PharmaCoNets of Ruxolitinib (SPCN: 271.02 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Ruxolitinibhsa00010Glycolysis / Gluconeogenesis1.89E-035P04075, P14550, P11766, P07195, P60174ALDOA, AKR1A1, ADH5, LDHB, TPI1More
Ruxolitinibhsa00020Citrate cycle (TCA cycle)3.41E-022P50213, O14521IDH3A, SDHDMore
Ruxolitinibhsa00030Pentose phosphate pathway3.59E-124P60891, P51854, P52209, P37837PRPS1, TKTL1, PGD, TALDO1More
Ruxolitinibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Ruxolitinibhsa00051Fructose and mannose metabolism2.63E-055P15121, P19367, P08237, P60174, P04075AKR1B1, HK1, PFKM, TPI1, ALDOAMore
Ruxolitinibhsa00052Galactose metabolism4.25E-056P06280, P08237, O43451, P15121, P19367, Q14376GLA, PFKM, MGAM, AKR1B1, HK1, GALEMore
Ruxolitinibhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Ruxolitinibhsa00071Fatty acid degradation2.44E-045P11310, O75521, P00325, P11766, P33121ACADM, ECI2, ADH1B, ADH5, ACSL1More
Ruxolitinibhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Ruxolitinibhsa00190Oxidative phosphorylation7.86E-053Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Ruxolitinibhsa00220Arginine biosynthesis2.22E-083P15104, P05089, P49448GLUL, ARG1, GLUD2More
Ruxolitinibhsa00230Purine metabolism3.35E-022Q7LG56, P51828RRM2B, ADCY7More
Ruxolitinibhsa00240Pyrimidine metabolism1.85E-022P31350, P04818RRM2, TYMSMore
Ruxolitinibhsa00250Alanine, aspartate and glutamate metabolism3.77E-063Q96RQ9, P49448, P15104IL4I1, GLUD2, GLULMore
Ruxolitinibhsa00270Cysteine and methionine metabolism2.39E-022Q96RQ9, P40926IL4I1, MDH2More
Ruxolitinibhsa00280Valine, leucine and isoleucine degradation1.93E-046P55809, Q9HCC0, Q96RQ9, P05166, Q02252, P11310OXCT1, MCCC2, IL4I1, PCCB, ALDH6A1, ACADMMore
Ruxolitinibhsa00310Lysine degradation1.59E-077Q9NVH6, Q96KQ7, Q8NEZ4, Q13029, O15047, Q02809, P51648TMLHE, EHMT2, MLL3, PRDM2, SETD1A, PLOD1, ALDH3A2More
Ruxolitinibhsa00330Arginine and proline metabolism1.41E-031P17707AMD1More
Ruxolitinibhsa00350Tyrosine metabolism1.76E-042P28332, P07101ADH6, THMore
Ruxolitinibhsa00380Tryptophan metabolism3.02E-021Q16613AANATMore
Ruxolitinibhsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Ruxolitinibhsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Ruxolitinibhsa00500Starch and sucrose metabolism3.05E-094O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Ruxolitinibhsa00510N-Glycan biosynthesis1.10E-034O94777, P15907, Q9BVK2, Q9NR34DPM2, ST6GAL1, ALG8, MAN1C1More
Ruxolitinibhsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Ruxolitinibhsa00513Various types of N-glycan biosynthesis4.83E-021Q9NR34MAN1C1More
Ruxolitinibhsa00520Amino sugar and nucleotide sugar metabolism2.98E-053Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Ruxolitinibhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Ruxolitinibhsa00562Inositol phosphate metabolism3.19E-056Q9NRR6, P27987, O14732, P19174, P42338, Q02252INPP5E, ITPKB, IMPA2, PLCG1, PIK3CB, ALDH6A1More
Ruxolitinibhsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.28E-032O94777, Q14442DPM2, PIGHMore
Ruxolitinibhsa00564Glycerophospholipid metabolism1.25E-046P48651, Q9Y6K0, P35790, P23743, O14494, Q3LIE5PTDSS1, CEPT1, CHKA, DGKA, PLPP1, ADPRMMore
Ruxolitinibhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Ruxolitinibhsa00590Arachidonic acid metabolism2.48E-033P11712, P09917, P09960CYP2C9, ALOX5, LTA4HMore
Ruxolitinibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Ruxolitinibhsa00600Sphingolipid metabolism2.65E-033Q9BX95, Q06136, P15289SGPP1, FVT1, ARSAMore
Ruxolitinibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.27E-072P06865, O75752HEXA, B3GALNT1More
Ruxolitinibhsa00604Glycosphingolipid biosynthesis - ganglio series2.46E-022P06865, Q9H4F1HEXA, ST6GALNAC4More
Ruxolitinibhsa00620Pyruvate metabolism9.80E-044P40926, P07195, P14550, P11766MDH2, LDHB, AKR1A1, ADH5More
Ruxolitinibhsa00630Glyoxylate and dicarboxylate metabolism1.99E-134P40925, P40926, P05166, P15104MDH1, MDH2, PCCB, GLULMore
Ruxolitinibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Ruxolitinibhsa00670One carbon pool by folate1.09E-063O95954, P04818, Q99707FTCD, TYMS, MTRMore
Ruxolitinibhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Ruxolitinibhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Ruxolitinibhsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Ruxolitinibhsa00770Pantothenate and CoA biosynthesis7.20E-043O95498, Q6ZQY3, Q9NRN7VNN2, GADL1, AASDHPPTMore
Ruxolitinibhsa00785Lipoic acid metabolism4.32E-021Q9Y234LIPT1More
Ruxolitinibhsa00790Folate biosynthesis2.18E-044Q92820, P05186, P07101, P42330GGH, ALPL, TH, AKR1C3More
Ruxolitinibhsa00830Retinol metabolism4.06E-066P00325, P11766, P28332, P00352, Q9BPW9, O75911ADH1B, ADH5, ADH6, ALDH1A1, DHRS9, DHRS3More
Ruxolitinibhsa00860Porphyrin and chlorophyll metabolism1.53E-043P36551, P53004, P30043CPOX, BLVRA, BLVRBMore
Ruxolitinibhsa00900Terpenoid backbone biosynthesis4.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Ruxolitinibhsa00910Nitrogen metabolism1.75E-042P15104, P49448GLUL, GLUD2More
Ruxolitinibhsa00970Aminoacyl-tRNA biosynthesis5.43E-074O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Ruxolitinibhsa00980Metabolism of xenobiotics by cytochrome P4508.40E-043P78417, P28332, P11712GSTO1, ADH6, CYP2C9More
Ruxolitinibhsa00982Drug metabolism - cytochrome P4508.40E-043P11712, P78417, P28332CYP2C9, GSTO1, ADH6More
Ruxolitinibhsa00983Drug metabolism - other enzymes9.69E-085P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Ruxolitinibhsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Ruxolitinibhsa01100Metabolic pathways8.01E-0769Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, Q9UJ14, P30041, P15104, P19367, P42338, Q9Y217, P48426, P27987, Q96DU7, P22557, Q6ZQY3, P32320, Q08828, Q02153, P20839, P22748, P40926, P55809, P06280, O94777, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P15121, P08237, Q86XP1, O95861, Q96RQ9, Q9HCC0, P33121, Q9UHK6, Q86VZ5, Q96G23, P09917, P48651, Q9BVK2, P57054, Q14442, Q9UNP4, Q9H4F1, Q9BX95, Q9BRR6, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P05166, P14927, P12074, P05496, Q99437, O15239, O15047, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GGTL3, PRDX6, GLUL, HK1, PIK3CB, MTMR6, PIP4K2A, ITPKB, ITPKC, ALAS2, GADL1, CDA, ADCY1, GUCY1B3, IMPDH1, CA4, MDH2, OXCT1, GLA, DPM2, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, AKR1B1, PFKM, DGKH, BPNT1, IL4I1, MCCC2, ACSL1, AMACR, SGMS1, LASS2, ALOX5, PTDSS1, ALG8, PIGP, PIGH, ST3GAL5, ST6GALNAC4, SGPP1, ADPGK, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PCCB, UQCRB, COX6A1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHEMore
Ruxolitinibhsa01200Carbon metabolism7.14E-034P51854, P52209, P37837, P60891TKTL1, PGD, TALDO1, PRPS1More
Ruxolitinibhsa01212Fatty acid metabolism4.62E-022P33121, P11310ACSL1, ACADMMore
