PharmaCoNets of Rizatriptan (SPCN: 168.91 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Rizatriptanhsa00030Pentose phosphate pathway3.06E-043P60891, P51854, P37837PRPS1, TKTL1, TALDO1More
Rizatriptanhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Rizatriptanhsa00190Oxidative phosphorylation2.35E-033Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Rizatriptanhsa00220Arginine biosynthesis3.83E-022P05089, P49448ARG1, GLUD2More
Rizatriptanhsa00230Purine metabolism1.81E-022P20839, Q02153IMPDH1, GUCY1B3More
Rizatriptanhsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Rizatriptanhsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Rizatriptanhsa00340Histidine metabolism4.52E-021O95954FTCDMore
Rizatriptanhsa00500Starch and sucrose metabolism1.83E-064O43451, P46976, P35573, P06737MGAM, GYG1, AGL, PYGLMore
Rizatriptanhsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Rizatriptanhsa00564Glycerophospholipid metabolism9.70E-032Q9Y259, P49619CHKB, DGKGMore
Rizatriptanhsa00565Ether lipid metabolism3.94E-021Q8N661TMEM86BMore
Rizatriptanhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Rizatriptanhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Rizatriptanhsa00630Glyoxylate and dicarboxylate metabolism2.22E-072P40925, P15104MDH1, GLULMore
Rizatriptanhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Rizatriptanhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Rizatriptanhsa00830Retinol metabolism3.93E-023P00352, Q9BPW9, O75911ALDH1A1, DHRS9, DHRS3More
Rizatriptanhsa00970Aminoacyl-tRNA biosynthesis2.41E-043O95363, P54136, P14868FARS2, RARS1, DARSMore
Rizatriptanhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Rizatriptanhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Rizatriptanhsa00983Drug metabolism - other enzymes3.50E-023P04183, P32320, P05164TK1, CDA, MPOMore
Rizatriptanhsa01100Metabolic pathways6.99E-0330Q9NR34, Q9Y259, P05089, P32320, Q13956, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, P49619, O95954, Q9HCC0, P33121, Q02318, P57054, Q9UBX8, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P35573, P06737MAN1C1, CHKB, ARG1, CDA, PDE6H, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, DGKG, FTCD, MCCC2, ACSL1, CYP27A1, PIGP, B4GALT6, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, AGL, PYGLMore
Rizatriptanhsa01200Carbon metabolism4.32E-023P51854, P37837, P60891TKTL1, TALDO1, PRPS1More
Rizatriptanhsa01230Biosynthesis of amino acids2.60E-023P51854, P60891, P37837TKTL1, PRPS1, TALDO1More
Rizatriptanhsa01240Biosynthesis of cofactors2.95E-022P13716, P14618ALAD, PKM2More
Rizatriptanhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Rizatriptanhsa02010ABC transporters2.29E-022P45844, P08183ABCG1, ABCB1More
Rizatriptanhsa03013RNA transport3.98E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Rizatriptanhsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Rizatriptanhsa03022Basal transcription factors2.72E-033O00268, Q12962, Q15544TAF4, TAF10, TAF11More
Rizatriptanhsa03040Spliceosome3.31E-059Q14562, O43143, O60508, P08579, Q07955, Q01130, Q13243, P11142, O43447DHX8, DHX15, CDC40, SNRPB2, SFRS1, SFRS2, SFRS5, HSPA8, PPIHMore
Rizatriptanhsa03050Proteasome4.83E-021P55036PSMD4More
Rizatriptanhsa03060Protein export4.97E-033Q15070, P37108, Q15005OXA1L, SRP14, SPCS2More
Rizatriptanhsa03320PPAR signaling pathway1.24E-033Q13418, Q13133, Q02318ILK, NR1H3, CYP27A1More
Rizatriptanhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Rizatriptanhsa04012ErbB signaling pathway3.15E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Rizatriptanhsa04014Ras signaling pathway8.66E-037Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Rizatriptanhsa04015Rap1 signaling pathway4.78E-025P09603, Q9GZP0, P11215, Q86WV1, P19174CSF1, PDGFD, ITGAM, SKAP1, PLCG1More
Rizatriptanhsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Rizatriptanhsa04060Cytokine-cytokine receptor interaction5.34E-0311P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4More
