PharmaCoNets of Rucaparib (SPCN: 242.07 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rucaparibhsa00020Citrate cycle (TCA cycle)2.78E-022O75390, P40926CS, MDH2More
Rucaparibhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Rucaparibhsa00040Pentose and glucuronate interconversions3.53E-021O60701UGDHMore
Rucaparibhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Rucaparibhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Rucaparibhsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Rucaparibhsa00310Lysine degradation4.57E-022Q96KQ7, Q02809EHMT2, PLOD1More
Rucaparibhsa00350Tyrosine metabolism3.40E-021P28332ADH6More
Rucaparibhsa00500Starch and sucrose metabolism2.52E-053O43451, P46976, P06737MGAM, GYG1, PYGLMore
Rucaparibhsa00510N-Glycan biosynthesis3.15E-022P15907, Q9NR34ST6GAL1, MAN1C1More
Rucaparibhsa00520Amino sugar and nucleotide sugar metabolism1.59E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Rucaparibhsa00562Inositol phosphate metabolism2.00E-024P27987, P19174, P42338, Q02252ITPKB, PLCG1, PIK3CB, ALDH6A1More
Rucaparibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Rucaparibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Rucaparibhsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Rucaparibhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.10E-032P06865, O75752HEXA, B3GALNT1More
Rucaparibhsa00630Glyoxylate and dicarboxylate metabolism2.39E-073P40925, P40926, P15104MDH1, MDH2, GLULMore
Rucaparibhsa00640Propanoate metabolism3.83E-022Q02252, Q9P2R7ALDH6A1, SUCLA2More
Rucaparibhsa00670One carbon pool by folate3.15E-022O95954, Q99707FTCD, MTRMore
Rucaparibhsa00730Thiamine metabolism1.13E-042P05186, P24666ALPL, ACP1More
Rucaparibhsa00740Riboflavin metabolism4.77E-021P30043BLVRBMore
Rucaparibhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Rucaparibhsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Rucaparibhsa00860Porphyrin and chlorophyll metabolism8.96E-042P36551, P30043CPOX, BLVRBMore
Rucaparibhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Rucaparibhsa00980Metabolism of xenobiotics by cytochrome P4508.40E-043P78417, P28332, P11712GSTO1, ADH6, CYP2C9More
Rucaparibhsa00982Drug metabolism - cytochrome P4508.40E-043P11712, P78417, P28332CYP2C9, GSTO1, ADH6More
Rucaparibhsa01100Metabolic pathways4.43E-0223Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGLMore
Rucaparibhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Rucaparibhsa01240Biosynthesis of cofactors2.05E-022P36551, O60701CPOX, UGDHMore
Rucaparibhsa01523Antifolate resistance1.43E-032Q92820, P04818GGH, TYMSMore
Rucaparibhsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Rucaparibhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Rucaparibhsa03013RNA transport1.47E-1224P62826, O14980, P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, Q14152, O75822, Q13310, P20042, Q14240, Q9BZI7, P23588, Q9Y6A5, Q14232, Q06787, P51114RAN, XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF3A, EIF3J, PABPC4, EIF2S2, EIF4A2, UPF3B, EIF4B, TACC3, EIF2B1, FMR1, FXR1More
Rucaparibhsa03015mRNA surveillance pathway5.50E-036Q9BZI7, Q13310, Q13362, O94913, Q15287, Q9UBU9UPF3B, PABPC4, PPP2R5C, PCF11, RNPS1, NXF1More
Rucaparibhsa03020RNA polymerase6.63E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Rucaparibhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Rucaparibhsa03040Spliceosome2.91E-0612Q14562, O43143, O60508, P17844, P08579, P51991, P61978, Q07955, Q01130, Q13243, P11142, O43447DHX8, DHX15, CDC40, DDX5, SNRPB2, HNRPA3, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8, PPIHMore