Ruxolitinibhsa01230Biosynthesis of amino acids1.63E-067P51854, P60891, Q99707, P50213, P05089, P15104, P37837TKTL1, PRPS1, MTR, IDH3A, ARG1, GLUL, TALDO1More
Ruxolitinibhsa01240Biosynthesis of cofactors2.85E-047Q969G6, P13716, P36551, P22557, O60701, P14618, Q9Y234RFK, ALAD, CPOX, ALAS2, UGDH, PKM2, LIPT1More
Ruxolitinibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Ruxolitinibhsa01522Endocrine resistance1.02E-047P04049, Q9UM47, P04637, P42773, P08069, P10415, Q13323RAF1, NOTCH3, TP53, CDKN2C, IGF1R, BCL2, BIKMore
Ruxolitinibhsa01523Antifolate resistance7.21E-075P41439, P41440, Q92820, P04818, P01375FOLR3, SLC19A1, GGH, TYMS, TNFMore
Ruxolitinibhsa01524Platinum drug resistance2.37E-058Q13489, Q14790, P48023, P78417, P40692, P23025, P52701, P31751BIRC3, CASP8, FASLG, GSTO1, MLH1, XPA, MSH6, AKT2More
Ruxolitinibhsa02010ABC transporters2.17E-031Q8IZY2ABCA7More
Ruxolitinibhsa03010Ribosome2.33E-1118P26373, P62753, P42677, P25398, P32969, P62917, P46776, Q9H0U6, Q07020, P62899, P62910, P18077, P61927, Q02878, P36578, P27635, P05386, P23396RPL13, RPS6, RPS27, RPS12, RPL9, RPL8, RPL27A, MRPL18, RPL18, RPL31, RPL32, RPL35A, RPL37, RPL6, RPL4, RPL10, RPLP1, RPS3More
Ruxolitinibhsa03013RNA transport5.82E-2129P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, P47813, O14602, Q14152, P55884, O15371, O75822, P78345, Q9H777, P11940, P20042, Q14240, Q9BZI7, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AX, EIF1AY, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, ELAC1, PABPC1, EIF2S2, EIF4A2, UPF3B, TACC3, EIF2B1, FMR1, FXR1More
Ruxolitinibhsa03015mRNA surveillance pathway4.81E-022Q9BZI7, O94913UPF3B, PCF11More
Ruxolitinibhsa03020RNA polymerase7.29E-084P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Ruxolitinibhsa03040Spliceosome7.19E-1115Q14562, O43143, O60508, P08579, P26368, O75940, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, SMNDC1, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Ruxolitinibhsa03050Proteasome4.83E-021P55036PSMD4More
Ruxolitinibhsa03060Protein export3.67E-094Q15070, P37108, O76094, Q15005OXA1L, SRP14, SRP72, SPCS2More
Ruxolitinibhsa03320PPAR signaling pathway4.33E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Ruxolitinibhsa03410Base excision repair7.59E-031P27695APEX1More
Ruxolitinibhsa03430Mismatch repair4.38E-021P20585MSH3More
Ruxolitinibhsa03450Non-homologous end-joining3.17E-032Q9NP87, P13010POLM, XRCC5More
Ruxolitinibhsa03460Fanconi anemia pathway8.90E-043P40692, O60673, Q9UNA4MLH1, REV3L, POLIMore
Ruxolitinibhsa04010MAPK signaling pathway8.69E-054P04049, P08069, Q9H2K8, Q12933RAF1, IGF1R, TAOK3, TRAF2More
Ruxolitinibhsa04012ErbB signaling pathway3.62E-068Q13153, P16333, Q13191, P17252, P19174, P42338, P01106, P04049PAK1, NCK1, CBLB, PRKCA, PLCG1, PIK3CB, MYC, RAF1More
Ruxolitinibhsa04014Ras signaling pathway8.61E-0715P04049, P31751, P42338, P20827, Q9NRA1, P49767, P08069, Q13009, P17252, P14921, P0DP23, P62873, P63218, P50151, P19174RAF1, AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, IGF1R, TIAM1, PRKCA, ETS1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Ruxolitinibhsa04015Rap1 signaling pathway7.98E-0613P04049, P20827, P49767, P08069, P06213, P11215, Q13009, O00522, P42338, P31751, P0DP23, P17252, P19174RAF1, EFNA1, VEGFC, IGF1R, INSR, ITGAM, TIAM1, KRIT1, PIK3CB, AKT2, CALM1, PRKCA, PLCG1More
Ruxolitinibhsa04020Calcium signaling pathway8.14E-0817P27987, Q96DU7, Q08828, P21796, P45880, Q13557, P17252, P21860, P30679, O15399, P19174, P0DP23, P0DP24, P05141, P51828, P23634, P49767ITPKB, ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, PRKCA, ERBB3, GNA15, GRIN2D, PLCG1, CALM1, CALM2, SLC25A5, ADCY7, ATP2B4, VEGFCMore
Ruxolitinibhsa04022cGMP-PKG signaling pathway1.32E-0712Q02153, P04049, Q99941, P18848, P23634, P31751, Q08828, P51828, P05141, P45880, P0DP24, P0DP23GUCY1B3, RAF1, CREBL1, ATF4, ATP2B4, AKT2, ADCY1, ADCY7, SLC25A5, VDAC2, CALM2, CALM1More
Ruxolitinibhsa04024cAMP signaling pathway6.83E-0713Q08828, P51828, P42338, P31751, P0DP23, P0DP24, P23634, P04049, Q13370, O15399, P25963, Q13009, Q13153ADCY1, ADCY7, PIK3CB, AKT2, CALM1, CALM2, ATP2B4, RAF1, PDE3B, GRIN2D, NFKBIA, TIAM1, PAK1More
Ruxolitinibhsa04060Cytokine-cytokine receptor interaction6.46E-0517P14784, P27930, P14778, P37173, P26842, Q06643, Q13651, Q9HBE5, P78552, P25024, Q9UBD3, P47992, P09341, P19875, P80075, P01730, Q93038IL2RB, IL1R2, IL1R1, TGFBR2, CD27, LTB, IL10RA, IL21R, IL13RA1, CXCR1, XCL2, XCL1, CXCL1, CXCL2, CCL8, CD4, TNFRSF25More
Ruxolitinibhsa04061Viral protein interaction with cytokine and cytokine receptor1.21E-059Q8NHW4, P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCL4L2, CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Ruxolitinibhsa04062Chemokine signaling pathway1.88E-0818P25024, P09341, P47992, Q9UBD3, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q13009, P14598, P42224, P04049, P25963CXCR1, CXCL1, XCL1, XCL2, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, TIAM1, NCF1, STAT1, RAF1, NFKBIAMore
Ruxolitinibhsa04064NF-kappa B signaling pathway4.96E-1825P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P29965, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, CD40LG, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLDMore
Ruxolitinibhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Ruxolitinibhsa04068FoxO signaling pathway4.41E-054P04049, P08069, P48023, Q96BR1RAF1, IGF1R, FASLG, SGK3More
Ruxolitinibhsa04070Phosphatidylinositol signaling system1.56E-0913P19174, P0DP23, Q14643, P42338, O14986, P23743, P49619, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, ITPR1, PIK3CB, PIP5K1B, DGKA, DGKG, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Ruxolitinibhsa04071Sphingolipid signaling pathway3.22E-0914P04049, P17252, P21453, Q9H228, P01375, Q96G23, Q13510, Q13362, Q9BX95, Q16539, P10415, Q9UQC2, Q12933, Q02156RAF1, PRKCA, S1PR1, EDG8, TNF, LASS2, ASAH1, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2, TRAF2, PRKCEMore
Ruxolitinibhsa04072Phospholipase D signaling pathway4.96E-058P04049, P31751, Q9UQC2, O14986, Q15438, Q08828, P51828, Q16760RAF1, AKT2, GAB2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Ruxolitinibhsa04080Neuroactive ligand-receptor interaction8.30E-0815P08311, P28472, P78334, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, Q16581, P30939, P14416, P07550, P35318CTSG, GABRB3, GABRE, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, C3AR1, HTR1F, DRD2, ADRB2, ADMMore
Ruxolitinibhsa04110Cell cycle6.12E-0912Q9UBD5, P30260, P06493, O60566, Q14683, P04637, P49918, P30304, P33981, P42773, P01106, Q13547ORC3, CDC27, CDK1, BUB1B, SMC1A, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Ruxolitinibhsa04114Oocyte meiosis8.69E-1313Q9Y6D9, P51812, Q02750, P0DP24, P0DP23, P16298, Q17RY0, Q08828, P51828, P27348, Q13362, Q14738, P08069MAD1L1, RPS6KA3, MAP2K1, CALM2, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, YWHAQ, PPP2R5C, PPP2R5D, IGF1RMore
