PharmaCoNets of Rosuvastatin (SPCN: 18.05 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rosuvastatinhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Rosuvastatinhsa00564Glycerophospholipid metabolism2.28E-023Q9Y259, P23743, Q3LIE5CHKB, DGKA, ADPRMMore
Rosuvastatinhsa00630Glyoxylate and dicarboxylate metabolism9.21E-032P40925, P15104MDH1, GLULMore
Rosuvastatinhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Rosuvastatinhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Rosuvastatinhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Rosuvastatinhsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Rosuvastatinhsa03040Spliceosome1.08E-027O43143, P08579, Q07955, P84103, Q13243, P11142, O75643DHX15, SNRPB2, SFRS1, SFRS3, SFRS5, HSPA8, ASCC3L1More
Rosuvastatinhsa04012ErbB signaling pathway4.75E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Rosuvastatinhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Rosuvastatinhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Rosuvastatinhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Rosuvastatinhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Rosuvastatinhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Rosuvastatinhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Rosuvastatinhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Rosuvastatinhsa04650Natural killer cell mediated cytotoxicity2.48E-038P19174, P06239, O60880, P20963, P42338, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3More
Rosuvastatinhsa04658Th1 and Th2 cell differentiation1.62E-059Q04759, P07766, P20963, P19174, P06239, P42224, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, STAT1, TBX21, IL2RB, RUNX3More
Rosuvastatinhsa04659Th17 cell differentiation2.08E-0410Q04759, P19174, P06239, P42224, P14784, P14778, Q9UL17, P08238, P07766, P20963PRKCQ, PLCG1, LCK, STAT1, IL2RB, IL1R1, TBX21, HSP90AB1, CD3E, CD247More
Rosuvastatinhsa04660T cell receptor signaling pathway3.37E-038Q04759, P42338, P19174, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, CD3E, CD247, CD8A, CBLB, LCKMore
Rosuvastatinhsa04664Fc epsilon RI signaling pathway4.75E-023P07948, P19174, P09917LYN, PLCG1, ALOX5More
Rosuvastatinhsa04727GABAergic synapse3.40E-023P63218, P50151, P15104GNG5, GNG10, GLULMore
Rosuvastatinhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Rosuvastatinhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Rosuvastatinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Rosuvastatinhsa05034Alcoholism8.66E-036Q13547, P63218, P50151, Q93077, P62807, O60814HDAC1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC12More
Rosuvastatinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Rosuvastatinhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Rosuvastatinhsa05145Toxoplasmosis3.59E-025P42224, P09917, Q13751, P11142, Q13651STAT1, ALOX5, LAMB3, HSPA8, IL10RAMore
Rosuvastatinhsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Rosuvastatinhsa05167Kaposi sarcoma-associated herpesvirus infection3.79E-026P42224, P63218, P50151, P19174, P07948, P01106STAT1, GNG5, GNG10, PLCG1, LYN, MYCMore
Rosuvastatinhsa05169Epstein-Barr virus infection1.43E-028P01106, Q13547, P07948, P30101, Q13761, O75293, P42224, P07766MYC, HDAC1, LYN, PDIA3, RUNX3, GADD45B, STAT1, CD3EMore
Rosuvastatinhsa05200Pathways in cancer5.69E-0314Q13751, P08238, P42224, P19174, P01106, P43246, P20585, Q13547, P49767, P63218, P50151, P78417, O75293, P14784LAMB3, HSP90AB1, STAT1, PLCG1, MYC, MSH2, MSH3, HDAC1, VEGFC, GNG5, GNG10, GSTO1, GADD45B, IL2RBMore
Rosuvastatinhsa05203Viral carcinogenesis4.33E-026P07948, P29083, Q13547, P12814, P62807, O60814LYN, GTF2E1, HDAC1, ACTN1, HIST1H2BC, H2BC12More
Rosuvastatinhsa05206MicroRNAs in cancer3.79E-026P30304, P09493, P01106, Q9Y4H2, Q13547, P19174CDC25A, TPM1, MYC, IRS2, HDAC1, PLCG1More
Rosuvastatinhsa05231Choline metabolism in cancer1.08E-024O15245, Q9Y259, P19174, P23743SLC22A1, CHKB, PLCG1, DGKAMore
Rosuvastatinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore

Community members of Rosuvastatin (SDC: 3.16)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P11215ITGAMIntegrin alphaNoneMPredicted10.18880.01130.8961.013
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)