Rizatriptanhsa04061Viral protein interaction with cytokine and cytokine receptor1.13E-038P09341, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CXCL1, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Rizatriptanhsa04062Chemokine signaling pathway4.01E-0515P25024, P09341, P47992, Q9UBD3, P07948, P19174, P62873, P63218, P50151, P43250, Q08881, Q13009, P14598, P42224, P25963CXCR1, CXCL1, XCL1, XCL2, LYN, PLCG1, GNB1, GNG5, GNG10, GRK6, ITK, TIAM1, NCF1, STAT1, NFKBIAMore
Rizatriptanhsa04064NF-kappa B signaling pathway3.33E-0618P10415, O00463, P14778, P01584, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7BCL2, TRAF5, IL1R1, IL1B, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLDMore
Rizatriptanhsa04070Phosphatidylinositol signaling system3.18E-047P19174, P0DP23, P42338, P23743, Q86XP1, P27987, Q96DU7PLCG1, CALM1, PIK3CB, DGKA, DGKH, ITPKB, ITPKCMore
Rizatriptanhsa04071Sphingolipid signaling pathway1.17E-036P21453, Q9H228, P01375, Q13362, Q9BX95, P10415S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2More
Rizatriptanhsa04080Neuroactive ligand-receptor interaction8.98E-0513P08311, P28472, Q15722, P21453, Q9H228, P43657, O00398, P21462, P21730, Q16581, P14416, P07550, P35318CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY5, P2RY10, FPR1, C5AR1, C3AR1, DRD2, ADRB2, ADMMore
Rizatriptanhsa04110Cell cycle7.40E-057Q9UBD5, P06493, O60566, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Rizatriptanhsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Rizatriptanhsa04120Ubiquitin mediated proteolysis2.51E-036Q14145, Q13042, P62837, Q15751, O95071, P0CG47KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBBMore
Rizatriptanhsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Rizatriptanhsa04141Protein processing in endoplasmic reticulum8.60E-036P30101, P60604, P11142, P08238, Q9H173, Q9UNL2PDIA3, UBE2G2, HSPA8, HSP90AB1, SIL1, SSR3More
Rizatriptanhsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Rizatriptanhsa04144Endocytosis2.54E-0411P0DMV8, Q9H444, O75351, Q9NZZ3, P62491, P42566, P61073, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, CHMP5, RAB11A, EPS15, CXCR4, SH3KBP1, PSCD1, GIT2, SNX12More
Rizatriptanhsa04145Phagosome3.78E-0511P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Rizatriptanhsa04151PI3K-Akt signaling pathway1.27E-029P43657, P01106, P09603, Q9GZP0, P63218, P50151, P13612, Q13751, P14784P2RY5, MYC, CSF1, PDGFD, GNG5, GNG10, ITGA4, LAMB3, IL2RBMore
Rizatriptanhsa04210Apoptosis3.77E-028Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Rizatriptanhsa04213Longevity regulating pathway - multiple species2.98E-033Q08828, P51828, P0DMV8ADCY1, ADCY7, HSPA1AMore
Rizatriptanhsa04217Necroptosis3.67E-0410P01375, P23458, P48023, Q9NQC7, Q14765, P0C0S5, Q99878, Q9H444, Q9NZZ3, O75351TNF, JAK1, FASLG, CYLD, STAT4, H2AFZ, H2AC14, CHMP4B, CHMP5, VPS4BMore
Rizatriptanhsa04261Adrenergic signaling in cardiomyocytes2.95E-024P07550, P22694, P18848, Q13362ADRB2, PRKACB, ATF4, PPP2R5CMore
Rizatriptanhsa04270Vascular smooth muscle contraction5.83E-047P0DP23, P0DP24, Q08828, P51828, P35579, P35749, P35318CALM1, CALM2, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Rizatriptanhsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Rizatriptanhsa04340Hedgehog signaling pathway3.91E-021P17612PRKACAMore
Rizatriptanhsa04360Axon guidance1.71E-024P20827, O95631, P42338, P23528EFNA1, NTN1, PIK3CB, CFL1More
Rizatriptanhsa04371Apelin signaling pathway7.95E-047P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1More
Rizatriptanhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Rizatriptanhsa04512ECM-receptor interaction1.90E-022P26012, P16070ITGB8, CD44More
Rizatriptanhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Rizatriptanhsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Rizatriptanhsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Rizatriptanhsa04612Antigen processing and presentation4.73E-0710P13765, P48382, P01730, Q14953, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Rizatriptanhsa04613Neutrophil extracellular trap formation1.49E-0416O60603, P05164, Q9UM07, Q13547, P04908, Q93077, P62807, O60814, P68431, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, PADI4, HDAC1, H2AC4; H2AC8, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Rizatriptanhsa04623Cytosolic DNA-sensing pathway6.63E-044P01584, P01568, P25963, Q8NHW4IL1B, IFNA21, NFKBIA, CCL4L2More
Rizatriptanhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Rizatriptanhsa04640Hematopoietic cell lineage5.68E-0613P13612, P14778, P27930, P11215, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P09603ITGA4, IL1R1, IL1R2, ITGAM, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, CSF1More
Rizatriptanhsa04650Natural killer cell mediated cytotoxicity3.23E-0711P01375, P06239, O60880, P20963, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Rizatriptanhsa04657IL-17 signaling pathway1.11E-058O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNFMore
Rizatriptanhsa04658Th1 and Th2 cell differentiation2.29E-0812Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Rizatriptanhsa04659Th17 cell differentiation7.80E-0817P25963, Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, P40189, Q9UL17, P23771, P84022, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL6ST, TBX21, GATA3, SMAD3, HSP90AB1, CD3E, CD3G, CD247More
Rizatriptanhsa04660T cell receptor signaling pathway8.91E-049Q04759, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239PRKCQ, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Rizatriptanhsa04662B cell receptor signaling pathway1.60E-046P42338, P60033, P13164, P07948, P21854, Q8N149PIK3CB, CD81, IFITM1, LYN, CD72, LILRA2More
Rizatriptanhsa04664Fc epsilon RI signaling pathway3.90E-068P01375, P04141, Q16539, P42338, Q9UQC2, P07948, P19174, P09917TNF, CSF2, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5More
Rizatriptanhsa04666Fc gamma R-mediated phagocytosis2.25E-036P42338, P23528, P06396, O14494, P14598, P17252PIK3CB, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Rizatriptanhsa04668TNF signaling pathway2.12E-037P01375, O00463, Q16539, P18848, P19875, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9More
Rizatriptanhsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Rizatriptanhsa04713Circadian entrainment2.18E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Rizatriptanhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Rizatriptanhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Rizatriptanhsa04724Glutamatergic synapse2.58E-045O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Rizatriptanhsa04725Cholinergic synapse5.17E-037P22694, Q14643, P63218, P50151, P18848, P42338, P10415PRKACB, ITPR1, GNG5, GNG10, ATF4, PIK3CB, BCL2More
Rizatriptanhsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Rizatriptanhsa04727GABAergic synapse1.66E-044P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Rizatriptanhsa04730Long-term depression4.86E-022Q14344, P07948GNA13, LYNMore
Rizatriptanhsa04740Olfactory transduction2.52E-021Q9H255OR51E2More
Rizatriptanhsa04742Taste transduction7.70E-042P30939, P17612HTR1F, PRKACAMore
Rizatriptanhsa04744Phototransduction2.97E-042P62873, P0DP23GNB1, CALM1More
Rizatriptanhsa04750Inflammatory mediator regulation of TRP channels4.01E-024P01584, Q08828, P51828, P0DP23IL1B, ADCY1, ADCY7, CALM1More
Rizatriptanhsa04913Ovarian steroidogenesis2.54E-022P42330, P22694AKR1C3, PRKACBMore
Rizatriptanhsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Rizatriptanhsa04915Estrogen signaling pathway2.45E-0411P14780, P22694, P18848, Q08828, P51828, P0DMV8, Q14643, P0DP23, P0DP24, Q15788, P10415MMP9, PRKACB, ATF4, ADCY1, ADCY7, HSPA1A, ITPR1, CALM1, CALM2, NCOA1, BCL2More
Rizatriptanhsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Rizatriptanhsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Rizatriptanhsa04922Glucagon signaling pathway4.18E-022P14618, P06737PKM2, PYGLMore
Rizatriptanhsa04924Renin secretion2.98E-034P22694, P07550, Q13370, P0DP23PRKACB, ADRB2, PDE3B, CALM1More