Ruxolitinibhsa04115p53 signaling pathway3.63E-036P24522, O15151, Q13315, Q53FA7, O95067, P10415GADD45A, MDM4, ATM, TP53I3, CCNB2, BCL2More
Ruxolitinibhsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Ruxolitinibhsa04136Autophagy - other7.59E-032O94817, Q9H1Y0ATG12, ATG5More
Ruxolitinibhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Ruxolitinibhsa04140Autophagy - animal3.90E-0515P08069, Q9Y4H2, P42338, P31751, P04049, Q7L523, Q9NQL2, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9IGF1R, IRS2, PIK3CB, AKT2, RAF1, RRAGA, RRAGD, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Ruxolitinibhsa04141Protein processing in endoplasmic reticulum4.15E-0613P18848, Q12933, P30101, Q15436, P60604, Q99941, P11142, Q9H3Z4, P07900, P08238, Q9NR31, Q9H173, Q9UNL2ATF4, TRAF2, PDIA3, SEC23A, UBE2G2, CREBL1, HSPA8, DNAJC5, HSP90AA1, HSP90AB1, SAR1A, SIL1, SSR3More
Ruxolitinibhsa04142Lysosome1.89E-0613Q99437, P25774, O14773, P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916, Q04900ATP6V0B, CTSS, TPP1, HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2, CD164More
Ruxolitinibhsa04144Endocytosis2.52E-0719Q13191, P0DMV8, P11142, Q9H444, O43633, O75351, P62491, P25024, Q96B97, P43250, Q6WKZ4, Q15438, Q8WU79, Q14161, P14784, O95219, O75154, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, CHMP2A, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, RAB11FIP1, PSCD1, SMAP1L, GIT2, IL2RB, SNX4, RAB11FIP3, SNX12, SNX5More
Ruxolitinibhsa04145Phagosome1.00E-0715O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSSMore
Ruxolitinibhsa04146Peroxisome1.43E-024O00623, P56589, Q9UKG9, P33121PEX12, PEX3, CROT, ACSL1More
Ruxolitinibhsa04150mTOR signaling pathway1.32E-035P08069, P04049, Q02750, Q9NQL2, P51812IGF1R, RAF1, MAP2K1, RRAGD, RPS6KA3More
Ruxolitinibhsa04151PI3K-Akt signaling pathway1.89E-0834P62753, P42338, P21860, P25116, O43521, P04637, P27348, P20827, P49767, Q13362, P07900, P08238, P62873, P50151, P61952, P16144, O15335, P02452, P24821, Q16363, Q13751, P22105, O60603, P14784, P23458, P01568, Q99941, P18848, P10415, P17252, Q96BR1, O00141, Q6ZUJ8, P56279RPS6, PIK3CB, ERBB3, F2R, BCL2L11, TP53, YWHAQ, EFNA1, VEGFC, PPP2R5C, HSP90AA1, HSP90AB1, GNB1, GNG10, GNG11, ITGB4, CHAD, COL1A1, TNC, LAMA4, LAMB3, TNXB, TLR2, IL2RB, JAK1, IFNA21, CREBL1, ATF4, BCL2, PRKCA, SGK3, SGK, PIK3AP1, TCL1AMore
Ruxolitinibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Ruxolitinibhsa04210Apoptosis5.51E-0412Q13315, P10415, O76075, Q14790, P48023, P24522, Q16548, P43234, P18848, Q14643, P42575, P04049ATM, BCL2, DFFB, CASP8, FASLG, GADD45A, BCL2A1, CTSO, ATF4, ITPR1, CASP2, RAF1More
Ruxolitinibhsa04211Longevity regulating pathway2.60E-046P31751, P08069, Q08828, P51828, P18848, Q96RR4AKT2, IGF1R, ADCY1, ADCY7, ATF4, CAMKK2More
Ruxolitinibhsa04213Longevity regulating pathway - multiple species1.23E-079P31751, P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Ruxolitinibhsa04217Necroptosis2.23E-1225P01375, Q12933, P01568, P23458, P48023, Q13489, Q9NQC7, Q13546, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, P10415, Q13557, Q9H444, O43633, O75351, P45880, Q08752TNF, TRAF2, IFNA21, JAK1, FASLG, BIRC3, CYLD, RIPK1, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, BCL2, CAMK2D, CHMP4B, CHMP2A, VPS4B, VDAC2, PPIDMore
Ruxolitinibhsa04218Cellular senescence1.96E-047P31751, P04049, P30281, P0DP23, P01889, P10321, P12236AKT2, RAF1, CCND3, CALM1, HLA-B, HLA-C, SLC25A6More
Ruxolitinibhsa04260Cardiac muscle contraction4.20E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Ruxolitinibhsa04261Adrenergic signaling in cardiomyocytes2.84E-1117P09493, P67936, P07550, Q08828, P51828, P22694, P31751, Q99941, P18848, Q13362, Q14738, P0DP24, P0DP23, Q13557, P17252, P10415, P23634TPM1, TPM4, ADRB2, ADCY1, ADCY7, PRKACB, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM2, CALM1, CAMK2D, PRKCA, BCL2, ATP2B4More
Ruxolitinibhsa04270Vascular smooth muscle contraction3.12E-0711P24723, Q04759, Q14643, P0DP23, P04049, Q08828, P51828, P22694, P35579, P35749, P35318PRKCH, PRKCQ, ITPR1, CALM1, RAF1, ADCY1, ADCY7, PRKACB, MYH9, MYH11, ADMMore
Ruxolitinibhsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Ruxolitinibhsa04330Notch signaling pathway4.54E-044Q92542, P49768, P46531, Q9UM47NCSTN, PSEN1, NOTCH1, NOTCH3More
Ruxolitinibhsa04340Hedgehog signaling pathway2.00E-045P49841, P17612, P22694, Q13635, P10415GSK3B, PRKACA, PRKACB, PTCH1, BCL2More
Ruxolitinibhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Ruxolitinibhsa04360Axon guidance4.89E-0713P16298, Q05397, P16333, P20827, O95631, P17252, Q13873, P42338, P23528, P04049, P19174, O14639, P24844PPP3CB, PTK2, NCK1, EFNA1, NTN1, PRKCA, BMPR2, PIK3CB, CFL1, RAF1, PLCG1, ABLIM1, MYL9More
Ruxolitinibhsa04370VEGF signaling pathway3.55E-168P19174, P16298, P31751, P42338, P17252, Q05397, Q02750, P04049PLCG1, PPP3CB, AKT2, PIK3CB, PRKCA, PTK2, MAP2K1, RAF1More
Ruxolitinibhsa04371Apelin signaling pathway6.52E-0714P62873, P63218, P50151, P61952, P31751, P04049, Q08828, P51828, Q13370, Q14344, P84022, P62753, P0DP23, P0DP24GNB1, GNG5, GNG10, GNG11, AKT2, RAF1, ADCY1, ADCY7, PDE3B, GNA13, SMAD3, RPS6, CALM1, CALM2More
Ruxolitinibhsa04380Osteoclast differentiation2.23E-0914Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Ruxolitinibhsa04390Hippo signaling pathway3.37E-055O95835, P04628, Q9UJU2, O43623, Q13489LATS1, WNT1, LEF1, SNAI2, BIRC3More
Ruxolitinibhsa04392Hippo signaling pathway - multiple species2.11E-053O95835, Q13153, Q6V0I7LATS1, PAK1, FAT4More
Ruxolitinibhsa04510Focal adhesion1.16E-0413P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, P51636, Q13489, P30281, P04049, P08069, P49767ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, CAV2, BIRC3, CCND3, RAF1, IGF1R, VEGFCMore
Ruxolitinibhsa04512ECM-receptor interaction2.77E-056P02452, P24821, P07359, P26012, P08514, P16070COL1A1, TNC, GP1BA, ITGB8, ITGA2B, CD44More
Ruxolitinibhsa04520Adherens junction1.81E-033Q13485, O43318, P08069SMAD4, MAP3K7, IGF1RMore
Ruxolitinibhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Ruxolitinibhsa04540Gap junction2.36E-067P17252, Q13509, P68371, Q71U36, P04049, Q9NRA1, Q14643PRKCA, TUBB3, TUBB2C, TUBA1A, RAF1, PDGFC, ITPR1More
Ruxolitinibhsa04550Signaling pathways regulating pluripotency of stem cells1.61E-035Q13873, P04049, Q02750, P08069, Q86SE9BMPR2, RAF1, MAP2K1, IGF1R, PCGF5More
Ruxolitinibhsa04610Complement and coagulation cascades1.51E-104P09871, P0C0L4, P20023, P05107C1S, C4A, CR2, ITGB2More
Ruxolitinibhsa04611Platelet activation2.65E-056Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Ruxolitinibhsa04612Antigen processing and presentation1.80E-1613P13765, P48382, P01730, Q14953, P26715, P26717, Q07444, Q13241, O43908, P01732, P30101, P11142, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8A, PDIA3, HSPA8, TNFMore
