PharmaCoNets of Rufinamide (SPCN: 4.93 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rufinamidehsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Rufinamidehsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Rufinamidehsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Rufinamidehsa04064NF-kappa B signaling pathway1.60E-028P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Rufinamidehsa04071Sphingolipid signaling pathway2.96E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Rufinamidehsa04080Neuroactive ligand-receptor interaction3.22E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1More
Rufinamidehsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Rufinamidehsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Rufinamidehsa04612Antigen processing and presentation3.21E-026P13765, P48382, P26715, P26717, Q13241, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8AMore
Rufinamidehsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Rufinamidehsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Rufinamidehsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Rufinamidehsa04927Cortisol synthesis and secretion8.60E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Rufinamidehsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Rufinamidehsa05202Transcriptional misregulation in cancer1.77E-0211Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Rufinamidehsa05321Inflammatory bowel disease2.29E-024P13765, Q14765, P23771, Q9HBE5HLA-DOB, STAT4, GATA3, IL21RMore
Rufinamidehsa05332Graft-versus-host disease7.89E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More

Community members of Rufinamide (SDC: 2.70)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)