PharmaCoNets of Romidepsin (SPCN: 19.12 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Romidepsinhsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Romidepsinhsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Romidepsinhsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Romidepsinhsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Romidepsinhsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Romidepsinhsa03020RNA polymerase1.81E-021P24928POLR2AMore
Romidepsinhsa04012ErbB signaling pathway3.31E-021Q13153PAK1More
Romidepsinhsa04024cAMP signaling pathway4.80E-021Q13153PAK1More
Romidepsinhsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Romidepsinhsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Romidepsinhsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Romidepsinhsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Romidepsinhsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Romidepsinhsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Romidepsinhsa04392Hippo signaling pathway - multiple species1.51E-021Q13153PAK1More
Romidepsinhsa04625C-type lectin receptor signaling pathway3.31E-021Q13153PAK1More
Romidepsinhsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Romidepsinhsa04650Natural killer cell mediated cytotoxicity2.60E-049P19174, P06239, O60880, P20963, P42338, Q13153, Q13241, P26718, O14931PLCG1, LCK, SH2D1A, CD247, PIK3CB, PAK1, KLRD1, KLRK1, NCR3More
Romidepsinhsa04658Th1 and Th2 cell differentiation2.21E-048Q04759, P07766, P20963, P19174, P06239, Q9UL17, P14784, Q13761PRKCQ, CD3E, CD247, PLCG1, LCK, TBX21, IL2RB, RUNX3More
Romidepsinhsa04659Th17 cell differentiation1.25E-038Q04759, P19174, P06239, P14784, P14778, Q9UL17, P07766, P20963PRKCQ, PLCG1, LCK, IL2RB, IL1R1, TBX21, CD3E, CD247More
Romidepsinhsa04660T cell receptor signaling pathway2.60E-049Q04759, P42338, P19174, Q13153, P07766, P20963, P01732, Q13191, P06239PRKCQ, PIK3CB, PLCG1, PAK1, CD3E, CD247, CD8A, CBLB, LCKMore
Romidepsinhsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Romidepsinhsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Romidepsinhsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Romidepsinhsa05120Epithelial cell signaling in Helicobacter pylori infection2.69E-046Q13153, P09341, P19875, P19174, P25024, P25025PAK1, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Romidepsinhsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Romidepsinhsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Romidepsinhsa05211Renal cell carcinoma2.42E-021Q13153PAK1More
Romidepsinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore

Community members of Romidepsin (SDC: 4.30)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q13547HDAC1Histone deacetylase 1Reported00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Reported10.047310.9863.0097
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
HDAC1Q13547IC500.2
HDAC1Q13547IC500.31
HDAC1Q13547IC501
HDAC2Q92769IC501