Ruxolitinibhsa04613Neutrophil extracellular trap formation4.24E-1031P19174, P17252, P04049, P16109, P11215, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P0C0S5, Q6FI13, Q99878, Q93077, P62807, Q16778, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PLCG1, PRKCA, RAF1, SELP, ITGAM, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Ruxolitinibhsa04614Renin-angiotensin system7.48E-034P50052, P15144, P08311, O75787AGTR2, ANPEP, CTSG, ATP6AP2More
Ruxolitinibhsa04620Toll-like receptor signaling pathway2.48E-055Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Ruxolitinibhsa04621NOD-like receptor signaling pathway1.98E-0416P01584, P07900, Q16539, Q14643, P23458, P45880, P10599, Q9H1Y0, P43490, O00463, P10415, P29728, Q05823, P01375, P09341, P12838IL1B, HSP90AA1, MAPK14, ITPR1, JAK1, VDAC2, TXN, ATG5, PBEF1, TRAF5, BCL2, OAS2, RNASEL, TNF, CXCL1, DEFA4More
Ruxolitinibhsa04622RIG-I-like receptor signaling pathway1.29E-075P01568, Q9NQC7, Q13546, Q12933, P10145IFNA21, CYLD, RIPK1, TRAF2, IL8More
Ruxolitinibhsa04623Cytosolic DNA-sensing pathway3.41E-126P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Ruxolitinibhsa04625C-type lectin receptor signaling pathway4.35E-0913Q9ULY5, P04049, Q13153, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, RAF1, PAK1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Ruxolitinibhsa04630JAK-STAT signaling pathway1.01E-048P01106, P31751, P42224, P23458, P14784, P16871, Q13651, P04049MYC, AKT2, STAT1, JAK1, IL2RB, IL7R, IL10RA, RAF1More
Ruxolitinibhsa04640Hematopoietic cell lineage3.29E-1019P13612, P07359, P08514, P14778, P27930, P11215, P15144, P20023, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, GP1BA, ITGA2B, IL1R1, IL1R2, ITGAM, ANPEP, CR2, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Ruxolitinibhsa04650Natural killer cell mediated cytotoxicity3.46E-2820P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13153, Q13241, P26718, O14931, O75015, P26717, Q07444, Q14953, P26715PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, PAK1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KIR2DS5, KLRC1More
Ruxolitinibhsa04657IL-17 signaling pathway3.77E-1015P25963, P07900, P08238, O00463, Q12933, Q07955, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, HSP90AB1, TRAF5, TRAF2, SFRS1, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, S100A9, IL1BMore
Ruxolitinibhsa04658Th1 and Th2 cell differentiation1.01E-3318P25963, Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, Q9UM47, P13765, P23458, Q13761NFKBIA, PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, NOTCH3, HLA-DOB, JAK1, RUNX3More
Ruxolitinibhsa04659Th17 cell differentiation1.57E-2622P25963, Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Ruxolitinibhsa04660T cell receptor signaling pathway1.48E-2519P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, Q13153, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, PAK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Ruxolitinibhsa04662B cell receptor signaling pathway3.04E-1213P31751, P42338, P20023, P60033, P13164, P16298, Q8WV28, P07948, P11912, P21854, Q8N149, Q02750, P04049AKT2, PIK3CB, CR2, CD81, IFITM1, PPP3CB, BLNK, LYN, CD79A, CD72, LILRA2, MAP2K1, RAF1More
Ruxolitinibhsa04664Fc epsilon RI signaling pathway1.80E-1012P01375, P31751, P04141, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P04049, P09917, P20292TNF, AKT2, CSF2, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, RAF1, ALOX5, ALOX5APMore
Ruxolitinibhsa04666Fc gamma R-mediated phagocytosis9.34E-059P08637, O75015, P42338, P19174, P04049, P23528, P06396, P14598, P17252FCGR3A, FCGR3B, PIK3CB, PLCG1, RAF1, CFL1, GSN, NCF1, PRKCAMore
Ruxolitinibhsa04668TNF signaling pathway5.92E-0612P01375, Q12933, O00463, Q16539, Q99941, P18848, P19875, P01584, P20749, P14780, P20333, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, ATF4, CXCL2, IL1B, BCL3, MMP9, TNFRSF1B, BAG4More
Ruxolitinibhsa04672Intestinal immune network for IgA production3.76E-033P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Ruxolitinibhsa04710Circadian rhythm4.86E-021O15516CLOCKMore
Ruxolitinibhsa04713Circadian entrainment6.04E-1013O15399, P0DP23, P0DP24, Q13557, Q02153, P17252, P62873, P63218, P50151, P61952, Q14643, Q08828, P51828GRIN2D, CALM1, CALM2, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG5, GNG10, GNG11, ITPR1, ADCY1, ADCY7More
Ruxolitinibhsa04714Thermogenesis4.42E-024Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Ruxolitinibhsa04720Long-term potentiation4.83E-1212P17252, Q13557, P16298, P0DP23, P0DP24, Q15418, P51812, P18848, Q08828, Q02750, P04049, Q14643PRKCA, CAMK2D, PPP3CB, CALM1, CALM2, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1, RAF1, ITPR1More
Ruxolitinibhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Ruxolitinibhsa04722Neurotrophin signaling pathway1.76E-0610Q05655, P31751, P04049, P49841, O43524, P48023, P52566, P51617, P10415, P0DP23PRKCD, AKT2, RAF1, GSK3B, FOXO3, FASLG, ARHGDIB, IRAK1, BCL2, CALM1More
Ruxolitinibhsa04723Retrograde endocannabinoid signaling1.69E-037Q14643, P17252, P62873, P61952, Q08828, O15239, Q16718ITPR1, PRKCA, GNB1, GNG11, ADCY1, NDUFA1, NDUFA5More
Ruxolitinibhsa04724Glutamatergic synapse3.62E-088O15399, Q08828, P17252, P62873, P63218, P50151, P61952, P15104GRIN2D, ADCY1, PRKCA, GNB1, GNG5, GNG10, GNG11, GLULMore
Ruxolitinibhsa04725Cholinergic synapse8.80E-0914Q08828, P51828, P22694, Q14643, P17252, P62873, P63218, P50151, P61952, P18848, Q13557, P42338, P31751, P10415ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNG5, GNG10, GNG11, ATF4, CAMK2D, PIK3CB, AKT2, BCL2More
Ruxolitinibhsa04726Serotonergic synapse4.22E-047P17252, P62873, P63218, P50151, P33260, P09917, P04049PRKCA, GNB1, GNG5, GNG10, CYP2C18, ALOX5, RAF1More
Ruxolitinibhsa04727GABAergic synapse7.47E-1110Q08828, P51828, P62873, P63218, P50151, P61952, P15104, P46459, Q15111, P17252ADCY1, ADCY7, GNB1, GNG5, GNG10, GNG11, GLUL, NSF, PLCL1, PRKCAMore
Ruxolitinibhsa04728Dopaminergic synapse1.32E-0918Q14643, P17252, P62873, P50151, P61952, P31751, P49841, Q99941, P18848, Q16539, Q13557, P49407, Q13362, Q14738, P0DP23, P0DP24, O15516, P48058ITPR1, PRKCA, GNB1, GNG10, GNG11, AKT2, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, PPP2R5C, PPP2R5D, CALM1, CALM2, CLOCK, GRIA4More
Ruxolitinibhsa04730Long-term depression4.37E-034Q14344, P08069, P04049, P07948GNA13, IGF1R, RAF1, LYNMore
Ruxolitinibhsa04740Olfactory transduction5.99E-065P62873, Q9H255, Q13557, P0DP23, P0DP24GNB1, OR51E2, CAMK2D, CALM1, CALM2More
Ruxolitinibhsa04742Taste transduction2.43E-052P30939, P17612HTR1F, PRKACAMore
Ruxolitinibhsa04744Phototransduction4.87E-123P62873, P0DP23, P0DP24GNB1, CALM1, CALM2More
Ruxolitinibhsa04750Inflammatory mediator regulation of TRP channels5.74E-1014P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP23, P0DP24IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM1, CALM2More
Ruxolitinibhsa04810Regulation of actin cytoskeleton1.78E-026Q13009, P04049, P11215, P16144, P60709, P01042TIAM1, RAF1, ITGAM, ITGB4, ACTB, KNG1More