Rizatriptanhsa04926Relaxin signaling pathway3.93E-049P42338, P63218, P50151, P18848, P22694, P49767, P14780, P30679, P49407PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15, ARRB1More
Rizatriptanhsa04927Cortisol synthesis and secretion4.44E-043Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Rizatriptanhsa04928Parathyroid hormone synthesis, secretion and action2.13E-025Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Rizatriptanhsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Rizatriptanhsa04932Non-alcoholic fatty liver disease7.01E-0511P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Rizatriptanhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Rizatriptanhsa04970Salivary secretion2.43E-036P07550, Q08828, P51828, P22694, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMPMore
Rizatriptanhsa04976Bile secretion3.50E-046O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Rizatriptanhsa05012Parkinson disease1.77E-026P60604, P19174, P0DP23, Q71U36, Q13509, P68371UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Rizatriptanhsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Rizatriptanhsa05020Prion disease3.80E-024Q16718, O14521, P49841, Q16539NDUFA5, SDHD, GSK3B, MAPK14More
Rizatriptanhsa05022Pathways of neurodegeneration - multiple diseases1.24E-026P49841, Q16718, O14521, Q13561, Q16539, Q08752GSK3B, NDUFA5, SDHD, DCTN2, MAPK14, PPIDMore
Rizatriptanhsa05031Amphetamine addiction4.32E-023P22694, P18848, Q13547PRKACB, ATF4, HDAC1More
Rizatriptanhsa05032Morphine addiction7.26E-046P62873, P63218, P50151, Q13370, Q07343, P43250GNB1, GNG5, GNG10, PDE3B, PDE4B, GRK6More
Rizatriptanhsa05034Alcoholism4.86E-048P0DP24, Q96RR4, P0C0S5, Q93077, P62807, O60814, P84243, P68431CALM2, CAMKK2, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Rizatriptanhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Rizatriptanhsa05120Epithelial cell signaling in Helicobacter pylori infection3.01E-0610Q16539, P25963, Q13488, Q99437, P09341, P19174, P25024, P25025, P41240, P07948MAPK14, NFKBIA, TCIRG1, ATP6V0B, CXCL1, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Rizatriptanhsa05130Pathogenic Escherichia coli infection3.19E-026Q71U36, P16333, Q13509, P68371, Q14344, P25963TUBA1A, NCK1, TUBB3, TUBB2C, GNA13, NFKBIAMore
Rizatriptanhsa05132Salmonella infection2.66E-0314P51617, P25963, P08238, Q9UJU2, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q71U36, Q13509, P68371, P49754IRAK1, NFKBIA, HSP90AB1, LEF1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBA1A, TUBB3, TUBB2C, VPS41More
Rizatriptanhsa05134Legionellosis3.51E-046P01584, P25963, Q9NR31, P11215, P0DMV8, P11142IL1B, NFKBIA, SAR1A, ITGAM, HSPA1A, HSPA8More
Rizatriptanhsa05140Leishmaniasis4.62E-0411O75015, P14598, P11215, P42224, P13765, O60603, P25963, P01375, P49006, Q16539, Q15080FCGR3B, NCF1, ITGAM, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, MARCKSL1, MAPK14, NCF4More
Rizatriptanhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Rizatriptanhsa05144Malaria1.38E-034O60603, P01375, P35443, P26718TLR2, TNF, THBS4, KLRK1More
Rizatriptanhsa05146Amoebiasis4.74E-0711P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Rizatriptanhsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Rizatriptanhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Rizatriptanhsa05162Measles2.57E-034P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Rizatriptanhsa05163Human cytomegalovirus infection3.80E-0622P01375, P25963, P62873, P63218, P50151, Q14643, P0DP23, Q14344, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463, P30101, P01568TNF, NFKBIA, GNB1, GNG5, GNG10, ITPR1, CALM1, GNA13, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5, PDIA3, IFNA21More
Rizatriptanhsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Rizatriptanhsa05168Herpes simplex virus 1 infection1.60E-0312P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, P42338, Q13398, Q03923, O75820, Q9UDV6NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, PIK3CB, ZNF211, ZNF85, ZNF189, ZNF212More