Rucaparibhsa03050Proteasome2.26E-022P55036, P28074PSMD4, PSMB5More
Rucaparibhsa03060Protein export2.97E-032P37108, Q15005SRP14, SPCS2More
Rucaparibhsa03410Base excision repair7.59E-031P27695APEX1More
Rucaparibhsa03430Mismatch repair4.38E-021P20585MSH3More
Rucaparibhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Rucaparibhsa04012ErbB signaling pathway2.00E-024P16333, P17252, P19174, P42338NCK1, PRKCA, PLCG1, PIK3CBMore
Rucaparibhsa04014Ras signaling pathway7.71E-0410P42338, P20827, P49767, Q13009, P17252, P14921, P0DP23, P62873, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, PRKCA, ETS1, CALM1, GNB1, GNG10, PLCG1More
Rucaparibhsa04015Rap1 signaling pathway1.42E-0310P20827, P49767, P06213, P11215, Q13009, O00522, P42338, P0DP23, P17252, P19174EFNA1, VEGFC, INSR, ITGAM, TIAM1, KRIT1, PIK3CB, CALM1, PRKCA, PLCG1More
Rucaparibhsa04020Calcium signaling pathway1.06E-0412P27987, Q96DU7, Q08828, Q13557, P17252, O15399, P19174, P61073, P0DP23, P05141, P51828, P49767ITPKB, ITPKC, ADCY1, CAMK2D, PRKCA, GRIN2D, PLCG1, CXCR4, CALM1, SLC25A5, ADCY7, VEGFCMore
Rucaparibhsa04022cGMP-PKG signaling pathway4.38E-036P18848, P31751, Q08828, P51828, P05141, P0DP23ATF4, AKT2, ADCY1, ADCY7, SLC25A5, CALM1More
Rucaparibhsa04024cAMP signaling pathway6.55E-049Q08828, P51828, P42338, P31751, P0DP23, Q13370, O15399, P25963, Q13009ADCY1, ADCY7, PIK3CB, AKT2, CALM1, PDE3B, GRIN2D, NFKBIA, TIAM1More
Rucaparibhsa04060Cytokine-cytokine receptor interaction3.20E-023P37173, P78552, P80075TGFBR2, IL13RA1, CCL8More
Rucaparibhsa04061Viral protein interaction with cytokine and cytokine receptor4.06E-048Q8NHW4, P09341, P19875, P25024, P25025, P61073, Q13651, P14784CCL4L2, CXCL1, CXCL2, CXCR1, CXCR2, CXCR4, IL10RA, IL2RBMore
Rucaparibhsa04062Chemokine signaling pathway7.18E-0414P25024, P25025, P09341, P19875, P42338, P19174, P62873, P63218, P50151, P43250, Q13009, P14598, P42224, P25963CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, TIAM1, NCF1, STAT1, NFKBIAMore
Rucaparibhsa04064NF-kappa B signaling pathway5.45E-1324P10415, Q13489, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, P67870, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, CSNK2B, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Rucaparibhsa04070Phosphatidylinositol signaling system1.32E-0611P19174, P0DP23, P42338, O14986, P23743, Q86XP1, Q16760, P48426, P27987, Q96DU7, P17252PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKB, ITPKC, PRKCAMore
Rucaparibhsa04071Sphingolipid signaling pathway3.10E-038P17252, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2PRKCA, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Rucaparibhsa04072Phospholipase D signaling pathway4.96E-0411P31751, P42338, P43657, P25024, P25025, P19174, O14986, Q15438, Q08828, P51828, Q16760AKT2, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Rucaparibhsa04080Neuroactive ligand-receptor interaction2.54E-027P08311, Q15722, Q9H228, P21462, P21730, Q16581, P35318CTSG, LTB4R, EDG8, FPR1, C5AR1, C3AR1, ADMMore
Rucaparibhsa04110Cell cycle1.97E-057P06493, O60566, O75293, P30304, P33981, P42773, P01106CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYCMore
Rucaparibhsa04114Oocyte meiosis4.34E-0512Q9Y6D9, P51812, Q02750, Q13557, P0DP23, P16298, Q17RY0, Q08828, P51828, P27348, Q13362, Q14738MAD1L1, RPS6KA3, MAP2K1, CAMK2D, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, YWHAQ, PPP2R5C, PPP2R5DMore
Rucaparibhsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Rucaparibhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Rucaparibhsa04140Autophagy - animal5.56E-0310P31751, Q7L523, O75460, P22694, Q14643, P10415, Q9H1Y0, Q04759, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ, TMEM49, SMCR8More
Rucaparibhsa04141Protein processing in endoplasmic reticulum1.91E-036P18848, Q15437, Q99941, P11142, P07900, Q9NR31ATF4, SEC23B, CREBL1, HSPA8, HSP90AA1, SAR1AMore
Rucaparibhsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Rucaparibhsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Rucaparibhsa04145Phagosome3.69E-027O75015, Q15080, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Rucaparibhsa04151PI3K-Akt signaling pathway3.71E-0419P62753, P42338, P27348, P20827, P49767, P07900, P08238, P62873, P50151, P16144, O15335, Q13751, P22105, P14784, P01568, Q99941, P18848, P17252, O00141RPS6, PIK3CB, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, GNB1, GNG10, ITGB4, CHAD, LAMB3, TNXB, IL2RB, IFNA21, CREBL1, ATF4, PRKCA, SGKMore
Rucaparibhsa04211Longevity regulating pathway7.06E-058Q12778, P31751, Q08828, P51828, Q99941, P18848, Q9UEF7, Q96KQ7FOXO1, AKT2, ADCY1, ADCY7, CREBL1, ATF4, KL, EHMT2More
Rucaparibhsa04213Longevity regulating pathway - multiple species3.34E-048P31751, P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547AKT2, PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Rucaparibhsa04217Necroptosis3.61E-0412P01375, P01568, P48023, Q13489, Q13546, P42224, Q14765, P08238, P15104, Q6FI13, Q99878, O43633TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT1, STAT4, HSP90AB1, GLUL, H2AC18; H2AC19, H2AC14, CHMP2AMore
Rucaparibhsa04218Cellular senescence4.79E-024P01106, O75293, P30304, P06493MYC, GADD45B, CDC25A, CDK1More
Rucaparibhsa04260Cardiac muscle contraction4.49E-023P67936, P13073, P12074TPM4, COX4I1, COX6A1More
Rucaparibhsa04261Adrenergic signaling in cardiomyocytes3.90E-069Q08828, P51828, P31751, Q99941, P18848, Q13362, Q14738, P0DP23, Q13557ADCY1, ADCY7, AKT2, CREBL1, ATF4, PPP2R5C, PPP2R5D, CALM1, CAMK2DMore
Rucaparibhsa04270Vascular smooth muscle contraction6.96E-036P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Rucaparibhsa04340Hedgehog signaling pathway1.43E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Rucaparibhsa04360Axon guidance1.16E-047P16333, P20827, O95631, P17252, P42338, P23528, P19174NCK1, EFNA1, NTN1, PRKCA, PIK3CB, CFL1, PLCG1More
Rucaparibhsa04370VEGF signaling pathway2.25E-046P19174, P16298, P42338, P17252, Q05397, Q02750PLCG1, PPP3CB, PIK3CB, PRKCA, PTK2, MAP2K1More
Rucaparibhsa04371Apelin signaling pathway3.94E-024P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Rucaparibhsa04380Osteoclast differentiation5.22E-0614Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPAMore
Rucaparibhsa04510Focal adhesion7.77E-039P16144, O75369, P42338, Q15942, P17252, O15335, Q13751, Q13489, P49767ITGB4, FLNB, PIK3CB, ZYX, PRKCA, CHAD, LAMB3, BIRC3, VEGFCMore
Rucaparibhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Rucaparibhsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Rucaparibhsa04612Antigen processing and presentation3.69E-027P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Rucaparibhsa04613Neutrophil extracellular trap formation5.29E-0520O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Rucaparibhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Rucaparibhsa04620Toll-like receptor signaling pathway4.30E-045Q13546, P01568, P01584, P31751, Q8NHW4RIPK1, IFNA21, IL1B, AKT2, CCL4L2More