Ruxolitinibhsa04910Insulin signaling pathway2.40E-053P0DP23, P04049, P31751CALM1, RAF1, AKT2More
Ruxolitinibhsa04911Insulin secretion1.04E-065Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Ruxolitinibhsa04912GnRH signaling pathway5.96E-0712P17252, Q08828, P51828, P18848, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049, P45985PRKCA, ADCY1, ADCY7, ATF4, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1, MAP2K4More
Ruxolitinibhsa04913Ovarian steroidogenesis5.67E-044P42330, P22694, P06213, P08069AKR1C3, PRKACB, INSR, IGF1RMore
Ruxolitinibhsa04914Progesterone-mediated oocyte maturation2.32E-1111P08069, Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750, P04049IGF1R, CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1, RAF1More
Ruxolitinibhsa04915Estrogen signaling pathway3.14E-1016P14780, P22694, P04049, Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, Q14643, P0DP23, P0DP24, Q15788, P10415MMP9, PRKACB, RAF1, CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, ITPR1, CALM1, CALM2, NCOA1, BCL2More
Ruxolitinibhsa04916Melanogenesis7.31E-044P0DP23, Q08828, P51828, P04049CALM1, ADCY1, ADCY7, RAF1More
Ruxolitinibhsa04917Prolactin signaling pathway3.49E-042P31751, P04049AKT2, RAF1More
Ruxolitinibhsa04918Thyroid hormone synthesis7.09E-057P22694, Q08828, Q99941, P18848, Q14643, P02768, P05543PRKACB, ADCY1, CREBL1, ATF4, ITPR1, ALB, SERPINA7More
Ruxolitinibhsa04919Thyroid hormone signaling pathway1.21E-047P19174, P04049, P42224, P60709, Q13547, Q9UM47, P01106PLCG1, RAF1, STAT1, ACTB, HDAC1, NOTCH3, MYCMore
Ruxolitinibhsa04920Adipocytokine signaling pathway4.19E-021P31751AKT2More
Ruxolitinibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Ruxolitinibhsa04922Glucagon signaling pathway3.10E-047P14618, P06737, Q12778, P31751, Q13370, P0DP23, Q14643PKM2, PYGL, FOXO1, AKT2, PDE3B, CALM1, ITPR1More
Ruxolitinibhsa04923Regulation of lipolysis in adipocytes5.39E-064Q08828, P51828, P06213, P31751ADCY1, ADCY7, INSR, AKT2More
Ruxolitinibhsa04924Renin secretion7.70E-095P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Ruxolitinibhsa04925Aldosterone synthesis and secretion8.75E-108Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, Q13557, P23634CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, CAMK2D, ATP2B4More
Ruxolitinibhsa04926Relaxin signaling pathway9.92E-1018P31751, P25963, P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P22694, P49767, P14780, Q08828, P51828, P04049, P17252, P30679, P49407AKT2, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, PRKACB, VEGFC, MMP9, ADCY1, ADCY7, RAF1, PRKCA, GNA15, ARRB1More
Ruxolitinibhsa04927Cortisol synthesis and secretion5.96E-086Q14643, Q99941, P18848, Q08828, P51828, P22694ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACBMore
Ruxolitinibhsa04928Parathyroid hormone synthesis, secretion and action9.56E-036Q14643, P22694, P23771, P04049, P18848, P10415ITPR1, PRKACB, GATA3, RAF1, ATF4, BCL2More
Ruxolitinibhsa04929GnRH secretion6.93E-064P42338, P31751, P49407, P04049PIK3CB, AKT2, ARRB1, RAF1More
Ruxolitinibhsa04930Type II diabetes mellitus6.29E-053P06213, Q05655, Q02156INSR, PRKCD, PRKCEMore
Ruxolitinibhsa04932Non-alcoholic fatty liver disease2.08E-1214P31751, P01375, P49841, Q14790, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, O95298, P19404AKT2, TNF, GSK3B, CASP8, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2, NDUFV2More
Ruxolitinibhsa04933AGE-RAGE signaling pathway in diabetic complications1.26E-037P42224, P10415, P42338, Q12778, P49767, P17252, P19174STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1More
Ruxolitinibhsa04934Cushing syndrome5.10E-076Q99941, P18848, Q08828, P51828, O15169, Q13557CREBL1, ATF4, ADCY1, ADCY7, AXIN1, CAMK2DMore
Ruxolitinibhsa04935Growth hormone synthesis, secretion and action5.87E-046Q08828, P51828, P04049, P18848, P31751, P45985ADCY1, ADCY7, RAF1, ATF4, AKT2, MAP2K4More
Ruxolitinibhsa04940Type I diabetes mellitus7.38E-044P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Ruxolitinibhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Ruxolitinibhsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Ruxolitinibhsa04962Vasopressin-regulated water reabsorption2.95E-043P52566, P62491, P46459ARHGDIB, RAB11A, NSFMore
Ruxolitinibhsa04964Proximal tubule bicarbonate reclamation2.17E-031P00918CA2More
Ruxolitinibhsa04966Collecting duct acid secretion1.26E-043Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Ruxolitinibhsa04970Salivary secretion2.50E-1210P07550, Q08828, P51828, P22694, Q14643, P23634, P0DP23, P0DP24, Q02153, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, ATP2B4, CALM1, CALM2, GUCY1B3, CAMPMore
Ruxolitinibhsa04971Gastric acid secretion3.36E-076Q08828, P51828, P15311, P0DP24, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM2, CALM1, CAMK2DMore
Ruxolitinibhsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Ruxolitinibhsa04973Carbohydrate digestion and absorption2.41E-021P31751AKT2More
Ruxolitinibhsa04974Protein digestion and absorption1.22E-032Q7Z2H8, P02452SLC36A1, COL1A1More
Ruxolitinibhsa04975Fat digestion and absorption4.83E-021O14494PLPP1More
Ruxolitinibhsa04976Bile secretion2.26E-056O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Ruxolitinibhsa04979Cholesterol metabolism1.37E-023P38571, P61916, P45880LIPA, NPC2, VDAC2More
Ruxolitinibhsa05010Alzheimer disease1.66E-0926P49768, Q92542, O15239, Q16718, O95298, P19404, O14521, P05496, P13073, P12074, Q14643, Q00535, O75460, P0DP23, P01584, Q12933, P18848, Q13509, P68371, O15169, P67870, P31751, P05141, Q08752, P28070, P43686PSEN1, NCSTN, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, CDK5, ERN1, CALM1, IL1B, TRAF2, ATF4, TUBB3, TUBB2C, AXIN1, CSNK2B, AKT2, SLC25A5, PPID, PSMB4, PSMC4More
Ruxolitinibhsa05012Parkinson disease3.20E-0622O15239, Q16718, O95298, O14521, P13073, P12074, P05496, P05141, P12236, P60604, O75460, P18848, P28070, P43686, Q14643, P19174, P0DP23, P0DP24, Q13557, Q71U36, Q13509, P68371NDUFA1, NDUFA5, NDUFC2, SDHD, COX4I1, COX6A1, ATP5G1, SLC25A5, SLC25A6, UBE2G2, ERN1, ATF4, PSMB4, PSMC4, ITPR1, PLCG1, CALM1, CALM2, CAMK2D, TUBA1A, TUBB3, TUBB2CMore
Ruxolitinibhsa05014Amyotrophic lateral sclerosis4.18E-025P19404, P12074, O75460, P28070, Q8TEV9NDUFV2, COX6A1, ERN1, PSMB4, SMCR8More
Ruxolitinibhsa05016Huntington disease1.51E-0612O95298, P19404, P13073, P12074, P24928, P30876, P62487, P05141, P45880, O75460, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC2, ERN1, PSMB4, PSMD12More
Ruxolitinibhsa05017Spinocerebellar ataxia1.88E-049Q92915, O75460, Q8TB72, O15399, P42338, P31751, P28070, P05141, P21796FGF14, ERN1, PUM2, GRIN2D, PIK3CB, AKT2, PSMB4, SLC25A5, VDAC1More
