68431, P12980, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, JMJD1C, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q12778	FOXO1	Forkhead box protein O1	0.714
P22894	MMP8	Neutrophil collagenase	Q12778	FOXO1	Forkhead box protein O1	-0.72
Q15722	LTB4R	Leukotriene B4 receptor 1	Q12778	FOXO1	Forkhead box protein O1	-0.769
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
P24158	PRTN3	Myeloblastin	Q15532	SS18	Protein SSXT	-0.732
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q15532	SS18	Protein SSXT	0.893
P22894	MMP8	Neutrophil collagenase	Q15532	SS18	Protein SSXT	-0.867
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15532	SS18	Protein SSXT	-0.803
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q15532	SS18	Protein SSXT	-0.829
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P08311	CTSG	Cathepsin G	Q13315	ATM	Serine-protein kinase ATM	-0.709
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P41732	TSPAN7	Tetraspanin-7	-0.834
Q15722	LTB4R	Leukotriene B4 receptor 1	P41732	TSPAN7	Tetraspanin-7	0.775
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
P24158	PRTN3	Myeloblastin	P14780	MMP9	Matrix metalloproteinase-9	0.837
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14780	MMP9	Matrix metalloproteinase-9	-0.72
P14780	MMP9	Matrix metalloproteinase-9	P14780	MMP9	Matrix metalloproteinase-9	1
P22894	MMP8	Neutrophil collagenase	P14780	MMP9	Matrix metalloproteinase-9	0.882
Q15722	LTB4R	Leukotriene B4 receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.861
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P08311	CTSG	Cathepsin G	P14780	MMP9	Matrix metalloproteinase-9	0.79
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
P24158	PRTN3	Myeloblastin	P27930	IL1R2	Interleukin-1 receptor type 2	0.735
P14780	MMP9	Matrix metalloproteinase-9	P27930	IL1R2	Interleukin-1 receptor type 2	0.851
Q15722	LTB4R	Leukotriene B4 receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.734
P08311	CTSG	Cathepsin G	P27930	IL1R2	Interleukin-1 receptor type 2	0.726
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P14923	JUP	Junction plakoglobin	0.914
P22894	MMP8	Neutrophil collagenase	P14923	JUP	Junction plakoglobin	-0.809
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P24158	PRTN3	Myeloblastin	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.741
P14780	MMP9	Matrix metalloproteinase-9	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.7
P08311	CTSG	Cathepsin G	Q15744	CEBPE	CCAAT/enhancer-binding protein epsilon	0.909
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
P24158	PRTN3	Myeloblastin	Q16548	BCL2A1	Bcl-2-related protein A1	0.802
P14780	MMP9	Matrix metalloproteinase-9	Q16548	BCL2A1	Bcl-2-related protein A1	0.921
P22894	MMP8	Neutrophil collagenase	Q16548	BCL2A1	Bcl-2-related protein A1	0.843
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.837
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08311	CTSG	Cathepsin G	Q16548	BCL2A1	Bcl-2-related protein A1	0.79
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q16548	BCL2A1	Bcl-2-related protein A1	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.71
P22894	MMP8	Neutrophil collagenase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.765
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.797
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.832
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P14780	MMP9	Matrix metalloproteinase-9	Q13077	TRAF1	TNF receptor-associated factor 1	-0.758
P22894	MMP8	Neutrophil collagenase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.806
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
P24158	PRTN3	Myeloblastin	O15550	UTX	Lysine-specific demethylase 6A	0.776
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	O15550	UTX	Lysine-specific demethylase 6A	-0.808
Q15722	LTB4R	Leukotriene B4 receptor 1	O15550	UTX	Lysine-specific demethylase 6A	0.789
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	O15550	UTX	Lysine-specific demethylase 6A	0.73
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P04637	TP53	Cellular tumor antigen p53	0.753
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
P14780	MMP9	Matrix metalloproteinase-9	P35226	BMI1	Polycomb complex protein BMI-1	-0.89
P22894	MMP8	Neutrophil collagenase	P35226	BMI1	Polycomb complex protein BMI-1	-0.821
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
P24158	PRTN3	Myeloblastin	P05164	MPO	Myeloperoxidase	0.979
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P05164	MPO	Myeloperoxidase	-0.754
P14780	MMP9	Matrix metalloproteinase-9	P05164	MPO	Myeloperoxidase	0.812
P22894	MMP8	Neutrophil collagenase	P05164	MPO	Myeloperoxidase	0.905
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P08311	CTSG	Cathepsin G	P05164	MPO	Myeloperoxidase	0.956
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P05164	MPO	Myeloperoxidase	0.711
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P14780	MMP9	Matrix metalloproteinase-9	P12838	DEFA4	Neutrophil defensin 4	0.858
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P08311	CTSG	Cathepsin G	P12838	DEFA4	Neutrophil defensin 4	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
P24158	PRTN3	Myeloblastin	P08246	ELA2	Neutrophil elastase	0.894
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P08246	ELA2	Neutrophil elastase	-0.833
P14780	MMP9	Matrix metalloproteinase-9	P08246	ELA2	Neutrophil elastase	0.859
P22894	MMP8	Neutrophil collagenase	P08246	ELA2	Neutrophil elastase	0.985
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P08311	CTSG	Cathepsin G	P08246	ELA2	Neutrophil elastase	0.792
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
P24158	PRTN3	Myeloblastin	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.777
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.741
P14780	MMP9	Matrix metalloproteinase-9	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.752
P22894	MMP8	Neutrophil collagenase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.778
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.808
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
P08311	CTSG	Cathepsin G	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.853
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P14780	MMP9	Matrix metalloproteinase-9	P41182	BCL6	B-cell lymphoma 6 protein	0.812
Q16581	C3AR1	C3a anaphylatoxin chemotactic receptor	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	-0.79
P14780	MMP9	Matrix metalloproteinase-9	P12980	LYL1	Protein lyl-1	0.716
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
P24158	PRTN3	Myeloblastin	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.772
Q13093	PLA2G7	Platelet-activating factor acetylhydrolase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.768
P14780	MMP9	Matrix metalloproteinase-9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.765
P22894	MMP8	Neutrophil collagenase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.766
Q15722	LTB4R	Leukotriene B4 receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.764
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P08311	CTSG	Cathepsin G	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.799
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Sacubitril

