PharmaCoNets of Rolapitant (SPCN: 11.36 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rolapitanthsa00030Pentose phosphate pathway7.84E-032P06744, P37837GPI, TALDO1More
Rolapitanthsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Rolapitanthsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Rolapitanthsa01200Carbon metabolism7.69E-033P06744, P37837, P40926GPI, TALDO1, MDH2More
Rolapitanthsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Rolapitanthsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Rolapitanthsa04014Ras signaling pathway1.74E-023Q15283, P61586, P62873RASA2, RHOA, GNB1More
Rolapitanthsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Rolapitanthsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Rolapitanthsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Rolapitanthsa04613Neutrophil extracellular trap formation4.20E-025P04908, Q93077, P68431, O43315, Q16539H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, AQP9, MAPK14More
Rolapitanthsa04659Th17 cell differentiation3.17E-023P25963, P84022, Q13485NFKBIA, SMAD3, SMAD4More
Rolapitanthsa04710Circadian rhythm2.43E-021O15516CLOCKMore
Rolapitanthsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Rolapitanthsa04723Retrograde endocannabinoid signaling2.68E-022P48169, P62873GABRA4, GNB1More
Rolapitanthsa04727GABAergic synapse3.69E-022P62873, P48169GNB1, GABRA4More
Rolapitanthsa04742Taste transduction4.80E-021P48169GABRA4More
Rolapitanthsa04932Non-alcoholic fatty liver disease3.62E-023P49841, Q16718, O14521GSK3B, NDUFA5, SDHDMore
Rolapitanthsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Rolapitanthsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Rolapitanthsa04976Bile secretion3.32E-022O43315, P08183AQP9, ABCB1More
Rolapitanthsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Rolapitanthsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Rolapitanthsa05032Morphine addiction1.42E-022P62873, P48169GNB1, GABRA4More
Rolapitanthsa05033Nicotine addiction2.43E-021P48169GABRA4More
Rolapitanthsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Rolapitanthsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Rolapitanthsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Rolapitanthsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Rolapitanthsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Rolapitanthsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Rolapitanthsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Rolapitanthsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Rolapitanthsa05414Dilated cardiomyopathy2.68E-022P09493, P26678TPM1, PLNMore
Rolapitanthsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore

Community members of Rolapitant (SDC: 2.98)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P61586RHOATransforming protein RhoAPredicted00.35410.068911.3149
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)