Rucaparibhsa04621NOD-like receptor signaling pathway7.00E-0313Q16539, Q14643, P01568, Q13489, P10599, Q9H1Y0, P43490, O00463, P10415, Q13546, P01375, P09341, P12838MAPK14, ITPR1, IFNA21, BIRC3, TXN, ATG5, PBEF1, TRAF5, BCL2, RIPK1, TNF, CXCL1, DEFA4More
Rucaparibhsa04622RIG-I-like receptor signaling pathway2.39E-022P01568, Q13546IFNA21, RIPK1More
Rucaparibhsa04623Cytosolic DNA-sensing pathway3.35E-106P01584, P01568, Q13546, P25963, Q9Y535, Q8NHW4IL1B, IFNA21, RIPK1, NFKBIA, POLR3H, CCL4L2More
Rucaparibhsa04625C-type lectin receptor signaling pathway4.13E-0511Q9ULY5, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14More
Rucaparibhsa04630JAK-STAT signaling pathway4.54E-023P31751, P23458, Q13651AKT2, JAK1, IL10RAMore
Rucaparibhsa04640Hematopoietic cell lineage1.78E-0517P13612, P21926, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, CD9, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Rucaparibhsa04650Natural killer cell mediated cytotoxicity1.95E-0513P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Rucaparibhsa04657IL-17 signaling pathway6.23E-068O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Rucaparibhsa04658Th1 and Th2 cell differentiation6.98E-0915Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P42226, P23771, Q9UL17, P14784, P13765, P23458, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, STAT6, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3More
Rucaparibhsa04659Th17 cell differentiation2.86E-0820P25963, Q04759, Q16539, P19174, P06239, P42224, P42226, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P01584, P08238, P07766, P09693, P20963, P23458NFKBIA, PRKCQ, MAPK14, PLCG1, LCK, STAT1, STAT6, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1More
Rucaparibhsa04660T cell receptor signaling pathway1.24E-0715P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Rucaparibhsa04662B cell receptor signaling pathway1.60E-046P42338, P60033, P13164, P07948, P21854, Q8N149PIK3CB, CD81, IFITM1, LYN, CD72, LILRA2More
Rucaparibhsa04664Fc epsilon RI signaling pathway1.25E-048P01375, Q16539, P42338, P17252, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, PRKCA, GAB2, LYN, PLCG1, ALOX5More
Rucaparibhsa04666Fc gamma R-mediated phagocytosis6.80E-045P42338, P19174, P23528, P14598, P17252PIK3CB, PLCG1, CFL1, NCF1, PRKCAMore
Rucaparibhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Rucaparibhsa04713Circadian entrainment1.43E-037O15399, P0DP23, P17252, P62873, P50151, Q08828, P51828GRIN2D, CALM1, PRKCA, GNB1, GNG10, ADCY1, ADCY7More
Rucaparibhsa04714Thermogenesis6.01E-048Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHDMore
Rucaparibhsa04720Long-term potentiation4.75E-036P16298, P0DP23, P51812, P18848, Q08828, Q02750PPP3CB, CALM1, RPS6KA3, ATF4, ADCY1, MAP2K1More
Rucaparibhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Rucaparibhsa04724Glutamatergic synapse1.44E-046O15399, P17252, P62873, P63218, P50151, P15104GRIN2D, PRKCA, GNB1, GNG5, GNG10, GLULMore
Rucaparibhsa04725Cholinergic synapse1.32E-0610Q08828, P51828, P17252, P62873, P63218, P50151, P18848, Q13557, P42338, P31751ADCY1, ADCY7, PRKCA, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, AKT2More
Rucaparibhsa04726Serotonergic synapse2.54E-025P17252, P62873, P50151, P33260, P09917PRKCA, GNB1, GNG10, CYP2C18, ALOX5More
Rucaparibhsa04727GABAergic synapse5.11E-045P62873, P63218, P50151, P15104, P17252GNB1, GNG5, GNG10, GLUL, PRKCAMore
