PharmaCoNets of Rolitetracycline (SPCN: 36.57 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rolitetracyclinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Rolitetracyclinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Rolitetracyclinehsa00600Sphingolipid metabolism1.34E-022P07602, Q13510PSAP, ASAH1More
Rolitetracyclinehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Rolitetracyclinehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Rolitetracyclinehsa01522Endocrine resistance4.55E-025P14780, P22694, Q9UM47, P10415, Q13323MMP9, PRKACB, NOTCH3, BCL2, BIKMore
Rolitetracyclinehsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Rolitetracyclinehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Rolitetracyclinehsa04020Calcium signaling pathway1.42E-023Q13557, P0DP24, P05141CAMK2D, CALM2, SLC25A5More
Rolitetracyclinehsa04022cGMP-PKG signaling pathway2.24E-023P18848, P05141, P0DP24ATF4, SLC25A5, CALM2More
Rolitetracyclinehsa04064NF-kappa B signaling pathway9.28E-0310P10415, Q13489, P51617, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, P24522BCL2, BIRC3, IRAK1, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, GADD45AMore
Rolitetracyclinehsa04070Phosphatidylinositol signaling system4.48E-022P0DP24, O14986CALM2, PIP5K1BMore
Rolitetracyclinehsa04071Sphingolipid signaling pathway4.78E-058P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Rolitetracyclinehsa04080Neuroactive ligand-receptor interaction4.72E-028P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1More
Rolitetracyclinehsa04114Oocyte meiosis1.67E-023Q13557, P0DP24, Q13362CAMK2D, CALM2, PPP2R5CMore
Rolitetracyclinehsa04140Autophagy - animal4.20E-035P22694, Q14643, P10415, Q9H1Y0, Q04759PRKACB, ITPR1, BCL2, ATG5, PRKCQMore
Rolitetracyclinehsa04142Lysosome2.91E-023Q13510, P07602, P61916ASAH1, PSAP, NPC2More
Rolitetracyclinehsa04145Phagosome1.08E-028O75015, Q15080, P14598, Q13509, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, MPO, TLR2, THBS4, HLA-DOBMore
Rolitetracyclinehsa04218Cellular senescence1.39E-034P0DP24, P01889, P10321, P05141CALM2, HLA-B, HLA-C, SLC25A5More
Rolitetracyclinehsa04261Adrenergic signaling in cardiomyocytes2.17E-034P18848, Q13362, P0DP24, Q13557ATF4, PPP2R5C, CALM2, CAMK2DMore
Rolitetracyclinehsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Rolitetracyclinehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Rolitetracyclinehsa04612Antigen processing and presentation8.65E-0512P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P61769, P01889, P10321, Q06323, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, B2M, HLA-B, HLA-C, PSME1, TNFMore
Rolitetracyclinehsa04613Neutrophil extracellular trap formation1.59E-0520P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Rolitetracyclinehsa04621NOD-like receptor signaling pathway2.62E-0211Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Rolitetracyclinehsa04640Hematopoietic cell lineage3.58E-028P13612, P27930, P15144, P25063, P09693, P01732, P13765, P01375ITGA4, IL1R2, ANPEP, CD24, CD3G, CD8A, HLA-DOB, TNFMore
Rolitetracyclinehsa04650Natural killer cell mediated cytotoxicity6.51E-033Q29983, P10321, P01889MICA, HLA-C, HLA-BMore
Rolitetracyclinehsa04657IL-17 signaling pathway3.91E-027O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Rolitetracyclinehsa04658Th1 and Th2 cell differentiation4.81E-048Q04759, P20963, P09693, Q16539, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, MAPK14, STAT4, GATA3, TBX21, HLA-DOBMore