Ruxolitinibhsa05020Prion disease4.07E-0825P01584, P46531, P0DMV8, P11142, O15239, Q16718, O95298, O14521, P05496, P13073, P12074, Q92736, Q14643, P18848, P05141, P12236, P28070, P43686, O60282, Q13509, P68371, P67870, Q99941, P14598, Q15080IL1B, NOTCH1, HSPA1A, HSPA8, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX4I1, COX6A1, RYR2, ITPR1, ATF4, SLC25A5, SLC25A6, PSMB4, PSMC4, KIF5C, TUBB3, TUBB2C, CSNK2B, CREBL1, NCF1, NCF4More
Ruxolitinibhsa05022Pathways of neurodegeneration - multiple diseases7.23E-1035Q14643, Q13509, P68371, P67870, P10415, O15239, Q16718, O95298, P19404, O14521, P13073, P12074, P05496, Q06055, Q8TEV9, O75460, P18848, Q12933, Q13561, P05141, P45880, P17252, Q15078, Q00535, O15169, P01584, P49768, Q08752, O15020, P0DP23, P0DP24, Q13557, P62987, P28070, P43686ITPR1, TUBB3, TUBB2C, CSNK2B, BCL2, NDUFA1, NDUFA5, NDUFC2, NDUFV2, SDHD, COX4I1, COX6A1, ATP5G1, ATP5G2, SMCR8, ERN1, ATF4, TRAF2, DCTN2, SLC25A5, VDAC2, PRKCA, CDK5R1, CDK5, AXIN1, IL1B, PSEN1, PPID, SPTBN2, CALM1, CALM2, CAMK2D, UBA52, PSMB4, PSMC4More
Ruxolitinibhsa05030Cocaine addiction5.99E-033Q00535, Q99941, P18848CDK5, CREBL1, ATF4More
Ruxolitinibhsa05031Amphetamine addiction6.41E-067P0DP24, P0DP23, Q13557, P22694, Q99941, P18848, Q13547CALM2, CALM1, CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Ruxolitinibhsa05032Morphine addiction5.66E-058P62873, P63218, P50151, Q13370, P78334, P17252, P32298, P43250GNB1, GNG5, GNG10, PDE3B, GABRE, PRKCA, GRK4, GRK6More
Ruxolitinibhsa05033Nicotine addiction4.01E-021P78334GABREMore
Ruxolitinibhsa05034Alcoholism1.20E-0716P07101, Q99941, P18848, Q13547, P0DP24, Q96RR4, P62873, P61952, P04049, P0C0S5, Q93077, P62807, Q16778, O60814, P84243, P68431TH, CREBL1, ATF4, HDAC1, CALM2, CAMKK2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Ruxolitinibhsa05100Bacterial invasion of epithelial cells3.14E-033Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Ruxolitinibhsa05110Vibrio cholerae infection7.20E-055Q13488, Q99437, P17252, P19174, P17612TCIRG1, ATP6V0B, PRKCA, PLCG1, PRKACAMore
Ruxolitinibhsa05120Epithelial cell signaling in Helicobacter pylori infection1.33E-1213Q16539, P25963, Q13488, Q99437, Q13153, P09341, P19875, P10145, P19174, P25024, P25025, P41240, P07948MAPK14, NFKBIA, TCIRG1, ATP6V0B, PAK1, CXCL1, CXCL2, IL8, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Ruxolitinibhsa05130Pathogenic Escherichia coli infection3.26E-0412Q71U36, P16333, Q13509, P68371, P60709, Q14344, P25963, P04406, P29350, Q15438, P35579, P55061TUBA1A, NCK1, TUBB3, TUBB2C, ACTB, GNA13, NFKBIA, GAPDH, PTPN6, PSCD1, MYH9, TEGTMore
Ruxolitinibhsa05131Shigellosis3.55E-0618Q12933, Q13546, P68431, Q05655, Q02156, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q14247, Q96JJ3, Q05397, Q14643, Q12778, Q13315, P10415, Q08752, P07737TRAF2, RIPK1, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCD, PRKCE, MALT1, RRAGD, UBB, SEPT6, CTTN, ELMO2, PTK2, ITPR1, FOXO1, ATM, BCL2, PPID, PFN1More
Ruxolitinibhsa05132Salmonella infection3.84E-1123P51617, P25963, P08238, P04049, Q9UJU2, P01106, P84095, P60709, O00471, Q13546, Q13489, P10415, P04406, O75369, P07737, O60603, Q9BQS8, Q13561, O60282, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, RAF1, LEF1, MYC, RHOG, ACTB, EXOC5, RIPK1, BIRC3, BCL2, GAPDH, FLNB, PFN1, TLR2, FYCO1, DCTN2, KIF5C, TUBA1A, TUBB3, TUBB2C, VPS41More
Ruxolitinibhsa05133Pertussis1.55E-063P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Ruxolitinibhsa05134Legionellosis3.53E-099P01584, P25963, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, NFKBIA, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Ruxolitinibhsa05135Yersinia infection1.86E-048Q05397, P51812, P06239, P19174, Q02750, P42338, Q96JJ3, P01732PTK2, RPS6KA3, LCK, PLCG1, MAP2K1, PIK3CB, ELMO2, CD8AMore
Ruxolitinibhsa05140Leishmaniasis4.71E-1215P13612, O75015, P14598, P11215, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, Q15080ITGA4, FCGR3B, NCF1, ITGAM, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, NCF4More
Ruxolitinibhsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Ruxolitinibhsa05143African trypanosomiasis5.79E-064P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Ruxolitinibhsa05144Malaria7.87E-1010P60033, P69905, P68871, O60603, P01375, P05107, P35443, P01584, P10145, P26718CD81, HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL1B, IL8, KLRK1More
Ruxolitinibhsa05145Toxoplasmosis1.19E-0310P25963, P10415, Q13489, P42224, P13765, P09917, Q13751, P11142, O60603, P29965NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, ALOX5, LAMB3, HSPA8, TLR2, CD40LGMore
Ruxolitinibhsa05146Amoebiasis5.74E-2014P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Ruxolitinibhsa05150Staphylococcus aureus infection5.41E-0815P09871, P0C0L4, P21730, P21462, O75015, P31995, P13765, P13646, Q14532, P05107, P16109, P59665, P59666, P12838, P49913C1S, C4A, C5AR1, FPR1, FCGR3B, FCGR2C, HLA-DOB, KRT13, KRT32, ITGB2, SELP, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Ruxolitinibhsa05152Tuberculosis4.74E-0714P04049, Q13488, Q99437, P0DP23, P42224, P48382, O60603, P31751, P10415, P13765, P25774, P01568, Q9UDY8, P51617RAF1, TCIRG1, ATP6V0B, CALM1, STAT1, RFX5, TLR2, AKT2, BCL2, HLA-DOB, CTSS, IFNA21, MALT1, IRAK1More
Ruxolitinibhsa05160Hepatitis C1.31E-047Q13546, P01568, P60033, P04049, P49841, P01375, P48023RIPK1, IFNA21, CD81, RAF1, GSK3B, TNF, FASLGMore
Ruxolitinibhsa05161Hepatitis B4.32E-034P04049, Q99941, P18848, P27348RAF1, CREBL1, ATF4, YWHAQMore
Ruxolitinibhsa05162Measles5.20E-046P23458, P31751, P0DMV8, P01584, P67870, Q9NP90JAK1, AKT2, HSPA1A, IL1B, CSNK2B, RAB9BMore
Ruxolitinibhsa05163Human cytomegalovirus infection1.93E-1331P31751, P42338, P04049, P01375, P25963, P62873, P63218, P50151, P61952, Q14643, P0DP23, P0DP24, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, Q99941, P18848, P04637, O00463, P30101, P61769, P01568AKT2, PIK3CB, RAF1, TNF, NFKBIA, GNB1, GNG5, GNG10, GNG11, ITPR1, CALM1, CALM2, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, TRAF5, PDIA3, B2M, IFNA21More
Ruxolitinibhsa05164Influenza A1.49E-026P31751, P01584, P23458, P05141, P04049, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, RAF1, NXF1More
Ruxolitinibhsa05165Human papillomavirus infection7.06E-0517P16144, P02452, P24821, Q16363, Q05086, P30281, Q9UM47, P01568, P42224, P01889, P10321, Q13488, Q99437, Q13362, Q12778, P04628, Q13315ITGB4, COL1A1, TNC, LAMA4, UBE3A, CCND3, NOTCH3, IFNA21, STAT1, HLA-B, HLA-C, TCIRG1, ATP6V0B, PPP2R5C, FOXO1, WNT1, ATMMore
Ruxolitinibhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Ruxolitinibhsa05167Kaposi sarcoma-associated herpesvirus infection7.44E-1121P01568, P31751, P42224, P25963, P42338, P40189, P62873, P62879, P63218, P50151, P19174, P16298, Q14643, P04049, Q02750, P07948, P01106, P04141, P0DP23, P0CG47, Q9UJU2IFNA21, AKT2, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNB2, GNG5, GNG10, PLCG1, PPP3CB, ITPR1, RAF1, MAP2K1, LYN, MYC, CSF2, CALM1, UBB, LEF1More