hsa05203

Viral carcinogenesis

8.69E-05

Q99941, P18848, P42338, P06746, P07948, P27348, P29083, Q13547, Q15283, P61586, P12814, P25963, P61978, P62807, Q93079

CREBL1, ATF4, PIK3CB, POLB, LYN, YWHAQ, GTF2E1, HDAC1, RASA2, RHOA, ACTN1, NFKBIA, HNRPK, HIST1H2BC, H2BC9

Sacubitril

hsa05205

Proteoglycans in cancer

2.66E-02

Q14643, P63261, P04637, P14780, P17252, O60603, Q13635, P08962

ITPR1, ACTG1, TP53, MMP9, PRKCA, TLR2, PTCH1, CD63

Sacubitril

hsa05206

MicroRNAs in cancer

1.34E-03

P30304, P09493, P21860, P01106, P42338, P61978, P46531, Q13547, P63279, P22105, P61586, P20827, P19174

CDC25A, TPM1, ERBB3, MYC, PIK3CB, HNRPK, NOTCH1, HDAC1, UBE2I, TNXB, RHOA, EFNA1, PLCG1

Sacubitril

hsa05214

Glioma

1.34E-02

P0DP23, P42338, P19174, O75293

CALM1, PIK3CB, PLCG1, GADD45B

Sacubitril

hsa05216

Thyroid cancer

3.59E-02

Q9UJU2, P04637, P24522

LEF1, TP53, GADD45A

Sacubitril

hsa05217

Basal cell carcinoma

4.56E-04

Q13635, P49841, Q9UJU2, P04637, P24522

PTCH1, GSK3B, LEF1, TP53, GADD45A

Sacubitril

hsa05218

Melanoma

2.31E-02

Q9NRA1, P42338, O75293

PDGFC, PIK3CB, GADD45B

Sacubitril

hsa05220

Chronic myeloid leukemia

2.17E-02

Q13547, P01106, P25963, P42338, O75293

HDAC1, MYC, NFKBIA, PIK3CB, GADD45B

Sacubitril

hsa05222

Small cell lung cancer

2.79E-02

Q13489, P10415, P25963, Q13077, O00463, P24522

BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Sacubitril

hsa05231

Choline metabolism in cancer

2.92E-03

P42338, Q9NRA1, Q9Y259, P19174, P23743

PIK3CB, PDGFC, CHKB, PLCG1, DGKA

Sacubitril

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.14E-05

P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759

NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.711
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.805
Q13547	HDAC1	Histone deacetylase 1	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	-0.774
P08311	CTSG	Cathepsin G	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.705
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.932
Q13547	HDAC1	Histone deacetylase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.7
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.839
Q13547	HDAC1	Histone deacetylase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.802
Q13547	HDAC1	Histone deacetylase 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.87
P08311	CTSG	Cathepsin G	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.888
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P08311	CTSG	Cathepsin G	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.706
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q13547	HDAC1	Histone deacetylase 1	P06239	LCK	Tyrosine-protein kinase Lck	0.811
P08311	CTSG	Cathepsin G	P06239	LCK	Tyrosine-protein kinase Lck	-0.816
P40925	MDH1	Malate dehydrogenase, cytoplasmic	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.838
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
Q13547	HDAC1	Histone deacetylase 1	Q04759	PRKCQ	Protein kinase C theta type	0.723
P08311	CTSG	Cathepsin G	Q04759	PRKCQ	Protein kinase C theta type	-0.913
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776