Rolitetracyclinehsa04660T cell receptor signaling pathway4.04E-0512P01375, Q9UDY8, Q04759, P10747, O95267, Q08881, P20963, P09693, P01732, Q13191, Q16539, P49841TNF, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, MAPK14, GSK3BMore
Rolitetracyclinehsa04666Fc gamma R-mediated phagocytosis3.08E-025O75015, P06396, O14494, P14598, P17252FCGR3B, GSN, PLPP1, NCF1, PRKCAMore
Rolitetracyclinehsa04672Intestinal immune network for IgA production1.66E-023P10747, P13765, P13612CD28, HLA-DOB, ITGA4More
Rolitetracyclinehsa04713Circadian entrainment2.91E-033P0DP24, Q13557, P62873CALM2, CAMK2D, GNB1More
Rolitetracyclinehsa04720Long-term potentiation2.91E-033Q13557, P0DP24, P18848CAMK2D, CALM2, ATF4More
Rolitetracyclinehsa04722Neurotrophin signaling pathway9.93E-033P18848, Q13557, P0DP24ATF4, CAMK2D, CALM2More
Rolitetracyclinehsa04723Retrograde endocannabinoid signaling4.48E-022P48169, P62873GABRA4, GNB1More
Rolitetracyclinehsa04725Cholinergic synapse5.11E-033P62873, P18848, Q13557GNB1, ATF4, CAMK2DMore
Rolitetracyclinehsa04728Dopaminergic synapse6.94E-055P62873, P18848, Q13557, Q13362, P0DP24GNB1, ATF4, CAMK2D, PPP2R5C, CALM2More
Rolitetracyclinehsa04740Olfactory transduction1.10E-043P62873, Q13557, P0DP24GNB1, CAMK2D, CALM2More
Rolitetracyclinehsa04744Phototransduction2.85E-032P62873, P0DP24GNB1, CALM2More
Rolitetracyclinehsa04750Inflammatory mediator regulation of TRP channels4.48E-022Q13557, P0DP24CAMK2D, CALM2More
Rolitetracyclinehsa04911Insulin secretion2.41E-022P18848, Q13557ATF4, CAMK2DMore
Rolitetracyclinehsa04912GnRH signaling pathway5.11E-033P18848, Q13557, P0DP24ATF4, CAMK2D, CALM2More
Rolitetracyclinehsa04915Estrogen signaling pathway2.24E-023P18848, P0DP24, Q15788ATF4, CALM2, NCOA1More
Rolitetracyclinehsa04916Melanogenesis2.41E-022Q13557, P0DP24CAMK2D, CALM2More
Rolitetracyclinehsa04918Thyroid hormone synthesis4.48E-022P18848, P05543ATF4, SERPINA7More
Rolitetracyclinehsa04922Glucagon signaling pathway5.11E-033P18848, P0DP24, Q13557ATF4, CALM2, CAMK2DMore
Rolitetracyclinehsa04924Renin secretion3.64E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Rolitetracyclinehsa04925Aldosterone synthesis and secretion3.91E-033P18848, P0DP24, Q13557ATF4, CALM2, CAMK2DMore
Rolitetracyclinehsa04927Cortisol synthesis and secretion1.66E-023Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Rolitetracyclinehsa04934Cushing syndrome3.73E-022P18848, Q13557ATF4, CAMK2DMore
Rolitetracyclinehsa04940Type I diabetes mellitus1.67E-035P10747, P13765, P01889, P10321, P01375CD28, HLA-DOB, HLA-B, HLA-C, TNFMore
Rolitetracyclinehsa04970Salivary secretion4.92E-024P07550, P22694, Q14643, P49913ADRB2, PRKACB, ITPR1, CAMPMore
Rolitetracyclinehsa04971Gastric acid secretion2.41E-022P0DP24, Q13557CALM2, CAMK2DMore
Rolitetracyclinehsa05012Parkinson disease1.71E-024P05141, P18848, P0DP24, Q13557SLC25A5, ATF4, CALM2, CAMK2DMore
Rolitetracyclinehsa05031Amphetamine addiction1.41E-033P0DP24, Q13557, P18848CALM2, CAMK2D, ATF4More
Rolitetracyclinehsa05032Morphine addiction2.41E-022P62873, P48169GNB1, GABRA4More
Rolitetracyclinehsa05033Nicotine addiction3.19E-021P48169GABRA4More
Rolitetracyclinehsa05034Alcoholism7.15E-057P18848, P0DP24, P62873, Q93077, P62807, O60814, P68431ATF4, CALM2, GNB1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Rolitetracyclinehsa05140Leishmaniasis4.75E-049P13612, O75015, P14598, P13765, O60603, P01375, Q16539, P51617, Q15080ITGA4, FCGR3B, NCF1, HLA-DOB, TLR2, TNF, MAPK14, IRAK1, NCF4More