Rucaparibhsa04728Dopaminergic synapse1.01E-037P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1More
Rucaparibhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Rucaparibhsa04742Taste transduction1.01E-021P30939HTR1FMore
Rucaparibhsa04744Phototransduction1.67E-022P62873, P0DP23GNB1, CALM1More
Rucaparibhsa04750Inflammatory mediator regulation of TRP channels9.35E-0814P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1More
Rucaparibhsa04911Insulin secretion5.68E-075Q08828, P51828, Q99941, P18848, Q13557ADCY1, ADCY7, CREBL1, ATF4, CAMK2DMore
Rucaparibhsa04912GnRH signaling pathway3.12E-0510Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACBMore
Rucaparibhsa04913Ovarian steroidogenesis2.52E-021P06213INSRMore
Rucaparibhsa04914Progesterone-mediated oocyte maturation7.78E-059Q17RY0, P42338, Q13370, Q9UJX4, Q9Y6D9, P30304, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, ANAPC5, MAD1L1, CDC25A, HSP90AB1, RPS6KA3, MAP2K1More
Rucaparibhsa04915Estrogen signaling pathway3.35E-0510Q99941, P18848, Q08828, P51828, P31751, P07900, P0DMV8, P11142, P0DP23, Q15788CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSPA1A, HSPA8, CALM1, NCOA1More
Rucaparibhsa04916Melanogenesis2.05E-034Q13557, P0DP23, Q08828, P51828CAMK2D, CALM1, ADCY1, ADCY7More
Rucaparibhsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Rucaparibhsa04923Regulation of lipolysis in adipocytes6.16E-057Q08828, P51828, P07550, P06213, P42338, Q9Y4H2, P31751ADCY1, ADCY7, ADRB2, INSR, PIK3CB, IRS2, AKT2More
Rucaparibhsa04924Renin secretion3.77E-022Q13370, P0DP23PDE3B, CALM1More
Rucaparibhsa04925Aldosterone synthesis and secretion3.41E-066Q99941, P18848, Q08828, P51828, P0DP23, Q13557CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2DMore
Rucaparibhsa04926Relaxin signaling pathway2.41E-0613P31751, P25963, P42338, P62873, P63218, P50151, Q99941, P18848, P49767, Q08828, P51828, P17252, P49407AKT2, NFKBIA, PIK3CB, GNB1, GNG5, GNG10, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, PRKCA, ARRB1More
Rucaparibhsa04927Cortisol synthesis and secretion1.29E-054Q99941, P18848, Q08828, P51828CREBL1, ATF4, ADCY1, ADCY7More
Rucaparibhsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Rucaparibhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Rucaparibhsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Rucaparibhsa04932Non-alcoholic fatty liver disease5.68E-0914P31751, P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521AKT2, TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Rucaparibhsa04933AGE-RAGE signaling pathway in diabetic complications3.43E-025P42224, P42338, P49767, P17252, P19174STAT1, PIK3CB, VEGFC, PRKCA, PLCG1More
Rucaparibhsa04934Cushing syndrome8.15E-065Q99941, P18848, Q08828, P51828, Q13557CREBL1, ATF4, ADCY1, ADCY7, CAMK2DMore
Rucaparibhsa04935Growth hormone synthesis, secretion and action1.32E-035Q08828, P51828, Q99941, P18848, P31751ADCY1, ADCY7, CREBL1, ATF4, AKT2More
Rucaparibhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Rucaparibhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Rucaparibhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Rucaparibhsa04966Collecting duct acid secretion4.48E-021P00918CA2More
Rucaparibhsa04970Salivary secretion1.89E-033Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Rucaparibhsa04971Gastric acid secretion2.95E-055Q08828, P51828, P15311, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM1, CAMK2DMore
Rucaparibhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Rucaparibhsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Rucaparibhsa04976Bile secretion1.26E-045O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Rucaparibhsa05010Alzheimer disease2.39E-0515O15239, O95298, P05496, P13073, P12074, Q00535, O75460, P0DP23, P01584, O95197, P18848, P67870, P31751, P05141, P28070NDUFA1, NDUFC2, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, RTN3, ATF4, CSNK2B, AKT2, SLC25A5, PSMB4More
Rucaparibhsa05012Parkinson disease1.20E-028O15239, P12074, P05496, P05141, O75460, P18848, P28070, Q13557NDUFA1, COX6A1, ATP5G1, SLC25A5, ERN1, ATF4, PSMB4, CAMK2DMore
Rucaparibhsa05016Huntington disease1.06E-0412O15239, O95298, P13073, P12074, P05496, P24928, P30876, P62487, P05141, O75460, P28070, O00232NDUFA1, NDUFC2, COX4I1, COX6A1, ATP5G1, POLR2A, POLR2B, POLR2G, SLC25A5, ERN1, PSMB4, PSMD12More
Rucaparibhsa05017Spinocerebellar ataxia1.04E-025O75460, P31751, P28070, P28074, P05141ERN1, AKT2, PSMB4, PSMB5, SLC25A5More
Rucaparibhsa05020Prion disease1.75E-0414P01584, P46531, O15239, Q16718, O14521, P05496, P12074, Q92736, P18848, P05141, P28070, O60282, P49841, Q16539IL1B, NOTCH1, NDUFA1, NDUFA5, SDHD, ATP5G1, COX6A1, RYR2, ATF4, SLC25A5, PSMB4, KIF5C, GSK3B, MAPK14More
Rucaparibhsa05022Pathways of neurodegeneration - multiple diseases2.49E-0519P49841, O15239, Q16718, O95298, O14521, P12074, P05496, Q8TEV9, O75460, P18848, Q13561, P05141, Q16539, Q00535, P01584, Q08752, P0DP23, Q13557, P28070GSK3B, NDUFA1, NDUFA5, NDUFC2, SDHD, COX6A1, ATP5G1, SMCR8, ERN1, ATF4, DCTN2, SLC25A5, MAPK14, CDK5, IL1B, PPID, CALM1, CAMK2D, PSMB4More
Rucaparibhsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Rucaparibhsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Rucaparibhsa05032Morphine addiction1.24E-025P62873, P50151, Q13370, P17252, P43250GNB1, GNG10, PDE3B, PRKCA, GRK6More
Rucaparibhsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Rucaparibhsa05100Bacterial invasion of epithelial cells4.54E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Rucaparibhsa05110Vibrio cholerae infection3.15E-023Q13488, P17252, P19174TCIRG1, PRKCA, PLCG1More
Rucaparibhsa05120Epithelial cell signaling in Helicobacter pylori infection1.96E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Rucaparibhsa05131Shigellosis2.93E-026Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q13315RRAGD, UBB, SEPT6, ELMO2, PTK2, ATMMore
Rucaparibhsa05132Salmonella infection1.18E-035O00471, Q13546, Q13489, O60282, P68371EXOC5, RIPK1, BIRC3, KIF5C, TUBB2CMore
Rucaparibhsa05133Pertussis3.51E-021P0C0L4C4AMore
Rucaparibhsa05134Legionellosis8.80E-047P01584, Q9NR31, P11215, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, HSPA1A, HSPA8, CXCL1, CXCL2More
Rucaparibhsa05140Leishmaniasis2.22E-0410P13612, O75015, P23458, P13765, O60603, P01375, P01584, P49006, Q16539, Q15080ITGA4, FCGR3B, JAK1, HLA-DOB, TLR2, TNF, IL1B, MARCKSL1, MAPK14, NCF4More
Rucaparibhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Rucaparibhsa05144Malaria8.73E-046P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Rucaparibhsa05145Toxoplasmosis3.45E-026P25963, Q13489, P42224, P09917, Q13751, P11142NFKBIA, BIRC3, STAT1, ALOX5, LAMB3, HSPA8More