Sacubitril

hsa05310

Asthma

6.61E-07

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Sacubitril

hsa05321

Inflammatory bowel disease

1.77E-16

O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771, Q9HBE5

TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3, IL21R

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
P24158	PRTN3	Myeloblastin	O60603	TLR2	Toll-like receptor 2	0.729
P14780	MMP9	Matrix metalloproteinase-9	O60603	TLR2	Toll-like receptor 2	0.89
P22894	MMP8	Neutrophil collagenase	O60603	TLR2	Toll-like receptor 2	0.89
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P15144	ANPEP	Aminopeptidase N	O60603	TLR2	Toll-like receptor 2	0.885
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P15144	ANPEP	Aminopeptidase N	P01375	TNF	Tumor necrosis factor	0.878
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q15722	LTB4R	Leukotriene B4 receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.792
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P24158	PRTN3	Myeloblastin	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.753
P14780	MMP9	Matrix metalloproteinase-9	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.861
P22894	MMP8	Neutrophil collagenase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.757
Q15722	LTB4R	Leukotriene B4 receptor 1	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.701
P08246	ELA2	Neutrophil elastase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.783
P08311	CTSG	Cathepsin G	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.81
P15144	ANPEP	Aminopeptidase N	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.86
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
P14780	MMP9	Matrix metalloproteinase-9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.808
P08311	CTSG	Cathepsin G	Q9UL17	TBX21	T-box transcription factor TBX21	-0.795
P15144	ANPEP	Aminopeptidase N	Q9UL17	TBX21	T-box transcription factor TBX21	-0.755
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P24158	PRTN3	Myeloblastin	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.81
P14780	MMP9	Matrix metalloproteinase-9	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.747
P22894	MMP8	Neutrophil collagenase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.751
Q15722	LTB4R	Leukotriene B4 receptor 1	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.768
P08246	ELA2	Neutrophil elastase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.724
P08311	CTSG	Cathepsin G	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.866
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P08311	CTSG	Cathepsin G	Q9HBE5	IL21R	Interleukin-21 receptor	-0.763

Sacubitril

hsa05322

Systemic lupus erythematosus

4.18E-04

O75015, P08246, P08311, P01375, P10747, P13765, Q6FI13, Q16778, P12814, P05455

FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST2H2BE, ACTN1, SSB

Sacubitril

hsa05323

Rheumatoid arthritis

1.08E-04

P01375, P13765, P10747, P09341, O60603

TNF, HLA-DOB, CD28, CXCL1, TLR2

Sacubitril

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Sacubitril

hsa05332

Graft-versus-host disease

1.28E-12

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P24158	PRTN3	Myeloblastin	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.796
P14780	MMP9	Matrix metalloproteinase-9	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.714
P22894	MMP8	Neutrophil collagenase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.797
Q15722	LTB4R	Leukotriene B4 receptor 1	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.792
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P08311	CTSG	Cathepsin G	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
P14416	DRD2	D(2) dopamine receptor	P48023	FASLG	Tumor necrosis factor ligand superfamily member 6	0.7
P22894	MMP8	Neutrophil collagenase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.801
Q15722	LTB4R	Leukotriene B4 receptor 1	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.81
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P15144	ANPEP	Aminopeptidase N	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.718
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P24158	PRTN3	Myeloblastin	P01375	TNF	Tumor necrosis factor	0.719
P14780	MMP9	Matrix metalloproteinase-9	P01375	TNF	Tumor necrosis factor	0.897
P22894	MMP8	Neutrophil collagenase	P01375	TNF	Tumor necrosis factor	0.728
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P14416	DRD2	D(2) dopamine receptor	P01375	TNF	Tumor necrosis factor	-0.767
P08311	CTSG	Cathepsin G	P01375	TNF	Tumor necrosis factor	0.733
P15144	ANPEP	Aminopeptidase N	P01375	TNF	Tumor necrosis factor	0.878
P24158	PRTN3	Myeloblastin	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
P14780	MMP9	Matrix metalloproteinase-9	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P22894	MMP8	Neutrophil collagenase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.77
Q15722	LTB4R	Leukotriene B4 receptor 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.793
P08246	ELA2	Neutrophil elastase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.775
P08311	CTSG	Cathepsin G	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.867
P15144	ANPEP	Aminopeptidase N	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.853
P24158	PRTN3	Myeloblastin	Q13241	KLRD1	Natural killer cells antigen CD94	-0.732
P14780	MMP9	Matrix metalloproteinase-9	Q13241	KLRD1	Natural killer cells antigen CD94	-0.837
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.755
P08246	ELA2	Neutrophil elastase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.7
P08311	CTSG	Cathepsin G	Q13241	KLRD1	Natural killer cells antigen CD94	-0.812
P15144	ANPEP	Aminopeptidase N	Q13241	KLRD1	Natural killer cells antigen CD94	-0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13241	KLRD1	Natural killer cells antigen CD94	0.863