Rolitetracyclinehsa05144Malaria4.92E-024O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Rolitetracyclinehsa05146Amoebiasis1.70E-037P09341, P27930, P01375, O60603, P05089, P22694, P08311CXCL1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Rolitetracyclinehsa05150Staphylococcus aureus infection1.65E-026P21730, P21462, O75015, P13765, Q16581, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, CAMPMore
Rolitetracyclinehsa05152Tuberculosis8.54E-039O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, P51617FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, IRAK1More
Rolitetracyclinehsa05163Human cytomegalovirus infection2.17E-046P01889, P10321, P62873, P0DP24, P18848, P61769HLA-B, HLA-C, GNB1, CALM2, ATF4, B2MMore
Rolitetracyclinehsa05166Human T-cell leukemia virus 1 infection5.66E-035P01889, P10321, P05141, P18848, P61769HLA-B, HLA-C, SLC25A5, ATF4, B2MMore
Rolitetracyclinehsa05167Kaposi sarcoma-associated herpesvirus infection2.27E-045P01889, P10321, P62873, Q29983, P0DP24HLA-B, HLA-C, GNB1, MICA, CALM2More
Rolitetracyclinehsa05168Herpes simplex virus 1 infection2.09E-024Q9UBU9, P01889, P10321, P61769NXF1, HLA-B, HLA-C, B2MMore
Rolitetracyclinehsa05169Epstein-Barr virus infection3.28E-023P01889, P10321, P61769HLA-B, HLA-C, B2MMore
Rolitetracyclinehsa05170Human immunodeficiency virus 1 infection4.62E-045P01889, P10321, P62873, P0DP24, P61769HLA-B, HLA-C, GNB1, CALM2, B2MMore
Rolitetracyclinehsa05202Transcriptional misregulation in cancer2.97E-0417Q12778, Q15532, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P12980, P24522FOXO1, SS18, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, LYL1, GADD45AMore
Rolitetracyclinehsa05203Viral carcinogenesis2.77E-036P18848, Q15283, P01889, P10321, P62807, O60814ATF4, RASA2, HLA-B, HLA-C, HIST1H2BC, H2BC12More
Rolitetracyclinehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Rolitetracyclinehsa05214Glioma1.85E-022P0DP24, Q13557CALM2, CAMK2DMore
Rolitetracyclinehsa05310Asthma2.84E-053P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Rolitetracyclinehsa05320Autoimmune thyroid disease2.41E-022P01889, P10321HLA-B, HLA-CMore
Rolitetracyclinehsa05321Inflammatory bowel disease3.13E-076O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Rolitetracyclinehsa05322Systemic lupus erythematosus1.24E-0413O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Rolitetracyclinehsa05323Rheumatoid arthritis1.58E-025P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Rolitetracyclinehsa05330Allograft rejection2.41E-022P01889, P10321HLA-B, HLA-CMore
Rolitetracyclinehsa05332Graft-versus-host disease6.35E-067P13765, P01889, P10321, P10747, P01375, P26715, Q13241HLA-DOB, HLA-B, HLA-C, CD28, TNF, KLRC1, KLRD1More
Rolitetracyclinehsa05416Viral myocarditis3.73E-022P01889, P10321HLA-B, HLA-CMore

Community members of Rolitetracycline (SDC: 2.88)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P61769B2MBetaNone2NonemicroglobulinPredicted10.15240.00610.67210.7605
Q9UM07PADI4ProteinNonearginine deiminase typeNone4Predicted10.14880.27780.42671.0567
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P22894MMP8Neutrophil collagenasePredicted10.10610.35700.767
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)