Rucaparibhsa05146Amoebiasis1.56E-0613P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Rucaparibhsa05150Staphylococcus aureus infection3.31E-0412P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, Q14532, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, KRT32, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Rucaparibhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Rucaparibhsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Rucaparibhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Rucaparibhsa05163Human cytomegalovirus infection4.63E-1025P31751, P42338, P01375, P25963, P62873, P50151, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P61073, P17252, Q13651, P25025, Q16539, P18848, P04637, O00463, P30101, P01568AKT2, PIK3CB, TNF, NFKBIA, GNB1, GNG10, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, CXCR4, PRKCA, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5, PDIA3, IFNA21More
Rucaparibhsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Rucaparibhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Rucaparibhsa05167Kaposi sarcoma-associated herpesvirus infection4.56E-039P01568, P42224, P25963, P42338, P40189, P62873, P50151, P19174, P0DP23IFNA21, STAT1, NFKBIA, PIK3CB, IL6ST, GNB1, GNG10, PLCG1, CALM1More
Rucaparibhsa05168Herpes simplex virus 1 infection5.04E-0517P25963, P01568, P42224, Q07955, Q01130, Q13243, Q13489, P30101, P42338, Q9Y2A4, Q13398, P51522, P17038, Q03923, P52738, O75820, Q9UDV6NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF443, ZNF211, ZNF83, ZNF43, ZNF85, ZNF140, ZNF189, ZNF212More
Rucaparibhsa05169Epstein-Barr virus infection6.15E-0317P13765, Q13547, O00463, P16070, P10415, Q16539, P42338, P07948, Q13761, P24522, O75293, Q8WV28, P01375, O60603, P07766, P09693, P20963HLA-DOB, HDAC1, TRAF5, CD44, BCL2, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, BLNK, TNF, TLR2, CD3E, CD3G, CD247More
Rucaparibhsa05170Human immunodeficiency virus 1 infection7.14E-0415P42338, Q02750, P62873, P62879, P50151, P16298, P0DP23, Q05397, P17252, P30101, P01568, P25963, Q13315, P19174, P23528PIK3CB, MAP2K1, GNB1, GNB2, GNG10, PPP3CB, CALM1, PTK2, PRKCA, PDIA3, IFNA21, NFKBIA, ATM, PLCG1, CFL1More
Rucaparibhsa05171Coronavirus disease - COVID-193.30E-027P25963, P42224, P01568, P40189, P42338, P19174, P17252NFKBIA, STAT1, IFNA21, IL6ST, PIK3CB, PLCG1, PRKCAMore
Rucaparibhsa05200Pathways in cancer2.03E-0521Q13751, P42338, P08238, P42224, P25963, P19174, P17252, P43246, P10826, P14923, Q13489, P49767, P14921, P62873, P50151, P78417, O75293, P0DP23, P01568, P14784, P40189LAMB3, PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, PRKCA, MSH2, RARB, JUP, BIRC3, VEGFC, ETS1, GNB1, GNG10, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Rucaparibhsa05202Transcriptional misregulation in cancer1.87E-0620Q15532, Q13315, P17844, P14780, P27930, Q15744, Q16548, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522SS18, ATM, DDX5, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Rucaparibhsa05203Viral carcinogenesis4.63E-049Q99941, P18848, P23458, P27348, Q7KZF4, Q15283, P61978, P62807, O60814CREBL1, ATF4, JAK1, YWHAQ, SND1, RASA2, HNRPK, HIST1H2BC, H2BC12More
Rucaparibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Rucaparibhsa05210Colorectal cancer3.43E-022Q9UKG1, P37173APPL1, TGFBR2More
Rucaparibhsa05212Pancreatic cancer9.49E-046P42338, P31751, Q15311, P23458, P42224, O75293PIK3CB, AKT2, RALBP1, JAK1, STAT1, GADD45BMore
Rucaparibhsa05214Glioma1.31E-045P0DP23, P17252, P42338, P19174, O75293CALM1, PRKCA, PIK3CB, PLCG1, GADD45BMore
Rucaparibhsa05216Thyroid cancer3.80E-022P01106, O75293MYC, GADD45BMore
Rucaparibhsa05217Basal cell carcinoma1.30E-034Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Rucaparibhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Rucaparibhsa05222Small cell lung cancer1.10E-026P10826, P42338, Q13751, Q13489, P25963, O75293RARB, PIK3CB, LAMB3, BIRC3, NFKBIA, GADD45BMore