Sacubitril

hsa05340

Primary immunodeficiency

3.73E-02

P11912, P16871

CD79A, IL7R

Sacubitril

hsa05410

Hypertrophic cardiomyopathy

2.60E-02

P26012, P09493

ITGB8, TPM1

Sacubitril

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Sacubitril

hsa05415

Diabetic cardiomyopathy

6.60E-04

P17252, P05141, P12236, P14598, Q15080, O15239, Q16718, O14521, P05496, Q13557, P04406, P26678

PRKCA, SLC25A5, SLC25A6, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, ATP5G1, CAMK2D, GAPDH, PLN

Sacubitril

hsa05416

Viral myocarditis

2.30E-02

P10747, P63261

CD28, ACTG1

Sacubitril

hsa05418

Fluid shear stress and atherosclerosis

4.26E-02

P14598, P14780, P63261, P04637, P10415, Q92974

NCF1, MMP9, ACTG1, TP53, BCL2, ARHGEF2

Community members of Sacubitril (S_DC: 6.28)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

HDAC1

Histone deacetylase 1

Predicted

0.0447

0.986

3.0084

P08311

CTSG

Cathepsin G

Predicted

0.4949

0.1874

0.6478

1.2701

P24158

PRTN3

Myeloblastin

Predicted

0.0516

0.0511

0.1281

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P14780

MMP9

Matrix metalloproteinaseNone9

Predicted

0.1696

0.8424

0.7315

2.5012

P22894

MMP8

Neutrophil collagenase

Predicted

0.1061

0.357

0.767

P40926

MDH2

Malate dehydrogenase, mitochondrial

Predicted

0.4721

0.1611

0.2474

0.8055

P40925

MDH1

Malate dehydrogenase, cytoplasmic

Predicted

0.3566

0.2746

0.2426

0.97

Q92769

HDAC2

Histone deacetylase 2

Predicted

0.0473

0.986

3.0097

Q9GZT9

EGLN1

Egl nine homolog 1

Predicted

0.5804

0.6061

0.2556

1.7581

P15144

ANPEP

Aminopeptidase N

Predicted

0.1875

0.2365

0.2934

0.8601

P13612

ITGA4

Integrin alphaNone4

Predicted

0.1165

0.2386

0.6862

1.2217

P06737

PYGL

Glycogen phosphorylase, liver form

Predicted

0.3733

0.2211

0.3169

0.9457

P07384

CAPN1

CalpainNone1 catalytic subunit

Predicted

0.023

0.1489

0.6038

0.9131

P14416

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P49768

PSEN1

PresenilinNone1

Predicted

0.2677

0.6599

0.3308

1.7845

Q13093

PLA2G7

PlateletNoneactivating factor acetylhydrolase

Predicted

0.0505

0.2096

0.1558

0.6001

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P08514

ITGA2B

Integrin alphaNoneIIb

Predicted

0.0782

0.3248

0.779

1.4677

Q14790

CASP8

CaspaseNone8

Predicted

0.15

0.0558

1.1867

Q96EB6

SIRT1

NADNonedependent protein deacetylase sirtuinNone1

Predicted

0.2865

0.4571

0.5784

1.6358

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

P42330

AKR1C3

AldoNoneketo reductase family 1 member C3

Predicted

0.4017

0.8348

0.1748

2.0453

P00734

Prothrombin

Predicted

0.0963

0.707

0.4977

1.9598

P43003

SLC1A3

Excitatory amino acid transporter 1

Predicted

0.0973

0.0774

0.1658

0.3692

P43005

SLC1A1

Excitatory amino acid transporter 3

Predicted

0.0827

0.0663

0.019

0.193

Q15722

LTB4R

Leukotriene B4 receptor 1

Predicted

0.0677

0.2199

0.4736

Q16581

C3AR1

C3a anaphylatoxin chemotactic receptor

Predicted

0.1388

0.0385

0.3428

0.4892

Q07817

BCL2L1

BclNone2Nonelike protein 1

Predicted

0.0872

0.4349

1.9134

P42892

ECE1

EndothelinNoneconverting enzyme 1

Predicted

0.4853

0.0922

0.4269

PharmaCoNets of Sacubitril (SPCN: 145.57 )

Sacubitril regulated-network (SDN: 23.18)

Community members of Sacubitril (SDC: 6.28)

PharmaCoNets of Sacubitril (S_PCN: 145.57 )

Sacubitril regulated-network (S_DN: 23.18)

Community members of Sacubitril (S_DC: 6.28)