Rizatriptanhsa05169Epstein-Barr virus infection5.94E-0412P13765, P01106, Q13547, O00463, P42338, P07948, Q13761, P24522, O75293, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, TRAF5, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, CD3E, CD3G, CD247More
Rizatriptanhsa05170Human immunodeficiency virus 1 infection2.58E-0417P62873, P63218, P50151, P0DP23, P17252, O00463, P30101, Q14643, P01568, P51617, P25963, O60603, P19174, P23528, P10415, Q93034, Q9Y6Q5GNB1, GNG5, GNG10, CALM1, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, NFKBIA, TLR2, PLCG1, CFL1, BCL2, CUL5, AP1M2More
Rizatriptanhsa05200Pathways in cancer2.98E-0418P42338, P08238, P42224, P25963, P19174, P43246, P84022, P20585, P14923, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784, P40189PIK3CB, HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, JUP, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RB, IL6STMore
Rizatriptanhsa05202Transcriptional misregulation in cancer2.08E-0316Q12778, Q15532, Q13315, P14780, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Rizatriptanhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Rizatriptanhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Rizatriptanhsa05205Proteoglycans in cancer1.39E-0313Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P01375, P23588, P04628, Q13635, P22694, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, TNF, EIF4B, WNT1, PTCH1, PRKACB, CD63More
Rizatriptanhsa05212Pancreatic cancer2.11E-034P42338, P42224, P84022, O75293PIK3CB, STAT1, SMAD3, GADD45BMore
Rizatriptanhsa05213Endometrial cancer3.60E-021Q13418ILKMore
Rizatriptanhsa05214Glioma2.11E-034P0DP23, P42338, P19174, O75293CALM1, PIK3CB, PLCG1, GADD45BMore
Rizatriptanhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Rizatriptanhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Rizatriptanhsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore
Rizatriptanhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.32E-039O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4More
Rizatriptanhsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Rizatriptanhsa05321Inflammatory bowel disease1.19E-036P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Rizatriptanhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Rizatriptanhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Rizatriptanhsa05332Graft-versus-host disease2.27E-066P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Rizatriptanhsa05340Primary immunodeficiency2.19E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Rizatriptanhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Rizatriptanhsa05418Fluid shear stress and atherosclerosis3.33E-0612Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Rizatriptan (SDC: 8.59)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P30939HTR1F5Nonehydroxytryptamine receptor 1FReported00.000910.01982.0202
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P06239LCKTyrosineNoneprotein kinase LckPredicted00.057610.72872.7575
Q02763TEKAngiopoietinNone1 receptorPredicted00.32060.62360.43041.8379
P07947YES1TyrosineNoneprotein kinase YesPredicted00.12120.43450.1651.0947
Q16539MAPK14MitogenNoneactivated protein kinase 14Predicted10.0149113.0075
P41240CSKTyrosineNoneprotein kinase CSKPredicted00.69860.36260.10231.1768
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
Q13510ASAH1Acid ceramidasePredicted00.40640.04230.28020.568
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
Q2M2I8AAK1AP2Noneassociated protein kinase 1Predicted10.37690.328800.846
Q16769QPCTGlutaminylNonepeptide cyclotransferasePredicted00.02450.241600.4954
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P43250GRK6G proteinNonecoupled receptor kinase 6Predicted10.15470.09550.29480.5632
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
Q13418ILKIntegrinNonelinked protein kinasePredicted00.58850.03880.3940.7658
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)