PharmaCoNets of Rosiglitazone (SPCN: 4.16 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rosiglitazonehsa00061Fatty acid biosynthesis1.52E-031Q9UKU0ACSL6More
Rosiglitazonehsa00071Fatty acid degradation4.55E-031Q9UKU0ACSL6More
Rosiglitazonehsa00280Valine, leucine and isoleucine degradation3.30E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Rosiglitazonehsa00520Amino sugar and nucleotide sugar metabolism7.87E-033Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Rosiglitazonehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Rosiglitazonehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Rosiglitazonehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.30E-032P06865, O75752HEXA, B3GALNT1More
Rosiglitazonehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Rosiglitazonehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Rosiglitazonehsa01212Fatty acid metabolism7.59E-031Q9UKU0ACSL6More
Rosiglitazonehsa03320PPAR signaling pathway4.38E-033Q6PCB7, Q9UKU0, Q9UNU6SLC27A1, ACSL6, CYP8B1More
Rosiglitazonehsa04071Sphingolipid signaling pathway2.08E-026P17252, Q13362, Q9BX95, Q16539, P10415, Q9UQC2PRKCA, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Rosiglitazonehsa04114Oocyte meiosis4.51E-035Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Rosiglitazonehsa04146Peroxisome1.37E-021Q9UKU0ACSL6More
Rosiglitazonehsa04216Ferroptosis1.52E-021Q9UKU0ACSL6More
Rosiglitazonehsa04370VEGF signaling pathway2.47E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Rosiglitazonehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Rosiglitazonehsa04613Neutrophil extracellular trap formation2.30E-0315P17252, O60603, P05164, P08246, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Rosiglitazonehsa04650Natural killer cell mediated cytotoxicity3.08E-023P16298, P50591, Q02750PPP3CB, TNFSF10, MAP2K1More
Rosiglitazonehsa04666Fc gamma R-mediated phagocytosis2.66E-025O75015, P06396, O14494, Q9UQC2, P17252FCGR3B, GSN, PLPP1, GAB2, PRKCAMore
Rosiglitazonehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Rosiglitazonehsa04714Thermogenesis3.64E-021Q9UKU0ACSL6More
Rosiglitazonehsa04720Long-term potentiation2.35E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Rosiglitazonehsa04912GnRH signaling pathway3.30E-024P17252, Q16539, Q9Y6R4, Q14643PRKCA, MAPK14, MAP3K4, ITPR1More
Rosiglitazonehsa04914Progesterone-mediated oocyte maturation7.70E-034Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Rosiglitazonehsa04920Adipocytokine signaling pathway4.85E-033Q9UKU0, Q9Y478, Q96RR4ACSL6, PRKAB1, CAMKK2More
Rosiglitazonehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Rosiglitazonehsa05135Yersinia infection2.58E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Rosiglitazonehsa05170Human immunodeficiency virus 1 infection4.37E-024Q02750, P62879, P16298, Q05397MAP2K1, GNB2, PPP3CB, PTK2More
Rosiglitazonehsa05202Transcriptional misregulation in cancer1.75E-0212Q15532, P14780, P27930, Q16548, Q13489, Q13077, P35226, P05164, P08246, P41182, P68431, P24522SS18, MMP9, IL1R2, BCL2A1, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL6, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, GADD45AMore
Rosiglitazonehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Rosiglitazonehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Rosiglitazonehsa05217Basal cell carcinoma3.30E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Rosiglitazonehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Rosiglitazonehsa05415Diabetic cardiomyopathy3.07E-027P17252, Q15080, Q16718, O14521, Q16539, P49841, P14780PRKCA, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, MMP9More

Community members of Rosiglitazone (SDC: 1.15)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P33121ACSL1LongNonechainNonefattyNoneacidNoneNoneCoA ligase 1Predicted00.03730.01320.27090.3161
Q9UKU0ACSL6LongNonechainNonefattyNoneacidNoneNoneCoA ligase 6Predicted00.45810.01110.27090.5222
P10588NR2F6Nuclear receptor subfamily 2 group F member 6Predicted00.39230.06800.3321
P10826RARBRetinoic acid receptor betaPredicted00.00940.34660.30050.9983
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)