Ruxolitinibhsa05168Herpes simplex virus 1 infection8.93E-0724O00463, O60603, P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q16629, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, Q9NR11, P17097, P17038, Q03923, P52738, O75820, Q9UDV6, P10415TRAF5, TLR2, NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, SFRS7, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF302, ZNF7, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212, BCL2More
Ruxolitinibhsa05169Epstein-Barr virus infection1.72E-0617P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, P42224, P01375, O60603, P29728, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, STAT1, TNF, TLR2, OAS2, CD3E, CD3G, CD247More
Ruxolitinibhsa05170Human immunodeficiency virus 1 infection1.76E-1224P31751, P42338, P04049, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P17252, P30101, Q14643, P01568, P51617, P25963, O60603, Q13315, P19174, P23528, P10415, Q9Y6Q5, P20333AKT2, PIK3CB, RAF1, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PRKCA, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, ATM, PLCG1, CFL1, BCL2, AP1M2, TNFRSF1BMore
Ruxolitinibhsa05171Coronavirus disease - COVID-194.44E-0824P25963, P42224, P01568, P23396, P62753, P25398, P42677, P36578, Q02878, P62917, P32969, P27635, P26373, Q07020, P46776, P62899, P62910, P18077, P61927, P05386, P40189, P42338, P19174, P17252NFKBIA, STAT1, IFNA21, RPS3, RPS6, RPS12, RPS27, RPL4, RPL6, RPL8, RPL9, RPL10, RPL13, RPL18, RPL27A, RPL31, RPL32, RPL35A, RPL37, RPLP1, IL6ST, PIK3CB, PLCG1, PRKCAMore
Ruxolitinibhsa05200Pathways in cancer1.03E-1237Q13751, P42338, P08238, P42224, P25963, P19174, P01106, Q9UJU2, P17252, P43246, P84022, Q13485, P20585, P52701, P10826, P14923, P30279, P10415, Q13489, Q13077, P49767, P14921, Q12778, P31751, P25116, P62873, P63218, P50151, Q14344, Q9UM47, P78417, O75293, P0DP23, P01568, P14784, P40189, P01042LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MYC, LEF1, PRKCA, MSH2, SMAD3, SMAD4, MSH3, MSH6, RARB, JUP, CCND2, BCL2, BIRC3, TRAF1, VEGFC, ETS1, FOXO1, AKT2, F2R, GNB1, GNG5, GNG10, GNA13, NOTCH3, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6ST, KNG1More
Ruxolitinibhsa05202Transcriptional misregulation in cancer2.15E-1122Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, Q15744, Q16548, Q13077, O15550, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, UTX, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Ruxolitinibhsa05203Viral carcinogenesis8.79E-0615Q12933, Q99941, P18848, P30281, P27348, Q13547, Q15283, P06396, P12814, P01889, P10321, P06493, P62807, Q16778, O60814TRAF2, CREBL1, ATF4, CCND3, YWHAQ, HDAC1, RASA2, GSN, ACTN1, HLA-B, HLA-C, CDK1, HIST1H2BC, HIST2H2BE, H2BC12More
Ruxolitinibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Ruxolitinibhsa05205Proteoglycans in cancer9.53E-0615Q13009, Q12955, O75369, P60709, P04049, P14780, P01106, P01375, P08069, P23588, P19174, Q13635, P22694, P29350, P08962TIAM1, ANK3, FLNB, ACTB, RAF1, MMP9, MYC, TNF, IGF1R, EIF4B, PLCG1, PTCH1, PRKACB, PTPN6, CD63More
Ruxolitinibhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Ruxolitinibhsa05210Colorectal cancer1.47E-049Q9UKG1, Q13485, P43246, P04049, P01106, P52701, P20585, P37173, O75293APPL1, SMAD4, MSH2, RAF1, MYC, MSH6, MSH3, TGFBR2, GADD45BMore
Ruxolitinibhsa05211Renal cell carcinoma5.09E-053Q13153, P31751, P04049PAK1, AKT2, RAF1More
Ruxolitinibhsa05212Pancreatic cancer1.27E-069P42338, P31751, P04049, Q15311, P23458, P42224, P37173, P84022, O75293PIK3CB, AKT2, RAF1, RALBP1, JAK1, STAT1, TGFBR2, SMAD3, GADD45BMore
Ruxolitinibhsa05213Endometrial cancer4.41E-044O15169, P31751, Q02750, P04049AXIN1, AKT2, MAP2K1, RAF1More
Ruxolitinibhsa05214Glioma1.32E-098P08069, P0DP23, P17252, P04049, P42338, P31751, P19174, O75293IGF1R, CALM1, PRKCA, RAF1, PIK3CB, AKT2, PLCG1, GADD45BMore
Ruxolitinibhsa05215Prostate cancer2.34E-045P10415, Q12778, P08069, Q9NRA1, P04049BCL2, FOXO1, IGF1R, PDGFC, RAF1More
Ruxolitinibhsa05217Basal cell carcinoma7.91E-035Q13635, P04628, P49841, Q9UJU2, P24522PTCH1, WNT1, GSK3B, LEF1, GADD45AMore
Ruxolitinibhsa05218Melanoma5.24E-063P08069, P31751, P04049IGF1R, AKT2, RAF1More
Ruxolitinibhsa05219Bladder cancer5.65E-033P14780, P04637, P04049MMP9, TP53, RAF1More
Ruxolitinibhsa05220Chronic myeloid leukemia9.63E-042P31751, P04049AKT2, RAF1More
Ruxolitinibhsa05221Acute myeloid leukemia8.73E-045P31751, P42338, P04049, Q15744, P11215AKT2, PIK3CB, RAF1, CEBPE, ITGAMMore
Ruxolitinibhsa05222Small cell lung cancer1.14E-037P10826, P31751, P42338, Q13751, Q13489, P25963, O75293RARB, AKT2, PIK3CB, LAMB3, BIRC3, NFKBIA, GADD45BMore
Ruxolitinibhsa05223Non-small cell lung cancer1.72E-057P17252, P31751, P42338, P19174, P10826, P04049, O75293PRKCA, AKT2, PIK3CB, PLCG1, RARB, RAF1, GADD45BMore
Ruxolitinibhsa05224Breast cancer2.75E-036P04049, P08069, P49841, Q92837, P04637, P24522RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45AMore
Ruxolitinibhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Ruxolitinibhsa05226Gastric cancer3.48E-044P04049, Q02750, P31751, O15169RAF1, MAP2K1, AKT2, AXIN1More
Ruxolitinibhsa05230Central carbon metabolism in cancer1.12E-032P04049, P31751RAF1, AKT2More
Ruxolitinibhsa05231Choline metabolism in cancer5.13E-0811P04049, P31751, P42338, Q9Y259, P19174, P23743, P49619, Q16760, O14986, O14494, P17252RAF1, AKT2, PIK3CB, CHKB, PLCG1, DGKA, DGKG, DGKD, PIP5K1B, PLPP1, PRKCAMore
Ruxolitinibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer5.46E-1618P25963, P42338, O95267, P19174, P07766, P20963, P09693, P06239, P29350, P04049, P23458, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730NFKBIA, PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, PTPN6, RAF1, JAK1, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Ruxolitinibhsa05310Asthma5.01E-093P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Ruxolitinibhsa05320Autoimmune thyroid disease1.27E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Ruxolitinibhsa05321Inflammatory bowel disease1.03E-188O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21RMore
Ruxolitinibhsa05322Systemic lupus erythematosus1.38E-1017P08637, O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, Q93077, P62807, Q16778, O60814, P68431, P14678, P12814FCGR3A, FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SNRPB, ACTN1More
Ruxolitinibhsa05323Rheumatoid arthritis7.52E-068P01375, Q06643, P13765, Q13488, P10747, P09341, P19875, O60603TNF, LTB, HLA-DOB, TCIRG1, CD28, CXCL1, CXCL2, TLR2More
Ruxolitinibhsa05330Allograft rejection7.88E-055P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Ruxolitinibhsa05332Graft-versus-host disease5.77E-176P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Ruxolitinibhsa05340Primary immunodeficiency2.96E-046P01730, P01732, P11912, Q8WV28, P07766, P06239CD4, CD8A, CD79A, BLNK, CD3E, LCKMore
Ruxolitinibhsa05410Hypertrophic cardiomyopathy3.63E-022P26012, P09493ITGB8, TPM1More
Ruxolitinibhsa05412Arrhythmogenic right ventricular cardiomyopathy2.17E-031P54284CACNB3More