Rucaparibhsa05223Non-small cell lung cancer2.07E-046P17252, P42338, P19174, P10826, Q9HC35, O75293PRKCA, PIK3CB, PLCG1, RARB, EML4, GADD45BMore
Rucaparibhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Rucaparibhsa05231Choline metabolism in cancer4.50E-048P31751, P42338, Q9Y259, P19174, P23743, Q16760, O14986, P17252AKT2, PIK3CB, CHKB, PLCG1, DGKA, DGKD, PIP5K1B, PRKCAMore
Rucaparibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.52E-0513P42338, O95267, P19174, P07766, P20963, P09693, P06239, P23458, O60603, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, JAK1, TLR2, PRKCQ, MAPK14, EML4, CD4More
Rucaparibhsa05310Asthma1.92E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Rucaparibhsa05321Inflammatory bowel disease4.42E-089O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771, P01584, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3, IL1B, IL21RMore
Rucaparibhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Rucaparibhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Rucaparibhsa05332Graft-versus-host disease2.50E-035P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Rucaparibhsa05340Primary immunodeficiency1.28E-034P01730, P11912, P07766, P06239CD4, CD79A, CD3E, LCKMore
Rucaparibhsa05412Arrhythmogenic right ventricular cardiomyopathy4.48E-021P54284CACNB3More
Rucaparibhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Rucaparibhsa05415Diabetic cardiomyopathy1.46E-036P30405, Q16718, O14521, Q16539, P49841, P37173PPIF, NDUFA5, SDHD, MAPK14, GSK3B, TGFBR2More
Rucaparibhsa05418Fluid shear stress and atherosclerosis1.56E-0512Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Rucaparib (SDC: 9.64)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09874PARP1Poly [ADPNoneribose] polymerase 1Reported10.553610.44822.725
Q9UGN5PARP2Poly [ADPNoneribose] polymerase 2Reported00.04350.26350.24610.7947
O95271TNKSPoly [ADPNoneribose] polymerase tankyraseNone1Predicted00.10170.222400.4957
P30939HTR1F5Nonehydroxytryptamine receptor 1FPredicted00.000910.01982.0202
Q08881ITKTyrosineNoneprotein kinase ITK/TSKPredicted10.16350.55450.4221.6127
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
Q00535CDK5CyclinNonedependentNonelike kinase 5Predicted00.19920.66330.29941.7256
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P37173TGFBR2TGFNonebeta receptor typeNone2Predicted00.28670.3790.87421.7755
P06737PYGLGlycogen phosphorylase, liver formPredicted00.37330.22110.31690.9457
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P52732KIF11KinesinNonelike protein KIF11Predicted00.00820.828101.6602
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q13627DYRK1ADual specificity tyrosineNonephosphorylationNoneregulated kinase 1APredicted00.0150.708201.4239
P49759CLK1Dual specificity protein kinase CLK1Predicted00.29680.45460.15871.2163
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P63279UBE2ISUMONoneconjugating enzyme UBC9Predicted00.23320.05120.49830.7173
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P62942FKBP1APeptidylNoneprolyl cisNonetrans isomerase FKBP1APredicted10.4320.269500.7551
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
P51812RPS6KA3Ribosomal protein S6 kinase alphaNone3Predicted00.28650.39360.41461.345
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
PARP1P09874IC500.8044
PARP1P09874IC502
PARP1P09874IC503.1
PARP1P09874Ki1.4
PARP2Q9UGN5IC5028
PARP2Q9UGN5IC50138