Ruxolitinibhsa05414Dilated cardiomyopathy3.78E-034P54284, P26012, P09493, P26678CACNB3, ITGB8, TPM1, PLNMore
Ruxolitinibhsa05415Diabetic cardiomyopathy4.77E-049P17252, P30405, P14598, Q15080, Q16718, O14521, Q16539, P14780, P37173PRKCA, PPIF, NCF1, NCF4, NDUFA5, SDHD, MAPK14, MMP9, TGFBR2More
Ruxolitinibhsa05416Viral myocarditis2.62E-023P13765, P29965, P10747HLA-DOB, CD40LG, CD28More
Ruxolitinibhsa05418Fluid shear stress and atherosclerosis4.22E-0713Q16539, P31751, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, AKT2, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Ruxolitinib (SDC: 12.57)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P23458JAK1TyrosineNoneprotein kinase JAK1Reported10.55460.921113.1195
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
Q9Y6R4MAP3K4MitogenNoneactivated protein kinase kinase kinase 4Predicted00.35280.24520.1730.8399
Q15418RPS6KA1Ribosomal protein S6 kinase alphaNone1Predicted10.8320.32450.41461.4796
Q15746MYLKMyosin light chain kinase, smooth musclePredicted00.04010.31160.42981.0731
Q9UEE5STK17ASerine/threonineNoneprotein kinase 17APredicted00.35040.337600.8504
P24723PRKCHProtein kinase C eta typePredicted00.19550.32940.20480.9614
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
Q99759MAP3K3MitogenNoneactivated protein kinase kinase kinase 3Predicted00.35450.24520.43781.1055
P51955NEK2Serine/threonineNoneprotein kinase Nek2Predicted00.65990.369201.0684
Q9UEW8STK39STE20/SPS1Nonerelated prolineNonealanineNonerich protein kinasePredicted00.25730.245200.6191
Q96BR1SGK3Serine/threonineNoneprotein kinase Sgk3Predicted00.0260.26840.31140.8612
Q9H2K8TAOK3Serine/threonineNoneprotein kinase TAO3Predicted00.06460.24520.14870.6715
Q9P289STK26Serine/threonineNoneprotein kinase 26Predicted10.02850.262800.5399
Q9NQU5PAK6Serine/threonineNoneprotein kinase PAK 6Predicted00.4090.26690.50031.2386
Q8NI60CABC1Atypical kinase COQ8A, mitochondrialPredicted00.62760.245200.8043
Q9HAZ1CLK4Dual specificity protein kinase CLK4Predicted00.28830.31110.15870.9251
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
Q86Z02HIPK1HomeodomainNoneinteracting protein kinase 1Predicted00.46310.28160.2181.0128
Q05397PTK2Focal adhesion kinase 1Predicted00.21530.58640.97132.2518
P32298GRK4G proteinNonecoupled receptor kinase 4Predicted00.03520.23860.29480.7896
O43283MAP3K13MitogenNoneactivated protein kinase kinase kinase 13Predicted00.45650.24520.14870.8674
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P51817PRKXcAMPNonedependent protein kinase catalytic subunit PRKXPredicted00.40630.276500.7562
O95747OXSR1Serine/threonineNoneprotein kinase OSR1Predicted00.18390.245200.5825
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
O14976GAKCyclinNoneGNoneassociated kinasePredicted10.57280.256200.7989
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q02156PRKCEProtein kinase C epsilon typePredicted00.11750.52870.53771.6539
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q9H422HIPK3HomeodomainNoneinteracting protein kinase 3Predicted00.3650.25080.2180.902
Q00536PCTK1CyclinNonedependent kinase 16Predicted00.27140.25600.6478
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q13557CAMK2DCalcium/calmodulinNonedependent protein kinase type II subunit deltaPredicted00.47780.3060.80951.6604
Q15831STK11Serine/threonineNoneprotein kinase STK11Predicted00.15110.24410.45491.0186
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
Q8IVW4CDKL3CyclinNonedependent kinaseNonelike 3Predicted00.41490.241600.6906
Q13873BMPR2Bone morphogenetic protein receptor typeNone2Predicted10.34760.24520.35481.019
P49336CDK8CyclinNonedependent kinase 8Predicted00.13560.64701.3618
O75460ERN1Serine/threonineNoneprotein kinase/endoribonuclease IRE1Predicted10.68060.29440.5571.4862
P51617IRAK1InterleukinNone1 receptorNoneassociated kinase 1Predicted00.02380.30.94441.5563
P31751AKT2RACNonebeta serine/threonineNoneprotein kinasePredicted00.46620.485612.2044
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
Q16566CAMK4Calcium/calmodulinNonedependent protein kinase type IVPredicted00.07180.24410.61761.1417
P19784CSNK2A2Casein kinase II subunit alpha'Predicted10.09660.32250.52971.2231
P21860ERBB3Receptor tyrosineNoneprotein kinase erbBNone3Predicted00.1260.27290.47881.0876
P07332FESTyrosineNoneprotein kinase Fes/FpsPredicted00.27220.26280.15130.8131
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
Q05655PRKCDProtein kinase C delta typePredicted00.08160.41940.65441.5339
Q16513PKN2Serine/threonineNoneprotein kinase N2Predicted00.04210.27780.33910.9157
Q04759PRKCQProtein kinase C theta typePredicted00.04050.42440.61731.4864
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P22694PRKACBcAMPNonedependent protein kinase catalytic subunit betaPredicted00.37370.298411.7836
Q02750MAP2K1Dual specificity mitogenNoneactivated protein kinase kinase 1Predicted00.3120.512912.1819
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P45985MAP2K4Dual specificity mitogenNoneactivated protein kinase kinase 4Predicted00.42480.24730.74031.4474
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P42681TXKTyrosineNoneprotein kinase TXKPredicted00.28040.30260.19130.9367
Q9Y6E0STK24Serine/threonineNoneprotein kinase 24Predicted00.54580.245200.7634
Q92630DYRK2Dual specificity tyrosineNonephosphorylationNoneregulated kinase 2Predicted00.17790.349400.7877
Q8IVH8MAP4K3MitogenNoneactivated protein kinase kinase kinase kinase 3Predicted00.38330.26730.14870.875
Q13546RIPK1ReceptorNoneinteracting serine/threonineNoneprotein kinase 1Predicted10.51990.41830.8431.9396
Q13523PRPF4BSerine/threonineNoneprotein kinase PRP4 homologPredicted00.13760.245200.5593
P49760CLK2Dual specificity protein kinase CLK2Predicted00.03030.295100.6053
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
O95835LATS1Serine/threonineNoneprotein kinase LATS1Predicted00.43320.24520.02170.7288
O94806PRKD3Serine/threonineNoneprotein kinase D3Predicted00.23120.24340.16920.7715
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
O95271TNKSPoly [ADPNoneribose] polymerase tankyraseNone1Predicted00.10170.222400.4957
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Predicted00.04350.26350.24610.7947
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
O95235KIF20AKinesinNonelike protein KIF20APredicted00.17140.016500.1187
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P25774CTSSCathepsin SPredicted00.31850.49320.51681.6625
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
P11766ADH5Alcohol dehydrogenase classNone3Predicted00.2650.13970.21460.6265
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
Q9GZT9EGLN1Egl nine homolog 1Predicted00.58040.60610.25561.7581
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
JAK1P23458IC500.43
JAK1P23458IC500.6
JAK1P23458IC500.8
JAK1P23458Ki0.09
JAK1P23458Ki0.2
JAK1P23458Ki0.2
JAK1P23458Kd3.4
JAK1P23458Kd>10000